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ONTOLOGY REPORT - ANNOTATIONS

Term:aspartic endopeptidase activity, intramembrane cleaving
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Accession:GO:0042500 term browser browse the term
Definition:Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane.
Comment:Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases.
Synonyms:xref: Reactome:R-HSA-9708457 "HM13 cleaves HMOX1 dimer";   reactome:R-HSA-8863101 "SPPL2a/b cleaves TNF(1-76)"


show annotations for term's descendants           Sort by:
aspartic endopeptidase activity, intramembrane cleaving term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HM13 histocompatibility minor 13 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr20:27,803,597...27,859,384
Ensembl chr20:28,441,285...28,501,001 		JBrowse link
G NCSTN nicastrin contributes_to IEA Ensembl GO_REF:0000107 NCBI chr 1:135,697,592...135,713,293
Ensembl chr 1:139,618,229...139,633,911 		JBrowse link
G PSEN1 presenilin 1 enables
contributes_to 		IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876 		JBrowse link
G PSEN2 presenilin 2 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295 		JBrowse link
G SPPL2A signal peptide peptidase like 2A enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr15:29,660,190...29,718,477
Ensembl chr15:47,997,304...48,055,239 		JBrowse link
G SPPL2B signal peptide peptidase like 2B NOT|enables ISO
IEA 		(PMID:16873890) UniProt
TreeGrafter
InterPro
Ensembl		 PMID:16873890 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr19:1,337,570...1,355,755
Ensembl chr19:2,309,360...2,331,951 		JBrowse link
G SPPL2C signal peptide peptidase like 2C enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr17:11,323,494...11,325,924
Ensembl chr17:11,637,880...11,639,934 		JBrowse link
G SPPL3 signal peptide peptidase like 3 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr12:118,351,199...118,489,579
Ensembl chr12:121,723,881...121,773,429 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19299
    catalytic activity 5408
      hydrolase activity 2250
        peptidase activity 581
          endopeptidase activity 380
            aspartic-type endopeptidase activity 24
              aspartic endopeptidase activity, intramembrane cleaving 8
paths to the root