ONTOLOGY REPORT - ANNOTATIONS
Term: T cell selection
Accession: GO:0045058
browse the term
Definition: The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
Synonyms: exact_synonym: T lymphocyte selection
xref: Wikipedia:Thymocyte
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Cd4
CD4 antigen
involved_in
ISO ISS
(PMID:9551897)
GO_Central UniProt
PMID:9551897
GO_REF:0000119
NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184
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Rhoa
ras homolog family member A
involved_in
IMP
(PMID:25398325)
CACAO
PMID:25398325
NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
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Syk
spleen tyrosine kinase
acts_upstream_of_or_within
IGI
(PMID:9275205)
MGI
PMID:9275205
NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828
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Zap70
zeta-chain (TCR) associated protein kinase
acts_upstream_of_or_within
IGI
(PMID:9275205)
MGI
PMID:9275205
NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899
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Braf
Braf transforming gene
acts_upstream_of_or_within
IMP
(PMID:18228248)
MGI
PMID:18228248
NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397
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Cyld
CYLD lysine 63 deubiquitinase
acts_upstream_of_or_within
IMP
(PMID:16501569)
MGI
PMID:16501569
NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573
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Shh
sonic hedgehog
involved_in
ISO IMP
(PMID:17227833)
GO_Central BHF-UCL
PMID:17227833
GO_REF:0000119
NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254
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Ctsl
cathepsin L
involved_in
IMP
(PMID:9545226)
UniProt
PMID:9545226
NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704
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Tox
thymocyte selection-associated high mobility group box
involved_in
IMP
(PMID:18195075)
UniProt
PMID:18195075
NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557
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Foxp3
forkhead box P3
involved_in
TAS
(PMID:18368049)
UniProt
PMID:18368049
NCBI chr X:7,445,915...7,461,482
Ensembl chr X:7,439,883...7,461,484
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Tgfb1
transforming growth factor, beta 1
involved_in
TAS
(PMID:18368049)
UniProt
PMID:18368049
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
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Tox
thymocyte selection-associated high mobility group box
involved_in
IMP
(PMID:18195075)
UniProt
PMID:18195075
NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557
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Bcl2
B cell leukemia/lymphoma 2
acts_upstream_of_or_within
IMP
(PMID:8170972)
MGI
PMID:8170972
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Tox
thymocyte selection-associated high mobility group box
involved_in
IMP
(PMID:11850626), (PMID:15078895)
UniProt
PMID:11850626 PMID:15078895
NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557
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Btnl1
butyrophilin-like 1
involved_in
IMP IGI
(PMID:27641500)
MGI
PMID:27641500
NCBI chr17:34,596,097...34,605,136
Ensembl chr17:34,596,106...34,605,002
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Btnl6
butyrophilin-like 6
involved_in
IGI
(PMID:27641500)
MGI
PMID:27641500
NCBI chr17:34,726,844...34,737,750
Ensembl chr17:34,726,778...34,736,326
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Il15
interleukin 15
acts_upstream_of_or_within
IMP
(PMID:10704459)
MGI
PMID:10704459
NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851
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Ptpn2
protein tyrosine phosphatase, non-receptor type 2
involved_in
IMP
(PMID:22080863)
UniProt
PMID:22080863
NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665
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Cd69
CD69 antigen
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:129,244,287...129,252,332
Ensembl chr 6:129,244,288...129,252,399
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Jak3
Janus kinase 3
involved_in
ISO
(PMID:20696842)
UniProt
PMID:20696842
NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219
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Lgals1
lectin, galactose binding, soluble 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:78,810,925...78,814,665
Ensembl chr15:78,810,925...78,814,665
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Loxl3
lysyl oxidase-like 3
involved_in
IMP ISO
(PMID:28065600)
UniProt GO_Central
PMID:28065600
GO_REF:0000119
NCBI chr 6:83,011,186...83,029,547
Ensembl chr 6:83,011,154...83,029,543
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Stat5a
signal transducer and activator of transcription 5A
involved_in
ISO
(PMID:20696842)
UniProt
PMID:20696842
NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995
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Tbx21
T-box 21
involved_in
IMP
(PMID:21151104)
UniProt
PMID:21151104
NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157
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Tnfsf18
tumor necrosis factor (ligand) superfamily, member 18
involved_in
IMP
(PMID:24107315)
UniProt
PMID:24107315
NCBI chr 1:161,322,221...161,333,903
Ensembl chr 1:161,322,224...161,332,859
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Themis
thymocyte selection associated
involved_in
IMP
(PMID:19597498), (PMID:19597499)
UniProt
PMID:19597498 PMID:19597499
NCBI chr10:28,544,356...28,759,816
Ensembl chr10:28,544,356...28,759,814
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Aire
autoimmune regulator
acts_upstream_of_or_within involved_in
IGI IBA
(PMID:23382543)
MGI GO_Central
PMID:23382543
GO_REF:0000033
NCBI chr10:77,865,856...77,879,444
Ensembl chr10:77,865,856...77,879,444
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Atg5
autophagy related 5
acts_upstream_of_or_within
IGI IMP
(PMID:23382543)
MGI
PMID:23382543
NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287
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Ccr7
C-C motif chemokine receptor 7
involved_in
IMP
(PMID:17785582)
BHF-UCL
PMID:17785582
NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903
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Cd28
CD28 antigen
acts_upstream_of_or_within
IMP
(PMID:10429671)
MGI
PMID:10429671
NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518
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Cd3e
CD3 antigen, epsilon polypeptide
acts_upstream_of_or_within
IDA
(PMID:7630421)
MGI
PMID:7630421
NCBI chr 9:44,910,033...44,920,961
Ensembl chr 9:44,910,038...44,920,925
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Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
acts_upstream_of_or_within
IMP
(PMID:7679955)
MGI
PMID:7679955
NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724
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Dock2
dedicator of cyto-kinesis 2
acts_upstream_of_or_within
IMP
(PMID:12871644)
MGI
PMID:12871644
NCBI chr11:34,176,815...34,674,732
Ensembl chr11:34,176,815...34,674,719
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Fas
Fas cell surface death receptor
acts_upstream_of_or_within
IMP
(PMID:10429671)
MGI
PMID:10429671
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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Gli3
GLI-Kruppel family member GLI3
involved_in
IMP
(PMID:19667090)
BHF-UCL
PMID:19667090
NCBI chr13:15,638,308...15,904,611
Ensembl chr13:15,637,820...15,904,611
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Mink1
misshapen-like kinase 1 (zebrafish)
acts_upstream_of_or_within
IMP
(PMID:15608642)
MGI
PMID:15608642
NCBI chr11:70,452,272...70,505,309
Ensembl chr11:70,453,707...70,505,309
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Ptprc
protein tyrosine phosphatase receptor type C
acts_upstream_of_or_within
IMP
(PMID:8666928)
MGI
PMID:8666928
NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446
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Shh
sonic hedgehog
involved_in
IMP
(PMID:17227833)
BHF-UCL
PMID:17227833
NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254
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Spn
sialophorin
acts_upstream_of_or_within
IMP
(PMID:10429671)
MGI
PMID:10429671
NCBI chr 7:126,731,404...126,743,785
Ensembl chr 7:126,731,404...126,736,995
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Zap70
zeta-chain (TCR) associated protein kinase
acts_upstream_of_or_within
IMP
(PMID:7630421)
MGI
PMID:7630421
NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899
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Brd2
bromodomain containing 2
involved_in
ISO IDA
(PMID:28262505)
GO_Central UniProt
PMID:28262505
GO_REF:0000119
NCBI chr17:34,330,993...34,341,581
Ensembl chr17:34,330,997...34,341,608
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Brd4
bromodomain containing 4
involved_in
IMP
(PMID:28262505)
UniProt
PMID:28262505
NCBI chr17:32,415,246...32,503,717
Ensembl chr17:32,415,248...32,503,696
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Ep300
E1A binding protein p300
involved_in
IEA ISO
Ensembl GO_Central
GO_REF:0000107 GO_REF:0000119
NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278
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Il23a
interleukin 23, alpha subunit p19
involved_in
IBA IDA
(PMID:19501566)
GO_Central BHF-UCL
PMID:19501566
GO_REF:0000033
NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621
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Opa1
OPA1, mitochondrial dynamin like GTPase
involved_in
IMP
(PMID:36171294)
UniProt
PMID:36171294
NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702
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Bcl11b
B cell leukemia/lymphoma 11B
acts_upstream_of_or_within
IMP
(PMID:17998389)
MGI
PMID:17998389
NCBI chr12:107,876,662...107,970,404
Ensembl chr12:107,876,662...107,969,861
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Braf
Braf transforming gene
acts_upstream_of_or_within
IMP
(PMID:23334952)
MGI
PMID:23334952
NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397
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Themis
thymocyte selection associated
involved_in
IMP
(PMID:19597497), (PMID:19597498), (PMID:19597499), (PMID:19805304)
UniProt
PMID:19597497 PMID:19597498 PMID:19597499 PMID:19805304
NCBI chr10:28,544,356...28,759,816
Ensembl chr10:28,544,356...28,759,814
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Cd1d1
CD1d1 antigen
acts_upstream_of_or_within
IMP
(PMID:9133426)
MGI
PMID:9133426
NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748
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Cd3d
CD3 antigen, delta polypeptide
involved_in
IBA IMP
(PMID:9135151)
GO_Central UniProt
PMID:9135151
GO_REF:0000033
NCBI chr 9:44,893,067...44,898,350
Ensembl chr 9:44,893,084...44,898,637
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Cd3e
CD3 antigen, epsilon polypeptide
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 9:44,910,033...44,920,961
Ensembl chr 9:44,910,038...44,920,925
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Cd3g
CD3 antigen, gamma polypeptide
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 9:44,880,870...44,891,729
Ensembl chr 9:44,880,870...44,891,729
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Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
acts_upstream_of_or_within
IMP
(PMID:7679955), (PMID:8598040) (PMID:9432982)
MGI
PMID:7679955 PMID:8598040 PMID:9432982
NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724
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Dock2
dedicator of cyto-kinesis 2
acts_upstream_of_or_within
IMP
(PMID:12871644)
MGI
PMID:12871644
NCBI chr11:34,176,815...34,674,732
Ensembl chr11:34,176,815...34,674,719
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H2-DMa
histocompatibility 2, class II, locus DMa
acts_upstream_of_or_within
IMP
(PMID:8598040) (PMID:8598041), (PMID:9432982) (PMID:8638109)
MGI
PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982
NCBI chr17:34,338,667...34,358,075
Ensembl chr17:34,338,515...34,358,075
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Itpkb
inositol 1,4,5-trisphosphate 3-kinase B
acts_upstream_of_or_within
IMP
(PMID:15064401)
MGI
PMID:15064401
NCBI chr 1:180,156,655...180,252,367
Ensembl chr 1:180,158,050...180,252,367
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Nfatc3
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
involved_in
IMP
(PMID:17579027)
UniProt
PMID:17579027
NCBI chr 8:106,785,450...106,857,169
Ensembl chr 8:106,785,472...106,857,169
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Ptprc
protein tyrosine phosphatase receptor type C
acts_upstream_of_or_within
IMP
(PMID:8666928)
MGI
PMID:8666928
NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446
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Shh
sonic hedgehog
involved_in
IMP
(PMID:17227833)
BHF-UCL
PMID:17227833
NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254
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Skint1
selection and upkeep of intraepithelial T cells 1
acts_upstream_of_or_within
IDA IMP
(PMID:21300860) (PMID:18408721)
MGI
PMID:18408721 PMID:21300860
NCBI chr 4:111,863,466...111,886,735
Ensembl chr 4:111,863,466...111,886,735
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Srf
serum response factor
acts_upstream_of_or_within
IMP
(PMID:21098124)
MGI
PMID:21098124
NCBI chr17:46,857,764...46,869,194
Ensembl chr17:46,859,255...46,867,101
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Stk11
serine/threonine kinase 11
acts_upstream_of_or_within
IMP
(PMID:21487392)
MGI
PMID:21487392
NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516
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Zap70
zeta-chain (TCR) associated protein kinase
acts_upstream_of_or_within
ISO IMP
(PMID:7630421)
MGI
PMID:7630421
GO_REF:0000008
NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899
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Foxn1
forkhead box N1
involved_in
IMP
(PMID:24184560)
UniProt
PMID:24184560
NCBI chr11:78,248,403...78,277,597
Ensembl chr11:78,248,403...78,277,384
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Tox
thymocyte selection-associated high mobility group box
involved_in
IMP
(PMID:18195075)
UniProt
PMID:18195075
NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557
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Il4
interleukin 4
acts_upstream_of_or_within
IGI
(PMID:20706986)
MGI
PMID:20706986
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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Mtor
mechanistic target of rapamycin kinase
involved_in
IMP
(PMID:26410627)
MGI
PMID:26410627
NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
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Spn
sialophorin
involved_in
ISO ISS
GO_Central UniProt
GO_REF:0000024 GO_REF:0000119
NCBI chr 7:126,731,404...126,743,785
Ensembl chr 7:126,731,404...126,736,995
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Stat6
signal transducer and activator of transcription 6
acts_upstream_of_or_within
IGI
(PMID:20706986)
MGI
PMID:20706986
NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
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Tbx21
T-box 21
involved_in
IDA
(PMID:10761931)
UniProt
PMID:10761931
NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157
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Batf
basic leucine zipper transcription factor, ATF-like
involved_in
IMP
(PMID:19578362), (PMID:22983707)
UniProt
PMID:19578362 PMID:22983707
NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861
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Il6
interleukin 6
involved_in
IDA IMP
(PMID:27893700) (PMID:16990136)
UniProt
PMID:16990136 PMID:27893700
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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Il6ra
interleukin 6 receptor, alpha
involved_in
IDA
(PMID:27893700)
UniProt
PMID:27893700
NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503
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Irf4
interferon regulatory factor 4
involved_in
IMP
(PMID:22983707)
UniProt
PMID:22983707
NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959
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Ly9
lymphocyte antigen 9
involved_in
IEA ISO
Ensembl GO_Central
GO_REF:0000107 GO_REF:0000119
NCBI chr 1:171,416,172...171,434,917
Ensembl chr 1:171,416,192...171,434,978
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Otud5
OTU domain containing 5
acts_upstream_of_or_within
IMP
(PMID:25470037)
MGI
PMID:25470037
NCBI chr X:7,705,852...7,742,861
Ensembl chr X:7,707,603...7,742,865
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Slamf6
SLAM family member 6
involved_in
ISO
GO_Central
GO_REF:0000119
NCBI chr 1:171,745,002...171,776,525
Ensembl chr 1:171,745,082...171,780,737
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Stat3
signal transducer and activator of transcription 3
involved_in
IMP
(PMID:28065600)
UniProt
PMID:28065600
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
G
Tgfb1
transforming growth factor, beta 1
involved_in
TAS
(PMID:18368049)
UniProt
PMID:18368049
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
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Card11
caspase recruitment domain family, member 11
acts_upstream_of_or_within
IMP
(PMID:12867038)
MGI
PMID:12867038
NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337
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Gata3
GATA binding protein 3
acts_upstream_of_or_within
IMP
(PMID:14670303)
MGI
PMID:14670303
NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845
G
Itpkb
inositol 1,4,5-trisphosphate 3-kinase B
acts_upstream_of_or_within
IMP
(PMID:14517551)
MGI
PMID:14517551
NCBI chr 1:180,156,655...180,252,367
Ensembl chr 1:180,158,050...180,252,367
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Jag2
jagged 2
involved_in
ISO ISS
(PMID:10383933)
GO_Central UniProt
PMID:10383933
GO_REF:0000119
NCBI chr12:112,871,439...112,893,437
Ensembl chr12:112,871,439...112,893,396
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Zap70
zeta-chain (TCR) associated protein kinase
acts_upstream_of_or_within
IMP
(PMID:9208839)
MGI
PMID:9208839
NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899
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