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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of lymphocyte differentiation
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Accession:GO:0045621 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: up regulation of lymphocyte differentiation;   upregulation of lymphocyte differentiation
 narrow_synonym: activation of lymphocyte differentiation;   stimulation of lymphocyte differentiation
 related_synonym: positive regulation of lymphocyte development

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positive regulation of lymphocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9620849) MGI
Ensembl		 PMID:9620849 GO_REF:0000107 NCBI chr10:119,093,160...119,244,128
Ensembl chr10:119,093,781...119,244,123 		JBrowse link
G LOC103243413 signal transducer and activator of transcription 5B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15294943) MGI
Ensembl		 PMID:15294943 GO_REF:0000107 NCBI chr16:63,997,486...64,070,392
Ensembl chr16:63,997,441...64,070,445 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in ISO (PMID:19015308) UniProt PMID:19015308 NCBI chr11:50,611,193...50,658,800 JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 Ensembl chr11:50,611,181...50,647,519 JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO (PMID:15294943) MGI PMID:15294943 NCBI chr16:63,959,265...63,986,627
Ensembl chr16:63,960,515...63,985,026 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 involved_in ISO (PMID:32103174) UniProt PMID:32103174 NCBI chr19:24,160,459...24,204,237
Ensembl chr19:24,160,483...24,206,320 		JBrowse link
positive regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase acts_upstream_of_or_within ISO (PMID:11067867), (PMID:12163459), (PMID:16670300)
(PMID:11067867), (PMID:16670300)		 MGI PMID:11067867 PMID:12163459 PMID:16670300 NCBI chr 2:19,167,209...19,200,233 JBrowse link
G GLI3 GLI family zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:16,386,700...16,665,648
Ensembl chr21:16,549,789...16,662,238 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:104,960,296...104,966,596
Ensembl chr10:104,960,120...104,966,585 		JBrowse link
G ITPKB inositol-trisphosphate 3-kinase B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15064401) Ensembl
MGI		 PMID:15064401 GO_REF:0000107 NCBI chr25:3,009,464...3,117,729
Ensembl chr25:3,009,353...3,118,235 		JBrowse link
G LOC103241092 tyrosine-protein kinase ZAP-70 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7630421)
(PMID:9275205)
(PMID:9208839)		 Ensembl
MGI		 PMID:7630421 PMID:9208839 PMID:9275205 GO_REF:0000107 NCBI chr14:1,403,294...1,430,205
Ensembl chr14:1,404,325...1,431,015 		JBrowse link
G NKAP NFKB activating protein involved_in IEA Ensembl GO_REF:0000107
G PNP purine nucleoside phosphorylase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16964310) MGI
Ensembl		 PMID:16964310 GO_REF:0000107 NCBI chr29:20,992,892...21,001,400
Ensembl chr29:20,993,280...21,001,606 		JBrowse link
G RHOA ras homolog family member A involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:10,757,381...10,809,257
Ensembl chr22:10,757,337...10,772,704 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:123,929,937...123,942,451
Ensembl chr21:123,932,900...123,942,395 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9275205) Ensembl
MGI		 PMID:9275205 GO_REF:0000107 NCBI chr12:101,254,085...101,374,724
Ensembl chr12:101,260,061...101,349,856 		JBrowse link
positive regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP11C ATPase phospholipid transporting 11C involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:114,812,948...115,013,557
Ensembl chr  X:114,812,930...115,013,538 		JBrowse link
G BAD BCL2 associated agonist of cell death acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12431371) MGI
Ensembl		 PMID:12431371 GO_REF:0000107 NCBI chr 1:9,949,717...9,964,433
Ensembl chr 1:9,949,762...9,964,432 		JBrowse link
G CD27 CD27 molecule involved_in IEA InterPro GO_REF:0000002 NCBI chr11:6,493,414...6,500,062
Ensembl chr11:6,493,542...6,499,738 		JBrowse link
G IL2RG interleukin 2 receptor subunit gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23918385)
(PMID:9252128)		 Ensembl
MGI		 PMID:9252128 PMID:23918385 GO_REF:0000107 NCBI chr  X:60,905,011...60,915,723
Ensembl chr  X:60,905,343...60,909,149 		JBrowse link
G IL7 interleukin 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16797412) MGI
Ensembl		 PMID:16797412 GO_REF:0000107 NCBI chr 8:74,230,493...74,292,985
Ensembl chr 8:74,231,809...74,292,384 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10704460), (PMID:9620849) MGI
Ensembl
TreeGrafter		 PMID:9620849 PMID:10704460 GO_REF:0000107 GO_REF:0000118 NCBI chr10:119,093,160...119,244,128
Ensembl chr10:119,093,781...119,244,123 		JBrowse link
G LOC103243413 signal transducer and activator of transcription 5B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10979977) MGI
Ensembl		 PMID:10979977 GO_REF:0000107 NCBI chr16:63,997,486...64,070,392
Ensembl chr16:63,997,441...64,070,445 		JBrowse link
G MMP14 matrix metallopeptidase 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:23,201,425...23,212,408
Ensembl chr29:23,201,112...23,212,679 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in ISO (PMID:19015308) UniProt PMID:19015308 NCBI chr11:50,611,193...50,658,800 JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 Ensembl chr11:50,611,181...50,647,519 JBrowse link
G PCID2 PCI domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:91,163,158...91,212,450
Ensembl chr 3:91,177,463...91,211,735 		JBrowse link
G PPP2R3C protein phosphatase 2 regulatory subunit B''gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16129705) Ensembl
TreeGrafter
MGI		 PMID:16129705 GO_REF:0000107 GO_REF:0000118 NCBI chr24:11,901,522...11,935,764
Ensembl chr24:11,900,604...11,935,560 		JBrowse link
G SH2D1B SH2 domain containing 1B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:1,667,247...1,684,951
Ensembl chr20:1,668,588...1,682,949 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:17,935,037...17,961,638
Ensembl chr 1:17,935,922...17,961,717 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO (PMID:10979977) MGI PMID:10979977 NCBI chr16:63,959,265...63,986,627
Ensembl chr16:63,960,515...63,985,026 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7477352)
(PMID:7477353)		 Ensembl
MGI		 PMID:7477352 PMID:7477353 GO_REF:0000107 NCBI chr12:101,254,085...101,374,724
Ensembl chr12:101,260,061...101,349,856 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (PMID:11460154) UniProt PMID:11460154 NCBI chr19:11,670,605...11,677,168 JBrowse link
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD83 CD83 molecule acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15322158) MGI
Ensembl		 PMID:15322158 GO_REF:0000107 NCBI chr17:58,022,817...58,052,041
Ensembl chr17:58,022,593...58,041,983 		JBrowse link
G FOXP3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:17028180) MGI PMID:17028180 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,346,754...46,356,928 JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in ISO (PMID:19015308) UniProt PMID:19015308 NCBI chr11:50,611,193...50,658,800 JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 Ensembl chr11:50,611,181...50,647,519 JBrowse link
G SASH3 SAM and SH3 domain containing 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16227612) Ensembl
MGI		 PMID:16227612 GO_REF:0000107 NCBI chr  X:105,057,782...105,072,994
Ensembl chr  X:105,057,570...105,073,354 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,731,866...10,733,745
Ensembl chr 5:10,732,350...10,732,991 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:20639485) BHF-UCL PMID:20639485 NCBI chr25:55,714,291...55,998,009
Ensembl chr25:55,974,691...55,997,374 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:8,812,514...8,829,128
Ensembl chr20:8,812,351...8,817,286 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16301745), (PMID:18573908)
(PMID:16275384)
(PMID:12612578)		 MGI PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908 NCBI chr  X:46,349,890...46,365,133 JBrowse link
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,346,754...46,356,928 JBrowse link
G IL2RG interleukin 2 receptor subunit gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16227984) Ensembl
MGI		 PMID:16227984 GO_REF:0000107 NCBI chr  X:60,905,011...60,915,723
Ensembl chr  X:60,905,343...60,909,149 		JBrowse link
G KLHL25 kelch like family member 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:4,376,292...4,412,778
Ensembl chr29:4,385,011...4,386,780 		JBrowse link
G LOC103221700 HLA class II histocompatibility antigen, DR beta 3 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,471,058...39,484,265 JBrowse link
G LOC103247148 HLA class II histocompatibility antigen, DRB1 beta chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,556,020...39,564,488 JBrowse link
G LOC119618083 HLA class II histocompatibility antigen, DRB1 beta chain-like involved_in IEA Ensembl GO_REF:0000107
G MHC-DRA major histocompatibility complex, class II, DR alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,623,324...39,628,464
Ensembl chr17:39,622,402...39,629,261 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G LOC103242599 galectin-9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chr16:21,421,034...21,439,583 JBrowse link
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBFB core-binding factor subunit beta involved_in ISO (PMID:18258917) UniProt PMID:18258917 NCBI chr 5:60,356,303...60,445,793
Ensembl chr 5:60,356,272...60,445,729 		JBrowse link
G LILRB4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18420485) ARUK-UCL PMID:18420485 NCBI chr 6:47,299,764...47,333,711 JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in ISO (PMID:19015308) UniProt PMID:19015308 NCBI chr11:50,611,193...50,658,800 JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 Ensembl chr11:50,611,181...50,647,519 JBrowse link
G RUNX3 RUNX family transcription factor 3 involved_in ISO (PMID:18258917) UniProt PMID:18258917 NCBI chr20:107,769,244...107,802,154
Ensembl chr20:107,736,683...107,802,307 		JBrowse link
positive regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SART1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:8,279,821...8,296,282
Ensembl chr 1:8,275,123...8,296,245 		JBrowse link
G TNFSF9 TNF superfamily member 9 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:19187795 GO_REF:0000118 RGD:2317344 NCBI chr 6:6,131,157...6,136,345
Ensembl chr 6:6,131,571...6,135,463 		JBrowse link
positive regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LCK LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO (PMID:7807014) MGI PMID:7807014 NCBI chr20:100,582,718...100,618,041 JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:55,974,770...56,096,214
Ensembl chr 7:55,990,621...56,094,110 		JBrowse link
G LOC103243413 signal transducer and activator of transcription 5B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15294943) MGI
Ensembl		 PMID:15294943 GO_REF:0000107 NCBI chr16:63,997,486...64,070,392
Ensembl chr16:63,997,441...64,070,445 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in ISO (PMID:19015308) UniProt PMID:19015308 NCBI chr11:50,611,193...50,658,800 JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 Ensembl chr11:50,611,181...50,647,519 JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7807014) Ensembl
MGI		 PMID:7807014 GO_REF:0000107 NCBI chr25:30,655,014...30,777,367
Ensembl chr25:30,653,044...30,777,303 		JBrowse link
G SOX13 SRY-box transcription factor 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:25,220,341...25,275,981
Ensembl chr25:25,221,945...25,235,449 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO (PMID:15294943) MGI PMID:15294943 NCBI chr16:63,959,265...63,986,627
Ensembl chr16:63,960,515...63,985,026 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7477352)
(PMID:8790395)		 Ensembl
MGI		 PMID:7477352 PMID:8790395 GO_REF:0000107 NCBI chr12:101,254,085...101,374,724
Ensembl chr12:101,260,061...101,349,856 		JBrowse link
positive regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD46 CD46 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:21,650,825...21,693,898
Ensembl chr25:21,655,969...21,693,878 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:52,289,486...52,296,735
Ensembl chr11:52,295,106...52,297,244 		JBrowse link
G LOC103221700 HLA class II histocompatibility antigen, DR beta 3 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,471,058...39,484,265 JBrowse link
G LOC103247148 HLA class II histocompatibility antigen, DRB1 beta chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,556,020...39,564,488 JBrowse link
G LOC119618083 HLA class II histocompatibility antigen, DRB1 beta chain-like involved_in IEA Ensembl GO_REF:0000107
G MHC-DRA major histocompatibility complex, class II, DR alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:39,623,324...39,628,464
Ensembl chr17:39,622,402...39,629,261 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:6,550,806...6,556,499
Ensembl chr 2:6,549,652...6,556,478 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:18713990) BHF-UCL PMID:18713990 NCBI chr25:55,714,291...55,998,009
Ensembl chr25:55,974,691...55,997,374 		JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AXL AXL receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:35,537,718...35,580,143
Ensembl chr 6:35,537,773...35,580,716 		JBrowse link
G FLT3LG fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO (PMID:14607906) MGI PMID:14607906 NCBI chr 6:42,653,820...42,665,017
Ensembl chr 6:42,654,412...42,660,458 		JBrowse link
G GAS6 growth arrest specific 6 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 3:91,720,882...91,738,069 JBrowse link
G IL15 interleukin 15 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14607906)
(PMID:17318811)		 Ensembl
MGI		 PMID:14607906 PMID:17318811 GO_REF:0000107 NCBI chr 7:88,548,773...88,644,977
Ensembl chr 7:88,548,671...88,645,488 		JBrowse link
G IL15RA interleukin 15 receptor subunit alpha acts_upstream_of_or_within ISO (PMID:14607906) MGI PMID:14607906 NCBI chr 9:6,061,475...6,096,370
Ensembl chr 9:6,061,197...6,096,250 		JBrowse link
G IL21 interleukin 21 acts_upstream_of_or_within ISO (PMID:14764669) MGI PMID:14764669 NCBI chr 7:69,859,793...69,872,237
Ensembl chr 7:69,863,535...69,872,025 		JBrowse link
G LOC103214855 growth arrest-specific protein 6 involved_in ISO (PMID:18840707) UniProt PMID:18840707 NCBI chr 3:91,720,871...91,762,712 JBrowse link
G LOC103243413 signal transducer and activator of transcription 5B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9841920) MGI
Ensembl		 PMID:9841920 GO_REF:0000107 NCBI chr16:63,997,486...64,070,392
Ensembl chr16:63,997,441...64,070,445 		JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in ISO (PMID:21957144) CACAO PMID:21957144 NCBI chr26:44,405,007...44,483,291 JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr26:44,451,634...44,486,570 JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO (PMID:9841920) MGI PMID:9841920 NCBI chr16:63,959,265...63,986,627
Ensembl chr16:63,960,515...63,985,026 		JBrowse link
G TOX thymocyte selection associated high mobility group box involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20818394) Ensembl
MGI		 PMID:20818394 GO_REF:0000107 NCBI chr 8:54,777,490...55,086,819
Ensembl chr 8:54,776,015...54,927,091 		JBrowse link
G ZBTB1 zinc finger and BTB domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:41,712,721...41,738,853
Ensembl chr24:41,712,114...41,740,654 		JBrowse link
positive regulation of NK T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3B1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14557411) MGI
Ensembl		 PMID:14557411 GO_REF:0000107 NCBI chr 4:72,225,658...72,524,971
Ensembl chr 4:72,225,599...72,524,933 		JBrowse link
G AP3D1 adaptor related protein complex 3 subunit delta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14557411) Ensembl
MGI		 PMID:14557411 GO_REF:0000107 NCBI chr 6:1,901,669...1,951,352
Ensembl chr 6:1,901,507...1,951,314 		JBrowse link
G CD1D CD1d molecule acts_upstream_of_or_within ISO (PMID:9133426)
(PMID:10201995)		 MGI PMID:9133426 PMID:10201995 NCBI chr20:5,726,307...5,733,355
Ensembl chr20:5,727,049...5,730,061 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16973387) Ensembl
MGI		 PMID:16973387 GO_REF:0000107 NCBI chr15:75,112,903...75,200,263
Ensembl chr15:75,112,561...75,197,711 		JBrowse link
G ZBTB16 zinc finger and BTB domain containing 16 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:105,446,067...105,648,771
Ensembl chr 1:105,449,994...105,643,344 		JBrowse link
positive regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDRGK1 DDRGK domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:33,846,591...33,879,770
Ensembl chr 2:33,860,439...33,880,101 		JBrowse link
G IL10 interleukin 10 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:22962438) ARUK-UCL
Ensembl		 PMID:22962438 GO_REF:0000107 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
G IL2 interleukin 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:22962438) ARUK-UCL
Ensembl		 PMID:22962438 GO_REF:0000107 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (PMID:11460154) UniProt PMID:11460154 NCBI chr19:11,670,605...11,677,168 JBrowse link
positive regulation of pro-T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZBTB1 zinc finger and BTB domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:41,712,721...41,738,853
Ensembl chr24:41,712,114...41,740,654 		JBrowse link
positive regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBRA1 autophagy and beclin 1 regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:18,777,807...18,932,784
Ensembl chr 1:18,734,926...18,932,785 		JBrowse link
G BCL6 BCL6 transcription repressor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:81,997,659...82,022,059
Ensembl chr15:81,998,545...82,009,946 		JBrowse link
G BTN2A2 butyrophilin subfamily 2 member A2 acts_upstream_of_or_within ISO (PMID:23589618) MGI PMID:23589618 NCBI chr17:45,857,898...45,869,901
Ensembl chr17:45,744,451...45,868,941 		JBrowse link
G CARMIL2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within ISO (PMID:23793062) MGI PMID:23793062 NCBI chr 5:59,787,069...59,801,615
Ensembl chr 5:59,787,120...59,801,122 		JBrowse link
G CD46 CD46 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:21,650,825...21,693,898
Ensembl chr25:21,655,969...21,693,878 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in ISO (PMID:25742728) ARUK-UCL PMID:25742728 NCBI chr25:21,787,237...21,909,462 JBrowse link
G DUSP10 dual specificity phosphatase 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:7,790,969...7,833,485
Ensembl chr25:7,792,913...7,834,346 		JBrowse link
G FOXO3 forkhead box O3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:65,175,764...65,303,107
Ensembl chr13:65,195,376...65,301,725 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 ISO (PMID:30513302)
(PMID:15780990)
(PMID:12522256), (PMID:15100250), (PMID:16769892), (PMID:17028180)		 UniProt
MGI		 PMID:12522256 PMID:15100250 PMID:15780990 PMID:16769892 PMID:17028180 More... NCBI chr  X:46,349,890...46,365,133 JBrowse link
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,346,754...46,356,928 JBrowse link
G IL2 interleukin 2 ISO RGD PMID:6233372 RGD:1600097 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969 		JBrowse link
G IL4I1 interleukin 4 induced 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:43,046,357...43,061,295
Ensembl chr 6:43,046,379...43,057,851 		JBrowse link
G KAT5 lysine acetyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:8,528,097...8,544,512
Ensembl chr 1:8,526,788...8,544,972 		JBrowse link
G LILRB4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:20935202), (PMID:22387553) BHF-UCL PMID:20935202 PMID:22387553 NCBI chr 6:47,299,764...47,333,711 JBrowse link
G LOC103242599 galectin-9 involved_in ISO (PMID:25065622) UniProt PMID:25065622 NCBI chr16:21,421,034...21,439,583 JBrowse link
G SOCS1 suppressor of cytokine signaling 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,731,866...10,733,745
Ensembl chr 5:10,732,350...10,732,991 		JBrowse link
G SOX12 SRY-box transcription factor 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:35,454,287...35,457,481
Ensembl chr 2:35,454,655...35,455,599 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
G VSIR V-set immunoregulatory receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:59,516,012...59,538,628
Ensembl chr 9:59,516,073...59,542,242 		JBrowse link
positive regulation of T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase acts_upstream_of_or_within ISO (PMID:9478961)
(PMID:7731963)		 MGI PMID:7731963 PMID:9478961 NCBI chr 2:19,167,209...19,200,233 JBrowse link
G BAD BCL2 associated agonist of cell death acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12431371) MGI
Ensembl		 PMID:12431371 GO_REF:0000107 NCBI chr 1:9,949,717...9,964,433
Ensembl chr 1:9,949,762...9,964,432 		JBrowse link
G CD27 CD27 molecule involved_in IEA InterPro GO_REF:0000002 NCBI chr11:6,493,414...6,500,062
Ensembl chr11:6,493,542...6,499,738 		JBrowse link
G CD74 CD74 molecule acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9432982)
(PMID:7679955), (PMID:8598040)		 MGI
Ensembl		 PMID:7679955 PMID:8598040 PMID:9432982 GO_REF:0000107 NCBI chr23:53,008,802...53,022,953
Ensembl chr23:53,009,394...53,022,923 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16501569) Ensembl
MGI		 PMID:16501569 GO_REF:0000107 NCBI chr 5:36,541,022...36,600,874
Ensembl chr 5:36,541,764...36,595,417 		JBrowse link
G GATA3 GATA binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:8,101,404...8,122,762
Ensembl chr 9:8,101,432...8,123,064 		JBrowse link
G IL12A interleukin 12A acts_upstream_of_or_within ISO (PMID:22968459) MGI PMID:22968459 NCBI chr15:30,887,048...30,896,577
Ensembl chr15:30,887,897...30,894,550 		JBrowse link
G IL1RL2 interleukin 1 receptor like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22968459) Ensembl
MGI		 PMID:22968459 GO_REF:0000107 NCBI chr14:5,862,140...5,912,789
Ensembl chr14:5,863,727...5,915,370 		JBrowse link
G IL2 interleukin 2 ISO RGD PMID:9352365 RGD:1600138 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969 		JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISO RGD PMID:9352365 RGD:1600138 NCBI chr 9:6,134,961...6,187,731
Ensembl chr 9:6,141,430...6,149,447 		JBrowse link
G IL36B interleukin 36 beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22968459) MGI
TreeGrafter		 PMID:22968459 GO_REF:0000118 NCBI chr14:16,043,133...16,054,750 JBrowse link
G IL4 interleukin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258 		JBrowse link
G IL7 interleukin 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12431371) MGI
Ensembl		 PMID:12431371 GO_REF:0000107 NCBI chr 8:74,230,493...74,292,985
Ensembl chr 8:74,231,809...74,292,384 		JBrowse link
G LOC103241092 tyrosine-protein kinase ZAP-70 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:7630421)
(PMID:9208839)		 MGI
Ensembl		 PMID:7630421 PMID:9208839 GO_REF:0000107 NCBI chr14:1,403,294...1,430,205
Ensembl chr14:1,404,325...1,431,015 		JBrowse link
G MDK midkine involved_in ISO (PMID:28183532) UniProt PMID:28183532 NCBI chr 1:18,945,355...18,948,394
Ensembl chr 1:18,946,378...18,947,134 		JBrowse link
G MHC-DMA HLA class II histocompatibility antigen, DM alpha chain acts_upstream_of_or_within ISO (PMID:8598040)
(PMID:8638109)
(PMID:8598041), (PMID:9432982)		 MGI PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 NCBI chr17:39,142,340...39,151,804
Ensembl chr17:39,142,395...39,146,252 		JBrowse link
G MHC-DQA1 major histocompatibility complex, class II, DQ alpha 1 acts_upstream_of_or_within ISO (PMID:8598041) MGI PMID:8598041 NCBI chr17:39,422,445...39,428,777
Ensembl chr17:39,420,134...39,428,871 		JBrowse link
G PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:8,158,842...8,224,192
Ensembl chr16:8,159,400...8,223,937 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8666928) Ensembl
MGI		 PMID:8666928 GO_REF:0000107 NCBI chr25:30,655,014...30,777,367
Ensembl chr25:30,653,044...30,777,303 		JBrowse link
G RAG1 recombination activating 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:28,667,996...28,701,002 JBrowse link
G RHOH ras homolog family member H involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:10,061,316...10,109,124
Ensembl chr27:10,062,014...10,062,589 		JBrowse link
G WNT10B Wnt family member 10B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:19723499) MGI
Ensembl		 PMID:19723499 GO_REF:0000107 NCBI chr11:45,205,728...45,229,050
Ensembl chr11:45,205,566...45,210,893 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (PMID:11460154) UniProt PMID:11460154 NCBI chr19:11,670,605...11,677,168 JBrowse link
G ZBTB1 zinc finger and BTB domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:41,712,721...41,738,853
Ensembl chr24:41,712,114...41,740,654 		JBrowse link
G ZMIZ1 zinc finger MIZ-type containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:52,150,810...52,414,793
Ensembl chr 9:52,148,075...52,259,728 		JBrowse link
positive regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase acts_upstream_of_or_within ISO (PMID:11067867), (PMID:16670300)
(PMID:11067867), (PMID:12163459), (PMID:16670300)
(PMID:11435465)		 MGI PMID:11067867 PMID:11435465 PMID:12163459 PMID:16670300 NCBI chr 2:19,167,209...19,200,233 JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 involved_in ISO (PMID:20856819) BHF-UCL PMID:20856819 NCBI chr26:53,114,184...53,129,650
Ensembl chr26:53,114,924...53,126,900 		JBrowse link
G EGR3 early growth response 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21737317) Ensembl
MGI		 PMID:21737317 GO_REF:0000107 NCBI chr 8:20,767,219...20,772,838
Ensembl chr 8:20,767,224...20,772,682 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:104,960,296...104,966,596
Ensembl chr10:104,960,120...104,966,585 		JBrowse link
G IL2RG interleukin 2 receptor subunit gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9252128)
(PMID:9916699)		 Ensembl
MGI		 PMID:9252128 PMID:9916699 GO_REF:0000107 NCBI chr  X:60,905,011...60,915,723
Ensembl chr  X:60,905,343...60,909,149 		JBrowse link
G IL7R interleukin 7 receptor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9215626) MGI
Ensembl		 PMID:9215626 GO_REF:0000107 NCBI chr 4:34,701,724...34,724,241
Ensembl chr 4:34,701,531...34,721,361 		JBrowse link
G LOC103240354 pantetheinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:40,819,738...40,853,827
Ensembl chr13:40,819,950...40,855,171 		JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in ISO (PMID:11017103) CACAO PMID:11017103 NCBI chr26:44,405,007...44,483,291 JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr26:44,451,634...44,486,570 JBrowse link
G SHH sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:123,929,937...123,942,451
Ensembl chr21:123,932,900...123,942,395 		JBrowse link
G TESPA1 thymocyte expressed, positive selection associated 1 involved_in ISO (PMID:22561606) UniProt PMID:22561606 NCBI chr11:51,044,269...51,079,210
Ensembl chr11:51,042,095...51,070,939 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:84,207,818...84,226,438
Ensembl chr12:84,207,820...84,226,562 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr12:45,928,212...45,930,897
Ensembl chr12:45,929,071...45,930,904 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr25:8,641,386...8,647,485
Ensembl chr25:8,641,752...8,646,563 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894097) Ensembl
MGI		 PMID:11894097 GO_REF:0000107 NCBI chr 8:84,843,391...84,881,087
Ensembl chr 8:84,843,471...84,881,303 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:60,330,192...60,335,477
Ensembl chr14:60,431,401...60,433,011
Ensembl chr14:60,431,401...60,433,011 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MALT1 MALT1 paracaspase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:20,984,985...21,064,198
Ensembl chr18:20,985,819...21,054,554 		JBrowse link
G NFKBID NFKB inhibitor delta involved_in ISO (PMID:25282160) UniProt PMID:25282160 NCBI chr 6:30,800,122...30,812,991
Ensembl chr 6:30,799,204...30,811,141 		JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:79,044,624...79,077,736
Ensembl chr22:79,044,619...79,055,776 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chr25:84,431,436...84,463,387
Ensembl chr25:84,434,527...84,463,249 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD2 bromodomain containing 2 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chr17:39,113,519...39,126,267 JBrowse link
G BRD2 bromodomain containing 2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr17:39,114,700...39,122,051 JBrowse link
G BRD4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chr 6:13,836,332...13,883,459
Ensembl chr 6:13,836,324...13,873,877 		JBrowse link
G EP300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:23,634,132...23,726,095
Ensembl chr19:23,634,571...23,724,979 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:52,289,486...52,296,735
Ensembl chr11:52,295,106...52,297,244 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:87,679,656...87,778,767
Ensembl chr15:87,679,077...87,779,102 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL18 interleukin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G IL4R interleukin 4 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015 		JBrowse link
G IL6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in ISO (PMID:26098997) UniProt PMID:26098997 NCBI chr25:84,431,436...84,463,387
Ensembl chr25:84,434,527...84,463,249 		JBrowse link
G PRKCZ protein kinase C zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:129,367,309...129,502,681
Ensembl chr20:129,365,679...129,485,818 		JBrowse link
G RARA retinoic acid receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:65,817,849...65,866,862
Ensembl chr16:65,817,757...65,866,878 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:18354165) BHF-UCL PMID:18354165 NCBI chr25:55,714,291...55,998,009
Ensembl chr25:55,974,691...55,997,374 		JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SHB SH2 domain containing adaptor protein B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24645804) Ensembl
MGI		 PMID:24645804 GO_REF:0000107 NCBI chr12:42,520,803...42,669,892
Ensembl chr12:42,520,905...42,669,211 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19822
    immune system process 2676
      leukocyte activation 1036
        lymphocyte activation 847
          lymphocyte differentiation 455
            positive regulation of lymphocyte differentiation 126
              positive regulation of B cell differentiation + 20
              positive regulation of T cell differentiation + 107
              positive regulation of natural killer cell differentiation + 13
Path 2
Term Annotations click to browse term
  biological_process 19822
    developmental process 6858
      cellular developmental process 4596
        cell differentiation 4595
          cell development 3274
            hemopoiesis 1055
              leukocyte differentiation 685
                mononuclear cell differentiation 556
                  lymphocyte differentiation 455
                    regulation of lymphocyte differentiation 214
                      positive regulation of lymphocyte differentiation 126
                        positive regulation of B cell differentiation + 20
                        positive regulation of T cell differentiation + 107
                        positive regulation of natural killer cell differentiation + 13
paths to the root