Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of innate immune response
go back to main search page
Accession:GO:0045824 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
Synonyms:exact_synonym: down regulation of innate immune response;   downregulation of innate immune response
 narrow_synonym: inhibition of innate immune response


show annotations for term's descendants           Sort by:
negative regulation of innate immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in ISO (PMID:23609450) RGD PMID:23609450 NCBI chr15:86,286,531...86,295,803
Ensembl chr15:79,871,827...79,880,529 		JBrowse link
G Atg12 autophagy related 12 involved_in ISO (PMID:17709747) RGD PMID:17709747 NCBI chr18:41,638,841...41,649,311
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg5 autophagy related 5 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17709747)		 Ensembl
RGD		 PMID:17709747 GO_REF:0000107 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Aurkb aurora kinase B involved_in ISO
IEA		 (PMID:33542149)
GO_REF:0000107		 RGD
Ensembl		 PMID:33542149 GO_REF:0000107 NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Banf1 barrier to autointegration nuclear assembly factor 1 involved_in ISO
IEA		 (PMID:32792394)
GO_REF:0000107		 RGD
Ensembl		 PMID:32792394 GO_REF:0000107 NCBI chr 1:212,101,523...212,103,568
Ensembl chr 1:202,671,305...202,674,188 		JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:9,042,125...9,047,807
Ensembl chr 7:8,391,397...8,396,829 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 involved_in ISO (PMID:15557190) RGD PMID:15557190 NCBI chr 8:132,433,711...132,439,266 JBrowse link
G Cep63 centrosomal protein 63 involved_in ISO
IEA		 (PMID:35793002)
GO_REF:0000107		 RGD
Ensembl		 PMID:35793002 GO_REF:0000107 NCBI chr 8:112,041,586...112,093,061
Ensembl chr 8:103,162,700...103,214,177 		JBrowse link
G Ddx39a DExD-box helicase 39A involved_in ISO
IEA		 (PMID:32393512)
GO_REF:0000107		 RGD
Ensembl		 PMID:32393512 GO_REF:0000107 NCBI chr19:41,323,465...41,331,413
Ensembl chr19:24,418,114...24,426,954 		JBrowse link
G Dhx58 DEXH-box helicase 58 involved_in ISO
IEA		 (PMID:21525357)
GO_REF:0000107		 RGD
Ensembl		 PMID:21525357 GO_REF:0000107 NCBI chr10:86,120,677...86,132,095
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO
IEA		 (PMID:23242137)
GO_REF:0000107		 RGD
Ensembl		 PMID:23242137 GO_REF:0000107 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 involved_in ISO (PMID:27692986), (PMID:35793002) RGD PMID:27692986 PMID:35793002 NCBI chr 1:218,882,391...218,969,837
Ensembl chr 1:209,460,735...209,492,818 		JBrowse link
G Grn granulin precursor involved_in ISS
ISO		 GO_REF:0000024
(PMID:20026663)		 UniProt
RGD		 PMID:20026663 GO_REF:0000024 NCBI chr10:87,887,834...87,893,938
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:22842346) RGD PMID:22842346 NCBI chr10:31,383,801...31,415,334
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in ISO
IEA		 (PMID:12150927)
GO_REF:0000107		 RGD
Ensembl		 PMID:12150927 GO_REF:0000107 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Lyar Ly1 antibody reactive involved_in IEA
ISO		 GO_REF:0000107
(PMID:31413131)		 Ensembl
RGD		 PMID:31413131 GO_REF:0000107 NCBI chr14:76,789,193...76,802,973
Ensembl chr14:72,576,879...72,590,612 		JBrowse link
G Mir181b1 microRNA 181b-1 involved_in ISO ENSEMBL_GeneID:ENSG00000171049 (PMID:25505240) RGD PMID:25505240 NCBI chr13:52,037,228...52,037,337
Ensembl chr13:49,485,688...49,485,797 		JBrowse link
G Mir181b2 microRNA 181b-2 involved_in ISO ENSEMBL_GeneID:ENSG00000171049 (PMID:25505240) RGD PMID:25505240 NCBI chr 3:43,026,666...43,026,753
Ensembl chr 3:22,616,948...22,617,035 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:22286305) RGD PMID:22286305 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO
IEA		 (PMID:23399697)
GO_REF:0000107		 RGD
Ensembl		 PMID:23399697 GO_REF:0000107 NCBI chr 5:155,936,112...155,945,163
Ensembl chr 5:150,652,812...150,661,863 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (PMID:24560620) RGD PMID:24560620 NCBI chr10:12,055,809...12,093,449
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Nlrp4 NLR family, pyrin domain containing 4 involved_in ISO (PMID:27692986) RGD PMID:27692986 NCBI chr 1:77,118,192...77,162,688
Ensembl chr 1:68,089,321...68,127,521 		JBrowse link
G Nlrx1 NLR family member X1 acts_upstream_of_or_within ISO
IEA		 MGI:5141085 (PMID:21703540)
GO_REF:0000107		 RGD
Ensembl		 PMID:21703540 GO_REF:0000107 NCBI chr 8:53,486,866...53,503,498
Ensembl chr 8:44,590,048...44,606,484 		JBrowse link
G Nmi N-myc (and STAT) interactor involved_in
acts_upstream_of_or_within		 ISO (PMID:26342464)
(PMID:23956435)		 RGD PMID:23956435 PMID:26342464 NCBI chr 3:56,824,778...56,848,891
Ensembl chr 3:36,415,607...36,439,498 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:35460603)
(PMID:32844745), (PMID:35460603)		 UniProt
Ensembl
RGD		 PMID:32844745 PMID:35460603 GO_REF:0000024 GO_REF:0000107 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:37797010)		 UniProt
Ensembl
RGD		 PMID:37797010 GO_REF:0000024 GO_REF:0000107 NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,554,921...7,559,174 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in ISO
IEA		 (PMID:34811497)
GO_REF:0000107		 RGD
Ensembl		 PMID:34811497 GO_REF:0000107 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Sfn stratifin involved_in ISO (PMID:37797010) RGD PMID:37797010 NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO
IEA		 (PMID:23609450)
GO_REF:0000107		 RGD
Ensembl		 PMID:23609450 GO_REF:0000107 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Trafd1 TRAF type zinc finger domain containing 1 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:18849341)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:18849341 GO_REF:0000024 GO_REF:0000033 NCBI chr12:40,826,251...40,840,169
Ensembl chr12:35,165,606...35,179,525 		JBrowse link
G Trex1 three prime repair exonuclease 1 involved_in ISO
IEA		 (PMID:33476576)
GO_REF:0000107		 RGD
Ensembl		 PMID:33476576 GO_REF:0000107 NCBI chr 8:118,585,082...118,586,382
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Trim21 tripartite motif-containing 21 involved_in ISO
IEA		 (PMID:26342464)
GO_REF:0000107		 RGD
Ensembl		 PMID:26342464 GO_REF:0000107 NCBI chr 1:166,376,829...166,399,441
Ensembl chr 1:156,964,913...156,987,440 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase involved_in ISS
ISO
IEA		 GO_REF:0000024
UniProtKB:Q00993|UniProtKB:Q60805 (PMID:18083102)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:18083102 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:127,231,468...127,254,806
Ensembl chr 3:106,777,635...106,797,142 		JBrowse link
G Usp38 ubiquitin specific peptidase 38 involved_in ISO
IEA		 (PMID:27692986)
GO_REF:0000107		 RGD
Ensembl		 PMID:27692986 GO_REF:0000107 NCBI chr19:43,910,459...43,941,875
Ensembl chr19:27,006,046...27,037,437 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta involved_in ISO
IEA		 (PMID:35662396)
GO_REF:0000107		 RGD
Ensembl		 PMID:35662396 GO_REF:0000107 NCBI chr 7:69,826,404...69,848,702
Ensembl chr 7:67,940,017...67,963,668 		JBrowse link
G Zdhhc18 zinc finger DHHC-type palmitoyltransferase 18 involved_in ISO
IEA
ISS		 (PMID:35438208)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:35438208 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:151,105,303...151,143,843
Ensembl chr 5:145,831,446...145,859,993 		JBrowse link
negative regulation of antifungal innate immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fam3a FAM3 metabolism regulating signaling molecule A involved_in ISO
IEA		 (PMID:18212107)
GO_REF:0000107		 RGD
Ensembl		 PMID:18212107 GO_REF:0000107 NCBI chr  X:157,317,993...157,326,640
Ensembl chr  X:152,165,535...152,175,362 		JBrowse link
G Usp15 ubiquitin specific peptidase 15 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:33093067)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:33093067 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:60,643,611...60,805,137
Ensembl chr 7:58,756,872...58,848,721 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) RGD PMID:9029106 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) RGD PMID:23482636 NCBI chr13:96,982,867...97,109,419
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO
IBA		 UniProtKB:P01024 (PMID:17051150)
GO_REF:0000033		 RGD
GO_Central		 PMID:17051150 GO_REF:0000033 NCBI chr  X:65,154,422...65,179,708
Ensembl chr  X:61,144,928...61,170,212 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO (PMID:12538697) RGD PMID:12538697 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Serping1 serpin family G member 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:10946292)		 UniProt
Ensembl
RGD		 PMID:10946292 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
negative regulation of natural killer cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd96 CD96 molecule acts_upstream_of_or_within ISO MGI:5617136 (PMID:24658051) RGD PMID:24658051 NCBI chr11:68,164,926...68,239,266
Ensembl chr11:54,702,290...54,776,621 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,407,880...3,484,130 JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) RGD PMID:23408620 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,407,880...3,484,130 JBrowse link
negative regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO (PMID:18604210) RGD PMID:18604210 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Clec12b C-type lectin domain family 12, member B involved_in ISO (PMID:17562706) RGD PMID:17562706 NCBI chr 4:164,512,893...164,529,846
Ensembl chr 4:162,827,462...162,838,946 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein IMP RGD PMID:18835194 RGD:11568650 NCBI chr10:61,028,736...61,054,971
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration IDA RGD PMID:9021955 RGD:9685777 NCBI chr10:14,223,023...14,225,736
Ensembl chr10:13,718,489...13,720,869 		JBrowse link
G Grb2 growth factor receptor bound protein 2 involved_in ISO
IEA		 (PMID:25870599)
GO_REF:0000107		 RGD
Ensembl		 PMID:25870599 GO_REF:0000107 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Igf2 insulin-like growth factor 2 IDA RGD PMID:9021955 RGD:9685777 NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in ISO
IEA		 (PMID:23154388)
GO_REF:0000107		 RGD
Ensembl		 PMID:23154388 GO_REF:0000107 NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Klrc1 killer cell lectin like receptor C1 involved_in ISO (PMID:9485206), (PMID:9486650) RGD PMID:9485206 PMID:9486650 NCBI chr 4:164,828,163...164,838,446
Ensembl chr 4:163,147,189...163,152,425 		JBrowse link
G Klrd1 killer cell lectin like receptor D1 involved_in ISO
IEA
ISS		 (PMID:9486650)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:9486650 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:164,730,833...164,742,539
Ensembl chr 4:163,045,067...163,056,518 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) RGD PMID:23408620 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Mill1 MHC I like leukocyte 1 involved_in ISO (PMID:20068167) RGD PMID:20068167 NCBI chr 1:87,500,591...87,526,983
Ensembl chr 1:78,372,802...78,398,930 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO
IEA		 (PMID:28515320)
GO_REF:0000107		 RGD
Ensembl		 PMID:28515320 GO_REF:0000107 NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:79,372,119...79,407,360 		JBrowse link
G Nectin4 nectin cell adhesion molecule 4 involved_in ISO
IEA		 (PMID:32503945)
GO_REF:0000107		 RGD
Ensembl		 PMID:32503945 GO_REF:0000107 NCBI chr13:86,335,027...86,354,152
Ensembl chr13:83,803,184...83,821,709 		JBrowse link
G Pvr PVR cell adhesion molecule involved_in ISO (PMID:23154388) RGD PMID:23154388 NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:79,546,879...79,576,715 		JBrowse link
G RT1-A1 RT1 class Ia, locus A1 IMP RGD PMID:10837412 RGD:2313500 NCBI chr20:4,907,139...4,910,798 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:10799855), (PMID:17179229), (PMID:23335510), (PMID:9486650) RGD PMID:9486650 PMID:10799855 PMID:17179229 PMID:23335510 NCBI chr20:4,872,720...4,876,425 JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,407,880...3,484,130 JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:10190900), (PMID:12874224) RGD PMID:10190900 PMID:12874224 NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Sh2d1b2 SH2 domain containing 1B2 acts_upstream_of_or_within ISO
IEA		 MGI:3641175 (PMID:16127454)
GO_REF:0000107		 RGD
Ensembl		 PMID:16127454 GO_REF:0000107 NCBI chr13:84,970,183...84,994,276
Ensembl chr13:82,437,428...82,461,509 		JBrowse link
G Tigit T cell immunoreceptor with Ig and ITIM domains involved_in ISO
IEA		 (PMID:23154388)
GO_REF:0000107		 RGD
Ensembl		 PMID:23154388 GO_REF:0000107 NCBI chr11:70,534,907...70,552,452
Ensembl chr11:57,029,118...57,045,994 		JBrowse link
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS		 (PMID:23696226)
GO_REF:0000024		 RGD
UniProt		 PMID:23696226 GO_REF:0000024 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:22842346) RGD PMID:22842346 NCBI chr10:31,383,801...31,415,334
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Klre1 killer cell lectin like receptor E1 IDA RGD PMID:12782717 RGD:1299590 NCBI chr 4:164,719,307...164,727,664
Ensembl chr 4:163,033,563...163,041,638 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
IEA		 (PMID:24586048)
GO_REF:0000107		 RGD
Ensembl		 PMID:24586048 GO_REF:0000107 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
negative regulation of respiratory burst involved in inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp10 dual specificity phosphatase 10 acts_upstream_of_or_within ISO
IEA		 MGI:3052343 (PMID:19696743)
GO_REF:0000107		 RGD
Ensembl		 PMID:19696743 GO_REF:0000107 NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Grn granulin precursor involved_in ISS
ISO		 GO_REF:0000024
(PMID:12526812)		 UniProt
RGD		 PMID:12526812 GO_REF:0000024 NCBI chr10:87,887,834...87,893,938
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Ins2 insulin 2 involved_in ISO (PMID:11443198) RGD PMID:11443198 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Rps19 ribosomal protein S19 involved_in ISO (PMID:15750715) RGD PMID:15750715 NCBI chr 1:89,608,408...89,614,390
Ensembl chr 1:80,480,951...80,486,508
Ensembl chr 7:80,480,951...80,486,508 		JBrowse link
G Slamf8 SLAM family member 8 acts_upstream_of_or_within ISO MGI:5442794 (PMID:25799045) RGD PMID:25799045 NCBI chr13:87,580,081...87,589,941
Ensembl chr13:85,047,727...85,057,211 		JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific acts_upstream_of_or_within ISO
IEA		 MGI:3828307 (PMID:19060901)
GO_REF:0000107		 RGD
Ensembl		 PMID:19060901 GO_REF:0000107 NCBI chr 2:177,436,076...177,475,969
Ensembl chr 2:175,138,403...175,178,282 		JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO
IEA		 (PMID:20829348)
GO_REF:0000107		 RGD
Ensembl		 PMID:20829348 GO_REF:0000107 NCBI chr 7:9,042,125...9,047,807
Ensembl chr 7:8,391,397...8,396,829 		JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 involved_in ISO
IEA		 (PMID:23386060)
GO_REF:0000107		 RGD
Ensembl		 PMID:23386060 GO_REF:0000107 NCBI chr16:58,478,882...58,498,046
Ensembl chr16:51,775,412...51,794,576 		JBrowse link
G Dcst1 DC-STAMP domain containing 1 involved_in ISO
IEA		 (PMID:27782195)
GO_REF:0000107		 RGD
Ensembl		 PMID:27782195 GO_REF:0000107 NCBI chr 2:177,063,083...177,079,914
Ensembl chr 2:174,765,350...174,781,806 		JBrowse link
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 involved_in ISO
IEA		 (PMID:35878012)
GO_REF:0000107		 RGD
Ensembl		 PMID:35878012 GO_REF:0000107 NCBI chr 9:95,333,439...95,362,366
Ensembl chr 9:87,878,085...87,914,482 		JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 involved_in ISO
IEA		 (PMID:35878012)
GO_REF:0000107		 RGD
Ensembl		 PMID:35878012 GO_REF:0000107 NCBI chr 9:95,449,143...95,574,927
Ensembl chr 9:88,001,301...88,125,715 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier involved_in ISO
IEA		 (PMID:28724761)
GO_REF:0000107		 RGD
Ensembl		 PMID:28724761 GO_REF:0000107 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in ISO
IEA		 (PMID:30559377)
GO_REF:0000107		 RGD
Ensembl		 PMID:30559377 GO_REF:0000107 NCBI chr15:27,476,659...27,491,134
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:23633945) RGD PMID:23633945 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mmp12 matrix metallopeptidase 12 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24784232)		 Ensembl
RGD		 PMID:24784232 GO_REF:0000107 NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO
IEA		 (PMID:23399697)
GO_REF:0000107		 RGD
Ensembl		 PMID:23399697 GO_REF:0000107 NCBI chr 5:155,936,112...155,945,163
Ensembl chr 5:150,652,812...150,661,863 		JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 involved_in ISO
IBA		 (PMID:20434986)
GO_REF:0000033		 RGD
GO_Central		 PMID:20434986 GO_REF:0000033 NCBI chr19:10,483,601...10,587,223
Ensembl chr19:10,477,628...10,562,121 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A involved_in ISO (PMID:30078389) RGD PMID:30078389 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:35,669,801...35,680,517 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 involved_in ISO
IEA		 (PMID:30078389)
GO_REF:0000107		 RGD
Ensembl		 PMID:30078389 GO_REF:0000107 NCBI chr12:41,439,645...41,463,392
Ensembl chr12:35,779,022...35,802,781 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA
ISS		 (PMID:11909529)
(PMID:11909529), (PMID:12138178)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:11909529 PMID:12138178 GO_REF:0000024 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in ISO
IEA		 (PMID:29670289)
GO_REF:0000107
(PMID:23972988)		 RGD
Ensembl		 PMID:23972988 PMID:29670289 GO_REF:0000107 NCBI chr 3:166,179,742...166,214,448
Ensembl chr 3:145,761,558...145,794,386 		JBrowse link
G Smim30 small integral membrane protein 30 involved_in ISO (PMID:37656786) RGD PMID:37656786 NCBI chr  X:38,251,825...38,252,063 JBrowse link
G Stat2 signal transducer and activator of transcription 2 involved_in ISO
IEA		 (PMID:28165510)
GO_REF:0000107		 RGD
Ensembl		 PMID:28165510 GO_REF:0000107 NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:702,495...718,967 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO
IEA		 MGI:3052754 (PMID:18724932)
GO_REF:0000107		 RGD
Ensembl		 PMID:18724932 GO_REF:0000107 NCBI chr 8:118,585,082...118,586,382
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Ttll12 tubulin tyrosine ligase like 12 involved_in ISO
IEA		 (PMID:28011935)
GO_REF:0000107		 RGD
Ensembl		 PMID:28011935 GO_REF:0000107 NCBI chr 7:116,612,609...116,631,244
Ensembl chr 7:114,731,892...114,751,356 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 involved_in ISO (PMID:28165510) RGD PMID:28165510 NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:154,471,592...154,499,144 		JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein F2 involved_in ISO
IEA		 (PMID:30559377)
GO_REF:0000107		 RGD
Ensembl		 PMID:30559377 GO_REF:0000107 NCBI chr 5:149,665,467...149,693,127
Ensembl chr 5:144,381,431...144,408,144 		JBrowse link
G Ythdf3 YTH N6-methyladenosine RNA binding protein F3 involved_in ISO
IEA		 (PMID:30591559)
GO_REF:0000107		 RGD
Ensembl		 PMID:30591559 GO_REF:0000107 NCBI chr 2:100,266,942...100,300,896
Ensembl chr 2:98,350,588...98,384,606 		JBrowse link
negative regulation of type II interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 involved_in ISO
IEA		 (PMID:16709924)
GO_REF:0000107		 RGD
Ensembl		 PMID:16709924 GO_REF:0000107 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 involved_in ISO (PMID:11679576) RGD PMID:11679576 NCBI chr10:11,361,168...11,386,599
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Otop1 otopetrin 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:24379350)		 UniProt
Ensembl
RGD		 PMID:24379350 GO_REF:0000024 GO_REF:0000107 NCBI chr14:76,717,330...76,744,785
Ensembl chr14:72,503,592...72,532,497 		JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 involved_in ISO
IEA
IBA		 (PMID:27796300)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:27796300 GO_REF:0000033 GO_REF:0000107 NCBI chr11:78,408,134...78,440,201
Ensembl chr11:64,902,785...64,934,916 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (PMID:21268089) RGD PMID:21268089 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in
NOT|involved_in		 ISS
ISO
IEA		 GO_REF:0000024
(PMID:12138178)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:12138178 GO_REF:0000024 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
protection from natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec2d C-type lectin domain family 2, member D acts_upstream_of_or_within ISO MGI:107539 (PMID:12858173), (PMID:14990792), (PMID:19535641) RGD PMID:12858173 PMID:14990792 PMID:19535641 NCBI chr 4:163,902,124...163,925,587
Ensembl chr 4:162,216,572...162,239,527 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:25631937), (PMID:9754572) RGD PMID:9754572 PMID:25631937 NCBI chr20:4,872,720...4,876,425 JBrowse link
G RT1-CE16 RT1 class I, locus CE16 NOT|involved_in ISO (PMID:18502829)
(PMID:18502829), (PMID:8839770)		 RGD PMID:8839770 PMID:18502829 NCBI chr20:3,261,656...3,265,548
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:11290782) RGD PMID:11290782 NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Serpinb3a serpin family B member 3A involved_in ISO (PMID:21857942) RGD PMID:21857942 NCBI chr13:23,755,690...23,766,188
Ensembl chr13:23,236,972...23,246,985 		JBrowse link
G Serpinb9 serpin family B member 9 involved_in ISO (PMID:21795594) RGD PMID:21795594 NCBI chr17:31,628,887...31,652,003
Ensembl chr17:31,420,125...31,443,230 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member IMP RGD PMID:8120379 RGD:2312378 NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,656,263...4,666,901 		JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member IMP RGD PMID:8120379 RGD:2312378 NCBI chr20:4,638,257...4,652,296
Ensembl chr20:4,636,357...4,650,407 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    response to stimulus 11067
      response to biotic stimulus 1943
        negative regulation of response to biotic stimulus 134
          negative regulation of innate immune response 101
            negative regulation of age-related resistance 0
            negative regulation of antifungal innate immune response 2
            negative regulation of complement activation, alternative pathway 3
            negative regulation of complement activation, lectin pathway 2
            negative regulation of innate immunity memory response 0
            negative regulation of melanization defense response + 0
            negative regulation of natural killer cell mediated immunity + 31
            negative regulation of plant-type hypersensitive response 0
            negative regulation of respiratory burst involved in inflammatory response 5
            negative regulation of response to type II interferon + 6
            negative regulation of type I interferon-mediated signaling pathway 23
Path 2
Term Annotations click to browse term
  biological_process 20558
    response to stimulus 11067
      response to external stimulus 2804
        response to external biotic stimulus 1894
          response to other organism 1890
            defense response to other organism 1336
              defense response to symbiont 1112
                innate immune response 1025
                  regulation of innate immune response 491
                    negative regulation of innate immune response 101
                      negative regulation of age-related resistance 0
                      negative regulation of antifungal innate immune response 2
                      negative regulation of complement activation, alternative pathway 3
                      negative regulation of complement activation, lectin pathway 2
                      negative regulation of innate immunity memory response 0
                      negative regulation of melanization defense response + 0
                      negative regulation of natural killer cell mediated immunity + 31
                      negative regulation of plant-type hypersensitive response 0
                      negative regulation of respiratory burst involved in inflammatory response 5
                      negative regulation of response to type II interferon + 6
                      negative regulation of type I interferon-mediated signaling pathway 23
paths to the root