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ONTOLOGY REPORT - ANNOTATIONS

Term:melanin biosynthetic process
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Accession:GO:0042438 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
Synonyms:exact_synonym: melanin anabolism;   melanin biosynthesis;   melanin formation;   melanin synthesis
 xref: Reactome:R-HSA-5662702 "Melanin biosynthesis"


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melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asip agouti signaling protein involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 GO_REF:0000107
(PMID:8449404)
MGI:1855937 (PMID:7665913)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:7665913 PMID:8449404 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:11434569)		 UniProt
RGD		 PMID:11434569 GO_REF:0000024 NCBI chr  X:71,390,328...71,395,023
Ensembl chr  X:67,350,373...67,355,162 		JBrowse link
G Dct dopachrome tautomerase acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1856379 (PMID:7665913)
GO_REF:0000043
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:7665913 GO_REF:0000043 GO_REF:0000107 NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Ddt D-dopachrome tautomerase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:12,883,025...12,886,121
Ensembl chr20:12,884,243...12,888,482 		JBrowse link
G Mc1r melanocortin 1 receptor acts_upstream_of_or_within ISO
IEA		 MGI:1856028 (PMID:7665913)
GO_REF:0000107		 RGD
Ensembl		 PMID:7665913 GO_REF:0000107 NCBI chr19:68,360,950...68,363,877
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Myo5a myosin VA acts_upstream_of_or_within ISO MGI:1856004 (PMID:7665913) RGD PMID:7665913 NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 MGI:1856114 (PMID:7665913), (PMID:9548375)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:7665913 PMID:9548375 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:116,252,026...116,581,838
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Pmel premelanosome protein acts_upstream_of_or_within ISO
IEA		 MGI:1857040 (PMID:7665913)
GO_REF:0000107		 RGD
Ensembl		 PMID:7665913 GO_REF:0000107 NCBI chr 7:1,721,948...1,733,248
Ensembl chr 7:1,138,586...1,148,746 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of ISO
IEA		 (PMID:18166528)
GO_REF:0000107		 RGD
Ensembl		 PMID:18166528 GO_REF:0000107 NCBI chr 3:132,772,804...132,792,342
Ensembl chr 3:112,319,308...112,339,231 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:8126111)		 Ensembl
RGD		 PMID:8126111 GO_REF:0000107 NCBI chr 8:105,142,931...105,193,842
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Tyr tyrosinase involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (PMID:8126111)
GO_REF:0000043
GO_REF:0000107
MGI:1855976|MGI:1855978 (PMID:7665913), (PMID:9548375)
GO_REF:0000033		 RGD
UniProt
Ensembl
GO_Central		 PMID:7665913 PMID:8126111 PMID:9548375 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dct dopachrome tautomerase involved_in ISO
IEA
IBA		 (PMID:2169885), (PMID:33100333)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:2169885 PMID:33100333 GO_REF:0000033 GO_REF:0000107 NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein involved_in ISO
IEA		 (PMID:25513726), (PMID:32966160)
GO_REF:0000107		 RGD
Ensembl		 PMID:25513726 PMID:32966160 GO_REF:0000107 NCBI chr 1:116,252,026...116,581,838
Ensembl chr 1:107,116,278...107,446,074 		JBrowse link
G Slc45a2 solute carrier family 45, member 2 involved_in ISO
IEA		 (PMID:32966160)
GO_REF:0000107
(PMID:35469906)		 RGD
Ensembl		 PMID:32966160 PMID:35469906 GO_REF:0000107 NCBI chr 2:61,690,828...61,723,437
Ensembl chr 2:59,963,706...59,996,317 		JBrowse link
negative regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO
IEA		 (PMID:29025994)
GO_REF:0000107		 RGD
Ensembl		 PMID:29025994 GO_REF:0000107 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988 		JBrowse link
G Opn3 opsin 3 involved_in ISO
IEA		 (PMID:31097585)
GO_REF:0000107		 RGD
Ensembl		 PMID:31097585 GO_REF:0000107 NCBI chr13:90,121,560...90,152,076
Ensembl chr13:87,589,333...87,619,847 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16272156)		 UniProt
RGD		 PMID:16272156 GO_REF:0000024 NCBI chr 2:166,505,868...166,728,139
Ensembl chr 2:164,207,513...164,244,247 		JBrowse link
G Slc24a5 solute carrier family 24 member 5 acts_upstream_of_or_within ISO
IEA		 (PMID:18166528)
GO_REF:0000107		 RGD
Ensembl		 PMID:18166528 GO_REF:0000107 NCBI chr 3:132,772,804...132,792,342
Ensembl chr 3:112,319,308...112,339,231 		JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO		 GO_REF:0000107
(PMID:23569434)		 Ensembl
RGD		 PMID:23569434 GO_REF:0000107 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
positive regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (PMID:21291857) RGD PMID:21291857 NCBI chr16:2,125,234...2,173,457
Ensembl chr16:2,121,255...2,166,692 		JBrowse link
G Asip agouti signaling protein involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P07147|UniProtKB:Q60696 (PMID:21949658)		 Ensembl
RGD		 PMID:21949658 GO_REF:0000107 NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Atp7a ATPase copper transporting alpha involved_in ISS
ISO		 GO_REF:0000024
(PMID:11092760)		 UniProt
RGD		 PMID:11092760 GO_REF:0000024 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Cdh3 cadherin 3 involved_in ISO (PMID:23334344) RGD PMID:23334344 NCBI chr19:51,303,414...51,353,900
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:21291857)		 UniProt
Ensembl
RGD		 PMID:21291857 GO_REF:0000024 GO_REF:0000107 NCBI chr19:41,380,125...41,392,078
Ensembl chr19:24,453,123...24,486,997 		JBrowse link
G Opn3 opsin 3 involved_in ISO
IEA		 (PMID:28842328)
GO_REF:0000107		 RGD
Ensembl		 PMID:28842328 GO_REF:0000107 NCBI chr13:90,121,560...90,152,076
Ensembl chr13:87,589,333...87,619,847 		JBrowse link
G Pmel premelanosome protein involved_in ISO
IEA		 (PMID:21949658)
GO_REF:0000107		 RGD
Ensembl		 PMID:21949658 GO_REF:0000107 NCBI chr 7:1,721,948...1,733,248
Ensembl chr 7:1,138,586...1,148,746 		JBrowse link
G Rab38 RAB38, member RAS oncogene family IMP RGD PMID:17043139 RGD:152025192 NCBI chr 1:151,595,153...151,675,492
Ensembl chr 1:142,182,556...142,262,924 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 involved_in ISO
IEA		 (PMID:21996312)
GO_REF:0000107
UniProtKB:Q03288|UniProtKB:Q60696 (PMID:21949658)		 RGD
Ensembl		 PMID:21949658 PMID:21996312 GO_REF:0000107 NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516 		JBrowse link
regulation of melanin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctns cystinosin, lysosomal cystine transporter involved_in ISO (PMID:22649030) RGD PMID:22649030 NCBI chr10:58,300,069...58,315,725
Ensembl chr10:57,801,456...57,817,120 		JBrowse link
G Mfsd12 major facilitator superfamily domain containing 12 involved_in ISO
IEA
IBA		 (PMID:33208952)
GO_REF:0000107
GO_REF:0000033
(PMID:31117290)		 RGD
Ensembl
GO_Central		 PMID:31117290 PMID:33208952 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:8,345,171...8,354,050
Ensembl chr 7:8,347,314...8,353,988 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:1857061 (PMID:16037214) RGD PMID:16037214 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        phenol-containing compound metabolic process 135
          melanin metabolic process 26
            melanin biosynthetic process 24
              1,8-dihydroxynaphthalene-melanin biosynthetic process 0
              melanin biosynthetic process from tyrosine 3
              negative regulation of melanin biosynthetic process 5
              positive regulation of melanin biosynthetic process 9
              regulation of melanin biosynthetic process + 15
paths to the root