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ONTOLOGY REPORT - ANNOTATIONS


Term:thymic T cell selection
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Accession:GO:0045061 term browser browse the term
Definition:The process of T cell selection that occurs in the thymus.
Synonyms:exact_synonym: thymic T lymphocyte selection



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thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 acts_upstream_of_or_within ISO MGI:3039682 (PMID:12867038) RGD PMID:12867038 NCBI chr12:13,621,140...13,758,115
Ensembl chr12:13,621,087...13,758,112
JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO MGI:2683927 (PMID:14670303) RGD PMID:14670303 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO MGI:2680720 (PMID:14517551) RGD PMID:14517551 NCBI chr13:94,601,072...94,696,180
Ensembl chr13:92,069,216...92,162,004
JBrowse link
G Jag2 jagged canonical Notch ligand 2 involved_in ISS
ISO
IEA
PMID:10383933
(PMID:10383933)
GO_REF:0000107
RGD
Ensembl
PMID:10383933 PMID:10383933 GO_REF:0000107, RGD:8553281 NCBI chr 6:137,804,133...137,826,738
Ensembl chr 6:131,983,056...132,005,818
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO MGI:2677447|MGI:3526403 (PMID:9208839) RGD PMID:9208839 NCBI chr 9:46,485,605...46,507,552
Ensembl chr 9:38,989,750...39,011,700
JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:22080863)
UniProt
Ensembl
RGD
PMID:22080863 GO_REF:0000024 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627
JBrowse link
negative thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:1277186 (PMID:23382543)
GO_Central
RGD
PMID:23382543 GO_REF:0000033 NCBI chr20:10,635,775...10,650,709
Ensembl chr20:10,636,123...10,651,060
JBrowse link
G Atg5 autophagy related 5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1338803|MGI:3612279 (PMID:23382543)
Ensembl
RGD
PMID:23382543 GO_REF:0000107 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (PMID:17785582) RGD PMID:17785582 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:1857150 (PMID:10429671) RGD PMID:10429671 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex acts_upstream_of_or_within ISO (PMID:7630421) RGD PMID:7630421 NCBI chr 8:54,200,617...54,211,770
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within ISO MGI:1927205 (PMID:7679955) RGD PMID:7679955 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO MGI:2152031 (PMID:12871644) RGD PMID:12871644 NCBI chr10:18,827,237...19,244,832
Ensembl chr10:18,827,239...19,244,808
JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO MGI:1856334 (PMID:10429671) RGD PMID:10429671 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gli3 GLI family zinc finger 3 involved_in ISO (PMID:19667090) RGD PMID:19667090 NCBI chr17:54,134,064...54,405,198
Ensembl chr17:49,438,567...49,709,712
JBrowse link
G Mink1 misshapen-like kinase 1 acts_upstream_of_or_within ISO (PMID:15608642) RGD PMID:15608642 NCBI chr10:55,776,879...55,829,406
Ensembl chr10:55,278,391...55,330,782
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:1857277 (PMID:8666928) RGD PMID:8666928 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:17227833)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17227833 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Spn sialophorin acts_upstream_of_or_within ISO MGI:1857246 (PMID:10429671) RGD PMID:10429671 NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:181,746,429...181,759,628
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO MGI:2677447 (PMID:7630421) RGD PMID:7630421 NCBI chr 9:46,485,605...46,507,552
Ensembl chr 9:38,989,750...39,011,700
JBrowse link
positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within ISO MGI:2180711 (PMID:9133426) RGD PMID:9133426 NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:172,423,582...172,427,089
JBrowse link
G Cd3d CD3 delta subunit of T-cell receptor complex involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:9135151)
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:9135151 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:54,184,573...54,190,112
Ensembl chr 8:45,288,749...45,301,809
JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:54,200,617...54,211,770
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Cd3g CD3 gamma subunit of T-cell receptor complex involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:54,177,572...54,184,087
Ensembl chr 8:45,281,204...45,287,147
JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within ISO MGI:1927205|MGI:1927530 (PMID:7679955), (PMID:8598040), (PMID:9432982) RGD PMID:7679955 PMID:8598040 PMID:9432982 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO MGI:2152031 (PMID:12871644) RGD PMID:12871644 NCBI chr10:18,827,237...19,244,832
Ensembl chr10:18,827,239...19,244,808
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO MGI:3039799 (PMID:15064401) RGD PMID:15064401 NCBI chr13:94,601,072...94,696,180
Ensembl chr13:92,069,216...92,162,004
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:17579027)
UniProt
RGD
PMID:17579027 GO_REF:0000024 NCBI chr19:50,870,464...50,944,992
Ensembl chr19:33,960,852...34,035,150
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:1857277 (PMID:8666928) RGD PMID:8666928 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G RT1-DMa RT1 class II, locus DMa acts_upstream_of_or_within ISO MGI:1861933|MGI:2384509|MGI:2652160 (PMID:8598040), (PMID:8598041), (PMID:8638109), (PMID:9432982) RGD PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:17227833)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17227833 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO MGI:2449947|MGI:3046779 (PMID:21098124) RGD PMID:21098124 NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
G Stk11 serine/threonine kinase 11 acts_upstream_of_or_within ISO MGI:2386448|MGI:2387402|MGI:3054844 (PMID:21487392) RGD PMID:21487392 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO (PMID:7630421)
MGI:2677447 (PMID:7630421)
RGD PMID:7630421 NCBI chr 9:46,485,605...46,507,552
Ensembl chr 9:38,989,750...39,011,700
JBrowse link
regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn1 forkhead box N1 involved_in ISO (PMID:24184560) RGD PMID:24184560 NCBI chr10:63,749,461...63,778,468
Ensembl chr10:63,251,400...63,273,710
JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO (PMID:18195075) RGD PMID:18195075 NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:19,874,467...20,171,272
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20553
    immune system process 3120
      T cell selection 62
        thymic T cell selection 28
          negative thymic T cell selection 14
          positive thymic T cell selection + 17
Path 2
Term Annotations click to browse term
  biological_process 20553
    developmental process 7140
      cellular developmental process 4831
        cell differentiation 4830
          cell development 3338
            hemopoiesis 1083
              leukocyte differentiation 688
                mononuclear cell differentiation 552
                  lymphocyte differentiation 449
                    T cell differentiation 335
                      T cell differentiation in thymus 104
                        thymic T cell selection 28
                          negative thymic T cell selection 14
                          positive thymic T cell selection + 17
paths to the root