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ONTOLOGY REPORT - ANNOTATIONS

Term:dopamine biosynthetic process
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Accession:GO:0042416 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
Synonyms:exact_synonym: dopamine anabolism;   dopamine biosynthesis;   dopamine formation;   dopamine synthesis


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dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:20097214 RGD:6903884 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:20097214 RGD:6903884 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit ISO RGD PMID:12438507 RGD:704388 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) ISO RGD PMID:19818757 RGD:5143981 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G DAO D-amino acid oxidase involved_in IDA
IEA 		(PMID:17303072) UniProt
Ensembl		 PMID:17303072 GO_REF:0000107 NCBI chr12:108,880,092...108,901,043
Ensembl chr12:108,858,932...108,901,043 		JBrowse link
G DDC dopa decarboxylase involved_in ISO
IDA
IEA 		(PMID:19703902) RGD
ParkinsonsUK-UCL
UniProt		 PMID:12703659 PMID:19703902 GO_REF:0000041 RGD:4139893 NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405 		JBrowse link
G GCH1 GTP cyclohydrolase 1 involved_in IDA (PMID:16338639) UniProt PMID:16338639 NCBI chr14:54,842,017...54,902,826
Ensembl chr14:54,842,008...54,902,826 		JBrowse link
G GPR37 G protein-coupled receptor 37 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:124,743,885...124,765,792
Ensembl chr 7:124,743,885...124,765,792 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440 		JBrowse link
G SNCA synuclein alpha involved_in
acts_upstream_of_or_within 		TAS
IEA 		(PMID:21320589) UniProt
Ensembl		 PMID:21320589 GO_REF:0000107 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TH tyrosine hydroxylase involved_in IEA
IDA 		(PMID:12457228), (PMID:19703902) UniProt
ParkinsonsUK-UCL		 PMID:12457228 PMID:19703902 GO_REF:0000041 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TH tyrosine hydroxylase acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA
NAS 		(PMID:10907721) RGD
Ensembl
GO_Central
BHF-UCL		 PMID:2427363 PMID:10907721 PMID:19584816 GO_REF:0000033 GO_REF:0000107 RGD:1580046 RGD:5130972 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NT5DC2 5'-nucleotidase domain containing 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 3:52,524,387...52,535,027
Ensembl chr 3:52,524,385...52,535,054 		JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in
acts_upstream_of 		IDA
IC 		(PMID:19703902)
(PMID:16731528) 		ParkinsonsUK-UCL PMID:16731528 PMID:19703902 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505 		JBrowse link
G VPS35 VPS35 retromer complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:46,656,132...46,689,178
Ensembl chr16:46,656,132...46,689,518 		JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27207
    cellular process 19782
      metabolic process 13524
        amine metabolic process 139
          biogenic amine metabolic process 124
            catecholamine metabolic process 76
              dopamine metabolic process 57
                dopamine biosynthetic process 18
                  dopamine biosynthetic process from tyrosine 1
                  negative regulation of dopamine biosynthetic process 1
                  positive regulation of dopamine biosynthetic process 3
                  regulation of dopamine biosynthetic process + 5
paths to the root