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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell selection
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Accession:GO:0045058 term browser browse the term
Definition:The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
Synonyms:exact_synonym: T lymphocyte selection
 xref: Wikipedia:Thymocyte


show annotations for term's descendants           Sort by:
T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD4 CD4 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:63,892,129...63,918,547
Ensembl chr 5:63,892,137...63,918,519 		JBrowse link
beta selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RHOA ras homolog family member A involved_in IEA
ISS		 Ensembl
AgBase		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9275205) Ensembl
MGI		 PMID:9275205 GO_REF:0000107 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,670...2,161,171 		JBrowse link
G ZAP70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO (PMID:9275205) MGI PMID:9275205 NCBI chr 3:56,515,446...56,541,806
Ensembl chr 3:56,515,449...56,541,740 		JBrowse link
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRAF B-Raf proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18228248) Ensembl
MGI		 PMID:18228248 GO_REF:0000107 NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16501569) Ensembl
MGI		 PMID:16501569 GO_REF:0000107 NCBI chr 6:34,058,091...34,121,939
Ensembl chr 6:34,059,081...34,121,264 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,994...2,555,484 		JBrowse link
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTSL cathepsin L involved_in ISO (PMID:9545226) UniProt PMID:9545226 NCBI chr10:27,668,523...27,674,705
Ensembl chr10:27,668,264...27,674,618 		JBrowse link
G CTSV cathepsin V involved_in ISS UniProt GO_REF:0000024 NCBI chr10:25,202,360...25,208,058
Ensembl chr10:25,202,389...25,209,210 		JBrowse link
G TOX thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:73,810,180...74,115,352
Ensembl chr 4:73,810,290...74,115,151 		JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TOX thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:73,810,180...74,115,352
Ensembl chr 4:73,810,290...74,115,151 		JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8170972) Ensembl
MGI		 PMID:8170972 GO_REF:0000107 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G TOX thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:73,810,180...74,115,352
Ensembl chr 4:73,810,290...74,115,151 		JBrowse link
extrathymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL15 interleukin 15 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10704459) Ensembl
MGI		 PMID:10704459 GO_REF:0000107 NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461 		JBrowse link
G LOC100512174 butyrophilin-like protein 1 involved_in ISO (PMID:27641500) MGI PMID:27641500 NCBI chr 7:24,271,839...24,290,750 JBrowse link
G LOC100513868 butyrophilin-like protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:24,764,445...24,773,528 JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD69 CD69 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:62,078,134...62,084,961
Ensembl chr 5:62,077,988...62,085,900 		JBrowse link
G JAK3 Janus kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495 		JBrowse link
G LGALS1 galectin 1 involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chr 5:10,149,069...10,152,514
Ensembl chr 5:10,149,068...10,156,023 		JBrowse link
G LOXL3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:68,498,114...68,516,829
Ensembl chr 3:68,498,189...68,517,445 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:20,474,221...20,498,785
Ensembl chr12:20,474,227...20,499,138 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (PMID:24107315) UniProt PMID:24107315 NCBI chr 9:115,447,438...115,460,649
Ensembl chr 9:115,448,973...115,460,950 		JBrowse link
negative T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THEMIS thymocyte selection associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:35,333,210...35,530,710
Ensembl chr 1:35,333,465...35,519,870 		JBrowse link
negative thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIRE autoimmune regulator involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:23382543) Ensembl
MGI
GO_Central		 PMID:23382543 GO_REF:0000033 GO_REF:0000107 NCBI chr13:207,148,401...207,158,355
Ensembl chr13:207,148,401...207,158,346 		JBrowse link
G ATG5 autophagy related 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23382543) Ensembl
MGI		 PMID:23382543 GO_REF:0000107 NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,396 		JBrowse link
G CCR7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:21,857,286...21,869,211
Ensembl chr12:21,857,286...21,872,475 		JBrowse link
G CD28 CD28 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10429671) Ensembl
MGI		 PMID:10429671 GO_REF:0000107 NCBI chr15:107,128,103...107,155,431
Ensembl chr15:107,128,203...107,162,935 		JBrowse link
G CD3E CD3 epsilon subunit of T-cell receptor complex involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7630421) Ensembl
MGI		 PMID:7630421 GO_REF:0000107 NCBI chr 9:45,619,730...45,633,972
Ensembl chr 9:45,619,482...45,633,968 		JBrowse link
G CD74 CD74 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7679955) Ensembl
MGI		 PMID:7679955 GO_REF:0000107 NCBI chr 2:151,402,210...151,409,924
Ensembl chr 2:151,402,211...151,409,833 		JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12871644) Ensembl
MGI		 PMID:12871644 GO_REF:0000107 NCBI chr16:53,843,248...54,248,708
Ensembl chr16:53,843,252...54,248,638 		JBrowse link
G FAS Fas cell surface death receptor acts_upstream_of_or_within ISO (PMID:10429671) MGI PMID:10429671 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G GLI3 GLI family zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:52,403,463...52,697,906
Ensembl chr18:52,404,072...52,697,900 		JBrowse link
G MINK1 misshapen like kinase 1 acts_upstream_of_or_within ISO (PMID:15608642) MGI PMID:15608642 NCBI chr12:52,016,297...52,066,687
Ensembl chr12:52,016,299...52,066,693 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8666928) Ensembl
MGI		 PMID:8666928 GO_REF:0000107 NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,560,073...21,601,308 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,994...2,555,484 		JBrowse link
G SPN sialophorin acts_upstream_of_or_within ISO (PMID:10429671) MGI PMID:10429671 NCBI chr 3:17,978,731...17,982,222
Ensembl chr 3:17,978,801...17,982,864 		JBrowse link
G ZAP70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO (PMID:7630421) MGI PMID:7630421 NCBI chr 3:56,515,446...56,541,806
Ensembl chr 3:56,515,449...56,541,740 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD2 bromodomain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,096,579...25,162,591
Ensembl chr 7:25,150,564...25,162,584 		JBrowse link
G BRD4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chr 2:62,250,958...62,345,851
Ensembl chr 2:62,250,989...62,345,362 		JBrowse link
G EP300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:21,732,416...21,733,981
Ensembl chr 5:21,732,165...21,734,267 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083 		JBrowse link
positive T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL11B BCL11 transcription factor B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17998389) Ensembl
MGI		 PMID:17998389 GO_REF:0000107 NCBI chr 7:120,205,008...120,295,737
Ensembl chr 7:120,205,008...120,295,936 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23334952) Ensembl
MGI		 PMID:23334952 GO_REF:0000107 NCBI chr18:8,957,963...9,132,558
Ensembl chr18:8,957,991...9,132,553 		JBrowse link
G THEMIS thymocyte selection associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:35,333,210...35,530,710
Ensembl chr 1:35,333,465...35,519,870 		JBrowse link
positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD3D CD3 delta subunit of T-cell receptor complex involved_in IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:45,640,475...45,644,153
Ensembl chr 9:45,637,129...45,644,221 		JBrowse link
G CD3E CD3 epsilon subunit of T-cell receptor complex involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:45,619,730...45,633,972
Ensembl chr 9:45,619,482...45,633,968 		JBrowse link
G CD3G CD3 gamma subunit of T-cell receptor complex involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:45,645,243...45,656,779
Ensembl chr 9:45,645,364...45,704,745 		JBrowse link
G CD74 CD74 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7679955), (PMID:8598040)
(PMID:9432982)		 Ensembl
MGI		 PMID:7679955 PMID:8598040 PMID:9432982 GO_REF:0000107 NCBI chr 2:151,402,210...151,409,924
Ensembl chr 2:151,402,211...151,409,833 		JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12871644) Ensembl
MGI		 PMID:12871644 GO_REF:0000107 NCBI chr16:53,843,248...54,248,708
Ensembl chr16:53,843,252...54,248,638 		JBrowse link
G ITPKB inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO (PMID:15064401) MGI PMID:15064401 NCBI chr10:14,362,883...14,469,586 JBrowse link
G NFATC3 nuclear factor of activated T cells 3 involved_in ISO (PMID:17579027) UniProt PMID:17579027 NCBI chr 6:28,666,458...28,806,432
Ensembl chr 6:28,666,549...28,806,419 		JBrowse link
G PCD1B CD1B antigen acts_upstream_of_or_within ISO (PMID:9133426) MGI PMID:9133426 NCBI chr 4:92,035,122...92,040,724
Ensembl chr 4:92,031,712...92,040,742 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8666928) Ensembl
MGI		 PMID:8666928 GO_REF:0000107 NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,560,073...21,601,308 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,994...2,555,484 		JBrowse link
G SLA-DMA SLA-DM alpha chain acts_upstream_of_or_within ISO (PMID:8598040)
(PMID:8598041), (PMID:9432982)
(PMID:8638109)		 MGI PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 NCBI chr 7:25,133,494...25,137,928
Ensembl chr 7:25,133,497...25,137,966 		JBrowse link
G SRF serum response factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21098124) Ensembl
MGI		 PMID:21098124 GO_REF:0000107 NCBI chr 7:38,213,300...38,223,686
Ensembl chr 7:38,213,487...38,222,144 		JBrowse link
G STK11 serine/threonine kinase 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21487392) Ensembl
MGI		 PMID:21487392 GO_REF:0000107 NCBI chr 2:77,229,888...77,249,322
Ensembl chr 2:77,230,372...77,249,327 		JBrowse link
G ZAP70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO (PMID:7630421) MGI PMID:7630421 NCBI chr 3:56,515,446...56,541,806
Ensembl chr 3:56,515,449...56,541,740 		JBrowse link
regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXN1 forkhead box N1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:44,764,427...44,796,138
Ensembl chr12:44,765,258...44,795,260 		JBrowse link
G TOX thymocyte selection associated high mobility group box involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:73,810,180...74,115,352
Ensembl chr 4:73,810,290...74,115,151 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G SPN sialophorin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:17,978,731...17,982,222
Ensembl chr 3:17,978,801...17,982,864 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20706986) Ensembl
MGI		 PMID:20706986 GO_REF:0000107 NCBI chr 5:22,406,356...22,422,412
Ensembl chr 5:22,406,368...22,421,989 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:98,670,211...98,692,230
Ensembl chr 7:98,670,211...98,692,230 		JBrowse link
G IL6 interleukin 6 involved_in ISS UniProt GO_REF:0000024 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G IL6R interleukin 6 receptor involved_in ISS UniProt GO_REF:0000024 NCBI chr 4:95,322,426...95,381,393
Ensembl chr 4:95,322,433...95,381,282 		JBrowse link
G IRF4 interferon regulatory factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:133,358...149,609
Ensembl chr 7:133,371...149,609 		JBrowse link
G LY9 lymphocyte antigen 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:89,701,806...89,728,848
Ensembl chr 4:89,701,359...89,729,855 		JBrowse link
G OTUD5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chr  X:43,001,491...43,029,471
Ensembl chr  X:43,000,231...43,029,468 		JBrowse link
G SLAMF6 SLAM family member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:89,980,592...90,004,222
Ensembl chr 4:89,980,786...90,003,645 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992 		JBrowse link
thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARD11 caspase recruitment domain family member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12867038) Ensembl
MGI		 PMID:12867038 GO_REF:0000107 NCBI chr 3:2,145,178...2,266,377
Ensembl chr 3:2,145,178...2,266,355 		JBrowse link
G GATA3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14670303) Ensembl
MGI		 PMID:14670303 GO_REF:0000107 NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,663...63,388,859 		JBrowse link
G ITPKB inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO (PMID:14517551) MGI PMID:14517551 NCBI chr10:14,362,883...14,469,586 JBrowse link
G JAG2 jagged canonical Notch ligand 2 involved_in IEA Ensembl GO_REF:0000107
G ZAP70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within ISO (PMID:9208839) MGI PMID:9208839 NCBI chr 3:56,515,446...56,541,806
Ensembl chr 3:56,515,449...56,541,740 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18954
    immune system process 2582
      T cell selection 64
        beta selection 3
        extrathymic T cell selection + 3
        negative T cell selection + 15
        positive T cell selection + 48
        thymic T cell selection + 28
Path 2
Term Annotations click to browse term
  biological_process 18954
    developmental process 6788
      cellular developmental process 4584
        cell differentiation 4583
          cell development 3241
            hemopoiesis 1046
              leukocyte differentiation 674
                mononuclear cell differentiation 548
                  lymphocyte differentiation 451
                    T cell differentiation 341
                      T cell selection 64
                        beta selection 3
                        extrathymic T cell selection + 3
                        negative T cell selection + 15
                        positive T cell selection + 48
                        thymic T cell selection + 28
paths to the root