ONTOLOGY REPORT - ANNOTATIONS
Term: T cell selection
Accession: GO:0045058
browse the term
Definition: The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
Synonyms: exact_synonym: T lymphocyte selection
xref: Wikipedia:Thymocyte
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CD4
CD4 molecule
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:6,824,797...6,856,440
Ensembl chr11:6,825,245...6,853,852
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LOC103241092
tyrosine-protein kinase ZAP-70
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:9275205)
Ensembl MGI
PMID:9275205
GO_REF:0000107
NCBI chr14:1,403,294...1,430,205
Ensembl chr14:1,404,325...1,431,015
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RHOA
ras homolog family member A
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr22:10,757,381...10,809,257
Ensembl chr22:10,757,337...10,772,704
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SYK
spleen associated tyrosine kinase
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:9275205)
Ensembl MGI
PMID:9275205
GO_REF:0000107
NCBI chr12:101,254,085...101,374,724
Ensembl chr12:101,260,061...101,349,856
G
BRAF
B-Raf proto-oncogene, serine/threonine kinase
acts_upstream_of_or_within
ISO
(PMID:18228248)
MGI
PMID:18228248
NCBI chr21:109,495,525...109,690,261
G
BRAF
B-Raf proto-oncogene, serine/threonine kinase
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr21:109,545,491...109,690,195
G
CYLD
CYLD lysine 63 deubiquitinase
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16501569)
Ensembl MGI
PMID:16501569
GO_REF:0000107
NCBI chr 5:36,541,022...36,600,874
Ensembl chr 5:36,541,764...36,595,417
G
SHH
sonic hedgehog signaling molecule
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr21:123,929,937...123,942,451
Ensembl chr21:123,932,900...123,942,395
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CTSL
cathepsin L
involved_in
ISO
(PMID:9545226)
UniProt
PMID:9545226
NCBI chr12:98,347,770...98,353,426
Ensembl chr12:98,347,800...98,353,467
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TOX
thymocyte selection associated high mobility group box
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:54,777,490...55,086,819
Ensembl chr 8:54,776,015...54,927,091
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TOX
thymocyte selection associated high mobility group box
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:54,777,490...55,086,819
Ensembl chr 8:54,776,015...54,927,091
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BCL2
BCL2 apoptosis regulator
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:8170972)
MGI Ensembl
PMID:8170972
GO_REF:0000107
NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895
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TOX
thymocyte selection associated high mobility group box
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:54,777,490...55,086,819
Ensembl chr 8:54,776,015...54,927,091
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IL15
interleukin 15
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:10704459)
Ensembl MGI
PMID:10704459
GO_REF:0000107
NCBI chr 7:88,548,773...88,644,977
Ensembl chr 7:88,548,671...88,645,488
G
LOC103221987
butyrophilin subfamily 3 member A3
involved_in
ISO
(PMID:27641500)
MGI
PMID:27641500
NCBI chr17:45,874,447...45,887,984
Ensembl chr17:45,876,877...45,884,925
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PTPN2
protein tyrosine phosphatase non-receptor type 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr18:71,302,082...71,400,201
Ensembl chr18:71,310,577...71,345,960
G
CD69
CD69 molecule
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:9,659,154...9,666,342
Ensembl chr11:9,659,029...9,665,914
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JAK3
Janus kinase 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:16,301,760...16,323,343
Ensembl chr 6:16,300,525...16,322,859
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LGALS1
galectin 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr19:20,379,144...20,383,303
Ensembl chr19:20,379,003...20,383,464
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LOC103243413
signal transducer and activator of transcription 5B
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:63,997,486...64,070,392
Ensembl chr16:63,997,441...64,070,445
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LOXL3
lysyl oxidase like 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr14:32,722,588...32,745,480
Ensembl chr14:32,725,112...32,745,004
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STAT5A
signal transducer and activator of transcription 5A
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:63,959,265...63,986,627
Ensembl chr16:63,960,515...63,985,026
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TBX21
T-box transcription factor 21
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415
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TNFSF18
TNF superfamily member 18
involved_in
ISO
(PMID:24107315)
UniProt
PMID:24107315
NCBI chr25:56,105,757...56,118,249
Ensembl chr25:56,106,584...56,118,758
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THEMIS
thymocyte selection associated
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr13:45,665,494...45,886,672
Ensembl chr13:45,682,663...45,884,856
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AIRE
autoimmune regulator
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:23382543)
Ensembl MGI
PMID:23382543
GO_REF:0000107
NCBI chr 2:88,019,122...88,031,998
Ensembl chr 2:88,019,522...88,031,801
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ATG5
autophagy related 5
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:23382543)
MGI Ensembl
PMID:23382543
GO_REF:0000107
NCBI chr13:67,482,538...67,619,201
Ensembl chr13:67,482,595...67,617,902
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CCR7
C-C motif chemokine receptor 7
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:65,620,632...65,632,394
Ensembl chr16:65,620,665...65,632,984
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CD28
CD28 molecule
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:10429671)
MGI Ensembl
PMID:10429671
GO_REF:0000107
NCBI chr10:89,471,710...89,505,152
Ensembl chr10:89,471,730...89,500,387
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CD3E
CD3e molecule
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:7630421)
MGI Ensembl
PMID:7630421
GO_REF:0000107
NCBI chr 1:109,681,142...109,692,835
Ensembl chr 1:109,681,065...109,692,839
G
CD74
CD74 molecule
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:7679955)
MGI Ensembl
PMID:7679955
GO_REF:0000107
NCBI chr23:53,008,802...53,022,953
Ensembl chr23:53,009,394...53,022,923
G
DOCK2
dedicator of cytokinesis 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:12871644)
Ensembl MGI
PMID:12871644
GO_REF:0000107
NCBI chr23:71,866,196...72,299,066
Ensembl chr23:71,866,251...72,299,056
G
GLI3
GLI family zinc finger 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr21:16,386,700...16,665,648
Ensembl chr21:16,549,789...16,662,238
G
LOC103241092
tyrosine-protein kinase ZAP-70
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:7630421)
Ensembl MGI
PMID:7630421
GO_REF:0000107
NCBI chr14:1,403,294...1,430,205
Ensembl chr14:1,404,325...1,431,015
G
MINK1
misshapen like kinase 1
acts_upstream_of_or_within
ISO
(PMID:15608642)
MGI
PMID:15608642
NCBI chr16:4,305,680...4,370,554
Ensembl chr16:4,305,701...4,369,780
G
PTPRC
protein tyrosine phosphatase receptor type C
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:8666928)
Ensembl MGI
PMID:8666928
GO_REF:0000107
NCBI chr25:30,655,014...30,777,367
Ensembl chr25:30,653,044...30,777,303
G
SHH
sonic hedgehog signaling molecule
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr21:123,929,937...123,942,451
Ensembl chr21:123,932,900...123,942,395
G
SPN
sialophorin
acts_upstream_of_or_within
ISO
(PMID:10429671)
MGI
PMID:10429671
NCBI chr 5:26,987,810...26,990,214
G
BRD2
bromodomain containing 2
involved_in
ISO
(PMID:28262505)
UniProt
PMID:28262505
NCBI chr17:39,113,519...39,126,267
G
BRD2
bromodomain containing 2
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr17:39,114,700...39,122,051
G
BRD4
bromodomain containing 4
involved_in
ISO
(PMID:28262505)
UniProt
PMID:28262505
NCBI chr 6:13,836,332...13,883,459
Ensembl chr 6:13,836,324...13,873,877
G
EP300
E1A binding protein p300
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr19:23,634,132...23,726,095
Ensembl chr19:23,634,571...23,724,979
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IL23A
interleukin 23 subunit alpha
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr11:52,289,486...52,296,735
Ensembl chr11:52,295,106...52,297,244
G
OPA1
OPA1 mitochondrial dynamin like GTPase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:87,679,656...87,778,767
Ensembl chr15:87,679,077...87,779,102
G
BCL11B
BCL11 transcription factor B
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:17998389)
MGI Ensembl
PMID:17998389
GO_REF:0000107
NCBI chr24:77,122,591...77,222,562
Ensembl chr24:77,122,689...77,221,454
G
BRAF
B-Raf proto-oncogene, serine/threonine kinase
acts_upstream_of_or_within
ISO
(PMID:23334952)
MGI
PMID:23334952
NCBI chr21:109,495,525...109,690,261
G
BRAF
B-Raf proto-oncogene, serine/threonine kinase
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr21:109,545,491...109,690,195
G
THEMIS
thymocyte selection associated
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr13:45,665,494...45,886,672
Ensembl chr13:45,682,663...45,884,856
G
CD1D
CD1d molecule
acts_upstream_of_or_within
ISO
(PMID:9133426)
MGI
PMID:9133426
NCBI chr20:5,726,307...5,733,355
Ensembl chr20:5,727,049...5,730,061
G
CD3D
CD3d molecule
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 1:109,715,148...109,719,576
Ensembl chr 1:109,713,017...109,719,950
G
CD3E
CD3e molecule
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 1:109,681,142...109,692,835
Ensembl chr 1:109,681,065...109,692,839
G
CD3G
CD3g molecule
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 1:109,721,150...109,730,267
Ensembl chr 1:109,720,789...109,732,014
G
CD74
CD74 molecule
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:9432982) (PMID:7679955), (PMID:8598040)
MGI Ensembl
PMID:7679955 PMID:8598040 PMID:9432982
GO_REF:0000107
NCBI chr23:53,008,802...53,022,953
Ensembl chr23:53,009,394...53,022,923
G
DOCK2
dedicator of cytokinesis 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:12871644)
Ensembl MGI
PMID:12871644
GO_REF:0000107
NCBI chr23:71,866,196...72,299,066
Ensembl chr23:71,866,251...72,299,056
G
ITPKB
inositol-trisphosphate 3-kinase B
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:15064401)
Ensembl MGI
PMID:15064401
GO_REF:0000107
NCBI chr25:3,009,464...3,117,729
Ensembl chr25:3,009,353...3,118,235
G
LOC103241092
tyrosine-protein kinase ZAP-70
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:7630421)
MGI Ensembl
PMID:7630421
GO_REF:0000107
NCBI chr14:1,403,294...1,430,205
Ensembl chr14:1,404,325...1,431,015
G
MHC-DMA
HLA class II histocompatibility antigen, DM alpha chain
acts_upstream_of_or_within
ISO
(PMID:8598040) (PMID:8638109) (PMID:8598041), (PMID:9432982)
MGI
PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982
NCBI chr17:39,142,340...39,151,804
Ensembl chr17:39,142,395...39,146,252
G
NFATC3
nuclear factor of activated T cells 3
involved_in
ISO
(PMID:17579027)
UniProt
PMID:17579027
NCBI chr 5:59,193,139...59,346,361
G
PTPRC
protein tyrosine phosphatase receptor type C
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:8666928)
Ensembl MGI
PMID:8666928
GO_REF:0000107
NCBI chr25:30,655,014...30,777,367
Ensembl chr25:30,653,044...30,777,303
G
SHH
sonic hedgehog signaling molecule
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr21:123,929,937...123,942,451
Ensembl chr21:123,932,900...123,942,395
G
SRF
serum response factor
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:21098124)
MGI Ensembl
PMID:21098124
GO_REF:0000107
NCBI chr17:28,983,161...28,993,465
Ensembl chr17:28,983,002...28,992,995
G
STK11
serine/threonine kinase 11
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:21487392)
Ensembl MGI
PMID:21487392
GO_REF:0000107
NCBI chr 6:973,033...996,857
Ensembl chr 6:974,144...995,136
G
FOXN1
forkhead box N1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:22,291,597...22,306,977
Ensembl chr16:22,292,330...22,305,968
G
TOX
thymocyte selection associated high mobility group box
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:54,777,490...55,086,819
Ensembl chr 8:54,776,015...54,927,091
G
IL4
interleukin 4
acts_upstream_of_or_within
ISO
(PMID:20706986)
MGI
PMID:20706986
NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
G
MTOR
mechanistic target of rapamycin kinase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020
G
SPN
sialophorin
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:26,987,810...26,990,214
G
STAT6
signal transducer and activator of transcription 6
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:20706986)
Ensembl MGI
PMID:20706986
GO_REF:0000107
NCBI chr11:53,005,378...53,020,899
Ensembl chr11:53,006,145...53,021,203
G
TBX21
T-box transcription factor 21
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415
G
BATF
basic leucine zipper ATF-like transcription factor
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr24:52,761,569...52,785,999
Ensembl chr24:52,761,651...52,785,978
G
IL6
interleukin 6
involved_in
ISO
(PMID:27893700) (PMID:16990136)
UniProt
PMID:16990136 PMID:27893700
NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237
G
IL6R
interleukin 6 receptor
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:9,345,723...9,418,963
Ensembl chr20:9,361,152...9,396,610
G
IRF4
interferon regulatory factor 4
involved_in
ISO
(PMID:22983707)
UniProt
PMID:22983707
NCBI chr17:71,739,920...71,758,811
G
IRF4
interferon regulatory factor 4
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr17:71,751,770...71,757,496
G
LY9
lymphocyte antigen 9
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:3,140,059...3,145,818
G
OTUD5
OTU deubiquitinase 5
acts_upstream_of_or_within
ISO
(PMID:25470037)
MGI
PMID:25470037
NCBI chr X:46,041,348...46,077,195
G
SLAMF6
SLAM family member 6
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr20:3,426,868...3,465,553
Ensembl chr20:3,453,370...3,463,901
G
STAT3
signal transducer and activator of transcription 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:63,877,884...63,957,894
Ensembl chr16:63,922,862...63,957,984
G
CARD11
caspase recruitment domain family member 11
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr28:18,675,524...18,715,388
G
GATA3
GATA binding protein 3
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:14670303)
MGI Ensembl
PMID:14670303
GO_REF:0000107
NCBI chr 9:8,101,404...8,122,762
Ensembl chr 9:8,101,432...8,123,064
G
ITPKB
inositol-trisphosphate 3-kinase B
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:14517551)
Ensembl MGI
PMID:14517551
GO_REF:0000107
NCBI chr25:3,009,464...3,117,729
Ensembl chr25:3,009,353...3,118,235
G
JAG2
jagged canonical Notch ligand 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr24:83,050,412...83,081,982
Ensembl chr24:83,051,368...83,076,820
G
LOC103241092
tyrosine-protein kinase ZAP-70
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:9208839)
Ensembl MGI
PMID:9208839
GO_REF:0000107
NCBI chr14:1,403,294...1,430,205
Ensembl chr14:1,404,325...1,431,015
G
LOC103246958
caspase recruitment domain-containing protein 11
acts_upstream_of_or_within
ISO
(PMID:12867038)
MGI
PMID:12867038
NCBI chr28:18,657,941...18,714,202
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all