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ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear replication fork
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Accession:GO:0043596 term browser browse the term
Definition:The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.


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nuclear replication fork term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAZ1B bromodomain adjacent to zinc finger domain 1B located_in IEA Ensembl GO_REF:0000107 Ensembl chr 7:80,594,626...80,675,709 JBrowse link
G CARM1 coactivator associated arginine methyltransferase 1 is_active_in IEA Ensembl GO_REF:0000107 NCBI chr19:10,424,993...10,476,702
Ensembl chr19:11,144,733...11,195,948 		JBrowse link
G ETAA1 ETAA1 activator of ATR kinase located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:67,455,668...67,470,509
Ensembl chr2A:68,578,554...68,591,534 		JBrowse link
G MCM10 minichromosome maintenance 10 replication initiation factor located_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:13,165,811...13,215,024
Ensembl chr10:13,138,824...13,187,991 		JBrowse link
G MMS22L MMS22 like, DNA repair protein located_in
is_active_in		 IEA
ISO		 (PMID:27797818) Ensembl
TreeGrafter
UniProt		 PMID:27797818 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:94,989,906...95,127,260
Ensembl chr 6:98,861,299...99,011,773 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 is_active_in IEA Ensembl GO_REF:0000107 NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356 		JBrowse link
G PCNA proliferating cell nuclear antigen located_in IEA Ensembl GO_REF:0000107 NCBI chr20:5,134,930...5,146,603
Ensembl chr20:4,927,731...4,939,440 		JBrowse link
G SMARCA5 SNF2 related chromatin remodeling ATPase 5 located_in IEA Ensembl GO_REF:0000107 NCBI chr 4:135,874,888...135,917,096
Ensembl chr 4:147,174,060...147,214,809 		JBrowse link
G SMARCAD1 SNF2 related chromatin remodeling ATPase with DExD box 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 4:86,567,722...86,651,527
Ensembl chr 4:97,240,614...97,324,366 		JBrowse link
G SMARCAL1 SNF2 related chromatin remodeling annealing helicase 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:103,672,934...103,743,802
Ensembl chr2B:222,276,353...222,347,258 		JBrowse link
G TONSL tonsoku like, DNA repair protein located_in
is_active_in		 IEA
ISO		 (PMID:26527279), (PMID:29478807) Ensembl
TreeGrafter
UniProt		 PMID:26527279 PMID:29478807 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:141,195,959...141,211,849
Ensembl chr 8:144,185,674...144,201,040 		JBrowse link
G TREX1 three prime repair exonuclease 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 3:48,387,762...48,389,693
Ensembl chr 3:49,470,222...49,471,331 		JBrowse link
G WDHD1 WD repeat and HMG-box DNA binding protein 1 located_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:35,528,981...35,614,145
Ensembl chr14:53,807,684...53,889,703 		JBrowse link
G ZMIZ2 zinc finger MIZ-type containing 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr 7:45,462,031...45,482,209
Ensembl chr 7:45,532,224...45,552,081 		JBrowse link
G ZRANB3 zinc finger RANBP2-type containing 3 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:24,331,731...24,665,652
Ensembl chr2B:139,234,909...139,577,193 		JBrowse link
alpha DNA polymerase:primase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLA1 DNA polymerase alpha 1, catalytic subunit part_of ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:7670930 GO_REF:0000107 GO_REF:0000118 RGD:1580605 NCBI chr  X:17,290,805...17,592,163
Ensembl chr  X:24,657,878...24,960,231 		JBrowse link
G POLA2 DNA polymerase alpha 2, accessory subunit part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:60,626,555...60,670,716
Ensembl chr11:63,966,531...64,001,335 		JBrowse link
G PRIM1 DNA primase subunit 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr12:32,155,541...32,176,363
Ensembl chr12:32,408,929...32,428,734 		JBrowse link
G PRIM2 DNA primase subunit 2 part_of ISO (PMID:8026492)
(PMID:10523676)
(PMID:26975377)
(PMID:26975377), (PMID:8026492)		 UniProt
ComplexPortal		 PMID:8026492 PMID:10523676 PMID:26975377 NCBI chr 6:56,875,331...56,884,118 JBrowse link
delta DNA polymerase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POLD1 DNA polymerase delta 1, catalytic subunit part_of ISO
IEA		 RGD
TreeGrafter
UniProt
Ensembl		 PMID:10541966 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:729526 NCBI chr19:47,347,919...47,381,772
Ensembl chr19:56,251,356...56,297,611 		JBrowse link
G POLD2 DNA polymerase delta 2, accessory subunit part_of ISO
IEA		 RGD
TreeGrafter
Ensembl
UniProt		 PMID:10541966 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:729526 NCBI chr 7:44,829,040...44,837,928
Ensembl chr 7:44,896,320...44,905,393 		JBrowse link
G POLD3 DNA polymerase delta 3, accessory subunit part_of IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr11:69,665,642...69,715,879
Ensembl chr11:72,969,844...73,018,295 		JBrowse link
G POLD4 DNA polymerase delta 4, accessory subunit part_of IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:62,709,988...62,712,038
Ensembl chr11:66,022,395...66,024,442 		JBrowse link
G SPIB Spi-B transcription factor part_of IEA UniProt
TreeGrafter		 GO_REF:0000117 GO_REF:0000118 NCBI chr19:47,382,653...47,395,178
Ensembl chr19:56,251,356...56,297,611 		JBrowse link
DNA replication factor A complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCAS2 BCAS2 pre-mRNA processing factor located_in IEA Ensembl GO_REF:0000107 NCBI chr 1:87,972,721...87,986,819
Ensembl chr 1:123,024,910...123,039,068 		JBrowse link
G CDC5L cell division cycle 5 like located_in IEA Ensembl GO_REF:0000107 NCBI chr 6:43,983,840...44,043,029
Ensembl chr 6:45,265,845...45,326,383 		JBrowse link
G ERCC5 ERCC excision repair 5, endonuclease located_in ISO (PMID:7700386) UniProt PMID:7700386 NCBI chr13:84,005,950...84,036,710
Ensembl chr13:103,096,344...103,174,182 		JBrowse link
G HELB DNA helicase B located_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,571,448...22,607,417
Ensembl chr12:23,078,732...23,114,134 		JBrowse link
G PLRG1 pleiotropic regulator 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 4:146,900,494...146,917,016
Ensembl chr 4:158,719,568...158,735,103 		JBrowse link
G PRPF19 pre-mRNA processing factor 19 located_in IEA Ensembl GO_REF:0000107 NCBI chr11:56,153,965...56,169,821
Ensembl chr11:59,595,120...59,607,828 		JBrowse link
G RPA1 replication protein A1 part_of ISO
IEA		 RGD
Ensembl		 PMID:7503737 PMID:8463251 GO_REF:0000107 RGD:2307012 RGD:2307013 NCBI chr17:1,813,610...1,886,093
Ensembl chr17:1,705,380...1,775,596 		JBrowse link
G RPA2 replication protein A2 part_of ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:7503737 PMID:8463251 GO_REF:0000107 GO_REF:0000118 RGD:2307012 RGD:2307013 NCBI chr 1:27,151,784...27,175,110
Ensembl chr 1:28,191,731...28,214,666 		JBrowse link
G RPA3 replication protein A3 part_of ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:7503737 GO_REF:0000107 GO_REF:0000118 RGD:2307013 NCBI chr 7:8,361,623...8,365,098
Ensembl chr 7:7,713,629...7,717,169 		JBrowse link
G RPA4 replication protein A4 part_of ISO (PMID:19116208)
(PMID:7760808)		 UniProt
ComplexPortal		 PMID:7760808 PMID:19116208 NCBI chr  X:86,114,330...86,116,687 JBrowse link
G SMARCAL1 SNF2 related chromatin remodeling annealing helicase 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr2B:103,672,934...103,743,802
Ensembl chr2B:222,276,353...222,347,258 		JBrowse link
G TONSL tonsoku like, DNA repair protein located_in IEA Ensembl GO_REF:0000107 NCBI chr 8:141,195,959...141,211,849
Ensembl chr 8:144,185,674...144,201,040 		JBrowse link
G XPA XPA, DNA damage recognition and repair factor located_in IEA Ensembl GO_REF:0000107 NCBI chr 9:68,726,723...68,788,049
Ensembl chr 9:96,886,795...96,909,254 		JBrowse link
replication fork protection complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TIMELESS timeless circadian regulator part_of IEA TreeGrafter GO_REF:0000118 NCBI chr12:32,465,529...32,497,581
Ensembl chr12:32,718,649...32,750,728 		JBrowse link
G TIPIN TIMELESS interacting protein part_of IEA TreeGrafter GO_REF:0000118 NCBI chr15:45,290,350...45,310,335
Ensembl chr15:63,566,463...63,585,717 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20337
    cellular anatomical structure 19903
      replication fork 73
        nuclear replication fork 37
          nuclear replisome + 22
          replication fork protection complex 2
Path 2
Term Annotations click to browse term
  cellular_component 20337
    cellular anatomical structure 19903
      organelle 14896
        intracellular organelle 14486
          intracellular membrane-bounded organelle 12905
            nucleus 8763
              nuclear lumen 4568
                nuclear chromosome 224
                  nuclear replication fork 37
                    nuclear replisome + 22
                    replication fork protection complex 2
paths to the root