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ONTOLOGY REPORT - ANNOTATIONS

Term:aspartic endopeptidase activity, intramembrane cleaving
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Accession:GO:0042500 term browser browse the term
Definition:Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane.
Comment:Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases.
Synonyms:xref: Reactome:R-HSA-9708457 "HM13 cleaves HMOX1 dimer";   reactome:R-HSA-8863101 "SPPL2a/b cleaves TNF(1-76)"

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show annotations for term's descendants           Sort by:
aspartic endopeptidase activity, intramembrane cleaving term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624741:924,040...977,646
Ensembl chrNW_004624741:921,023...977,703 		JBrowse link
G Ncstn nicastrin contributes_to IEA Ensembl GO_REF:0000107 NCBI chrNW_004624794:908,227...923,474
Ensembl chrNW_004624794:905,857...924,003 		JBrowse link
G Psen1 presenilin 1 enables
contributes_to 		IEA
ISO 		(PMID:16371134) InterPro
TreeGrafter
MGI		 PMID:16371134 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624734:28,200,358...28,272,684
Ensembl chrNW_004624734:28,200,140...28,272,743 		JBrowse link
G Psen2 presenilin 2 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624771:17,183,538...17,205,460
Ensembl chrNW_004624771:17,183,447...17,224,188 		JBrowse link
G Sppl2a signal peptide peptidase like 2A enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624731:9,430,702...9,469,961
Ensembl chrNW_004624731:9,430,790...9,473,839 		JBrowse link
G Sppl2b signal peptide peptidase like 2B NOT|enables ISO
IEA 		(PMID:16873890) UniProt
TreeGrafter
InterPro		 PMID:16873890 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624828:6,564,127...6,576,663
Ensembl chrNW_004624828:6,562,426...6,576,609 		JBrowse link
G Sppl2c signal peptide peptidase like 2C enables IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624849:2,469,076...2,471,365
Ensembl chrNW_004624849:2,468,699...2,471,428 		JBrowse link
G Sppl3 signal peptide peptidase like 3 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624747:12,795,803...12,925,319
Ensembl chrNW_004624747:12,795,563...12,928,649 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 18443
    catalytic activity 5677
      hydrolase activity 2291
        peptidase activity 611
          endopeptidase activity 399
            aspartic-type endopeptidase activity 39
              aspartic endopeptidase activity, intramembrane cleaving 8
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