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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid precursor protein biosynthetic process
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Accession:GO:0042983 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP biosynthesis;   APP biosynthetic process;   amyloid precursor protein anabolism;   amyloid precursor protein biosynthesis;   amyloid precursor protein formation;   amyloid precursor protein synthesis


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amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncstn nicastrin acts_upstream_of_or_within ISO
IEA		 (PMID:18201567)
GO_REF:0000107		 RGD
Ensembl		 PMID:18201567 GO_REF:0000107 NCBI chr13:87,062,827...87,078,839
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor acts_upstream_of_or_within ISO (PMID:14627703) RGD PMID:14627703 NCBI chr10:69,796,502...69,889,671
Ensembl chr10:69,299,037...69,392,201 		JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18429932)		 Alzheimers_University_of_Toronto
RGD		 PMID:18429932 GO_REF:0000024 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in IMP PMID:20395292 ARUK-UCL PMID:20395292 RGD:14390059 NCBI chr 7:106,907,209...106,994,124
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Bace2 beta-secretase 2 involved_in ISO
ISS		 (PMID:12801932)
GO_REF:0000024		 RGD
UniProt		 PMID:12801932 GO_REF:0000024 NCBI chr11:50,176,852...50,258,948
Ensembl chr11:36,707,458...36,789,546 		JBrowse link
G Itm2b integral membrane protein 2B involved_in ISO
IBA
IEA
ISS		 (PMID:16027166), (PMID:18524908)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:16027166 PMID:18524908 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917 		JBrowse link
G Itm2c integral membrane protein 2C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:86,545,927...86,559,745
Ensembl chr 9:86,545,921...86,559,742 		JBrowse link
G Mir106a microRNA 106a involved_in ISO (PMID:18684319) RGD PMID:18684319 NCBI chr  X:137,343,570...137,343,647
Ensembl chr  X:132,422,584...132,422,661 		JBrowse link
G Mir144 microRNA 144 involved_in ISO (PMID:27329039) RGD PMID:27329039 NCBI chr10:63,459,397...63,459,479
Ensembl chr10:62,961,348...62,961,430 		JBrowse link
G Mir153 microRNA 153 involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr 6:144,306,594...144,306,680
Ensembl chr 6:138,163,595...138,163,681 		JBrowse link
G Mir17 microRNA 17 involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr15:98,587,848...98,587,931
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir20a microRNA 20a involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr15:98,588,303...98,588,387
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir298 microRNA 298 involved_in ISO (PMID:31942037) RGD PMID:31942037 NCBI chr 3:163,052,291...163,052,372
Ensembl chr 3:163,052,291...163,052,372 		JBrowse link
G Mir31 microRNA 31 involved_in ISO UniProtKB:P05067 (PMID:32069773) RGD PMID:32069773 NCBI chr 5:108,714,849...108,714,954 JBrowse link
G Mir323 microRNA 323 involved_in ISO (PMID:21982160) RGD PMID:21982160 NCBI chr 6:128,725,539...128,725,624
Ensembl chr 6:128,725,539...128,725,624 		JBrowse link
G Mir455 microRNA 455 involved_in ISO (PMID:31181293) RGD PMID:31181293 NCBI chr 5:81,704,834...81,704,911
Ensembl chr 5:76,689,313...76,689,390 		JBrowse link
positive regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO
IEA		 (PMID:20704561)
GO_REF:0000107		 RGD
Ensembl		 PMID:20704561 GO_REF:0000107 NCBI chr 3:28,642,660...28,662,689
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Ncstn nicastrin acts_upstream_of_or_within ISO
IEA		 (PMID:23826707)
GO_REF:0000107		 RGD
Ensembl		 PMID:23826707 GO_REF:0000107 NCBI chr13:87,062,827...87,078,839
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Pawr pro-apoptotic WT1 regulator acts_upstream_of_or_within ISO (PMID:14627703) RGD PMID:14627703 NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in ISO
IEA		 (PMID:17412327)
GO_REF:0000107		 RGD
Ensembl		 PMID:17412327 GO_REF:0000107 NCBI chr13:71,105,178...71,147,776
Ensembl chr13:68,552,317...68,597,494 		JBrowse link
regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab1 N-terminal EF-hand calcium binding protein 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:33,155,078...33,375,707
Ensembl chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642 		JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:64,409,627...64,436,371
Ensembl chr19:47,501,302...47,527,684 		JBrowse link
G Necab3 N-terminal EF-hand calcium binding protein 3 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 3:143,049,477...143,064,372
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    cellular process 19557
      metabolic process 12206
        biosynthetic process 8676
          macromolecule biosynthetic process 7662
            amyloid precursor protein biosynthetic process 22
              negative regulation of amyloid precursor protein biosynthetic process 15
              positive regulation of amyloid precursor protein biosynthetic process 4
              regulation of amyloid precursor protein biosynthetic process + 22
Path 2
Term Annotations click to browse term
  biological_process 20567
    cellular process 19557
      metabolic process 12206
        macromolecule metabolic process 10018
          protein metabolic process 5227
            amyloid precursor protein metabolic process 95
              amyloid precursor protein biosynthetic process 22
                negative regulation of amyloid precursor protein biosynthetic process 15
                positive regulation of amyloid precursor protein biosynthetic process 4
                regulation of amyloid precursor protein biosynthetic process + 22
paths to the root