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ONTOLOGY REPORT - ANNOTATIONS

Term:alpha-ketoacid dehydrogenase complex
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Accession:GO:0045240 term browser browse the term
Definition:A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present.
Synonyms:exact_synonym: 2-oxoacid dehydrogenase complex;   dihydrolipoyl dehydrogenase complex


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branched-chain alpha-ketoacid dehydrogenase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha part_of ISS
ISO		 GO_REF:0000024
(PMID:10745006), (PMID:3593587), (PMID:7883996), (PMID:9582350)		 HGNC-UCL
RGD		 PMID:3593587 PMID:7883996 PMID:9582350 PMID:10745006 GO_REF:0000024 NCBI chr 1:90,266,731...90,295,521
Ensembl chr 1:81,138,947...81,167,862 		JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta part_of ISS
ISO		 GO_REF:0000024
(PMID:10745006), (PMID:2022752), (PMID:3593587), (PMID:9582350)		 UniProt
RGD		 PMID:2022752 PMID:3593587 PMID:9582350 PMID:10745006 GO_REF:0000024 NCBI chr 8:93,725,277...93,907,799
Ensembl chr 8:84,845,264...85,027,812 		JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 part_of ISO
IEA		 (PMID:3593587)
GO_REF:0000107		 RGD
Ensembl		 PMID:3593587 GO_REF:0000107 NCBI chr 2:207,166,660...207,195,528
Ensembl chr 2:204,481,737...204,510,609 		JBrowse link
G Dld dihydrolipoamide dehydrogenase part_of ISO
IEA		 (PMID:3593587)
GO_REF:0000107		 RGD
Ensembl		 PMID:3593587 GO_REF:0000107 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
oxoadipate dehydrogenase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 part_of ISO
IEA		 (PMID:29191460)
GO_REF:0000107		 RGD
Ensembl		 PMID:29191460 GO_REF:0000107 NCBI chr17:77,242,512...77,316,074
Ensembl chr17:72,355,201...72,406,723 		JBrowse link
G Dld dihydrolipoamide dehydrogenase part_of ISO
IEA		 (PMID:29191460)
GO_REF:0000107		 RGD
Ensembl		 PMID:29191460 GO_REF:0000107 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase part_of ISO (PMID:29191460) RGD PMID:29191460 NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
oxoglutarate dehydrogenase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd11 abhydrolase domain containing 11 part_of ISO
IEA		 (PMID:32792488)
GO_REF:0000107		 RGD
Ensembl		 PMID:32792488 GO_REF:0000107 NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398 		JBrowse link
G AC132020.1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 9:76,367,193...76,367,615 JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase part_of IDA PMID:1377677 HGNC-UCL PMID:1377677 RGD:68712 NCBI chr 1:191,945,809...191,950,480
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Dld dihydrolipoamide dehydrogenase part_of IDA
IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:29211711)		 Ensembl
GO_Central
RGD		 PMID:29211711 PMID:3571202 GO_REF:0000033 GO_REF:0000107, RGD:2306876 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase part_of IDA
ISO
IEA		 (PMID:29211711)
GO_REF:0000002		 RGD
InterPro		 PMID:29211711 PMID:9405249 PMID:3571202 GO_REF:0000002, RGD:1359804, RGD:2306876 NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G ENSRNOG00000069392 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 6:132,462,789...132,465,038 JBrowse link
G Kat2a lysine acetyltransferase 2A located_in ISO
IEA		 (PMID:29211711)
GO_REF:0000107		 RGD
Ensembl		 PMID:29211711 GO_REF:0000107 NCBI chr10:86,132,535...86,140,877
Ensembl chr10:85,632,216...85,640,166 		JBrowse link
G Kgd4 alpha-ketoglutarate dehydrogenase subunit 4 part_of IBA
ISO		 GO_REF:0000033
(PMID:25165143), (PMID:36854377)		 GO_Central
RGD		 PMID:25165143 PMID:36854377 GO_REF:0000033 NCBI chr 2:33,604,611...33,614,988
Ensembl chr 2:31,870,551...31,880,730 		JBrowse link
G Ogdh oxoglutarate dehydrogenase part_of IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:29211711)
GO_REF:0000107		 GO_Central
RGD
Ensembl		 PMID:29211711 PMID:3571202 GO_REF:0000033 GO_REF:0000107, RGD:2306876 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Ogdhl oxoglutarate dehydrogenase L part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:7,584,666...7,610,705
Ensembl chr16:7,578,367...7,604,386 		JBrowse link
pyruvate dehydrogenase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlat dihydrolipoamide S-acetyltransferase part_of TAS
IEA
IBA
ISO
IDA		 GO_REF:0000104
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:19240034), (PMID:25525879), (PMID:9242632)		 UniProt
Ensembl
InterPro
GO_Central
RGD		 PMID:9242632 PMID:19240034 PMID:25525879 PMID:1581353 PMID:7487891 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107, RGD:728205, RGD:1599112 NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479 		JBrowse link
G Dld dihydrolipoamide dehydrogenase part_of IDA
IEA
ISO		 GO_REF:0000107
MGI:2182403 (PMID:9405644)
(PMID:19240034), (PMID:9242632)		 Ensembl
RGD		 PMID:9242632 PMID:9405644 PMID:19240034 PMID:7487891 GO_REF:0000107, RGD:1599112 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 part_of IDA
ISO		 (PMID:19081061), (PMID:19240034)
GO_REF:0000114		 RGD
ComplexPortal		 PMID:19081061 PMID:19240034 PMID:7487891 GO_REF:0000114, RGD:1599112 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 IDA RGD PMID:7487891 RGD:1599112 NCBI chr 2:232,545,550...232,547,098 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta part_of IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:19081061), (PMID:19240034)
GO_REF:0000114
GO_REF:0000107		 GO_Central
RGD
ComplexPortal
Ensembl		 PMID:19081061 PMID:19240034 PMID:7487891 GO_REF:0000033 GO_REF:0000107 GO_REF:0000114, RGD:1599112 NCBI chr15:19,182,789...19,188,731
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X part_of ISO
IEA
IBA		 (PMID:19240034), (PMID:25525879), (PMID:9242632)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033		 RGD
Ensembl
InterPro
GO_Central		 PMID:9242632 PMID:19240034 PMID:25525879 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:109,826,579...109,886,869
Ensembl chr 3:89,371,497...89,431,773 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 part_of IDA
ISO
IEA		 (PMID:22195962)
GO_REF:0000107		 RGD
Ensembl		 PMID:22195962 PMID:12573248 GO_REF:0000107, RGD:2307429 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 part_of IDA
ISS
ISO		 GO_REF:0000024
(PMID:21190881)		 UniProt
RGD		 PMID:21190881 PMID:12573248 GO_REF:0000024, RGD:2307429 NCBI chr10:80,469,388...80,483,988
Ensembl chr10:79,972,556...79,987,085 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21364
    protein-containing complex 6830
      catalytic complex 1960
        oxidoreductase complex 194
          alpha-ketoacid dehydrogenase complex 21
            branched-chain alpha-ketoacid dehydrogenase complex 4
            oxoadipate dehydrogenase complex 3
            oxoglutarate dehydrogenase complex 10
            pyruvate dehydrogenase complex 8
paths to the root