Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:T cell selection
go back to main search page
Accession:GO:0045058 term browser browse the term
Definition:The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
Synonyms:exact_synonym: T lymphocyte selection
 xref: Wikipedia:Thymocyte


GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd4 CD4 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936709:997,776...1,022,791
Ensembl chrNW_004936709:997,750...1,022,884
JBrowse link
beta selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101971458 tyrosine-protein kinase ZAP-70 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9275205) Ensembl
MGI
PMID:9275205 GO_REF:0000107 NCBI chrNW_004936744:1,000,105...1,012,712
Ensembl chrNW_004936744:1,000,105...1,012,433
JBrowse link
G Rhoa ras homolog family member A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:1,000,050...1,045,655
Ensembl chrNW_004936529:999,935...1,045,681
JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9275205) Ensembl
MGI
PMID:9275205 GO_REF:0000107 NCBI chrNW_004936780:1,553,605...1,601,036
Ensembl chrNW_004936780:1,553,605...1,598,158
JBrowse link
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:18228248) Ensembl
MGI
PMID:18228248 GO_REF:0000107 NCBI chrNW_004936592:4,728,371...4,833,830
Ensembl chrNW_004936592:4,737,011...4,834,664
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:16501569) Ensembl
MGI
PMID:16501569 GO_REF:0000107 NCBI chrNW_004936475:3,750,917...3,812,118
Ensembl chrNW_004936475:3,750,882...3,812,118
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:10,033,095...10,042,713
Ensembl chrNW_004936527:10,033,299...10,042,599
JBrowse link
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsl cathepsin L involved_in ISO (PMID:9545226) UniProt PMID:9545226 NCBI chrNW_004936680:3,047,355...3,050,640 JBrowse link
G Tox thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:13,847,210...14,146,110
Ensembl chrNW_004936496:13,847,210...14,147,886
JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:13,847,210...14,146,110
Ensembl chrNW_004936496:13,847,210...14,147,886
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2 apoptosis regulator involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:8170972) Ensembl
MGI
PMID:8170972 GO_REF:0000107 NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921
JBrowse link
G Tox thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:13,847,210...14,146,110
Ensembl chrNW_004936496:13,847,210...14,147,886
JBrowse link
extrathymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il15 interleukin 15 acts_upstream_of_or_within ISO (PMID:10704459) MGI PMID:10704459 NCBI chrNW_004936535:6,344,348...6,358,803
Ensembl chrNW_004936535:6,344,395...6,350,197
JBrowse link
G LOC101971454 butyrophilin-like protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:610,676...617,206 JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936626:2,390,004...2,472,039
Ensembl chrNW_004936626:2,389,868...2,445,927
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak3 Janus kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936596:3,212,593...3,224,426
Ensembl chrNW_004936596:3,212,593...3,224,048
JBrowse link
G Lgals1 galectin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:3,407,704...3,411,197
Ensembl chrNW_004936492:3,407,049...3,411,222
JBrowse link
G LOC101954799 signal transducer and activator of transcription 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,095,047...17,115,945
Ensembl chrNW_004936490:17,095,954...17,114,866
JBrowse link
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936556:745,798...765,926
Ensembl chrNW_004936556:745,798...765,918
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635
JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:14,499,495...14,508,074
Ensembl chrNW_004936481:14,499,577...14,508,017
JBrowse link
negative T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Themis thymocyte selection associated involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936639:1,739,380...1,915,545
Ensembl chrNW_004936639:1,739,380...1,915,560
JBrowse link
negative thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23382543) Ensembl
MGI
PMID:23382543 GO_REF:0000107 NCBI chrNW_004936500:125,589...137,071
Ensembl chrNW_004936500:125,795...137,056
JBrowse link
G Atg5 autophagy related 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23382543) Ensembl
MGI
PMID:23382543 GO_REF:0000107 NCBI chrNW_004936564:2,759,085...2,885,394
Ensembl chrNW_004936564:2,758,598...2,885,420
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:15,575,764...15,579,766
Ensembl chrNW_004936490:15,575,764...15,579,757
JBrowse link
G Cd28 CD28 molecule involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10429671) Ensembl
MGI
PMID:10429671 GO_REF:0000107 NCBI chrNW_004936631:335,411...363,407
Ensembl chrNW_004936631:335,411...363,407
JBrowse link
G Cd3e CD3e molecule acts_upstream_of_or_within ISO (PMID:7630421) MGI PMID:7630421 NCBI chrNW_004936542:3,379,361...3,390,677 JBrowse link
G Cd74 CD74 molecule involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7679955) Ensembl
MGI
PMID:7679955 GO_REF:0000107 NCBI chrNW_004936504:4,522,576...4,532,289
Ensembl chrNW_004936504:4,522,751...4,531,750
JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:12871644) MGI
Ensembl
PMID:12871644 GO_REF:0000107 NCBI chrNW_004936609:4,695,202...5,099,038
Ensembl chrNW_004936609:4,695,628...5,099,038
JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO (PMID:10429671) MGI PMID:10429671 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Gli3 GLI family zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:17,129,922...17,403,630
Ensembl chrNW_004936478:17,126,911...17,403,011
JBrowse link
G LOC101971458 tyrosine-protein kinase ZAP-70 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7630421) Ensembl
MGI
PMID:7630421 GO_REF:0000107 NCBI chrNW_004936744:1,000,105...1,012,712
Ensembl chrNW_004936744:1,000,105...1,012,433
JBrowse link
G Mink1 misshapen like kinase 1 acts_upstream_of_or_within ISO (PMID:15608642) MGI PMID:15608642 NCBI chrNW_004936677:2,813,899...2,864,366
Ensembl chrNW_004936677:2,813,899...2,864,366
JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:8666928) Ensembl
MGI
PMID:8666928 GO_REF:0000107 NCBI chrNW_004936567:5,266,653...5,378,464
Ensembl chrNW_004936567:5,267,615...5,378,258
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:10,033,095...10,042,713
Ensembl chrNW_004936527:10,033,299...10,042,599
JBrowse link
G Spn sialophorin acts_upstream_of_or_within ISO (PMID:10429671) MGI PMID:10429671 NCBI chrNW_004936501:12,773,967...12,776,642 JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:25,807,179...25,818,914
Ensembl chrNW_004936476:25,807,163...25,818,899
JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004936596:5,176,682...5,246,102
Ensembl chrNW_004936596:5,177,147...5,246,518
JBrowse link
G Ep300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:696,982...778,132
Ensembl chrNW_004936492:696,960...778,138
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936646:743,630...745,998
Ensembl chrNW_004936646:743,688...745,836
JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936711:1,027,531...1,113,796
Ensembl chrNW_004936711:1,032,935...1,106,847
JBrowse link
positive T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b BCL11 transcription factor B involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17998389) Ensembl
MGI
PMID:17998389 GO_REF:0000107 NCBI chrNW_004936604:3,023,781...3,110,104
Ensembl chrNW_004936604:3,023,844...3,110,083
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23334952) Ensembl
MGI
PMID:23334952 GO_REF:0000107 NCBI chrNW_004936592:4,728,371...4,833,830
Ensembl chrNW_004936592:4,737,011...4,834,664
JBrowse link
G Themis thymocyte selection associated involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936639:1,739,380...1,915,545
Ensembl chrNW_004936639:1,739,380...1,915,560
JBrowse link
positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd3d CD3d molecule involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936542:3,400,129...3,403,628
Ensembl chrNW_004936542:3,399,845...3,403,634
JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:9432982)
(PMID:7679955), (PMID:8598040)
MGI
Ensembl
PMID:7679955 PMID:8598040 PMID:9432982 GO_REF:0000107 NCBI chrNW_004936504:4,522,576...4,532,289
Ensembl chrNW_004936504:4,522,751...4,531,750
JBrowse link
G Dock2 dedicator of cytokinesis 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:12871644) Ensembl
MGI
PMID:12871644 GO_REF:0000107 NCBI chrNW_004936609:4,695,202...5,099,038
Ensembl chrNW_004936609:4,695,628...5,099,038
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15064401) Ensembl
MGI
PMID:15064401 GO_REF:0000107 NCBI chrNW_004936526:3,378,046...3,477,177
Ensembl chrNW_004936526:3,376,786...3,477,554
JBrowse link
G LOC101963772 HLA class II histocompatibility antigen, DM alpha chain acts_upstream_of_or_within ISO (PMID:8598040)
(PMID:8638109)
(PMID:8598041), (PMID:9432982)
MGI PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 NCBI chrNW_004936476:25,836,163...25,840,191
Ensembl chrNW_004936476:25,836,142...25,840,197
JBrowse link
G LOC101971458 tyrosine-protein kinase ZAP-70 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:7630421) MGI
Ensembl
PMID:7630421 GO_REF:0000107 NCBI chrNW_004936744:1,000,105...1,012,712
Ensembl chrNW_004936744:1,000,105...1,012,433
JBrowse link
G Nfatc3 nuclear factor of activated T cells 3 involved_in ISO (PMID:17579027) UniProt PMID:17579027 NCBI chrNW_004936475:18,462,424...18,557,832
Ensembl chrNW_004936475:18,462,298...18,555,220
JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:8666928) Ensembl
MGI
PMID:8666928 GO_REF:0000107 NCBI chrNW_004936567:5,266,653...5,378,464
Ensembl chrNW_004936567:5,267,615...5,378,258
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:10,033,095...10,042,713
Ensembl chrNW_004936527:10,033,299...10,042,599
JBrowse link
G Srf serum response factor involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21098124) Ensembl
MGI
PMID:21098124 GO_REF:0000107 NCBI chrNW_004936476:16,779,941...16,789,499
Ensembl chrNW_004936476:16,782,233...16,789,130
JBrowse link
G Stk11 serine/threonine kinase 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21487392) Ensembl
MGI
PMID:21487392 GO_REF:0000107 NCBI chrNW_004936588:579,816...601,033
Ensembl chrNW_004936588:579,816...603,654
JBrowse link
regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn1 forkhead box N1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:4,717,509...4,745,504
Ensembl chrNW_004936538:4,731,958...4,744,796
JBrowse link
G Tox thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:13,847,210...14,146,110
Ensembl chrNW_004936496:13,847,210...14,147,886
JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtor mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:158,376...282,310
Ensembl chrNW_004936474:157,590...282,342
JBrowse link
G Spn sialophorin involved_in ISO (PMID:18036228) UniProt PMID:18036228 NCBI chrNW_004936501:12,773,967...12,776,642 JBrowse link
G Stat6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:20706986) Ensembl
MGI
PMID:20706986 GO_REF:0000107 NCBI chrNW_004936646:1,297,530...1,312,508
Ensembl chrNW_004936646:1,296,290...1,312,157
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635
JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936488:4,607,716...4,631,237
Ensembl chrNW_004936488:4,607,716...4,631,283
JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:16990136)
(PMID:27893700)
UniProt PMID:16990136 PMID:27893700 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Il6r interleukin 6 receptor involved_in ISO (PMID:27893700) UniProt PMID:27893700 NCBI chrNW_004936580:4,055,438...4,081,876
Ensembl chrNW_004936580:4,057,771...4,081,885
JBrowse link
G Irf4 interferon regulatory factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936633:1,565,293...1,580,859
Ensembl chrNW_004936633:1,564,637...1,580,859
JBrowse link
G LOC101968708 T-lymphocyte surface antigen Ly-9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936903:53,648...143,272
Ensembl chrNW_004936903:111,986...143,081
JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chrNW_004936721:847,360...876,912
Ensembl chrNW_004936721:848,324...877,068
JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:22184727) UniProt PMID:22184727 NCBI chrNW_004936740:155,268...165,536 JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,119,189...17,178,402
Ensembl chrNW_004936490:17,117,290...17,178,402
JBrowse link
thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family member 11 acts_upstream_of_or_within ISO (PMID:12867038) MGI PMID:12867038 NCBI chrNW_004936823:580,438...621,298
Ensembl chrNW_004936823:581,955...621,208
JBrowse link
G Gata3 GATA binding protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14670303) Ensembl
MGI
PMID:14670303 GO_REF:0000107 NCBI chrNW_004936484:6,780,692...6,800,883
Ensembl chrNW_004936484:6,780,692...6,800,966
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14517551) Ensembl
MGI
PMID:14517551 GO_REF:0000107 NCBI chrNW_004936526:3,378,046...3,477,177
Ensembl chrNW_004936526:3,376,786...3,477,554
JBrowse link
G Jag2 jagged canonical Notch ligand 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936621:363,489...380,616
Ensembl chrNW_004936621:366,616...380,618
JBrowse link
G LOC101971458 tyrosine-protein kinase ZAP-70 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9208839) Ensembl
MGI
PMID:9208839 GO_REF:0000107 NCBI chrNW_004936744:1,000,105...1,012,712
Ensembl chrNW_004936744:1,000,105...1,012,433
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17435
    immune system process 2316
      T cell selection 58
        beta selection 3
        extrathymic T cell selection + 2
        negative T cell selection + 15
        positive T cell selection + 42
        thymic T cell selection + 26
Path 2
Term Annotations click to browse term
  biological_process 17435
    developmental process 6454
      cellular developmental process 4356
        cell differentiation 4355
          cell development 3114
            hemopoiesis 986
              leukocyte differentiation 629
                mononuclear cell differentiation 508
                  lymphocyte differentiation 413
                    T cell differentiation 310
                      T cell selection 58
                        beta selection 3
                        extrathymic T cell selection + 2
                        negative T cell selection + 15
                        positive T cell selection + 42
                        thymic T cell selection + 26
paths to the root