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ONTOLOGY REPORT - ANNOTATIONS

Term:catecholamine biosynthetic process
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Accession:GO:0042423 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
Synonyms:exact_synonym: catecholamine anabolism;   catecholamine biosynthesis;   catecholamine formation;   catecholamine synthesis
 xref: Reactome:R-HSA-209905 "Catecholamine biosynthesis";   Wikipedia:Catecholamines


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catecholamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:17194738 RGD:5131263 NCBI chr 4:85,553,163...85,596,203
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Dbh dopamine beta-hydroxylase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Ddc dopa decarboxylase involved_in TAS
IEA		 GO_REF:0000043 UniProt
RGD		 PMID:12047348 GO_REF:0000043, RGD:727571 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Hdc histidine decarboxylase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:83,881,211...83,882,849
Ensembl chr10:83,384,923...83,386,556 		JBrowse link
G Th tyrosine hydroxylase involved_in IDA
IEA		 GO_REF:0000002
GO_REF:0000043		 InterPro
UniProt
RGD		 PMID:20025246 GO_REF:0000002 GO_REF:0000043, RGD:4139888 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:20097214 RGD:6903884 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:20097214 RGD:6903884 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEP RGD PMID:12438507 RGD:704388 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:19818757 RGD:5143981 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Dao D-amino-acid oxidase involved_in ISO
IEA
ISS		 (PMID:17303072)
GO_REF:0000107
(PMID:17042912)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17042912 PMID:17303072 GO_REF:0000024 GO_REF:0000107 NCBI chr12:48,252,900...48,275,964
Ensembl chr12:42,592,343...42,612,741 		JBrowse link
G Ddc dopa decarboxylase involved_in IDA
ISO
IEA		 (PMID:19703902)
GO_REF:0000107
GO_REF:0000041		 RGD
Ensembl
UniProt		 PMID:19703902 PMID:12703659 GO_REF:0000041 GO_REF:0000107, RGD:4139893 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO (PMID:16338639) RGD PMID:16338639 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gpr37 G protein-coupled receptor 37 acts_upstream_of_or_within ISO
IEA		 MGI:3027995 (PMID:15218106)
GO_REF:0000107		 RGD
Ensembl		 PMID:15218106 GO_REF:0000107 NCBI chr 4:55,104,355...55,126,420
Ensembl chr 4:54,138,870...54,161,001 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 acts_upstream_of_or_within ISO MGI:2429971 (PMID:16782508), (PMID:9608532) RGD PMID:9608532 PMID:16782508 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 acts_upstream_of_or_within ISO
IEA		 MGI:2386303 (PMID:9520487)
GO_REF:0000107		 RGD
Ensembl		 PMID:9520487 GO_REF:0000107 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO
IEA		 MGI:1888382 (PMID:10707987)
GO_REF:0000107		 RGD
Ensembl		 PMID:10707987 GO_REF:0000107 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:16257223)		 UniProt
Ensembl
RGD		 PMID:16257223 GO_REF:0000024 GO_REF:0000107 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Th tyrosine hydroxylase involved_in IEA
ISO		 GO_REF:0000041
(PMID:12457228), (PMID:19703902)		 UniProt
RGD		 PMID:12457228 PMID:19703902 GO_REF:0000041 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Th tyrosine hydroxylase acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA
IMP		 MGI:1860450 (PMID:7592982), (PMID:7715703), (PMID:9520487)
GO_REF:0000033
PMID:11943812		 RGD
GO_Central		 PMID:7592982 PMID:7715703 PMID:9520487 PMID:2427363 PMID:11943812 More... GO_REF:0000033, RGD:1580046, RGD:5129111, RGD:5130972 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
epinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnmt phenylethanolamine-N-methyltransferase involved_in TAS
IEA
IDA
IC		 GO_REF:0000041 UniProt
RGD		 PMID:11514309 PMID:7914070 PMID:7503429 GO_REF:0000041, RGD:628457, RGD:4139902, RGD:4139901 NCBI chr10:83,881,211...83,882,849
Ensembl chr10:83,384,923...83,386,556 		JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nt5dc2 5'-nucleotidase domain containing 2 involved_in IMP PMID:31279527 UniProt PMID:31279527 RGD:408345212 NCBI chr16:6,328,925...6,336,978
Ensembl chr16:6,322,236...6,330,537 		JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856097|MGI:1856098 (PMID:4405722), (PMID:4858102) RGD PMID:4405722 PMID:4858102 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Dbh dopamine beta-hydroxylase acts_upstream_of_or_within
involved_in		 TAS
IEA
IMP
ISS
ISO
IBA		 GO_REF:0000107
GO_REF:0000041
GO_REF:0000024
(PMID:27148966)
GO_REF:0000033
MGI:1857556 (PMID:10051631), (PMID:9603211)
(PMID:27148966), (PMID:7715704)		 Ensembl
UniProt
RGD
GO_Central		 PMID:7715704 PMID:9603211 PMID:10051631 PMID:27148966 PMID:11914591 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:727567, RGD:1625403 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO
IEA		 MGI:2153826 (PMID:10835639)
GO_REF:0000107		 RGD
Ensembl		 PMID:10835639 GO_REF:0000107 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 acts_upstream_of_positive_effect ISO
IEA		 (PMID:19008477)
GO_REF:0000107		 RGD
Ensembl		 PMID:19008477 GO_REF:0000107 NCBI chr16:37,928,145...37,931,488
Ensembl chr16:32,917,823...32,919,891 		JBrowse link
G Insm1 INSM transcriptional repressor 1 involved_in ISO (PMID:18094025) RGD PMID:18094025 NCBI chr 3:154,093,310...154,096,243
Ensembl chr 3:133,639,580...133,643,003 		JBrowse link
G Kl Klotho IMP RGD PMID:20086041 RGD:10403068 NCBI chr12:5,326,003...5,367,016
Ensembl chr12:490,399...530,080 		JBrowse link
G Moxd1 monooxygenase, DBH-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:22,894,543...22,984,599
Ensembl chr 1:21,075,122...21,161,779 		JBrowse link
G Moxd2 monooxygenase, DBH-like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:70,691,373...70,699,868
Ensembl chr 4:69,724,239...69,733,299 		JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISS
ISO		 GO_REF:0000024
(PMID:19703902)		 ParkinsonsUK-UCL
RGD		 PMID:19703902 GO_REF:0000024 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO
IEA		 (PMID:26203154)
GO_REF:0000107		 RGD
Ensembl		 PMID:26203154 GO_REF:0000107 NCBI chr19:37,938,989...37,974,887
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:26711020)		 UniProt
Ensembl
RGD		 PMID:26711020 GO_REF:0000024 GO_REF:0000107 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        amine metabolic process 124
          biogenic amine metabolic process 112
            catecholamine metabolic process 67
              catecholamine biosynthetic process 29
                dopamine biosynthetic process + 18
                epinephrine biosynthetic process 2
                norepinephrine biosynthetic process 10
paths to the root