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ONTOLOGY REPORT - ANNOTATIONS


Term:secondary metabolite biosynthetic process
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Accession:GO:0044550 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
Synonyms:exact_synonym: secondary metabolite biosynthesis



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melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asip agouti signaling protein involved_in
acts_upstream_of_or_within
IEA
ISO
ISS
GO_REF:0000107
(PMID:8449404)
MGI:1855937 (PMID:7665913)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:7665913 PMID:8449404 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:11434569)
UniProt
RGD
PMID:11434569 GO_REF:0000024 NCBI chr  X:67,350,376...67,355,072
Ensembl chr  X:67,350,373...67,355,162
JBrowse link
G Dct dopachrome tautomerase acts_upstream_of_or_within ISO MGI:1856379 (PMID:7665913) RGD PMID:7665913 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
JBrowse link
G Ddt D-dopachrome tautomerase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482
JBrowse link
G Mc1r melanocortin 1 receptor acts_upstream_of_or_within ISO MGI:1856028 (PMID:7665913) RGD PMID:7665913 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO MGI:1856004 (PMID:7665913) RGD PMID:7665913 NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:75,812,412...75,975,918
JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:1856114 (PMID:7665913), (PMID:9548375)
GO_REF:0000033
RGD
GO_Central
PMID:7665913 PMID:9548375 GO_REF:0000033 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074
JBrowse link
G Pmel premelanosome protein acts_upstream_of_or_within ISO MGI:1857040 (PMID:7665913) RGD PMID:7665913 NCBI chr 7:1,138,202...1,148,735
Ensembl chr 7:1,138,586...1,148,746
JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of ISO (PMID:18166528) RGD PMID:18166528 NCBI chr 3:112,319,349...112,338,889
Ensembl chr 3:112,319,308...112,339,231
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:8126111)
Ensembl
RGD
PMID:8126111 GO_REF:0000107 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
JBrowse link
G Tyr tyrosinase involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:8126111)
MGI:1855976|MGI:1855978 (PMID:7665913), (PMID:9548375)
GO_REF:0000033
RGD
GO_Central
PMID:7665913 PMID:8126111 PMID:9548375 GO_REF:0000033 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dct dopachrome tautomerase involved_in ISO
IBA
(PMID:2169885), (PMID:33100333)
GO_REF:0000033
RGD
GO_Central
PMID:2169885 PMID:33100333 GO_REF:0000033 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein involved_in ISO (PMID:25513726), (PMID:32966160) RGD PMID:25513726 PMID:32966160 NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074
JBrowse link
G Slc45a2 solute carrier family 45, member 2 involved_in ISO (PMID:32966160)
(PMID:35469906)
RGD PMID:32966160 PMID:35469906 NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317
JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO (PMID:29025994) RGD PMID:29025994 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988
JBrowse link
G Opn3 opsin 3 involved_in ISO (PMID:31097585) RGD PMID:31097585 NCBI chr13:90,121,560...90,152,076
Ensembl chr13:87,589,333...87,619,847
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:16272156)
UniProt
RGD
PMID:16272156 GO_REF:0000024 NCBI chr 2:166,505,868...166,728,139
Ensembl chr 2:164,207,513...164,244,247
JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of_or_within ISO (PMID:18166528) RGD PMID:18166528 NCBI chr 3:112,319,349...112,338,889
Ensembl chr 3:112,319,308...112,339,231
JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO
GO_REF:0000107
(PMID:23569434)
Ensembl
RGD
PMID:23569434 GO_REF:0000107 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234
JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (PMID:21291857) RGD PMID:21291857 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
JBrowse link
G Asip agouti signaling protein involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P07147|UniProtKB:Q60696 (PMID:21949658)
Ensembl
RGD
PMID:21949658 GO_REF:0000107 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
JBrowse link
G Atp7a ATPase copper transporting alpha involved_in ISS
ISO
GO_REF:0000024
(PMID:11092760)
UniProt
RGD
PMID:11092760 GO_REF:0000024 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Cdh3 cadherin 3 involved_in ISO (PMID:23334344) RGD PMID:23334344 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:21291857)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:21291857 GO_REF:0000024 GO_REF:0000107 NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997
JBrowse link
G Opn3 opsin 3 involved_in ISO (PMID:28842328) RGD PMID:28842328 NCBI chr13:90,121,560...90,152,076
Ensembl chr13:87,589,333...87,619,847
JBrowse link
G Pmel premelanosome protein involved_in ISO (PMID:21949658) RGD PMID:21949658 NCBI chr 7:1,138,202...1,148,735
Ensembl chr 7:1,138,586...1,148,746
JBrowse link
G Rab38 RAB38, member RAS oncogene family IMP RGD PMID:17043139 RGD:152025192 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in ISO (PMID:21996312)
UniProtKB:Q03288|UniProtKB:Q60696 (PMID:21949658)
RGD PMID:21949658 PMID:21996312 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO (PMID:22649030) RGD PMID:22649030 NCBI chr10:57,801,551...57,817,213
Ensembl chr10:57,801,456...57,817,120
JBrowse link
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO
IBA
(PMID:33208952)
GO_REF:0000033
(PMID:31117290)
RGD
GO_Central
PMID:31117290 PMID:33208952 GO_REF:0000033 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988
JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (PMID:16037214) RGD PMID:16037214 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
siderophore biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdh2 3-hydroxybutyrate dehydrogenase 2 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:20550936)
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:20550936 GO_REF:0000024 GO_REF:0000033 NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
JBrowse link
toxin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 involved_in ISO
IEA
(PMID:11511187)
GO_REF:0000107
RGD
Ensembl
PMID:11511187 GO_REF:0000107 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      metabolic process 12160
        secondary metabolic process 72
          secondary metabolite biosynthetic process 26
            (+)-kotanin biosynthetic process + 0
            (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process 0
            N',N'',N'''-triacetylfusarinine C biosynthetic process + 0
            alkaloid biosynthetic process + 0
            arugosin biosynthetic process + 0
            asperthecin biosynthetic process + 0
            cichorine biosynthetic process 0
            cordyol C biosynthetic process + 0
            cspyrone B1 biosynthetic process 0
            cyanogenic glycoside biosynthetic process + 0
            dehydroaustinol biosynthetic process + 0
            demethylkotanin biosynthetic process + 0
            diorcinol biosynthetic process + 0
            emericellamide biosynthetic process + 0
            emericellin biosynthetic process + 0
            emodin biosynthetic process + 0
            endocrocin biosynthetic process + 0
            fumonisin biosynthetic process + 0
            gerfelin biosynthetic process + 0
            helvolic acid biosynthetic process + 0
            melanin biosynthetic process + 24
            monodictyphenone biosynthetic process + 0
            negative regulation of secondary metabolite biosynthetic process + 5
            o-orsellinic acid biosynthetic process + 0
            ocellus pigment biosynthetic process + 0
            ochratoxin A biosynthetic process 0
            orcinol biosynthetic process + 0
            orlandin biosynthetic process 0
            penicillin biosynthetic process + 0
            phenylpropanoid biosynthetic process + 0
            pheromone biosynthetic process 0
            phytochelatin biosynthetic process 0
            polyketide biosynthetic process + 0
            positive regulation of secondary metabolite biosynthetic process + 9
            regulation of secondary metabolite biosynthetic process + 15
            shamixanthone biosynthetic process 0
            siderophore biosynthetic process + 1
            tensidol A biosynthetic process + 0
            tensidol B biosynthetic process + 0
            toxin biosynthetic process + 1
            violaceol I biosynthetic process + 0
            violaceol II biosynthetic process + 0
paths to the root