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ONTOLOGY REPORT - ANNOTATIONS

Term:pigment metabolic process
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Accession:GO:0042440 term browser browse the term
Definition:The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.
Synonyms:exact_synonym: pigment metabolism


show annotations for term's descendants           Sort by:
flavone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a PPARG coactivator 1 alpha IEP hesperetin RGD PMID:22767158 RGD:7242166 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 involved_in ISO (PMID:18052087) RGD PMID:18052087 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 involved_in ISO (PMID:18052087) RGD PMID:18052087 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
heme A biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase involved_in ISO
IEA		 (PMID:14050799), (PMID:5393940)
GO_REF:0000107		 RGD
Ensembl		 PMID:5393940 PMID:14050799 GO_REF:0000107 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:4440831 (PMID:33307066)		 Ensembl
RGD		 PMID:33307066 GO_REF:0000107 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:12928484)
GO_REF:0000107
GO_REF:0000033
UniProtKB:Q12887 (PMID:12928484)
(PMID:16103131), (PMID:16782876)		 RGD
Ensembl
GO_Central		 PMID:12928484 PMID:16103131 PMID:16782876 GO_REF:0000033 GO_REF:0000107 NCBI chr10:49,130,209...49,242,009
Ensembl chr10:48,630,676...48,746,667 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 involved_in ISO
IEA
IBA		 UniProtKB:Q7KZN9-1 (PMID:12474143)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033		 RGD
Ensembl
InterPro
GO_Central		 PMID:12474143 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:252,554,811...252,571,471
Ensembl chr 1:242,605,588...242,622,261 		JBrowse link
G Cpox coproporphyrinogen oxidase involved_in IEA
ISO		 GO_REF:0000107
(PMID:8407975)		 Ensembl
RGD		 PMID:8407975 GO_REF:0000107 NCBI chr11:55,405,778...55,415,761
Ensembl chr11:41,936,591...41,946,746 		JBrowse link
G Fech ferrochelatase involved_in ISO
IEA		 MGI:1858114 (PMID:15677551)
GO_REF:0000107		 RGD
Ensembl		 PMID:15677551 GO_REF:0000107 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in IEA
ISO		 GO_REF:0000107
MGI:2182340 (PMID:8563760)		 Ensembl
RGD		 PMID:8563760 GO_REF:0000107 NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Ppox protoporphyrinogen oxidase involved_in ISO
IEA		 (PMID:3346226)
GO_REF:0000107		 RGD
Ensembl		 PMID:3346226 GO_REF:0000107 NCBI chr13:86,230,111...86,235,028
Ensembl chr13:83,664,891...83,701,805 		JBrowse link
G Urod uroporphyrinogen decarboxylase involved_in IEA
ISO		 GO_REF:0000107
MGI:2687172 (PMID:17360334)		 Ensembl
RGD		 PMID:17360334 GO_REF:0000107 NCBI chr 5:135,701,294...135,705,380
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO
IEA		 MGI:3776884 (PMID:16532394)
GO_REF:0000107		 RGD
Ensembl		 PMID:16532394 GO_REF:0000107 NCBI chr 1:197,920,827...197,943,183
Ensembl chr 1:188,490,323...188,512,249 		JBrowse link
heme B biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 NOT|involved_in ISO (PMID:22655043) RGD PMID:22655043 NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:76,668,554...76,676,924 		JBrowse link
G Alad aminolevulinate dehydratase involved_in ISO
IEA		 (PMID:14050799), (PMID:5393940)
(PMID:11032836)
GO_REF:0000107		 RGD
Ensembl		 PMID:5393940 PMID:11032836 PMID:14050799 GO_REF:0000107 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:4440831 (PMID:33307066)		 Ensembl
RGD		 PMID:33307066 GO_REF:0000107 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in ISO (PMID:2050125) RGD PMID:2050125 NCBI chr  X:22,890,650...22,914,046
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Cpox coproporphyrinogen oxidase involved_in IEA
ISO		 GO_REF:0000107
(PMID:7987309)
(PMID:8407975)		 Ensembl
RGD		 PMID:7987309 PMID:8407975 GO_REF:0000107 NCBI chr11:55,405,778...55,415,761
Ensembl chr11:41,936,591...41,946,746 		JBrowse link
G Fech ferrochelatase involved_in ISO
IEA		 MGI:1858114 (PMID:15677551)
(PMID:27599036)
GO_REF:0000107		 RGD
Ensembl		 PMID:15677551 PMID:27599036 GO_REF:0000107 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in IEA
ISO		 GO_REF:0000107
(PMID:18004775)
MGI:2182340 (PMID:8563760)		 Ensembl
RGD		 PMID:8563760 PMID:18004775 GO_REF:0000107 NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Ppox protoporphyrinogen oxidase involved_in ISO
IEA		 (PMID:3346226)
(PMID:7713909)
GO_REF:0000107		 RGD
Ensembl		 PMID:3346226 PMID:7713909 GO_REF:0000107 NCBI chr13:86,230,111...86,235,028
Ensembl chr13:83,664,891...83,701,805 		JBrowse link
G Urod uroporphyrinogen decarboxylase involved_in IEA
ISO		 GO_REF:0000107
(PMID:11069625)
MGI:2687172 (PMID:17360334)		 Ensembl
RGD		 PMID:11069625 PMID:17360334 GO_REF:0000107 NCBI chr 5:135,701,294...135,705,380
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO
IEA		 MGI:3776884 (PMID:16532394)
(PMID:18004775)
GO_REF:0000107		 RGD
Ensembl		 PMID:16532394 PMID:18004775 GO_REF:0000107 NCBI chr 1:197,920,827...197,943,183
Ensembl chr 1:188,490,323...188,512,249 		JBrowse link
heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP binding cassette subfamily B member 10 involved_in ISO
IEA		 (PMID:24421385)
GO_REF:0000107		 RGD
Ensembl		 PMID:24421385 GO_REF:0000107 NCBI chr19:51,952,655...51,982,910
Ensembl chr19:51,952,681...51,982,753 		JBrowse link
G Alad aminolevulinate dehydratase acts_upstream_of_or_within
involved_in		 IDA
IEA
ISO
IBA
ISS		 GO_REF:0000107
GO_REF:0000043
(PMID:14050799), (PMID:4959158), (PMID:4981581)
GO_REF:0000033
(PMID:11032836)
GO_REF:0000024		 Ensembl
UniProt
RGD
GO_Central		 PMID:4959158 PMID:4981581 PMID:11032836 PMID:14050799 PMID:1764448 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107, RGD:1599020 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000043		 GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000043
(PMID:9446639)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:9446639 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 NCBI chr  X:22,890,650...22,914,046
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:23135403)		 UniProt
GO_Central
RGD		 PMID:23135403 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:150,022,960...150,026,677
Ensembl chr 5:144,738,950...144,742,668 		JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in IEA GO_REF:0000002
GO_REF:0000043		 InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr10:49,130,209...49,242,009
Ensembl chr10:48,630,676...48,746,667 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:252,554,811...252,571,471
Ensembl chr 1:242,605,588...242,622,261 		JBrowse link
G Cpox coproporphyrinogen oxidase involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO		 GO_REF:0000043
GO_REF:0000117
GO_REF:0000107
(PMID:8407975)		 UniProt
Ensembl
RGD		 PMID:8407975 PMID:3955059 GO_REF:0000043 GO_REF:0000107 GO_REF:0000117, RGD:1600961 NCBI chr11:55,405,778...55,415,761
Ensembl chr11:41,936,591...41,946,746 		JBrowse link
G Fech ferrochelatase involved_in
acts_upstream_of_or_within		 IDA
ISO
IEA
IBA		 (PMID:15123683), (PMID:27599036)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000104
GO_REF:0000043
GO_REF:0000033
MGI:1858114|MGI:2384729 (PMID:15496139), (PMID:16306232), (PMID:16503645), (PMID:8611576), (PMID:9989256)		 RGD
Ensembl
InterPro
UniProt
GO_Central		 PMID:8611576 PMID:9989256 PMID:15123683 PMID:15496139 PMID:16306232 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107, RGD:1600961 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Fxn frataxin involved_in IEA
ISO		 GO_REF:0000043
(PMID:15123683)		 UniProt
RGD		 PMID:15123683 GO_REF:0000043 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in ISO
IEA
IBA		 (PMID:18936296)
GO_REF:0000107
GO_REF:0000043
GO_REF:0000033		 RGD
Ensembl
UniProt
GO_Central		 PMID:18936296 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within ISO
IEA		 MGI:2384429 (PMID:10617683)
GO_REF:0000107		 RGD
Ensembl		 PMID:10617683 GO_REF:0000107 NCBI chr12:47,299,171...47,333,457
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 involved_in ISO
IEA
ISS		 (PMID:27599036)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27599036 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:120,698,610...120,706,805
Ensembl chr  X:115,832,884...115,888,682 		JBrowse link
G Ppox protoporphyrinogen oxidase involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO
IBA		 GO_REF:0000107
GO_REF:0000043
(PMID:3346226)
GO_REF:0000033
(PMID:7713909)		 Ensembl
UniProt
RGD
GO_Central		 PMID:3346226 PMID:7713909 PMID:3955059 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107, RGD:1600961 NCBI chr13:86,230,111...86,235,028
Ensembl chr13:83,664,891...83,701,805 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 acts_upstream_of_or_within ISO
IEA		 MGI:1856400 (PMID:11739192)
GO_REF:0000107		 RGD
Ensembl		 PMID:11739192 GO_REF:0000107 NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc25a39 solute carrier family 25, member 39 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:87,862,630...87,867,626
Ensembl chr10:87,362,490...87,367,260 		JBrowse link
G Tmem14c transmembrane protein 14C involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:23,733,769...23,739,906
Ensembl chr17:23,733,894...23,753,320 		JBrowse link
G Tmem14cl1 transmembrane protein 14C like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:100,656,576...100,657,086
Ensembl chr13:100,656,593...100,657,445 		JBrowse link
G Urod uroporphyrinogen decarboxylase acts_upstream_of_or_within
involved_in		 NAS
IEA
ISO
IBA
IC		 GO_REF:0000107
GO_REF:0000043
MGI:2687172 (PMID:17360334)
GO_REF:0000033		 Ensembl
UniProt
RGD
GO_Central		 PMID:17360334 PMID:3658690 PMID:15736160 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107, RGD:70052, RGD:2301379 NCBI chr 5:135,701,294...135,705,380
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO
IEA		 (PMID:3805019)
GO_REF:0000107		 RGD
Ensembl		 PMID:3805019 GO_REF:0000107 NCBI chr 1:197,920,827...197,943,183
Ensembl chr 1:188,490,323...188,512,249 		JBrowse link
heme catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blvra biliverdin reductase A involved_in ISO
IEA		 (PMID:10858451)
GO_REF:0000002
GO_REF:0000104		 RGD
InterPro
UniProt		 PMID:10858451 GO_REF:0000002 GO_REF:0000104 NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033 		JBrowse link
G Blvrb biliverdin reductase B involved_in ISO (PMID:10858451), (PMID:7929092) RGD PMID:7929092 PMID:10858451 NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375 		JBrowse link
G Hmox1 heme oxygenase 1 acts_upstream_of_or_within
involved_in		 IDA
IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
MGI:1914989 (PMID:31571584)
(PMID:17915953)		 Ensembl
GO_Central
RGD		 PMID:17915953 PMID:31571584 PMID:15226268 GO_REF:0000033 GO_REF:0000107, RGD:1547877 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:11,303,512...11,337,640
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Hmox2-ps1 heme oxygenase (decycling) 2, pseudogene 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:200,299,951...200,302,161 JBrowse link
heme metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 involved_in ISO
IEA
ISS		 (PMID:33007128)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:33007128 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:76,668,554...76,676,924 		JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072 		JBrowse link
G Fech ferrochelatase TAS RGD PMID:9113083 RGD:1598930 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Hmox1 heme oxygenase 1 acts_upstream_of_or_within ISO
IEA		 (PMID:16183037)
GO_REF:0000107		 RGD
Ensembl		 PMID:16183037 GO_REF:0000107 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpx hemopexin involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
MGI:2447193 (PMID:18556779)		 GO_Central
Ensembl
RGD		 PMID:18556779 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:159,932,755...159,940,328 		JBrowse link
G Slc48a1 solute carrier family 48 member 1 involved_in ISO
IEA		 MGI:6711492 (PMID:31571584)
GO_REF:0000107		 RGD
Ensembl		 PMID:31571584 GO_REF:0000107 NCBI chr 7:128,915,136...128,923,929
Ensembl chr 7:128,915,195...128,923,024 		JBrowse link
G Slco1a6 solute carrier organic anion transporter family, member 1a6 acts_upstream_of_or_within IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:175,072,143...175,107,950
Ensembl chr 4:175,072,143...175,117,263 		JBrowse link
G Urod uroporphyrinogen decarboxylase acts_upstream_of_or_within ISO
IEA		 MGI:2687172 (PMID:11134514)
GO_REF:0000107		 RGD
Ensembl		 PMID:11134514 GO_REF:0000107 NCBI chr 5:135,701,294...135,705,380
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
heme O biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase involved_in ISO
IEA		 (PMID:14050799), (PMID:5393940)
GO_REF:0000107		 RGD
Ensembl		 PMID:5393940 PMID:14050799 GO_REF:0000107 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:4440831 (PMID:33307066)		 Ensembl
RGD		 PMID:33307066 GO_REF:0000107 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 involved_in ISO
IEA		 UniProtKB:Q12887 (PMID:12928484)
GO_REF:0000107		 RGD
Ensembl		 PMID:12928484 GO_REF:0000107 NCBI chr10:49,130,209...49,242,009
Ensembl chr10:48,630,676...48,746,667 		JBrowse link
G Cpox coproporphyrinogen oxidase involved_in IEA
ISO		 GO_REF:0000107
(PMID:8407975)		 Ensembl
RGD		 PMID:8407975 GO_REF:0000107 NCBI chr11:55,405,778...55,415,761
Ensembl chr11:41,936,591...41,946,746 		JBrowse link
G Fech ferrochelatase involved_in ISO
IEA		 MGI:1858114 (PMID:15677551)
GO_REF:0000107		 RGD
Ensembl		 PMID:15677551 GO_REF:0000107 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in IEA
ISO		 GO_REF:0000107
MGI:2182340 (PMID:8563760)		 Ensembl
RGD		 PMID:8563760 GO_REF:0000107 NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Ppox protoporphyrinogen oxidase involved_in ISO
IEA		 (PMID:3346226)
GO_REF:0000107		 RGD
Ensembl		 PMID:3346226 GO_REF:0000107 NCBI chr13:86,230,111...86,235,028
Ensembl chr13:83,664,891...83,701,805 		JBrowse link
G Urod uroporphyrinogen decarboxylase involved_in IEA
ISO		 GO_REF:0000107
MGI:2687172 (PMID:17360334)		 Ensembl
RGD		 PMID:17360334 GO_REF:0000107 NCBI chr 5:135,701,294...135,705,380
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
G Uros uroporphyrinogen III synthase involved_in ISO
IEA		 MGI:3776884 (PMID:16532394)
GO_REF:0000107		 RGD
Ensembl		 PMID:16532394 GO_REF:0000107 NCBI chr 1:197,920,827...197,943,183
Ensembl chr 1:188,490,323...188,512,249 		JBrowse link
heme oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 involved_in ISO
IEA
IBA		 (PMID:17915953)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
GO_REF:0000104		 RGD
Ensembl
InterPro
GO_Central
UniProt		 PMID:17915953 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 involved_in TAS
IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro
RGD		 PMID:12114211 GO_REF:0000002 GO_REF:0000033, RGD:625638 NCBI chr10:11,303,512...11,337,640
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Hmox2-ps1 heme oxygenase (decycling) 2, pseudogene 1 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 2:200,299,951...200,302,161 JBrowse link
melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asip agouti signaling protein involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 GO_REF:0000107
(PMID:8449404)
MGI:1855937 (PMID:7665913)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:7665913 PMID:8449404 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:11434569)		 UniProt
RGD		 PMID:11434569 GO_REF:0000024 NCBI chr  X:71,390,328...71,395,023
Ensembl chr  X:67,350,373...67,355,162 		JBrowse link
G Dct dopachrome tautomerase acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1856379 (PMID:7665913)
GO_REF:0000043
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:7665913 GO_REF:0000043 GO_REF:0000107 NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Ddt D-dopachrome tautomerase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:12,883,025...12,886,121
Ensembl chr20:12,884,243...12,888,482 		JBrowse link
G Mc1r melanocortin 1 receptor acts_upstream_of_or_within ISO
IEA		 MGI:1856028 (PMID:7665913)
GO_REF:0000107		 RGD
Ensembl		 PMID:7665913 GO_REF:0000107 NCBI chr19:68,360,950...68,363,877
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO MGI:1856004 (PMID:7665913) RGD PMID:7665913 NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 MGI:1856114 (PMID:7665913), (PMID:9548375)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:7665913 PMID:9548375 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:116,252,026...116,581,838
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Pmel premelanosome protein acts_upstream_of_or_within ISO
IEA		 MGI:1857040 (PMID:7665913)
GO_REF:0000107		 RGD
Ensembl		 PMID:7665913 GO_REF:0000107 NCBI chr 7:1,721,948...1,733,248
Ensembl chr 7:1,138,586...1,148,746 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of ISO
IEA		 (PMID:18166528)
GO_REF:0000107		 RGD
Ensembl		 PMID:18166528 GO_REF:0000107 NCBI chr 3:132,772,804...132,792,342
Ensembl chr 3:112,319,308...112,339,231 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:8126111)		 Ensembl
RGD		 PMID:8126111 GO_REF:0000107 NCBI chr 8:105,142,931...105,193,842
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Tyr tyrosinase involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:8126111)
GO_REF:0000043
GO_REF:0000107
MGI:1855976|MGI:1855978 (PMID:7665913), (PMID:9548375)
GO_REF:0000033		 RGD
UniProt
Ensembl
GO_Central		 PMID:7665913 PMID:8126111 PMID:9548375 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dct dopachrome tautomerase involved_in ISO
IEA
IBA		 (PMID:2169885), (PMID:33100333)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:2169885 PMID:33100333 GO_REF:0000033 GO_REF:0000107 NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein involved_in ISO
IEA		 (PMID:25513726), (PMID:32966160)
GO_REF:0000107		 RGD
Ensembl		 PMID:25513726 PMID:32966160 GO_REF:0000107 NCBI chr 1:116,252,026...116,581,838
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Slc45a2 solute carrier family 45, member 2 involved_in ISO
IEA		 (PMID:32966160)
GO_REF:0000107
(PMID:35469906)		 RGD
Ensembl		 PMID:32966160 PMID:35469906 GO_REF:0000107 NCBI chr 2:61,690,828...61,723,437
Ensembl chr 2:59,963,706...59,996,317 		JBrowse link
melanin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:2156165 (PMID:11709185) RGD PMID:11709185 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO MGI:1856004 (PMID:9548375) RGD PMID:9548375 NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 acts_upstream_of_or_within ISO
IEA		 MGI:1855960 (PMID:9548375)
GO_REF:0000107		 RGD
Ensembl		 PMID:9548375 GO_REF:0000107 NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO
IEA		 MGI:2136645 (PMID:22627278)
GO_REF:0000107		 RGD
Ensembl		 PMID:22627278 GO_REF:0000107 NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO
IEA		 (PMID:29025994)
GO_REF:0000107		 RGD
Ensembl		 PMID:29025994 GO_REF:0000107 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988 		JBrowse link
G Opn3 opsin 3 involved_in ISO
IEA		 (PMID:31097585)
GO_REF:0000107		 RGD
Ensembl		 PMID:31097585 GO_REF:0000107 NCBI chr13:90,121,560...90,152,076
Ensembl chr13:87,589,333...87,619,847 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16272156)		 UniProt
RGD		 PMID:16272156 GO_REF:0000024 NCBI chr 2:166,505,868...166,728,139
Ensembl chr 2:164,207,513...164,244,247 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of_or_within ISO
IEA		 (PMID:18166528)
GO_REF:0000107		 RGD
Ensembl		 PMID:18166528 GO_REF:0000107 NCBI chr 3:132,772,804...132,792,342
Ensembl chr 3:112,319,308...112,339,231 		JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO		 GO_REF:0000107
(PMID:23569434)		 Ensembl
RGD		 PMID:23569434 GO_REF:0000107 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
pigment biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO MGI:2447996 (PMID:12036291) RGD PMID:12036291 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
pigment metabolic process involved in pigmentation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO
IEA
IBA		 (PMID:33208952)
GO_REF:0000107
GO_REF:0000033
(PMID:31117290)		 RGD
Ensembl
GO_Central		 PMID:31117290 PMID:33208952 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988 		JBrowse link
G Tbx2 T-box transcription factor 2 acts_upstream_of_negative_effect ISO
IEA		 (PMID:26971330)
GO_REF:0000107		 RGD
Ensembl		 PMID:26971330 GO_REF:0000107 NCBI chr10:71,177,082...71,186,275
Ensembl chr10:70,679,518...70,688,529 		JBrowse link
positive regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:30765471)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:30765471 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:73,361,296...73,502,464
Ensembl chr  X:69,295,552...69,436,858 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 involved_in ISO
IEA		 (PMID:28495915)
GO_REF:0000107		 RGD
Ensembl		 PMID:28495915 GO_REF:0000107 NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:131,374,542...131,408,728 		JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (PMID:21291857) RGD PMID:21291857 NCBI chr16:2,125,234...2,173,457
Ensembl chr16:2,121,255...2,166,692 		JBrowse link
G Asip agouti signaling protein involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P07147|UniProtKB:Q60696 (PMID:21949658)		 Ensembl
RGD		 PMID:21949658 GO_REF:0000107 NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Atp7a ATPase copper transporting alpha involved_in ISS
ISO		 GO_REF:0000024
(PMID:11092760)		 UniProt
RGD		 PMID:11092760 GO_REF:0000024 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Cdh3 cadherin 3 involved_in ISO (PMID:23334344) RGD PMID:23334344 NCBI chr19:51,303,414...51,353,900
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:21291857)		 UniProt
Ensembl
RGD		 PMID:21291857 GO_REF:0000024 GO_REF:0000107 NCBI chr19:41,380,125...41,392,078
Ensembl chr19:24,453,123...24,486,997 		JBrowse link
G Opn3 opsin 3 involved_in ISO
IEA		 (PMID:28842328)
GO_REF:0000107		 RGD
Ensembl		 PMID:28842328 GO_REF:0000107 NCBI chr13:90,121,560...90,152,076
Ensembl chr13:87,589,333...87,619,847 		JBrowse link
G Pmel premelanosome protein involved_in ISO
IEA		 (PMID:21949658)
GO_REF:0000107		 RGD
Ensembl		 PMID:21949658 GO_REF:0000107 NCBI chr 7:1,721,948...1,733,248
Ensembl chr 7:1,138,586...1,148,746 		JBrowse link
G Rab38 RAB38, member RAS oncogene family IMP RGD PMID:17043139 RGD:152025192 NCBI chr 1:151,595,153...151,675,492
Ensembl chr 1:142,182,556...142,262,924 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in ISO
IEA		 (PMID:21996312)
GO_REF:0000107
UniProtKB:Q03288|UniProtKB:Q60696 (PMID:21949658)		 RGD
Ensembl		 PMID:21949658 PMID:21996312 GO_REF:0000107 NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
protoporphyrinogen IX biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase involved_in IEA
ISO		 GO_REF:0000041
(PMID:11032836)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:11032836 GO_REF:0000041 GO_REF:0000107 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 involved_in IEA GO_REF:0000041
GO_REF:0000104		 UniProt GO_REF:0000041 GO_REF:0000104 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 involved_in IEA
ISO		 GO_REF:0000041
(PMID:32499479)
GO_REF:0000104		 UniProt
RGD		 PMID:32499479 GO_REF:0000041 GO_REF:0000104 NCBI chr  X:22,890,650...22,914,046
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Cpox coproporphyrinogen oxidase involved_in IDA
ISO
IEA
IBA		 (PMID:7987309)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000041		 RGD
Ensembl
GO_Central
UniProt		 PMID:7987309 PMID:3814086 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:4145128 NCBI chr11:55,405,778...55,415,761
Ensembl chr11:41,936,591...41,946,746 		JBrowse link
G Hmbs hydroxymethylbilane synthase involved_in IEA
ISO		 GO_REF:0000041
(PMID:18004775)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:18004775 GO_REF:0000041 GO_REF:0000107 NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Ireb2 iron responsive element binding protein 2 acts_upstream_of_or_within ISO
IEA		 MGI:2181660 (PMID:15831703)
GO_REF:0000107		 RGD
Ensembl		 PMID:15831703 GO_REF:0000107 NCBI chr 8:64,124,152...64,207,702
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Ppox protoporphyrinogen oxidase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr13:86,230,111...86,235,028
Ensembl chr13:83,664,891...83,701,805 		JBrowse link
G Urod uroporphyrinogen decarboxylase involved_in IEA
ISO		 GO_REF:0000041
(PMID:11069625)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:11069625 GO_REF:0000041 GO_REF:0000107 NCBI chr 5:135,701,294...135,705,380
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
G Uros uroporphyrinogen III synthase involved_in IEA
ISO		 GO_REF:0000041
(PMID:18004775)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:18004775 GO_REF:0000041 GO_REF:0000107 NCBI chr 1:197,920,827...197,943,183
Ensembl chr 1:188,490,323...188,512,249 		JBrowse link
quercetin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lct lactase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:12594539)		 UniProt
Ensembl
RGD		 PMID:12594539 GO_REF:0000024 GO_REF:0000107 NCBI chr13:42,334,347...42,376,872
Ensembl chr13:39,781,929...39,824,456 		JBrowse link
regulation of heme biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srrd SRR1 domain containing involved_in ISO (PMID:28802827) RGD PMID:28802827 NCBI chr12:44,294,675...44,300,287
Ensembl chr12:44,294,271...44,300,287 		JBrowse link
G Tmem14a transmembrane protein 14A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:31,137,011...31,148,794
Ensembl chr 9:23,733,039...23,734,463
Ensembl chr 9:23,733,039...23,734,463 		JBrowse link
G Tmem14c transmembrane protein 14C involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:4351741 (PMID:25157825)		 GO_Central
RGD		 PMID:25157825 GO_REF:0000033 NCBI chr17:23,733,769...23,739,906
Ensembl chr17:23,733,894...23,753,320 		JBrowse link
G Tmem14cl1 transmembrane protein 14C like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:100,656,576...100,657,086
Ensembl chr13:100,656,593...100,657,445 		JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO (PMID:22649030) RGD PMID:22649030 NCBI chr10:58,300,069...58,315,725
Ensembl chr10:57,801,456...57,817,120 		JBrowse link
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO
IEA
IBA		 (PMID:33208952)
GO_REF:0000107
GO_REF:0000033
(PMID:31117290)		 RGD
Ensembl
GO_Central		 PMID:31117290 PMID:33208952 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (PMID:16037214) RGD PMID:16037214 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
rhodopsin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk3 G protein-coupled receptor kinase 3 IMP RGD PMID:17573483 RGD:5685371 NCBI chr12:49,285,228...49,395,803
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
zeaxanthin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpe65 retinoid isomerohydrolase RPE65 involved_in ISO
ISS
IBA
IEA		 (PMID:28874556)
GO_REF:0000024
GO_REF:0000033
GO_REF:0000107		 RGD
UniProt
GO_Central
Ensembl		 PMID:28874556 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:251,425,228...251,457,209
Ensembl chr 2:248,766,612...248,798,403 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        pigment metabolic process 69
          anthocyanin-containing compound metabolic process + 0
          aurone metabolic process + 0
          flavone metabolic process + 4
          heme metabolic process + 35
          melanin metabolic process + 26
          phlobaphene metabolic process + 0
          pigment biosynthetic process + 52
          pigment catabolic process + 5
          pigment metabolic process involved in pigmentation + 3
paths to the root