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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of heart contraction
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Accession:GO:0045823 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of heart contraction.
Synonyms:exact_synonym: positive regulation of cardiac contraction;   up regulation of heart contraction;   upregulation of heart contraction
 narrow_synonym: activation of heart contraction;   stimulation of heart contraction



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positive regulation of heart contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in IMP PMID:26611206 UniProt PMID:26611206 RGD:11534624 NCBI chr16:24,694,356...24,703,466
Ensembl chr16:24,694,324...24,703,465
JBrowse link
G Apln apelin involved_in IMP PMID:26611206 UniProt PMID:26611206 RGD:11534624 NCBI chr  X:132,058,739...132,091,518
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2451290 (PMID:10360172)
Ensembl
RGD
PMID:10360172 GO_REF:0000107 NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in IEA
ISO
GO_REF:0000107
(PMID:20516643)
Ensembl
RGD
PMID:20516643 GO_REF:0000107 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Hrc histidine rich calcium binding protein involved_in ISO UniProtKB:B9EIW1 (PMID:24125847) RGD PMID:24125847 NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984
JBrowse link
G Nkx2-5 NK2 homeobox 5 involved_in IEA
ISO
GO_REF:0000107
(PMID:18689573)
Ensembl
RGD
PMID:18689573 GO_REF:0000107 NCBI chr10:16,844,888...16,851,458
Ensembl chr10:16,344,159...16,346,934
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:15896309)
AgBase
RGD
PMID:15896309 GO_REF:0000024 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405
JBrowse link
positive regulation of cardiac muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:12075344)
Ensembl
RGD
PMID:12075344 GO_REF:0000107 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Adra1a adrenoceptor alpha 1A involved_in IMP PMID:19011682 BHF-UCL PMID:19011682 RGD:5688340 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Ccn2 cellular communication network factor 2 IMP RGD PMID:19707545 RGD:2314476 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Chga chromogranin A involved_in IDA PMID:22459152 UniProt PMID:22459152 RGD:6906968 NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:121,696,051...121,707,398
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 IEP RGD PMID:21620734 RGD:5686387 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:19646991)
Ensembl
RGD
PMID:19646991 GO_REF:0000107 NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:198,291,766...198,624,669
JBrowse link
G Nppa natriuretic peptide A involved_in ISO
IEA
(PMID:19646991)
GO_REF:0000107
RGD
Ensembl
PMID:19646991 GO_REF:0000107 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Rgs2 regulator of G-protein signaling 2 involved_in ISO (PMID:19127022), (PMID:21291891) RGD PMID:19127022 PMID:21291891 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Smtn smoothelin acts_upstream_of_or_within ISO MGI:3613292|MGI:3613293 (PMID:18678771) RGD PMID:18678771 NCBI chr14:82,622,223...82,644,525
Ensembl chr14:78,397,778...78,420,886
JBrowse link
G Ucn urocortin IDA RGD PMID:19460778 RGD:5508168 NCBI chr 6:30,958,086...30,958,916
Ensembl chr 6:25,238,120...25,238,950
JBrowse link
positive regulation of heart rate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857117|MGI:2681791 (PMID:16626672)
Ensembl
RGD
PMID:16626672 GO_REF:0000107 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Adm adrenomedullin involved_in IDA
ISO
IBA
(PMID:18434369)
GO_REF:0000033
RGD
GO_Central
PMID:18434369 PMID:19520650 GO_REF:0000033, RGD:2325635 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adm2 adrenomedullin 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:122,272,808...122,274,594
Ensembl chr 7:120,393,179...120,396,331
JBrowse link
G Adra1a adrenoceptor alpha 1A IMP RGD PMID:22040923 RGD:5688308 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:9089896 RGD:5129112 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Apln apelin IDA RGD PMID:12798955 RGD:1626237 NCBI chr  X:132,058,739...132,091,518
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 IDA RGD PMID:12686462 RGD:13800918 NCBI chr11:37,368,045...37,375,721
Ensembl chr11:23,881,592...23,889,119
JBrowse link
G Avpr1a arginine vasopressin receptor 1A IMP RGD PMID:18339407 RGD:2300339 NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:20060787 RGD:5130949 NCBI chr 4:85,553,163...85,596,203
Ensembl chr 4:84,224,002...84,265,904
JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:2649896) RGD PMID:2649896 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Edn2 endothelin 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:2649896)
Ensembl
RGD
PMID:2649896 GO_REF:0000107 NCBI chr 5:139,036,576...139,042,074
Ensembl chr 5:133,751,217...133,756,814
JBrowse link
G Edn3 endothelin 3 involved_in ISO (PMID:2649896) RGD PMID:2649896 NCBI chr 3:183,980,458...184,004,958
Ensembl chr 3:163,562,520...163,585,093
JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO (PMID:25557619) RGD PMID:25557619 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO MGI:3574394 (PMID:15297376) RGD PMID:15297376 NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Hrc histidine rich calcium binding protein involved_in ISO UniProtKB:B9EIW1 (PMID:24125847) RGD PMID:24125847 NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO
IEA
(PMID:19646991)
GO_REF:0000107
RGD
Ensembl
PMID:19646991 GO_REF:0000107 NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:198,291,766...198,624,669
JBrowse link
G Nmu neuromedin U involved_in IDA PMID:11853869 UniProt PMID:11853869 RGD:13461753 NCBI chr14:32,198,789...32,226,397
Ensembl chr14:31,844,728...31,872,192
JBrowse link
G Nppa natriuretic peptide A involved_in ISO
IEA
(PMID:19646991)
GO_REF:0000107
RGD
Ensembl
PMID:19646991 GO_REF:0000107 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Pde4d phosphodiesterase 4D involved_in IMP PMID:19801680 BHF-UCL PMID:19801680 RGD:7327160 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:40,019,933...41,525,884
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 IMP RGD PMID:22569287 RGD:401976380 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Rgs4 regulator of G-protein signaling 4 IMP RGD PMID:25844489 RGD:13524517 NCBI chr13:84,469,593...84,475,884
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Ryr2 ryanodine receptor 2 acts_upstream_of_or_within ISO MGI:2183509|MGI:3713774 (PMID:12089338), (PMID:17431507) RGD PMID:12089338 PMID:17431507 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:19796257) RGD PMID:19796257 NCBI chr 8:49,527,529...49,550,019
Ensembl chr 8:40,630,455...40,652,868
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 IMP RGD PMID:17259145 RGD:6484226 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:22113495 RGD:7240568 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in ISO (PMID:23361868) RGD PMID:23361868 NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Tacr3 tachykinin receptor 3 IDA RGD PMID:2471579 RGD:2305984 NCBI chr 2:225,940,497...226,037,756
Ensembl chr 2:223,266,536...223,363,791
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:23954346 RGD:10003031 NCBI chr 1:104,918,462...104,949,453
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:18597948 PMID:12217424 RGD:2306810, RGD:2306871 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237
JBrowse link
positive regulation of heart rate by epinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tpm1 tropomyosin 1 involved_in ISO (PMID:17556658) RGD PMID:17556658 NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:67,635,479...67,662,802
JBrowse link
positive regulation of heart rate by epinephrine-norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104774 (PMID:12782680)
Ensembl
RGD
PMID:12782680 GO_REF:0000107 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B acts_upstream_of_or_within ISO MGI:104773 (PMID:12782680) RGD PMID:12782680 NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adrb1 adrenoceptor beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857120 (PMID:10358009), (PMID:8693001)
Ensembl
RGD
PMID:8693001 PMID:10358009 GO_REF:0000107 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1888407 (PMID:10942027)
Ensembl
RGD
PMID:10942027 GO_REF:0000107 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
positive regulation of the force of heart contraction by epinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IDA RGD PMID:19133992 RGD:5129126 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512
JBrowse link
positive regulation of the force of heart contraction by epinephrine-norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104774 (PMID:12595294)
Ensembl
RGD
PMID:12595294 GO_REF:0000107 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B acts_upstream_of_or_within ISO MGI:104773 (PMID:12595294) RGD PMID:12595294 NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adrb1 adrenoceptor beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857120 (PMID:7761854), (PMID:8693001)
Ensembl
RGD
PMID:7761854 PMID:8693001 GO_REF:0000107 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
positive regulation of the force of heart contraction by norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IDA RGD PMID:19133992 RGD:5129126 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20553
    multicellular organismal process 9002
      positive regulation of multicellular organismal process 1895
        positive regulation of blood circulation 49
          positive regulation of heart contraction 45
            positive regulation of cardiac muscle contraction 10
            positive regulation of heart rate + 32
            positive regulation of the force of heart contraction by chemical signal + 4
Path 2
Term Annotations click to browse term
  biological_process 20553
    multicellular organismal process 9002
      system process 3567
        circulatory system process 628
          blood circulation 599
            regulation of blood circulation 290
              positive regulation of blood circulation 49
                positive regulation of heart contraction 45
                  positive regulation of cardiac muscle contraction 10
                  positive regulation of heart rate + 32
                  positive regulation of the force of heart contraction by chemical signal + 4
paths to the root