ONTOLOGY REPORT - ANNOTATIONS
Term: regulatory T cell differentiation
Accession: GO:0045066
browse the term
Definition: The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types.
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms: exact_synonym: regulatory T lymphocyte differentiation; suppressor T cell differentiation; suppressor T lymphocyte differentiation
related_synonym: regulatory T cell development
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Cd28
Cd28 molecule
involved_in
IEA ISO
GO_REF:0000107 (PMID:18641304)
Ensembl RGD
PMID:18641304
GO_REF:0000107
NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:62,166,192...62,194,685
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Foxp3
forkhead box P3
involved_in acts_upstream_of
ISO
(PMID:32644293) (PMID:16769892), (PMID:17028180)
RGD
PMID:16769892 PMID:17028180 PMID:32644293
NCBI chr X:17,580,380...17,601,181
Ensembl chr X:14,908,494...14,923,838
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Tgfb1
transforming growth factor, beta 1
involved_in acts_upstream_of_or_within
ISO
(PMID:32644293) MGI:3576270|MGI:3719583 (PMID:15100250), (PMID:17481928)
RGD
PMID:15100250 PMID:17481928 PMID:32644293
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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Usp44
ubiquitin specific peptidase 44
involved_in
ISO
(PMID:32644293)
RGD
PMID:32644293
NCBI chr 7:30,251,142...30,301,185
Ensembl chr 7:28,364,033...28,410,053
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Foxp3
forkhead box P3
involved_in acts_upstream_of
ISO
(PMID:22079196) MGI:1857034|MGI:3696705 (PMID:16275384), (PMID:16301745), (PMID:18573908)
RGD
PMID:16275384 PMID:16301745 PMID:18573908 PMID:22079196
NCBI chr X:17,580,380...17,601,181
Ensembl chr X:14,908,494...14,923,838
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Fut7
fucosyltransferase 7
acts_upstream_of_or_within
ISO
MGI:2387664 (PMID:18573908)
RGD
PMID:18573908
NCBI chr 3:28,635,913...28,640,407
Ensembl chr 3:8,239,384...8,242,260
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Il2rg
interleukin 2 receptor subunit gamma
acts_upstream_of
ISO
MGI:1857455 (PMID:16227984)
RGD
PMID:16227984
NCBI chr X:70,435,340...70,439,052
Ensembl chr X:66,392,542...66,399,823
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Ncor1
nuclear receptor co-repressor 1
acts_upstream_of_or_within
ISO
MGI:2677822 (PMID:11030619)
RGD
PMID:11030619
NCBI chr10:47,498,852...47,641,612
Ensembl chr10:46,999,536...47,141,032
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Pla2g2d
phospholipase A2, group IID
acts_upstream_of_or_within
ISO
(PMID:19564598)
RGD
PMID:19564598
NCBI chr 5:156,299,374...156,305,816
Ensembl chr 5:151,018,870...151,022,525
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Tox
thymocyte selection-associated high mobility group box
involved_in
ISO
(PMID:18195075)
RGD
PMID:18195075
NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:19,874,467...20,171,272
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Cd44
CD44 molecule
involved_in
ISO
(PMID:25065622)
RGD
PMID:25065622
NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
involved_in
ISO IBA
(PMID:18641304) GO_REF:0000033
RGD GO_Central
PMID:18641304
GO_REF:0000033
NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:62,319,312...62,324,963
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Hspb1
heat shock protein family B (small) member 1
IMP
RGD
PMID:30287503
RGD:38549580
NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743
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Irf1
interferon regulatory factor 1
involved_in
ISS ISO
GO_REF:0000024 (PMID:18641303)
UniProt RGD
PMID:18641303
GO_REF:0000024
NCBI chr10:38,417,935...38,424,946
Ensembl chr10:37,916,670...37,924,166
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Lag3
lymphocyte activating 3
involved_in
ISO ISS
(PMID:15485628) GO_REF:0000024
RGD UniProt
PMID:15485628
GO_REF:0000024
NCBI chr 4:159,398,930...159,407,001
Ensembl chr 4:157,712,667...157,720,404
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Mdk
midkine
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:22323540) GO_REF:0000107
UniProt RGD Ensembl
PMID:22323540
GO_REF:0000024 GO_REF:0000107
NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:77,901,158...77,903,130
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Mir21
microRNA 21
involved_in
ISO
RNAcentral:URS0000338542_9606 (PMID:22387553)
RGD
PMID:22387553
NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
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Mir30b
microRNA 30b
involved_in
ISO
RNAcentral:URS000039ED8D_9606 (PMID:22387553)
RGD
PMID:22387553
NCBI chr 7:102,021,543...102,021,629
Ensembl chr 7:100,132,589...100,132,675
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Tnfsf4
TNF superfamily member 4
involved_in
ISO
(PMID:18713990)
RGD
PMID:18713990
NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788
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Tug1
taurine up-regulated 1
IMP
RGD
PMID:30287503
RGD:38549580
NCBI chr14:82,743,501...82,750,534
Ensembl chr14:78,522,506...78,526,927
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Foxp3
forkhead box P3
acts_upstream_of_or_within
ISO
MGI:1857034|MGI:2654936|MGI:3696705 (PMID:12612578), (PMID:16275384), (PMID:16301745), (PMID:18573908)
RGD
PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908
NCBI chr X:17,580,380...17,601,181
Ensembl chr X:14,908,494...14,923,838
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Gimap5
GTPase, IMAP family member 5
IMP
RGD
PMID:15778366
RGD:2303772
NCBI chr 4:79,025,151...79,031,917
Ensembl chr 4:77,687,564...77,703,086
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Il2rg
interleukin 2 receptor subunit gamma
acts_upstream_of_or_within
ISO
MGI:1857455 (PMID:16227984)
RGD
PMID:16227984
NCBI chr X:70,435,340...70,439,052
Ensembl chr X:66,392,542...66,399,823
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Klhl25
kelch-like family member 25
involved_in
ISO ISS
(PMID:34491895) GO_REF:0000024
RGD UniProt
PMID:34491895
GO_REF:0000024
NCBI chr 1:139,134,655...139,159,898
Ensembl chr 1:129,722,026...129,750,227
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RT1-Da
RT1 class II, locus Da
involved_in
ISO
(PMID:28467828)
RGD
PMID:28467828
NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,512,911...4,518,455
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RT1-Db1
RT1 class II, locus Db1
involved_in
ISO
(PMID:28467828)
RGD
PMID:28467828
NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258
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Ifng
interferon gamma
involved_in
ISO
(PMID:20209097)
RGD
PMID:20209097
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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Lgals9
galectin 9
involved_in
ISO
(PMID:20209097)
RGD
PMID:20209097
NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045
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Ambra1
autophagy and beclin 1 regulator 1
involved_in
ISO
(PMID:30513302)
RGD
PMID:30513302
NCBI chr 3:98,156,626...98,345,876
Ensembl chr 3:77,700,936...77,890,221
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Bcl6
BCL6, transcription repressor
involved_in
ISO
(PMID:20935202), (PMID:22387553)
RGD
PMID:20935202 PMID:22387553
NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389
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Btn2a2
butyrophilin, subfamily 2, member A2
acts_upstream_of_or_within
ISO
(PMID:23589618)
RGD
PMID:23589618
NCBI chr17:41,620,807...41,632,621
Ensembl chr17:41,620,839...41,632,618
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Carmil2
capping protein regulator and myosin 1 linker 2
acts_upstream_of_or_within
ISO
MGI:4462559|MGI:5547539 (PMID:23793062)
RGD
PMID:23793062
NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965
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Cd46
CD46 molecule
involved_in
ISO
(PMID:12540904)
RGD
PMID:12540904
NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445
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Dusp10
dual specificity phosphatase 10
involved_in
ISO
(PMID:22387553)
RGD
PMID:22387553
NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716
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Foxo3
forkhead box O3
involved_in
ISO
(PMID:30513302)
RGD
PMID:30513302
NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
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Foxp3
forkhead box P3
involved_in acts_upstream_of_or_within
ISO
(PMID:30513302) MGI:2654936 (PMID:12522256), (PMID:15100250), (PMID:15780990), (PMID:16769892), (PMID:17028180)
RGD
PMID:12522256 PMID:15100250 PMID:15780990 PMID:16769892 PMID:17028180 PMID:30513302 More...
NCBI chr X:17,580,380...17,601,181
Ensembl chr X:14,908,494...14,923,838
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Il2
interleukin 2
IDA
RGD
PMID:6233372
RGD:1600097
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
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Il4i1
interleukin 4 induced 1
involved_in
ISO
(PMID:25778793)
RGD
PMID:25778793
NCBI chr 1:104,435,540...104,461,049
Ensembl chr 1:95,295,601...95,324,562
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Kat5
lysine acetyltransferase 5
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:24835996)
UniProt Ensembl RGD
PMID:24835996
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:212,325,089...212,332,640
Ensembl chr 1:202,895,751...202,903,458
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Lgals9
galectin 9
involved_in
ISO
(PMID:25065622)
RGD
PMID:25065622
NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045
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Lilrb4
leukocyte immunoglobulin like receptor B4
involved_in
ISO
(PMID:20935202), (PMID:22387553)
RGD
PMID:20935202 PMID:22387553
NCBI chr 1:78,847,685...78,853,294
Ensembl chr 1:69,805,250...69,810,660
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Mir214
microRNA 214
IMP
RGD
PMID:30287503
RGD:38549580
NCBI chr13:77,121,645...77,121,752
Ensembl chr13:74,588,372...74,588,481
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RT1-M3-1
RT1 class Ib, locus M3, gene 1
involved_in
ISO
(PMID:20448110)
RGD
PMID:20448110
NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,287,521...1,328,117
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Socs1
suppressor of cytokine signaling 1
involved_in
IEA ISO
GO_REF:0000107 (PMID:22387553)
Ensembl RGD
PMID:22387553
GO_REF:0000107
NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383
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Sox12
SRY-box transcription factor 12
involved_in
ISO
(PMID:30190287)
RGD
PMID:30190287
NCBI chr 3:161,319,800...161,320,819
Ensembl chr 3:140,856,579...140,860,975
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Tgfb1
transforming growth factor, beta 1
involved_in
ISO
(PMID:25065622)
RGD
PMID:25065622
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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Vsir
V-set immunoregulatory receptor
involved_in
ISO
(PMID:24691993)
RGD
PMID:24691993
NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
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Kcnk18
potassium two pore domain channel subfamily K member 18
involved_in
ISS ISO
GO_REF:0000024 (PMID:34702947)
UniProt RGD
PMID:34702947
GO_REF:0000024
NCBI chr 1:258,374,671...258,388,945
Ensembl chr 1:258,374,671...258,388,945
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Cd28
Cd28 molecule
acts_upstream_of_or_within
ISO
MGI:96756|MGI:98725 (PMID:21245484)
RGD
PMID:21245484
NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:62,166,192...62,194,685
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Dicer1
dicer 1 ribonuclease III
acts_upstream_of_or_within
ISO
(PMID:18725527)
RGD
PMID:18725527
NCBI chr 6:129,392,298...129,457,252
Ensembl chr 6:123,631,250...123,693,965
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Drosha
drosha ribonuclease III
acts_upstream_of_or_within
ISO
(PMID:18725527)
RGD
PMID:18725527
NCBI chr 2:63,591,885...63,703,688
Ensembl chr 2:61,864,970...61,976,688
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Fanca
FA complementation group A
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 MGI:2674094 (PMID:24501220)
GO_Central RGD
PMID:24501220
GO_REF:0000033
NCBI chr19:68,210,562...68,271,080
Ensembl chr19:51,304,021...51,362,527
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Fancd2
FA complementation group D2
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:2673422 (PMID:24501220)
Ensembl RGD
PMID:24501220
GO_REF:0000107
NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:146,679,179...146,743,412
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Kat2a
lysine acetyltransferase 2A
involved_in
ISO
(PMID:28424240)
RGD
PMID:28424240
NCBI chr10:86,132,535...86,140,877
Ensembl chr10:85,632,216...85,640,166
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Lck
LCK proto-oncogene, Src family tyrosine kinase
acts_upstream_of_or_within
ISO
MGI:88327 (PMID:21245484)
RGD
PMID:21245484
NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:141,888,326...141,903,794
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Sh2b3
SH2B adaptor protein 3
IMP
RGD
PMID:25776069
RGD:13442483
NCBI chr12:40,391,755...40,414,336
Ensembl chr12:34,731,911...34,753,616
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Tgfb1
transforming growth factor, beta 1
acts_upstream_of_or_within
ISO
MGI:88327 (PMID:21245484)
RGD
PMID:21245484
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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