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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of lymphocyte differentiation
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Accession:GO:0045620 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: down regulation of lymphocyte differentiation;   downregulation of lymphocyte differentiation
 narrow_synonym: inhibition of lymphocyte differentiation
 related_synonym: negative regulation of lymphocyte development

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negative regulation of lymphocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo7 F-box protein 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21652635) MGI
Ensembl		 PMID:21652635 GO_REF:0000107 NCBI chrNW_004936492:7,261,442...7,276,779
Ensembl chrNW_004936492:7,261,009...7,276,943 		JBrowse link
negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli3 GLI family zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:17,129,922...17,403,630
Ensembl chrNW_004936478:17,126,911...17,403,011 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:1,474,693...1,480,562
Ensembl chrNW_004936569:1,474,665...1,480,568 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10981962) Ensembl
MGI		 PMID:10981962 GO_REF:0000107 NCBI chrNW_004936527:10,033,095...10,042,713
Ensembl chrNW_004936527:10,033,299...10,042,599 		JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt3 fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (PMID:16618805) MGI PMID:16618805 NCBI chrNW_004936472:23,169,967...23,239,178
Ensembl chrNW_004936472:23,170,470...23,256,904 		JBrowse link
G Hmgb3 high mobility group box 3 acts_upstream_of_or_within ISO (PMID:12714519) MGI PMID:12714519 NCBI chrNW_004936714:1,523,016...1,527,301 JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (PMID:18523151) MGI PMID:18523151 NCBI chrNW_004936532:5,236,175...5,238,689
Ensembl chrNW_004936532:5,236,037...5,238,881 		JBrowse link
G Sfrp1 secreted frizzled related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936785:1,276,478...1,320,397
Ensembl chrNW_004936785:1,276,420...1,321,017 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:17,537,273...17,589,383
Ensembl chrNW_004936475:17,537,236...17,589,330 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:22473704) UniProt PMID:22473704 NCBI chrNW_004936472:25,236,728...25,246,585
Ensembl chrNW_004936472:25,236,728...25,246,580 		JBrowse link
G Runx3 RUNX family transcription factor 3 involved_in ISO (PMID:18258917) UniProt PMID:18258917 NCBI chrNW_004936474:9,751,946...9,802,910
Ensembl chrNW_004936474:9,751,946...9,802,910 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc4a2 solute carrier family 4 member 2 involved_in ISO (PMID:24515893) UniProt PMID:24515893 NCBI chrNW_004936527:6,485,566...6,499,901
Ensembl chrNW_004936527:6,485,511...6,499,924 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936530:9,312,965...9,315,593
Ensembl chrNW_004936530:9,312,965...9,316,165 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,546,139...4,560,157
Ensembl chrNW_004936580:4,551,304...4,560,163 		JBrowse link
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936697:1,054,237...1,061,468
Ensembl chrNW_004936697:1,056,636...1,061,468 		JBrowse link
G Clec4g C-type lectin domain family 4 member G involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23487419) Ensembl
MGI		 PMID:23487419 GO_REF:0000107 NCBI chrNW_004936588:4,737,278...4,740,750
Ensembl chrNW_004936588:4,738,182...4,740,750 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16230479) Ensembl
MGI		 PMID:16230479 GO_REF:0000107 NCBI chrNW_004936490:14,887,062...14,910,038
Ensembl chrNW_004936490:14,887,043...14,909,956 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:1,474,693...1,480,562
Ensembl chrNW_004936569:1,474,665...1,480,568 		JBrowse link
G Tmem131l transmembrane 131 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936576:311,649...479,507
Ensembl chrNW_004936576:420,502...479,513 		JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgl2 fibrinogen like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29341118) Ensembl
MGI		 PMID:29341118 GO_REF:0000107 NCBI chrNW_004936479:20,619,955...20,625,416
Ensembl chrNW_004936479:20,619,931...20,652,981 		JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101970371 peptidoglycan recognition protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:3,184,904...3,197,203
Ensembl chrNW_004936580:3,184,904...3,194,319 		JBrowse link
G Pglyrp1 peptidoglycan recognition protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20709292) Ensembl
MGI		 PMID:20709292 GO_REF:0000107 NCBI chrNW_004936706:2,317,137...2,320,993
Ensembl chrNW_004936706:2,315,132...2,320,796 		JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20709292) Ensembl
MGI		 PMID:20709292 GO_REF:0000107 NCBI chrNW_004936596:5,038,452...5,043,172
Ensembl chrNW_004936596:5,038,452...5,044,569 		JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15240705) MGI
Ensembl		 PMID:15240705 GO_REF:0000107 NCBI chrNW_004936578:2,371,976...2,395,034
Ensembl chrNW_004936578:2,371,945...2,395,071 		JBrowse link
G LOC101964865 complement receptor type 1 acts_upstream_of ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936626:2,390,004...2,472,039
Ensembl chrNW_004936626:2,389,868...2,445,927 		JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (IN blood group) involved_in ISO (PMID:25065622) UniProt PMID:25065622 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936631:484,356...489,643
Ensembl chrNW_004936631:484,356...489,643 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO RGD PMID:30287503 RGD:38549580 NCBI chrNW_004936543:2,110,351...2,111,896
Ensembl chrNW_004936543:2,110,304...2,112,186 		JBrowse link
G Irf1 interferon regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936647:2,686,247...2,693,633
Ensembl chrNW_004936647:2,686,414...2,693,636 		JBrowse link
G Lag3 lymphocyte activating 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936709:1,041,519...1,048,630
Ensembl chrNW_004936709:1,041,530...1,047,280 		JBrowse link
G Mdk midkine involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936562:2,687,825...2,690,292
Ensembl chrNW_004936562:2,687,825...2,689,484 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18713990) BHF-UCL PMID:18713990 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
negative regulation of T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:7679955) MGI
Ensembl		 PMID:7679955 GO_REF:0000107 NCBI chrNW_004936504:4,522,576...4,532,289
Ensembl chrNW_004936504:4,522,751...4,531,750 		JBrowse link
G Ifnb1 interferon beta 1 involved_in ISO (PMID:20554961) UniProt PMID:20554961 NCBI chrNW_004936652:2,736,270...2,736,833 JBrowse link
G LOC106145247 E3 ubiquitin-protein ligase DTX1 acts_upstream_of_or_within ISO (PMID:12794108) MGI PMID:12794108 NCBI chrNW_004936668:3,006,539...3,021,066 JBrowse link
G Nrarp NOTCH regulated ankyrin repeat protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12794108) Ensembl
MGI		 PMID:12794108 GO_REF:0000107 NCBI chrNW_004936669:702,825...705,009
Ensembl chrNW_004936669:702,853...703,197 		JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within ISO (PMID:16290204) MGI PMID:16290204 NCBI chrNW_004936659:1,894,423...1,897,690 JBrowse link
negative regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936697:1,054,237...1,061,468
Ensembl chrNW_004936697:1,056,636...1,061,468 		JBrowse link
G Foxj1 forkhead box J1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:1,284,799...1,288,898
Ensembl chrNW_004936594:1,284,781...1,289,361 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:1,474,693...1,480,562
Ensembl chrNW_004936569:1,474,665...1,480,568 		JBrowse link
G Nfkbid NFKB inhibitor delta acts_upstream_of_or_within ISO (PMID:11931770) MGI PMID:11931770 NCBI chrNW_004936570:464,513...471,333
Ensembl chrNW_004936570:463,974...471,344 		JBrowse link
G Rag2 recombination activating 2 ISO RGD PMID:30206106 RGD:38508903 NCBI chrNW_004936533:1,801,207...1,807,431
Ensembl chrNW_004936533:1,801,391...1,807,431 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10981962) Ensembl
MGI		 PMID:10981962 GO_REF:0000107 NCBI chrNW_004936527:10,033,095...10,042,713
Ensembl chrNW_004936527:10,033,299...10,042,599 		JBrowse link
G Zc3h8 zinc finger CCCH-type containing 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936783:834,804...863,751
Ensembl chrNW_004936783:834,790...864,330 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:567,462...569,195
Ensembl chrNW_004936794:568,567...569,139 		JBrowse link
G Il4r interleukin 4 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chrNW_004936501:11,025,590...11,058,807
Ensembl chrNW_004936501:11,025,567...11,058,818 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:16020505) BHF-UCL PMID:16020505 NCBI chrNW_004936596:3,212,593...3,224,426
Ensembl chrNW_004936596:3,212,593...3,224,048 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:9670042) BHF-UCL PMID:9670042 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:567,462...569,195
Ensembl chrNW_004936794:568,567...569,139 		JBrowse link
G Foxp3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936721:1,118,376...1,125,282
Ensembl chrNW_004936721:1,118,782...1,132,308 		JBrowse link
G Il2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936662:1,594,953...1,599,625
Ensembl chrNW_004936662:1,594,953...1,599,625 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:13,919,006...13,973,868
Ensembl chrNW_004936481:13,919,257...13,966,677 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:11,341,663...11,393,275
Ensembl chrNW_004936487:11,341,700...11,389,859 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:13,894,586...13,921,978
Ensembl chrNW_004936497:13,894,580...13,922,065 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23034280) MGI
Ensembl		 PMID:23034280 GO_REF:0000107 NCBI chrNW_004936580:4,546,139...4,560,157
Ensembl chrNW_004936580:4,551,304...4,560,163 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:19,714,145...19,722,512
Ensembl chrNW_004936474:19,714,153...19,722,528 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak3 Janus kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936596:3,212,593...3,224,426
Ensembl chrNW_004936596:3,212,593...3,224,048 		JBrowse link
G Lgals1 galectin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:3,407,704...3,411,197
Ensembl chrNW_004936492:3,407,049...3,411,222 		JBrowse link
G LOC101954799 signal transducer and activator of transcription 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,095,047...17,115,945
Ensembl chrNW_004936490:17,095,954...17,114,866 		JBrowse link
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936556:745,798...765,926
Ensembl chrNW_004936556:745,798...765,918 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:14,499,495...14,508,074
Ensembl chrNW_004936481:14,499,577...14,508,017 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:9,124,314...9,142,372
Ensembl chrNW_004936503:9,124,264...9,142,413 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936794:567,462...569,195
Ensembl chrNW_004936794:568,567...569,139 		JBrowse link
G Bcl6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12594267) Ensembl
MGI		 PMID:12594267 GO_REF:0000107 NCBI chrNW_004936578:2,371,976...2,395,034
Ensembl chrNW_004936578:2,371,945...2,395,071 		JBrowse link
G Hlx H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chrNW_004936650:1,416,825...1,422,595
Ensembl chrNW_004936650:1,416,812...1,422,588 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:5,531,002...5,588,022
Ensembl chrNW_004936508:5,531,002...5,587,549 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15917799) Ensembl
MGI		 PMID:15917799 GO_REF:0000107 NCBI chrNW_004936481:13,919,006...13,973,868
Ensembl chrNW_004936481:13,919,257...13,966,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17429
    immune system process 2316
      leukocyte activation 948
        lymphocyte activation 771
          lymphocyte differentiation 413
            negative regulation of lymphocyte differentiation 58
              negative regulation of B cell differentiation + 6
              negative regulation of T cell differentiation + 49
              negative regulation of natural killer cell differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 17429
    developmental process 6454
      cellular developmental process 4356
        cell differentiation 4355
          cell development 3127
            hemopoiesis 986
              leukocyte differentiation 629
                mononuclear cell differentiation 508
                  lymphocyte differentiation 413
                    regulation of lymphocyte differentiation 194
                      negative regulation of lymphocyte differentiation 58
                        negative regulation of B cell differentiation + 6
                        negative regulation of T cell differentiation + 49
                        negative regulation of natural killer cell differentiation + 3
paths to the root