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ONTOLOGY REPORT - ANNOTATIONS


Term:T cell selection
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Accession:GO:0045058 term browser browse the term
Definition:The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
Synonyms:exact_synonym: T lymphocyte selection
 xref: Wikipedia:Thymocyte


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T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd4 CD4 molecule involved_in ISO (PMID:9551897) UniProt PMID:9551897 NCBI chrNW_004624860:3,470,886...3,492,247
Ensembl chrNW_004624860:3,470,631...3,492,846
JBrowse link
beta selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101716577 tyrosine-protein kinase ZAP-70 acts_upstream_of_or_within ISO (PMID:9275205) MGI PMID:9275205 NCBI chrNW_004624749:2,893,601...2,901,256
Ensembl chrNW_004624749:2,893,601...2,901,035
JBrowse link
G Rhoa ras homolog family member A involved_in ISO (PMID:25398325) CACAO PMID:25398325 NCBI chrNW_004624730:3,316,122...3,361,820 JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9275205) Ensembl
MGI
PMID:9275205 GO_REF:0000107 NCBI chrNW_004624868:1,654,079...1,738,648
Ensembl chrNW_004624868:1,653,997...1,701,391
JBrowse link
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO (PMID:18228248) MGI PMID:18228248 NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (PMID:16501569) MGI PMID:16501569 NCBI chrNW_004624757:5,895,912...5,953,485 JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISO (PMID:17227833) BHF-UCL PMID:17227833 NCBI chrNW_004624800:2,202,986...2,215,309
Ensembl chrNW_004624800:2,203,393...2,212,068
JBrowse link
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection associated high mobility group box involved_in ISO (PMID:18195075) UniProt PMID:18195075 NCBI chrNW_004624744:32,865,781...33,218,453
Ensembl chrNW_004624744:32,865,720...33,218,643
JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection associated high mobility group box involved_in ISO (PMID:18195075) UniProt PMID:18195075 NCBI chrNW_004624744:32,865,781...33,218,453
Ensembl chrNW_004624744:32,865,720...33,218,643
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2 apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:8170972) MGI
Ensembl
PMID:8170972 GO_REF:0000107 NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344
JBrowse link
G Tox thymocyte selection associated high mobility group box involved_in ISO (PMID:11850626), (PMID:15078895) UniProt PMID:11850626 PMID:15078895 NCBI chrNW_004624744:32,865,781...33,218,453
Ensembl chrNW_004624744:32,865,720...33,218,643
JBrowse link
extrathymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il15 interleukin 15 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10704459) Ensembl
MGI
PMID:10704459 GO_REF:0000107 NCBI chrNW_004624853:1,059,625...1,144,799
Ensembl chrNW_004624853:1,128,519...1,144,941
JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (PMID:22080863) UniProt PMID:22080863 NCBI chrNW_004624770:19,808,400...19,877,494
Ensembl chrNW_004624770:19,808,400...19,876,503
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 CD69 molecule involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004624860:4,345,497...4,364,251
Ensembl chrNW_004624860:4,345,232...4,365,817
JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:20696842) UniProt PMID:20696842 NCBI chrNW_004624908:1,371,595...1,383,879
Ensembl chrNW_004624908:1,371,595...1,383,879
JBrowse link
G Lgals1 galectin 1 involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004624752:10,220,115...10,223,434
Ensembl chrNW_004624752:10,219,872...10,223,317
JBrowse link
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624749:28,959,682...28,980,428
Ensembl chrNW_004624749:28,960,593...28,980,428
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) UniProt PMID:21151104 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143
JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) UniProt PMID:24107315 NCBI chrNW_004624771:8,711,093...8,722,518
Ensembl chrNW_004624771:8,711,017...8,722,539
JBrowse link
negative T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Themis thymocyte selection associated involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624753:2,214,779...2,292,936 JBrowse link
negative thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aire autoimmune regulator acts_upstream_of_or_within ISO (PMID:23382543) MGI PMID:23382543 NCBI chrNW_004624745:29,850,410...29,857,351
Ensembl chrNW_004624745:29,850,560...29,857,029
JBrowse link
G Atg5 autophagy related 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23382543) Ensembl
MGI
PMID:23382543 GO_REF:0000107 NCBI chrNW_004624780:15,987,483...16,124,158
Ensembl chrNW_004624780:15,987,397...16,124,151
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (PMID:17785582) BHF-UCL PMID:17785582 NCBI chrNW_004624795:2,777,766...2,787,664
Ensembl chrNW_004624795:2,779,627...2,788,897
JBrowse link
G Cd28 CD28 molecule acts_upstream_of_or_within ISO (PMID:10429671) MGI PMID:10429671 NCBI chrNW_004624765:12,650,092...12,667,168 JBrowse link
G Cd3e CD3e molecule acts_upstream_of_or_within ISO (PMID:7630421) MGI PMID:7630421 NCBI chrNW_004624784:13,714,667...13,726,881
Ensembl chrNW_004624784:13,712,920...13,726,950
JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within ISO (PMID:7679955) MGI PMID:7679955 NCBI chrNW_004624774:9,699,876...9,708,871
Ensembl chrNW_004624774:9,700,393...9,709,514
JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO (PMID:12871644) MGI PMID:12871644 NCBI chrNW_004624733:19,882,234...20,315,211
Ensembl chrNW_004624733:19,883,027...20,315,128
JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO (PMID:10429671) MGI PMID:10429671 NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848
JBrowse link
G Gli3 GLI family zinc finger 3 involved_in ISO (PMID:19667090) BHF-UCL PMID:19667090 NCBI chrNW_004624740:18,961,395...19,238,760
Ensembl chrNW_004624740:18,975,596...19,235,900
JBrowse link
G LOC101716577 tyrosine-protein kinase ZAP-70 acts_upstream_of_or_within ISO (PMID:7630421) MGI PMID:7630421 NCBI chrNW_004624749:2,893,601...2,901,256
Ensembl chrNW_004624749:2,893,601...2,901,035
JBrowse link
G Mink1 misshapen like kinase 1 acts_upstream_of_or_within ISO (PMID:15608642) MGI PMID:15608642 NCBI chrNW_004624786:8,711,388...8,764,102
Ensembl chrNW_004624786:8,711,263...8,763,343
JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of_or_within ISO (PMID:8666928) MGI PMID:8666928 NCBI chrNW_004624798:1,700,732...1,814,603
Ensembl chrNW_004624798:1,699,541...1,814,656
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISO (PMID:17227833) BHF-UCL PMID:17227833 NCBI chrNW_004624800:2,202,986...2,215,309
Ensembl chrNW_004624800:2,203,393...2,212,068
JBrowse link
G Spn sialophorin acts_upstream_of_or_within ISO (PMID:10429671) MGI PMID:10429671 NCBI chrNW_004624782:13,471,083...13,483,712 JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004624754:23,742,506...23,750,668
Ensembl chrNW_004624754:23,742,509...23,750,062
JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004624901:2,348,218...2,434,429
Ensembl chrNW_004624901:2,346,734...2,380,852
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624802:11,662,851...11,664,444
Ensembl chrNW_004624802:11,662,753...11,665,418
JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase involved_in ISO (PMID:36171294) UniProt PMID:36171294 NCBI chrNW_004624730:63,911,066...63,994,886
Ensembl chrNW_004624730:63,911,066...63,995,596
JBrowse link
positive T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within ISO (PMID:17998389) MGI PMID:17998389 NCBI chrNW_004624734:4,560,362...4,649,219
Ensembl chrNW_004624734:4,560,699...4,647,858
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO (PMID:23334952) MGI PMID:23334952 NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736
JBrowse link
G Themis thymocyte selection associated involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624753:2,214,779...2,292,936 JBrowse link
positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd3d CD3d molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624784:13,733,465...13,754,248
Ensembl chrNW_004624784:13,733,403...13,737,356
JBrowse link
G Cd3e CD3e molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624784:13,714,667...13,726,881
Ensembl chrNW_004624784:13,712,920...13,726,950
JBrowse link
G Cd3g CD3g molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624784:13,738,424...13,748,311
Ensembl chrNW_004624784:13,738,686...13,748,415
JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within ISO (PMID:9432982)
(PMID:7679955), (PMID:8598040)
MGI PMID:7679955 PMID:8598040 PMID:9432982 NCBI chrNW_004624774:9,699,876...9,708,871
Ensembl chrNW_004624774:9,700,393...9,709,514
JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO (PMID:12871644) MGI PMID:12871644 NCBI chrNW_004624733:19,882,234...20,315,211
Ensembl chrNW_004624733:19,883,027...20,315,128
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO (PMID:15064401) MGI PMID:15064401 NCBI chrNW_004624807:658,334...741,018
Ensembl chrNW_004624807:658,231...741,195
JBrowse link
G LOC101700274 HLA class II histocompatibility antigen, DM alpha chain acts_upstream_of_or_within ISO (PMID:8638109)
(PMID:8598041), (PMID:9432982)
(PMID:8598040)
MGI PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 NCBI chrNW_004624754:23,752,352...23,765,319
Ensembl chrNW_004624754:23,762,051...23,765,593
JBrowse link
G LOC101716577 tyrosine-protein kinase ZAP-70 acts_upstream_of_or_within ISO (PMID:7630421) MGI PMID:7630421 NCBI chrNW_004624749:2,893,601...2,901,256
Ensembl chrNW_004624749:2,893,601...2,901,035
JBrowse link
G Nfatc3 nuclear factor of activated T cells 3 involved_in ISO (PMID:17579027) UniProt PMID:17579027 NCBI chrNW_004624746:18,083,051...18,210,399
Ensembl chrNW_004624746:18,085,518...18,210,401
JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of_or_within ISO (PMID:8666928) MGI PMID:8666928 NCBI chrNW_004624798:1,700,732...1,814,603
Ensembl chrNW_004624798:1,699,541...1,814,656
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISO (PMID:17227833) BHF-UCL PMID:17227833 NCBI chrNW_004624800:2,202,986...2,215,309
Ensembl chrNW_004624800:2,203,393...2,212,068
JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO (PMID:21098124) MGI PMID:21098124 NCBI chrNW_004624754:16,371,995...16,381,287 JBrowse link
G Stk11 serine/threonine kinase 11 acts_upstream_of_or_within ISO (PMID:21487392) MGI PMID:21487392 NCBI chrNW_004624828:7,444,339...7,466,926
Ensembl chrNW_004624828:7,445,069...7,467,298
JBrowse link
regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn1 forkhead box N1 involved_in ISO (PMID:24184560) UniProt PMID:24184560 NCBI chrNW_004624786:1,114,305...1,127,787
Ensembl chrNW_004624786:1,114,305...1,127,683
JBrowse link
G Tox thymocyte selection associated high mobility group box involved_in ISO (PMID:18195075) UniProt PMID:18195075 NCBI chrNW_004624744:32,865,781...33,218,453
Ensembl chrNW_004624744:32,865,720...33,218,643
JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chrNW_004624733:39,412,800...39,420,079 JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO (PMID:26410627) MGI PMID:26410627 NCBI chrNW_004624818:1,570,155...1,698,264
Ensembl chrNW_004624818:1,570,276...1,698,259
JBrowse link
G Spn sialophorin involved_in ISO (PMID:18036228) UniProt PMID:18036228 NCBI chrNW_004624782:13,471,083...13,483,712 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chrNW_004624802:10,809,234...10,847,762
Ensembl chrNW_004624802:10,809,252...10,846,693
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:10761931) UniProt PMID:10761931 NCBI chrNW_004624795:4,442,188...4,453,544
Ensembl chrNW_004624795:4,442,188...4,453,143
JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:26,118,840...26,139,328
Ensembl chrNW_004624734:26,118,754...26,139,468
JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:27893700)
(PMID:16990136)
UniProt PMID:16990136 PMID:27893700 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318
JBrowse link
G Il6r interleukin 6 receptor involved_in ISO (PMID:27893700) UniProt PMID:27893700 NCBI chrNW_004624885:2,910,367...2,946,916
Ensembl chrNW_004624885:2,910,112...2,946,886
JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (PMID:22983707) UniProt PMID:22983707 NCBI chrNW_004624756:23,917,111...23,931,482
Ensembl chrNW_004624756:23,918,323...23,931,501
JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chrNW_004624893:702,895...736,623 JBrowse link
G Slamf6 SLAM family member 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624794:754,530...796,732 JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO (PMID:28065600) UniProt PMID:28065600 NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200
JBrowse link
thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family member 11 acts_upstream_of_or_within ISO (PMID:12867038) MGI PMID:12867038 NCBI chrNW_004624740:29,974,707...30,085,498
Ensembl chrNW_004624740:29,974,689...30,085,981
JBrowse link
G Gata3 GATA binding protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14670303) Ensembl
MGI
PMID:14670303 GO_REF:0000107 NCBI chrNW_004624775:2,985,077...3,014,567
Ensembl chrNW_004624775:2,994,164...3,015,392
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO (PMID:14517551) MGI PMID:14517551 NCBI chrNW_004624807:658,334...741,018
Ensembl chrNW_004624807:658,231...741,195
JBrowse link
G Jag2 jagged canonical Notch ligand 2 involved_in ISO (PMID:10383933) UniProt PMID:10383933 NCBI chrNW_004624734:308,371...327,496
Ensembl chrNW_004624734:308,375...327,604
JBrowse link
G LOC101716577 tyrosine-protein kinase ZAP-70 acts_upstream_of_or_within ISO (PMID:9208839) MGI PMID:9208839 NCBI chrNW_004624749:2,893,601...2,901,256
Ensembl chrNW_004624749:2,893,601...2,901,035
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17638
    immune system process 2276
      T cell selection 56
        beta selection 3
        extrathymic T cell selection + 1
        negative T cell selection + 15
        positive T cell selection + 42
        thymic T cell selection + 27
Path 2
Term Annotations click to browse term
  biological_process 17638
    developmental process 6397
      cellular developmental process 4308
        cell differentiation 4307
          cell development 3060
            hemopoiesis 945
              leukocyte differentiation 609
                mononuclear cell differentiation 493
                  lymphocyte differentiation 401
                    T cell differentiation 300
                      T cell selection 56
                        beta selection 3
                        extrathymic T cell selection + 1
                        negative T cell selection + 15
                        positive T cell selection + 42
                        thymic T cell selection + 27
paths to the root