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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of isotype switching
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Accession:GO:0045829 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: down regulation of isotype switching;   downregulation of isotype switching;   negative regulation of class switch recombination;   negative regulation of class switching;   negative regulation of isotype switch recombination
 narrow_synonym: inhibition of isotype switching


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negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO
IEA		 (PMID:26000965)
GO_REF:0000107		 RGD
Ensembl		 PMID:26000965 GO_REF:0000107 NCBI chr 8:115,989,721...115,995,822
Ensembl chr 8:107,111,012...107,116,782 		JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein involved_in ISO MGI:6723808|MGI:7719862 (PMID:24399151) RGD PMID:24399151 NCBI chr14:20,447,761...20,453,227
Ensembl chr14:20,169,691...20,173,983 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO
IEA		 MGI:103034|MGI:2158438 (PMID:10490661)
GO_REF:0000107		 RGD
Ensembl		 PMID:10490661 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO
IEA		 MGI:3696705 (PMID:16275384)
GO_REF:0000107		 RGD
Ensembl		 PMID:16275384 GO_REF:0000107 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO
IEA		 MGI:3695433 (PMID:17137798)
GO_REF:0000107		 RGD
Ensembl		 PMID:17137798 GO_REF:0000107 NCBI chr18:30,516,931...30,567,199
Ensembl chr18:30,250,613...30,322,311 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    developmental process 7149
      negative regulation of developmental process 1114
        negative regulation of isotype switching 5
          negative regulation of isotype switching to IgA isotypes 1
          negative regulation of isotype switching to IgD isotypes 0
          negative regulation of isotype switching to IgE isotypes 3
          negative regulation of isotype switching to IgG isotypes 0
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        primary metabolic process 10745
          nucleobase-containing compound metabolic process 5888
            nucleic acid metabolic process 5280
              DNA metabolic process 976
                DNA recombination 340
                  somatic cell DNA recombination 80
                    somatic diversification of immune receptors via germline recombination within a single locus 80
                      somatic recombination of immunoglobulin gene segments 68
                        somatic recombination of immunoglobulin genes involved in immune response 60
                          isotype switching 60
                            regulation of isotype switching 42
                              negative regulation of isotype switching 5
                                negative regulation of isotype switching to IgA isotypes 1
                                negative regulation of isotype switching to IgD isotypes 0
                                negative regulation of isotype switching to IgE isotypes 3
                                negative regulation of isotype switching to IgG isotypes 0
paths to the root