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ONTOLOGY REPORT - ANNOTATIONS

Term:dopamine biosynthetic process
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Accession:GO:0042416 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
Synonyms:exact_synonym: dopamine anabolism;   dopamine biosynthesis;   dopamine formation;   dopamine synthesis


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dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:20097214 RGD:6903884 NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:20097214 RGD:6903884 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit ISO RGD PMID:12438507 RGD:704388 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO RGD PMID:19818757 RGD:5143981 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,642 		JBrowse link
G DAO D-amino acid oxidase involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633 		JBrowse link
G DDC dopa decarboxylase involved_in ISO
IEA 		RGD
Ensembl
UniProt		 PMID:12703659 GO_REF:0000041 GO_REF:0000107 RGD:4139893 NCBI chr 9:136,496,364...136,571,220
Ensembl chr 9:136,496,365...136,571,212 		JBrowse link
G GCH1 GTP cyclohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:184,201,232...184,264,060
Ensembl chr 1:184,199,679...184,257,315 		JBrowse link
G GPR37 G protein-coupled receptor 37 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr18:23,019,752...23,036,483
Ensembl chr18:23,019,749...23,038,356 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:63,487,051...63,506,249
Ensembl chr15:63,487,731...63,495,299 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:79,186,114...79,220,302
Ensembl chr16:79,186,108...79,220,297 		JBrowse link
G SNCA synuclein alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:129,247,724...129,388,307
Ensembl chr 8:129,248,819...129,271,128 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341 		JBrowse link
G TH tyrosine hydroxylase involved_in IEA Ensembl
UniProt		 GO_REF:0000041 GO_REF:0000107 NCBI chr 2:1,499,628...1,506,180
Ensembl chr 2:1,499,620...1,506,170 		JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TH tyrosine hydroxylase acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		RGD
Ensembl
GO_Central		 PMID:2427363 PMID:19584816 GO_REF:0000033 GO_REF:0000107 RGD:1580046 RGD:5130972 NCBI chr 2:1,499,628...1,506,180
Ensembl chr 2:1,499,620...1,506,170 		JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NT5DC2 5'-nucleotidase domain containing 2 involved_in ISO PMID:31279527 UniProt PMID:31279527 RGD:408345212 NCBI chr13:34,659,249...34,679,530
Ensembl chr13:34,659,249...34,679,535 		JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chr 3:94,167,759...94,253,662
Ensembl chr 3:94,165,816...94,254,079 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,516 		JBrowse link
G VPS35 VPS35 retromer complex component involved_in ISO (PMID:26203154) ParkinsonsUK-UCL PMID:26203154 NCBI chr 6:37,944,099...37,977,091
Ensembl chr 6:37,944,127...37,986,171 		JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member involved_in ISS UniProt GO_REF:0000024 NCBI chr14:39,902,317...39,933,113
Ensembl chr14:39,896,565...39,933,124 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18945
    cellular process 18488
      metabolic process 11687
        amine metabolic process 120
          biogenic amine metabolic process 108
            catecholamine metabolic process 64
              dopamine metabolic process 49
                dopamine biosynthetic process 18
                  dopamine biosynthetic process from tyrosine 1
                  negative regulation of dopamine biosynthetic process 1
                  positive regulation of dopamine biosynthetic process 3
                  regulation of dopamine biosynthetic process + 5
paths to the root