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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of blood pressure
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Accession:GO:0045776 term browser browse the term
Definition:Any process in which the force of blood traveling through the circulatory system is decreased.
Synonyms:exact_synonym: down regulation of blood pressure;   downregulation of blood pressure
 narrow_synonym: inhibition of blood pressure



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negative regulation of blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IMP RGD PMID:8336820 RGD:1598530 NCBI chr10:7,503,351...7,599,474 JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:6389242 (PMID:31575858)
Ensembl
RGD
PMID:31575858 GO_REF:0000107 NCBI chr 4:177,262,848...177,386,837 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO
GO_REF:0000024
(PMID:17327472)
UniProt
RGD
PMID:17327472 GO_REF:0000024 NCBI chr11:91,226,524...91,240,244 JBrowse link
G Adm2 adrenomedullin 2 IMP RGD PMID:14615490 RGD:1304019 NCBI chr 7:120,393,179...120,394,965 JBrowse link
G Adora1 adenosine A1 receptor IMP RGD PMID:16690710 RGD:5129101 NCBI chr13:48,210,922...48,247,826 JBrowse link
G Apln apelin involved_in IDA
IMP
PMID:11359874 RGD
UniProt
PMID:15486224 PMID:10617103 PMID:11359874 RGD:1576349, RGD:632247, RGD:12907555 NCBI chr  X:127,180,801...127,213,567 JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:16507603 PMID:15253105 RGD:1625747, RGD:1625759 NCBI chr 6:130,275,631...130,284,968 JBrowse link
G Bdkrb2 bradykinin receptor B2 IMP RGD PMID:16507603 RGD:1625747 NCBI chr 6:130,237,055...130,267,205 JBrowse link
G Calca calcitonin-related polypeptide alpha acts_upstream_of_or_within IMP
ISO
(PMID:10642343)
MGI:3527257 (PMID:10642343), (PMID:15583078)
RGD PMID:10642343 PMID:15583078 PMID:11230364 RGD:68890 NCBI chr 1:178,312,636...178,317,588 JBrowse link
G Cnr1 cannabinoid receptor 1 IMP RGD PMID:19295473 RGD:2314676 NCBI chr 5:53,204,867...53,230,396 JBrowse link
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO MGI:1857875 (PMID:11566895) RGD PMID:11566895 NCBI chr 8:58,605,403...58,669,339 JBrowse link
G Drd3 dopamine receptor D3 acts_upstream_of_or_within ISO MGI:1857159 (PMID:9691085) RGD PMID:9691085 NCBI chr11:70,385,586...70,437,793 JBrowse link
G Drd5 dopamine receptor D5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:109147|MGI:3528074 (PMID:12486173), (PMID:15598876)
Ensembl
RGD
PMID:12486173 PMID:15598876 GO_REF:0000107 NCBI chr14:72,487,950...72,491,050 JBrowse link
G Ffar3 free fatty acid receptor 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:23401498)
UniProt
RGD
PMID:23401498 GO_REF:0000024 NCBI chr 1:86,105,388...86,106,728 JBrowse link
G Gch1 GTP cyclohydrolase 1 IMP RGD PMID:12855421 RGD:1601283 NCBI chr15:22,884,006...22,917,412 JBrowse link
G Gja5 gap junction protein, alpha 5 IMP RGD PMID:18046320 RGD:7207467 NCBI chr 2:187,291,227...187,310,770 JBrowse link
G Glp1r glucagon-like peptide 1 receptor involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
MGI:2150310 (PMID:23542788)
Ensembl
RGD
PMID:23542788 GO_REF:0000107 NCBI chr20:8,972,004...9,010,241 JBrowse link
G Gnas GNAS complex locus IMP RGD PMID:21895632 RGD:5509797 NCBI chr 3:183,489,648...183,554,570 JBrowse link
G Guca2b guanylate cyclase activator 2B acts_upstream_of_or_within ISO MGI:2679505 (PMID:14561709) RGD PMID:14561709 NCBI chr 5:133,246,891...133,248,941 JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 IDA RGD PMID:15962106 RGD:1599364 NCBI chr10:15,337,265...15,338,121 JBrowse link
G Hrh3 histamine receptor H3 IMP RGD PMID:9050021 RGD:1626409 NCBI chr 3:187,569,174...187,575,263 JBrowse link
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO MGI:3526444 (PMID:18317593) RGD PMID:18317593 NCBI chr 3:124,201,877...124,221,142 JBrowse link
G Nos1 nitric oxide synthase 1 involved_in IMP
IBA
GO_REF:0000033 GO_Central
RGD
PMID:15331368 GO_REF:0000033, RGD:1598375 NCBI chr12:44,276,011...44,456,371 JBrowse link
G Nos2 nitric oxide synthase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nos3 nitric oxide synthase 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:11,686,088...11,706,604 JBrowse link
G Nppa natriuretic peptide A acts_upstream_of_or_within
involved_in
ISO MGI:1857231 (PMID:23542788)
MGI:1857231 (PMID:23981445), (PMID:26536903)
RGD PMID:23542788 PMID:23981445 PMID:26536903 NCBI chr 5:163,712,184...163,713,493 JBrowse link
G Npy neuropeptide Y IMP RGD PMID:15699473 RGD:1357410 NCBI chr 4:80,212,111...80,219,310 JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:10651151 RGD:9835014 NCBI chr 3:168,831,934...168,839,920 JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IMP RGD PMID:18562099 RGD:2304105 NCBI chr 3:138,235,754...138,236,594 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IMP RGD PMID:19015400 RGD:4108483 NCBI chr 2:34,612,946...34,697,660 JBrowse link
G Pmch pro-melanin-concentrating hormone IDA RGD PMID:17045349 RGD:1642492 NCBI chr 7:24,399,404...24,400,720 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IMP RGD PMID:15967866 RGD:1580222 NCBI chr 7:118,712,261...118,780,723 JBrowse link
G Ptafr platelet-activating factor receptor IMP RGD PMID:9548392 PMID:3019921 RGD:10041048, RGD:10043185 NCBI chr 5:150,049,322...150,079,060 JBrowse link
G Rnls renalase, FAD-dependent amine oxidase involved_in ISO (PMID:15841207) RGD PMID:15841207 NCBI chr 1:240,450,702...240,723,472 JBrowse link
G Rnpep arginyl aminopeptidase IMP RGD PMID:3001599 RGD:2325950 NCBI chr13:46,699,458...46,717,829 JBrowse link
G Scpep1 serine carboxypeptidase 1 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P16675 (PMID:24586188)
Ensembl
RGD
PMID:24586188 GO_REF:0000107 NCBI chr10:73,703,275...73,732,892 JBrowse link
G Snx5 sorting nexin 5 IMP RGD PMID:23195037 RGD:13508622 NCBI chr 3:131,621,875...131,641,127 JBrowse link
G Ucn urocortin IDA RGD PMID:15604589 RGD:1642785 NCBI chr 6:30,958,086...30,958,916 JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:16531985 PMID:12217424 RGD:2306837, RGD:2306871 NCBI chr 5:166,725,471...166,739,063 JBrowse link
G Uts2r urotensin 2 receptor IMP RGD PMID:16531985 RGD:2306837 NCBI chr10:106,936,398...106,937,558 JBrowse link
G Vegfc vascular endothelial growth factor C IMP RGD PMID:19412173 RGD:2315485 NCBI chr16:44,445,293...44,560,887 JBrowse link
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO MGI:1857129|MGI:1857480 (PMID:16873728) RGD PMID:16873728 NCBI chr 1:50,043,323...50,050,168 JBrowse link
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO MGI:1857123|MGI:2158808|MGI:5050632 (PMID:10425188), (PMID:27217404) RGD PMID:10425188 PMID:27217404 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Agtr2 angiotensin II receptor, type 2 acts_upstream_of_or_within
involved_in
ISO MGI:1857123 (PMID:10425188) RGD PMID:10425188 NCBI chr  X:116,914,320...116,918,504 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase acts_upstream_of_or_within ISO MGI:2182739 (PMID:15998684) RGD PMID:15998684 NCBI chr  X:157,352,364...157,372,144 JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor involved_in ISO
IEA
MGI:2158808 (PMID:27217404)
GO_REF:0000107
RGD
Ensembl
PMID:27217404 GO_REF:0000107 NCBI chr 1:47,879,956...47,911,500 JBrowse link
G Mrgprd MAS related GPR family member D involved_in ISO
IEA
MGI:5050632 (PMID:27217404)
GO_REF:0000107
RGD
Ensembl
PMID:27217404 GO_REF:0000107 NCBI chr 1:200,479,204...200,487,902 JBrowse link
artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha acts_upstream_of_or_within ISO MGI:2445489 (PMID:11717154) RGD PMID:11717154 NCBI chr 1:178,312,636...178,317,588 JBrowse link
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2387663 (PMID:12093905)
Ensembl
RGD
PMID:12093905 GO_REF:0000107 NCBI chr15:45,005,648...45,111,416 JBrowse link
negative regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor IDA RGD PMID:9597368 RGD:1625365 NCBI chr13:48,210,922...48,247,826 JBrowse link
G Ahr aryl hydrocarbon receptor involved_in ISO (PMID:14644620) RGD PMID:14644620 NCBI chr 6:57,961,423...57,998,901 JBrowse link
G Apln apelin IDA RGD PMID:12798955 RGD:1626237 NCBI chr  X:127,180,801...127,213,567 JBrowse link
G Arhgap42 Rho GTPase activating protein 42 acts_upstream_of_or_within ISO MGI:1096342 (PMID:24335996) RGD PMID:24335996 NCBI chr 8:6,154,759...6,384,497 JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 acts_upstream_of_or_within ISO MGI:3045473 (PMID:18317593) RGD PMID:18317593 NCBI chr 8:59,731,912...59,765,408 JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:18364108) RGD PMID:18364108 NCBI chr 9:68,685,942...68,801,353 JBrowse link
G Cd36 CD36 molecule IMP RGD PMID:22128087 RGD:6893560 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Crh corticotropin releasing hormone IDA RGD PMID:7477349 RGD:70047 NCBI chr 2:104,059,184...104,061,048 JBrowse link
G Gpr37l1 G protein-coupled receptor 37-like 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:29625592)
UniProt
Ensembl
RGD
PMID:29625592 GO_REF:0000024 GO_REF:0000107 NCBI chr13:49,150,355...49,157,204 JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO MGI:3773690 (PMID:16166241) RGD PMID:16166241 NCBI chr20:2,933,173...2,934,377 JBrowse link
G Kcnk6 potassium two pore domain channel subfamily K member 6 acts_upstream_of_or_within ISO MGI:2155245 (PMID:23637138) RGD PMID:23637138 NCBI chr 1:84,525,613...84,533,948 JBrowse link
G Kdr kinase insert domain receptor IGI RGD PMID:12052848 RGD:2292104 NCBI chr14:32,572,031...32,615,204 JBrowse link
G Kl Klotho IMP RGD PMID:20086041 RGD:10403068 NCBI chr12:5,326,003...5,367,016 JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:3846431 (PMID:18524855) RGD PMID:18524855 NCBI chr18:60,663,918...60,996,824 JBrowse link
G Nppa natriuretic peptide A involved_in IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:2136863 GO_REF:0000033, RGD:7247720 NCBI chr 5:163,712,184...163,713,493 JBrowse link
G Nppb natriuretic peptide B involved_in IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:8289999 PMID:21403100 GO_REF:0000033, RGD:7247315, RGD:5685657 NCBI chr 5:163,699,955...163,701,314 JBrowse link
G Ntsr1 neurotensin receptor 1 IMP RGD PMID:22211865 RGD:9727449 NCBI chr 3:167,606,215...167,656,371 JBrowse link
G Prcp prolylcarboxypeptidase involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:4123993 (PMID:21297000)
GO_Central
RGD
PMID:21297000 GO_REF:0000033 NCBI chr 1:156,343,894...156,396,295 JBrowse link
G Smtn smoothelin acts_upstream_of_or_within ISO MGI:3613293 (PMID:18678771) RGD PMID:18678771 NCBI chr14:78,398,595...78,420,908 JBrowse link
G Tac1 tachykinin, precursor 1 involved_in ISO (PMID:12716968) RGD PMID:12716968 NCBI chr 4:36,645,344...36,653,548 JBrowse link
G Tac4 tachykinin precursor 4 involved_in ISO (PMID:12716968) RGD PMID:12716968 NCBI chr10:80,207,824...80,216,156 JBrowse link
G Tnf tumor necrosis factor IMP RGD PMID:7875478 RGD:14975128 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:27335281 RGD:13792700 NCBI chr10:58,349,936...58,375,021 JBrowse link
negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1d adrenoceptor alpha 1D acts_upstream_of_or_within ISO (PMID:12595294) RGD PMID:12595294 NCBI chr 3:139,246,333...139,262,331 JBrowse link
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:1857120|MGI:87938 (PMID:10358009), (PMID:11641423)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:10358009 PMID:11641423 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:265,777,103...265,780,114 JBrowse link
G Adrb2 adrenoceptor beta 2 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:1859675|MGI:87937 (PMID:10358009), (PMID:11641423)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:10358009 PMID:11641423 GO_REF:0000033 GO_REF:0000107 NCBI chr18:57,912,760...57,914,802 JBrowse link
G Adrb3 adrenoceptor beta 3 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:10358009)
GO_Central
RGD
PMID:10358009 GO_REF:0000033 NCBI chr16:71,544,603...71,547,410 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological quality 3448
        regulation of blood pressure 242
          negative regulation of blood pressure 72
            negative regulation of blood pressure in another organism 0
            negative regulation of systemic arterial blood pressure + 35
Path 2
Term Annotations click to browse term
  biological_process 20534
    multicellular organismal process 8969
      system process 3558
        circulatory system process 627
          blood circulation 598
            regulation of blood pressure 242
              negative regulation of blood pressure 72
                negative regulation of blood pressure in another organism 0
                negative regulation of systemic arterial blood pressure + 35
paths to the root