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ONTOLOGY REPORT - ANNOTATIONS

Term:MHC class II biosynthetic process
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Accession:GO:0045342 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II.
Synonyms:exact_synonym: MHC class II anabolism;   MHC class II biosynthesis;   MHC class II formation;   MHC class II synthesis;   major histocompatibility complex class II biosynthesis;   major histocompatibility complex class II biosynthetic process


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MHC class II biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of ISO (PMID:10549626) RGD PMID:10549626 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857755 (PMID:8301134)		 Ensembl
RGD		 PMID:8301134 GO_REF:0000107 NCBI chr 9:83,406,327...83,417,252
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:1860885 (PMID:10549626)		 Ensembl
RGD		 PMID:10549626 GO_REF:0000107 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
negative regulation of MHC class II biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 involved_in ISO (PMID:1940799) RGD PMID:1940799 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Marchf8 membrane associated ring-CH-type finger 8 involved_in ISO (PMID:16785530) RGD PMID:16785530 NCBI chr 4:149,415,642...149,530,771
Ensembl chr 4:149,416,071...149,530,770 		JBrowse link
G Nfx1 nuclear transcription factor, X-box binding 1 acts_upstream_of_or_within ISO (PMID:12047746) RGD PMID:12047746 NCBI chr 5:56,104,945...56,162,912
Ensembl chr 5:56,105,234...56,162,912 		JBrowse link
G Pf4 platelet factor 4 involved_in ISO (PMID:10666185) RGD PMID:10666185 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (PMID:7592651) RGD PMID:7592651 NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Taf7 TATA-box binding protein associated factor 7 involved_in ISO (PMID:20937824) RGD PMID:20937824 NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134 		JBrowse link
positive regulation of MHC class II biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40lg CD40 ligand IDA RGD PMID:18262271 RGD:2313421 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 involved_in ISO (PMID:29020624) RGD PMID:29020624 NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Ciita class II, major histocompatibility complex, transactivator involved_in IEP
IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:11477547 PMID:11071855 GO_REF:0000033, RGD:632487, RGD:632488 NCBI chr10:5,646,854...5,694,393
Ensembl chr10:5,140,178...5,187,440 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within
involved_in		 IEP
ISO		 (PMID:11027433)
UniProtKB:P05067|UniProtKB:P49768 (PMID:1845803), (PMID:2493384), (PMID:2502420), (PMID:26227742)		 RGD PMID:1845803 PMID:2493384 PMID:2502420 PMID:11027433 PMID:26227742 More... RGD:8547557 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 acts_upstream_of_or_within ISO (PMID:11027433) RGD PMID:11027433 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il33 interleukin 33 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:26936882)		 Ensembl
RGD		 PMID:26936882 GO_REF:0000107 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:10549626), (PMID:11027433) RGD PMID:10549626 PMID:11027433 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Jak2 Janus kinase 2 involved_in ISO UniProtKB:P01580 (PMID:26227742) RGD PMID:26227742 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (PMID:21890893)
GO_REF:0000107		 RGD
Ensembl		 PMID:21890893 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1860885 (PMID:10549626)		 Ensembl
RGD		 PMID:10549626 GO_REF:0000107 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmem106a transmembrane protein 106A involved_in ISS
ISO		 GO_REF:0000024
(PMID:26215746)		 UniProt
RGD		 PMID:26215746 GO_REF:0000024 NCBI chr10:87,007,144...87,016,161
Ensembl chr10:86,506,936...86,515,892 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:1903538)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:1903538 GO_REF:0000024 GO_REF:0000107 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      metabolic process 12171
        macromolecule metabolic process 9985
          macromolecule biosynthetic process 7656
            MHC class II biosynthetic process 18
              negative regulation of MHC class II biosynthetic process 6
              positive regulation of MHC class II biosynthetic process 12
              regulation of MHC class II biosynthetic process + 17
paths to the root