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ONTOLOGY REPORT - ANNOTATIONS

Term:aspartic endopeptidase activity, intramembrane cleaving
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Accession:GO:0042500 term browser browse the term
Definition:Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane.
Comment:Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases.
Synonyms:xref: Reactome:R-HSA-9708457 "HM13 cleaves HMOX1 dimer";   reactome:R-HSA-8863101 "SPPL2a/b cleaves TNF(1-76)"


show annotations for term's descendants           Sort by:
aspartic endopeptidase activity, intramembrane cleaving term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 enables ISO
IBA
IEA 		(PMID:16873890), (PMID:25239945)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002 		RGD
GO_Central
Ensembl
InterPro		 PMID:16873890 PMID:25239945 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:161,606,059...161,641,382
Ensembl chr 3:141,145,782...141,184,703 		JBrowse link
G Mcts2 MCTS family member 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:161,623,597...161,624,375 JBrowse link
G Ncstn nicastrin contributes_to ISO
IEA 		MGI:1202717|MGI:3522097 (PMID:16371134)
GO_REF:0000107 		RGD
Ensembl		 PMID:16371134 GO_REF:0000107 NCBI chr13:87,062,827...87,078,839
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Psen1 presenilin 1 enables
contributes_to 		ISS
ISO
IBA
IEA 		GO_REF:0000024
(PMID:17428795), (PMID:26280335)
GO_REF:0000033
MGI:1891700|MGI:3522097 (PMID:16371134)
MGI:109284 (PMID:21206757)
GO_REF:0000107
GO_REF:0000002 		UniProt
RGD
GO_Central
Ensembl
InterPro		 PMID:16371134 PMID:17428795 PMID:21206757 PMID:26280335 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 enables IBA
ISO
IEA 		GO_REF:0000033
MGI:1202717|MGI:1930939 (PMID:12684521), (PMID:21206757)
GO_REF:0000002 		GO_Central
RGD
InterPro		 PMID:12684521 PMID:21206757 GO_REF:0000002 GO_REF:0000033 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Sppl2a signal peptide peptidase-like 2A enables ISO
IBA
IEA 		(PMID:2313285)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000107 		RGD
GO_Central
InterPro
Ensembl		 PMID:2313285 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:134,602,684...134,646,752
Ensembl chr 3:114,151,069...114,193,264 		JBrowse link
G Sppl2b signal peptide peptidase-like 2B NOT|enables ISS
ISO
IEA
IBA 		GO_REF:0000024
(PMID:16873890)
(PMID:19114711), (PMID:22194595), (PMID:2313285)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033 		UniProt
RGD
Ensembl
InterPro
GO_Central		 PMID:2313285 PMID:16873890 PMID:19114711 PMID:22194595 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:9,494,593...9,507,317
Ensembl chr 7:8,843,918...8,856,608 		JBrowse link
G Sppl2c signal peptide peptidase like 2C enables IBA
ISO
IEA 		GO_REF:0000033
(PMID:30733280), (PMID:30733281), (PMID:35960805)
GO_REF:0000107
GO_REF:0000002 		GO_Central
RGD
Ensembl
InterPro		 PMID:30733280 PMID:30733281 PMID:35960805 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr10:89,595,265...89,597,470
Ensembl chr10:89,095,261...89,098,580 		JBrowse link
G Sppl3 signal peptide peptidase like 3 enables ISO
IBA
IEA 		(PMID:16873890), (PMID:2313285)
GO_REF:0000033
GO_REF:0000002 		RGD
GO_Central
InterPro		 PMID:2313285 PMID:16873890 GO_REF:0000002 GO_REF:0000033 NCBI chr12:47,176,317...47,260,756
Ensembl chr12:41,515,640...41,600,126 		JBrowse link
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Term Annotations click to browse term
  molecular_function 21102
    catalytic activity 6213
      hydrolase activity 2572
        peptidase activity 706
          endopeptidase activity 469
            aspartic-type endopeptidase activity 32
              aspartic endopeptidase activity, intramembrane cleaving 9
paths to the root