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ONTOLOGY REPORT - ANNOTATIONS

Term:cell dedifferentiation
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Accession:GO:0043697 term browser browse the term
Definition:The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
Comment:Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer.


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cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk6 cyclin-dependent kinase 6 involved_in ISO (PMID:12861051) RGD PMID:12861051 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Esrrb estrogen-related receptor beta involved_in ISS
ISO		 GO_REF:0000024
(PMID:23040477)		 UniProt
RGD		 PMID:23040477 GO_REF:0000024 NCBI chr 6:106,007,701...106,163,136
Ensembl chr 6:106,008,095...106,160,791 		JBrowse link
G Fezf1 Fez family zinc finger 1 involved_in ISO UniProtKB:Q9VQ56 (PMID:20152183) RGD PMID:20152183 NCBI chr 4:51,762,751...51,766,078
Ensembl chr 4:51,762,751...51,766,078 		JBrowse link
G Fezf2 Fez family zinc finger 2 involved_in ISO UniProtKB:Q9VQ56 (PMID:20152183) RGD PMID:20152183 NCBI chr15:12,768,614...12,777,554
Ensembl chr15:12,773,762...12,777,554 		JBrowse link
G Nanog Nanog homeobox involved_in ISO (PMID:23040477) RGD PMID:23040477 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23019124)		 UniProt
RGD		 PMID:23019124 GO_REF:0000024 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
hepatocyte dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpd heterogeneous nuclear ribonucleoprotein D IEP RGD PMID:20102719 RGD:10042969 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786 		JBrowse link
negative regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir182 microRNA 182 involved_in ISO (PMID:28259995) RGD PMID:28259995 NCBI chr 4:58,784,818...58,784,879
Ensembl chr 4:58,784,818...58,784,879 		JBrowse link
positive regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir214 microRNA 214 involved_in ISO (PMID:27144530) RGD PMID:27144530 NCBI chr13:77,121,645...77,121,752
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir221 microRNA 221 involved_in ISO (PMID:19088079) RGD PMID:19088079 NCBI chr  X:6,023,182...6,023,290
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO
IEA		 (PMID:19088079)
GO_REF:0000107		 RGD
Ensembl		 PMID:19088079 GO_REF:0000107 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm2 olfactomedin 2 involved_in IMP PMID:28062493 UniProt PMID:28062493 RGD:13441204 NCBI chr 8:19,204,472...19,282,154
Ensembl chr 8:19,204,475...19,282,117 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    developmental process 7139
      dedifferentiation 12
        cell dedifferentiation 12
          cell dedifferentiation involved in phenotypic switching + 5
          hepatocyte dedifferentiation 1
          kidney cortex tubule cell dedifferentiation 0
paths to the root