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ONTOLOGY REPORT - ANNOTATIONS

Term:hemoglobin biosynthetic process
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Accession:GO:0042541 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
Synonyms:exact_synonym: haemoglobin biosynthesis;   haemoglobin biosynthetic process;   hemoglobin anabolism;   hemoglobin biosynthesis;   hemoglobin formation;   hemoglobin synthesis
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa


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hemoglobin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:9446639)		 UniProt
GO_Central
RGD		 PMID:9446639 GO_REF:0000024 GO_REF:0000033 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Epo erythropoietin acts_upstream_of_or_within ISO
IEA		 (PMID:17300687)
GO_REF:0000107		 RGD
Ensembl		 PMID:17300687 GO_REF:0000107 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within ISO
IEA		 MGI:1857719 (PMID:16787915)
GO_REF:0000107		 RGD
Ensembl		 PMID:16787915 GO_REF:0000107 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Inha inhibin subunit alpha involved_in ISO
ISS
IEA		 (PMID:1310063)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:1310063 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248 		JBrowse link
G Inhba inhibin subunit beta A involved_in ISO
IEA
ISS		 (PMID:1310063)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:1310063 GO_REF:0000024 GO_REF:0000107 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Snx3 sorting nexin 3 acts_upstream_of_or_within ISO (PMID:23416069) RGD PMID:23416069 NCBI chr20:45,992,446...46,025,361
Ensembl chr20:45,992,720...46,025,379 		JBrowse link
negative regulation of hemoglobin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:11050009)		 UniProt
Ensembl
RGD		 PMID:11050009 GO_REF:0000024 GO_REF:0000107 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573 		JBrowse link
positive regulation of hemoglobin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP binding cassette subfamily B member 10 involved_in ISO
IEA		 (PMID:22085049), (PMID:28808058)
GO_REF:0000107		 RGD
Ensembl		 PMID:22085049 PMID:28808058 GO_REF:0000107 NCBI chr19:51,952,655...51,982,910
Ensembl chr19:51,952,681...51,982,753 		JBrowse link
G Klf4 KLF transcription factor 4 involved_in ISO
IEA		 (PMID:21539536)
GO_REF:0000107		 RGD
Ensembl		 PMID:21539536 GO_REF:0000107 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Ldb1 LIM domain binding 1 involved_in ISO
IEA		 (PMID:20570862)
GO_REF:0000107		 RGD
Ensembl		 PMID:20570862 GO_REF:0000107 NCBI chr 1:244,864,168...244,890,007
Ensembl chr 1:244,877,173...244,890,013 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 involved_in IDA PMID:23483889 BHF-UCL PMID:23483889 RGD:10047341 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Slc25a37 solute carrier family 25 member 37 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19805291)		 UniProt
RGD		 PMID:19805291 GO_REF:0000024 NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 involved_in ISO
IEA		 (PMID:28495915)
GO_REF:0000107		 RGD
Ensembl		 PMID:28495915 GO_REF:0000107 NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:131,374,542...131,408,728 		JBrowse link
regulation of hemoglobin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 acts_upstream_of_or_within ISO
IEA		 MGI:1353448|MGI:95513 (PMID:15931390)
GO_REF:0000107		 RGD
Ensembl		 PMID:15931390 GO_REF:0000107 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573 		JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within ISO
IEA		 MGI:1353448|MGI:95513 (PMID:15931390)
GO_REF:0000107		 RGD
Ensembl		 PMID:15931390 GO_REF:0000107 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        biosynthetic process 8654
          macromolecule biosynthetic process 7646
            hemoglobin biosynthetic process 15
              negative regulation of hemoglobin biosynthetic process 1
              positive regulation of hemoglobin biosynthetic process 6
              regulation of hemoglobin biosynthetic process + 8
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        macromolecule metabolic process 9996
          protein metabolic process 5212
            hemoglobin metabolic process 22
              hemoglobin biosynthetic process 15
                negative regulation of hemoglobin biosynthetic process 1
                positive regulation of hemoglobin biosynthetic process 6
                regulation of hemoglobin biosynthetic process + 8
paths to the root