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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of T-helper cell differentiation
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Accession:GO:0045623 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: down regulation of T-helper cell differentiation;   downregulation of T-helper cell differentiation
 narrow_synonym: inhibition of T-helper cell differentiation
 related_synonym: negative regulation of T-helper cell development


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negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO
IEA 		MGI:3581675 (PMID:15917799)
GO_REF:0000107 		RGD
Ensembl		 PMID:15917799 GO_REF:0000107 NCBI chr13:75,707,098...75,779,114
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO
IEA 		(PMID:24463518)
GO_REF:0000107 		RGD
Ensembl		 PMID:24463518 GO_REF:0000107 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:16020505) 		BHF-UCL
RGD		 PMID:16020505 GO_REF:0000024 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO
IEA 		(PMID:9670042)
GO_REF:0000107 		RGD
Ensembl		 PMID:9670042 GO_REF:0000107 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO
IEA 		(PMID:24463518)
GO_REF:0000107 		RGD
Ensembl		 PMID:24463518 GO_REF:0000107 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Foxp3 forkhead box P3 involved_in ISO
IEA 		(PMID:23169781)
GO_REF:0000107 		RGD
Ensembl		 PMID:23169781 GO_REF:0000107 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il2 interleukin 2 involved_in ISO RNAcentral:URS000039ED8D_10090 (PMID:25642768) RGD PMID:25642768 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) RGD PMID:18792410 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Pf4 platelet factor 4 IDA RGD PMID:24986443 RGD:329901907 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO
IEA 		(PMID:25282160)
GO_REF:0000107 		RGD
Ensembl		 PMID:25282160 GO_REF:0000107 NCBI chr13:75,707,098...75,779,114
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr 3:41,531,319...41,596,496
Ensembl chr 3:21,110,679...21,179,933 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO 		GO_REF:0000107
(PMID:25642768) 		Ensembl
RGD		 PMID:25642768 GO_REF:0000107 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO
IEA 		(PMID:21151104)
GO_REF:0000107 		RGD
Ensembl		 PMID:21151104 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO
IEA 		MGI:3530739 (PMID:23034280)
GO_REF:0000107 		RGD
Ensembl		 PMID:23034280 GO_REF:0000107 NCBI chr 2:177,093,569...177,111,894
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:25282160) 		UniProt
Ensembl
RGD		 PMID:25282160 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:142,661,193...142,670,051
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule involved_in ISO (PMID:24752896) RGD PMID:24752896 NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:20696842) RGD PMID:20696842 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lgals1 galectin 1 involved_in ISO
IEA 		(PMID:24752896)
GO_REF:0000107 		RGD
Ensembl		 PMID:24752896 GO_REF:0000107 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Loxl3 lysyl oxidase-like 3 involved_in ISO (PMID:28065600) RGD PMID:28065600 NCBI chr 4:117,098,358...117,114,673
Ensembl chr 4:115,540,685...115,557,466 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A involved_in ISO
IEA 		(PMID:20696842)
GO_REF:0000107 		RGD
Ensembl		 PMID:20696842 GO_REF:0000107 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO
IEA 		(PMID:21151104)
GO_REF:0000107 		RGD
Ensembl		 PMID:21151104 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) RGD PMID:24107315 NCBI chr13:76,366,790...76,440,673
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:17008549)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:17008549 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO
IEA 		(PMID:24463518)
GO_REF:0000107 		RGD
Ensembl		 PMID:24463518 GO_REF:0000107 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO
IEA 		MGI:96559 (PMID:12594267)
GO_REF:0000107 		RGD
Ensembl		 PMID:12594267 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO
IEA 		MGI:105367|MGI:2182089 (PMID:16424184)
GO_REF:0000107 		RGD
Ensembl		 PMID:16424184 GO_REF:0000107 NCBI chr13:98,811,852...98,817,264
Ensembl chr13:96,280,339...96,285,750 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) RGD PMID:12242343 NCBI chr 6:13,235,157...13,266,161
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Zfp35 zinc finger protein 35 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:15,543,604...15,559,084
Ensembl chr18:15,268,814...15,285,088 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    immune system process 3132
      immune effector process 847
        negative regulation of immune effector process 153
          negative regulation of T-helper cell differentiation 24
            negative regulation of T-helper 1 cell differentiation 4
            negative regulation of T-helper 17 cell differentiation + 17
            negative regulation of T-helper 2 cell differentiation 6
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cellular developmental process 4838
        cell differentiation 4837
          cell development 3352
            hemopoiesis 1084
              leukocyte differentiation 690
                mononuclear cell differentiation 556
                  lymphocyte differentiation 455
                    T cell differentiation 337
                      T cell differentiation involved in immune response 98
                        alpha-beta T cell differentiation involved in immune response 88
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 87
                            T-helper cell differentiation 85
                              regulation of T-helper cell differentiation 49
                                negative regulation of T-helper cell differentiation 24
                                  negative regulation of T-helper 1 cell differentiation 4
                                  negative regulation of T-helper 17 cell differentiation + 17
                                  negative regulation of T-helper 2 cell differentiation 6
paths to the root