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ONTOLOGY REPORT - ANNOTATIONS


Term:indole-containing compound metabolic process
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Accession:GO:0042430 term browser browse the term
Definition:The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton.
Synonyms:exact_synonym: indole and derivative metabolic process;   indole and derivative metabolism;   indole-containing compound metabolism;   ketole metabolic process;   ketole metabolism
 narrow_synonym: indole derivative metabolic process;   indole derivative metabolism
 alt_id: GO:0042434



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indole metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc34a1 solute carrier family 34 member 1 IEP bisindolylmaleimide I RGD PMID:10332085 RGD:7243183 NCBI chr17:9,224,010...9,238,983 JBrowse link
L-tryptophan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase IDA RGD PMID:11802786 RGD:70243 NCBI chr13:39,200,412...39,245,954 JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 6:10,845,235...10,864,863 JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:17356132), (PMID:25767141) RGD PMID:17356132 PMID:25767141 NCBI chr 1:95,299,457...95,324,564 JBrowse link
G Kmo kynurenine 3-monooxygenase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr13:87,557,080...87,589,334 JBrowse link
G Kynu kynureninase involved_in ISO
IEA
(PMID:17334708)
GO_REF:0000104
RGD
UniProt
PMID:17334708 GO_REF:0000104 NCBI chr 3:27,778,646...27,929,470 JBrowse link
L-tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase IDA RGD PMID:7236232 RGD:2303721 NCBI chr 3:27,778,646...27,929,470 JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase involved_in IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:7236232 GO_REF:0000033, RGD:2303721 NCBI chr 2:169,567,656...169,585,586 JBrowse link
L-tryptophan catabolic process to indole-3-acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:32818467), (PMID:32866000) RGD PMID:32818467 PMID:32866000 NCBI chr 1:95,299,457...95,324,564 JBrowse link
L-tryptophan catabolic process to kynurenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afmid arylformamidase involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000041
(PMID:15866519)
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:15866519 GO_REF:0000033 GO_REF:0000041 NCBI chr10:103,046,129...103,061,718 JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 involved_in
acts_upstream_of_or_within
IDA
IEA
ISO
IBA
GO_REF:0000104
(PMID:11751753), (PMID:2419335)
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:2419335 PMID:11751753 PMID:10719243 PMID:11513477 GO_REF:0000033 GO_REF:0000104, RGD:2290190, RGD:2290543 NCBI chr16:74,133,259...74,145,328 JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 involved_in
acts_upstream_of_or_within
ISO
IEA
IBA
(PMID:17671174)
GO_REF:0000104
(PMID:17499941), (PMID:17671174)
GO_REF:0000033
GO_REF:0000041
RGD
UniProt
GO_Central
PMID:17499941 PMID:17671174 GO_REF:0000033 GO_REF:0000041 GO_REF:0000104 NCBI chr16:67,459,158...67,498,052 JBrowse link
G Kynu kynureninase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:27,778,646...27,929,470 JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:27762317)
GO_REF:0000041
UniProt
RGD
PMID:27762317 GO_REF:0000024 GO_REF:0000041 NCBI chr 2:169,567,656...169,585,586 JBrowse link
L-tryptophan metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856102 (PMID:4147174) RGD PMID:4147174 NCBI chr  X:75,159,635...75,267,094 JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase IDA RGD PMID:10719243 PMID:3899109 PMID:3400092 RGD:2290190, RGD:2291804, RGD:2290313 NCBI chr 2:169,567,656...169,585,586 JBrowse link
melatonin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aanat aralkylamine N-acetyltransferase involved_in TAS
ISS
ISO
IEA
IBA
GO_REF:0000024
(PMID:11313340)
GO_REF:0000041
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:11313340 PMID:9054387 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041, RGD:67926 NCBI chr10:101,827,072...101,831,805 JBrowse link
G Asmt acetylserotonin O-methyltransferase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
IEA
(PMID:20308563), (PMID:3941912)
GO_REF:0000033
(PMID:22775292)
GO_REF:0000041
RGD
GO_Central
UniProt
PMID:3941912 PMID:20308563 PMID:22775292 PMID:8930356 PMID:12198599 GO_REF:0000033 GO_REF:0000041, RGD:1299464, RGD:1359073 NCBI chr12:16,304,719...16,309,568 JBrowse link
melatonin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEP RGD PMID:17700567 RGD:4890365 NCBI chr 8:63,449,148...63,476,534 JBrowse link
regulation of serotonin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member involved_in ISS
ISO
GO_REF:0000024
(PMID:26711020)
UniProt
RGD
PMID:26711020 GO_REF:0000024 NCBI chr12:40,610,244...40,643,220 JBrowse link
serotonin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddc dopa decarboxylase involved_in IDA
IBA
GO_REF:0000033 GO_Central
RGD
PMID:10027744 GO_REF:0000033, RGD:5129182 NCBI chr14:86,378,685...86,469,189 JBrowse link
G Tph1 tryptophan hydroxylase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:14697203)
UniProt
RGD
PMID:14697203 GO_REF:0000024 NCBI chr 1:97,157,375...97,178,415 JBrowse link
G Tph2 tryptophan hydroxylase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 7:50,685,694...50,789,424 JBrowse link
serotonin biosynthetic process from tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:23098818 RGD:11353778 NCBI chr 7:115,762,662...115,771,832 JBrowse link
G Tph1 tryptophan hydroxylase 1 TAS RGD PMID:12153488 RGD:625621 NCBI chr 1:97,157,375...97,178,415 JBrowse link
serotonin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857092 (PMID:2765934) RGD PMID:2765934 NCBI chr 4:148,450,207...148,763,653 JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856098 (PMID:8174230) RGD PMID:8174230 NCBI chr  X:75,159,635...75,267,094 JBrowse link
G Btbd9 BTB domain containing 9 acts_upstream_of_or_within ISO MGI:4127237 (PMID:22678064) RGD PMID:22678064 NCBI chr20:8,286,337...8,645,567 JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1928285 (PMID:11160454)
Ensembl
RGD
PMID:11160454 GO_REF:0000107 NCBI chr10:6,136,458...6,560,003 JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A involved_in ISS
ISO
GO_REF:0000024
(PMID:11080193)
UniProt
RGD
PMID:11080193 GO_REF:0000024 NCBI chr 2:36,693,462...36,698,026 JBrowse link
G Maoa monoamine oxidase A IDA
IMP
Y402A, Y407A, Y410A had an impact on the properties of the protein while Y402F, Y410F had little effect; the residues are near the C406 FAD binding site RGD PMID:11754741 PMID:11263670 PMID:11754741 RGD:1600709, RGD:1600713, RGD:1600709 NCBI chr  X:8,615,239...8,681,372 JBrowse link
G Pde1b phosphodiesterase 1B acts_upstream_of_or_within ISO MGI:3604470 (PMID:17559891) RGD PMID:17559891 NCBI chr 7:134,627,378...134,654,581 JBrowse link
G Rnf180 ring finger protein 180 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:23926250)
GO_Central
RGD
PMID:23926250 GO_REF:0000033 NCBI chr 2:36,330,285...36,511,168 JBrowse link
G Spr sepiapterin reductase acts_upstream_of_or_within ISO MGI:3757641 (PMID:16532389) RGD PMID:16532389 NCBI chr 4:117,671,948...117,676,292 JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 IEP RGD PMID:15936112 RGD:4891926 NCBI chr 1:35,514,914...35,548,898 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      metabolic process 12157
        indole-containing compound metabolic process 28
          indolalkylamine metabolic process + 12
          indole glucosinolate metabolic process + 0
          indole metabolic process + 1
          indole phytoalexin metabolic process + 0
          indole-containing compound biosynthetic process + 7
          indole-containing compound catabolic process + 9
          indoleacetic acid metabolic process + 1
          indolebutyric acid metabolic process 0
          melatonin metabolic process + 3
          serotonin metabolic process + 15
paths to the root