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ONTOLOGY REPORT - ANNOTATIONS


Term:regulatory T cell differentiation
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Accession:GO:0045066 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: regulatory T lymphocyte differentiation;   suppressor T cell differentiation;   suppressor T lymphocyte differentiation
 related_synonym: regulatory T cell development



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regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 Cd28 molecule involved_in IEA
ISO
GO_REF:0000107
(PMID:18641304)
Ensembl
RGD
PMID:18641304 GO_REF:0000107 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of
ISO (PMID:32644293)
(PMID:16769892), (PMID:17028180)
RGD PMID:16769892 PMID:17028180 PMID:32644293 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in
acts_upstream_of_or_within
ISO (PMID:32644293)
MGI:3576270|MGI:3719583 (PMID:15100250), (PMID:17481928)
RGD PMID:15100250 PMID:17481928 PMID:32644293 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO (PMID:32644293) RGD PMID:32644293 NCBI chr 7:30,251,142...30,301,185
Ensembl chr 7:28,364,033...28,410,053
JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in
acts_upstream_of
ISO (PMID:22079196)
MGI:1857034|MGI:3696705 (PMID:16275384), (PMID:16301745), (PMID:18573908)
RGD PMID:16275384 PMID:16301745 PMID:18573908 PMID:22079196 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Fut7 fucosyltransferase 7 acts_upstream_of_or_within ISO MGI:2387664 (PMID:18573908) RGD PMID:18573908 NCBI chr 3:28,635,913...28,640,407
Ensembl chr 3:8,239,384...8,242,260
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of ISO MGI:1857455 (PMID:16227984) RGD PMID:16227984 NCBI chr  X:70,435,340...70,439,052
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 acts_upstream_of_or_within ISO MGI:2677822 (PMID:11030619) RGD PMID:11030619 NCBI chr10:47,498,852...47,641,612
Ensembl chr10:46,999,536...47,141,032
JBrowse link
G Pla2g2d phospholipase A2, group IID acts_upstream_of_or_within ISO (PMID:19564598) RGD PMID:19564598 NCBI chr 5:156,299,374...156,305,816
Ensembl chr 5:151,018,870...151,022,525
JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection-associated high mobility group box involved_in ISO (PMID:18195075) RGD PMID:18195075 NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule involved_in ISO (PMID:25065622) RGD PMID:25065622 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 involved_in ISO
IBA
(PMID:18641304)
GO_REF:0000033
RGD
GO_Central
PMID:18641304 GO_REF:0000033 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IMP RGD PMID:30287503 RGD:38549580 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Irf1 interferon regulatory factor 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:18641303)
UniProt
RGD
PMID:18641303 GO_REF:0000024 NCBI chr10:38,417,935...38,424,946
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Lag3 lymphocyte activating 3 involved_in ISO
ISS
(PMID:15485628)
GO_REF:0000024
RGD
UniProt
PMID:15485628 GO_REF:0000024 NCBI chr 4:159,398,930...159,407,001
Ensembl chr 4:157,712,667...157,720,404
JBrowse link
G Mdk midkine involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:22323540)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:22323540 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:77,901,158...77,903,130
JBrowse link
G Mir21 microRNA 21 involved_in ISO RNAcentral:URS0000338542_9606 (PMID:22387553) RGD PMID:22387553 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir30b microRNA 30b involved_in ISO RNAcentral:URS000039ED8D_9606 (PMID:22387553) RGD PMID:22387553 NCBI chr 7:102,021,543...102,021,629
Ensembl chr 7:100,132,589...100,132,675
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18713990) RGD PMID:18713990 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788
JBrowse link
G Tug1 taurine up-regulated 1 IMP RGD PMID:30287503 RGD:38549580 NCBI chr14:82,743,501...82,750,534
Ensembl chr14:78,522,506...78,526,927
JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034|MGI:2654936|MGI:3696705 (PMID:12612578), (PMID:16275384), (PMID:16301745), (PMID:18573908) RGD PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:15778366 RGD:2303772 NCBI chr 4:79,025,151...79,031,917
Ensembl chr 4:77,687,564...77,703,086
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:1857455 (PMID:16227984) RGD PMID:16227984 NCBI chr  X:70,435,340...70,439,052
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G Klhl25 kelch-like family member 25 involved_in ISO
ISS
(PMID:34491895)
GO_REF:0000024
RGD
UniProt
PMID:34491895 GO_REF:0000024 NCBI chr 1:139,134,655...139,159,898
Ensembl chr 1:129,722,026...129,750,227
JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258
JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045
JBrowse link
positive regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy and beclin 1 regulator 1 involved_in ISO (PMID:30513302) RGD PMID:30513302 NCBI chr 3:98,156,626...98,345,876
Ensembl chr 3:77,700,936...77,890,221
JBrowse link
G Bcl6 BCL6, transcription repressor involved_in ISO (PMID:20935202), (PMID:22387553) RGD PMID:20935202 PMID:22387553 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO (PMID:23589618) RGD PMID:23589618 NCBI chr17:41,620,807...41,632,621
Ensembl chr17:41,620,839...41,632,618
JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within ISO MGI:4462559|MGI:5547539 (PMID:23793062) RGD PMID:23793062 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965
JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in ISO (PMID:22387553) RGD PMID:22387553 NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Foxo3 forkhead box O3 involved_in ISO (PMID:30513302) RGD PMID:30513302 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of_or_within
ISO (PMID:30513302)
MGI:2654936 (PMID:12522256), (PMID:15100250), (PMID:15780990), (PMID:16769892), (PMID:17028180)
RGD PMID:12522256 PMID:15100250 PMID:15780990 PMID:16769892 PMID:17028180 More... NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Il2 interleukin 2 IDA RGD PMID:6233372 RGD:1600097 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:25778793) RGD PMID:25778793 NCBI chr 1:104,435,540...104,461,049
Ensembl chr 1:95,295,601...95,324,562
JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:24835996)
UniProt
Ensembl
RGD
PMID:24835996 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:212,325,089...212,332,640
Ensembl chr 1:202,895,751...202,903,458
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:25065622) RGD PMID:25065622 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:20935202), (PMID:22387553) RGD PMID:20935202 PMID:22387553 NCBI chr 1:78,847,685...78,853,294
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G Mir214 microRNA 214 IMP RGD PMID:30287503 RGD:38549580 NCBI chr13:77,121,645...77,121,752
Ensembl chr13:74,588,372...74,588,481
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:20448110) RGD PMID:20448110 NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:22387553)
Ensembl
RGD
PMID:22387553 GO_REF:0000107 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Sox12 SRY-box transcription factor 12 involved_in ISO (PMID:30190287) RGD PMID:30190287 NCBI chr 3:161,319,800...161,320,819
Ensembl chr 3:140,856,579...140,860,975
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO (PMID:25065622) RGD PMID:25065622 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:24691993) RGD PMID:24691993 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
JBrowse link
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnk18 potassium two pore domain channel subfamily K member 18 involved_in ISS
ISO
GO_REF:0000024
(PMID:34702947)
UniProt
RGD
PMID:34702947 GO_REF:0000024 NCBI chr 1:258,374,671...258,388,945
Ensembl chr 1:258,374,671...258,388,945
JBrowse link
regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:96756|MGI:98725 (PMID:21245484) RGD PMID:21245484 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Dicer1 dicer 1 ribonuclease III acts_upstream_of_or_within ISO (PMID:18725527) RGD PMID:18725527 NCBI chr 6:129,392,298...129,457,252
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Drosha drosha ribonuclease III acts_upstream_of_or_within ISO (PMID:18725527) RGD PMID:18725527 NCBI chr 2:63,591,885...63,703,688
Ensembl chr 2:61,864,970...61,976,688
JBrowse link
G Fanca FA complementation group A involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:2674094 (PMID:24501220)
GO_Central
RGD
PMID:24501220 GO_REF:0000033 NCBI chr19:68,210,562...68,271,080
Ensembl chr19:51,304,021...51,362,527
JBrowse link
G Fancd2 FA complementation group D2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2673422 (PMID:24501220)
Ensembl
RGD
PMID:24501220 GO_REF:0000107 NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Kat2a lysine acetyltransferase 2A involved_in ISO (PMID:28424240) RGD PMID:28424240 NCBI chr10:86,132,535...86,140,877
Ensembl chr10:85,632,216...85,640,166
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO MGI:88327 (PMID:21245484) RGD PMID:21245484 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Sh2b3 SH2B adaptor protein 3 IMP RGD PMID:25776069 RGD:13442483 NCBI chr12:40,391,755...40,414,336
Ensembl chr12:34,731,911...34,753,616
JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO MGI:88327 (PMID:21245484) RGD PMID:21245484 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    immune system process 3112
      leukocyte activation 1069
        lymphocyte activation 866
          lymphocyte differentiation 446
            T cell differentiation 332
              regulatory T cell differentiation 49
                CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 13
                CD8-positive, alpha-beta regulatory T cell differentiation 0
                negative regulation of regulatory T cell differentiation + 10
                positive regulation of regulatory T cell differentiation + 25
                regulation of regulatory T cell differentiation + 44
Path 2
Term Annotations click to browse term
  biological_process 20536
    developmental process 7109
      cellular developmental process 4812
        cell differentiation 4811
          cell development 3339
            hemopoiesis 1079
              leukocyte differentiation 685
                mononuclear cell differentiation 549
                  lymphocyte differentiation 446
                    T cell differentiation 332
                      regulatory T cell differentiation 49
                        CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 13
                        CD8-positive, alpha-beta regulatory T cell differentiation 0
                        negative regulation of regulatory T cell differentiation + 10
                        positive regulation of regulatory T cell differentiation + 25
                        regulation of regulatory T cell differentiation + 44
paths to the root