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ONTOLOGY REPORT - ANNOTATIONS

Term:dopamine biosynthetic process
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Accession:GO:0042416 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
Synonyms:exact_synonym: dopamine anabolism;   dopamine biosynthesis;   dopamine formation;   dopamine synthesis


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dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:20097214 RGD:6903884 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:20097214 RGD:6903884 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEP RGD PMID:12438507 RGD:704388 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:19818757 RGD:5143981 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Dao D-amino-acid oxidase involved_in ISO
IEA
ISS		 (PMID:17303072)
GO_REF:0000107
(PMID:17042912)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17042912 PMID:17303072 GO_REF:0000024 GO_REF:0000107 NCBI chr12:48,252,900...48,275,964
Ensembl chr12:42,592,343...42,612,741 		JBrowse link
G Ddc dopa decarboxylase involved_in IDA
IEA
ISO		 GO_REF:0000041
GO_REF:0000107
(PMID:19703902)		 UniProt
Ensembl
RGD		 PMID:19703902 PMID:12703659 GO_REF:0000041 GO_REF:0000107, RGD:4139893 NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO (PMID:16338639) RGD PMID:16338639 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gpr37 G protein-coupled receptor 37 acts_upstream_of_or_within ISO
IEA		 MGI:3027995 (PMID:15218106)
GO_REF:0000107		 RGD
Ensembl		 PMID:15218106 GO_REF:0000107 NCBI chr 4:55,104,355...55,126,420
Ensembl chr 4:54,138,870...54,161,001 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 acts_upstream_of_or_within ISO MGI:2429971 (PMID:16782508), (PMID:9608532) RGD PMID:9608532 PMID:16782508 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 acts_upstream_of_or_within ISO
IEA		 MGI:2386303 (PMID:9520487)
GO_REF:0000107		 RGD
Ensembl		 PMID:9520487 GO_REF:0000107 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO
IEA		 MGI:1888382 (PMID:10707987)
GO_REF:0000107		 RGD
Ensembl		 PMID:10707987 GO_REF:0000107 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:16257223)		 UniProt
Ensembl
RGD		 PMID:16257223 GO_REF:0000024 GO_REF:0000107 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Th tyrosine hydroxylase involved_in IEA
ISO		 GO_REF:0000041
(PMID:12457228), (PMID:19703902)		 UniProt
RGD		 PMID:12457228 PMID:19703902 GO_REF:0000041 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Th tyrosine hydroxylase acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA
IMP		 MGI:1860450 (PMID:7592982), (PMID:7715703), (PMID:9520487)
GO_REF:0000033
PMID:11943812		 RGD
GO_Central		 PMID:7592982 PMID:7715703 PMID:9520487 PMID:2427363 PMID:11943812 More... GO_REF:0000033, RGD:1580046, RGD:5129111, RGD:5130972 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nt5dc2 5'-nucleotidase domain containing 2 involved_in IMP PMID:31279527 UniProt PMID:31279527 RGD:408345212 NCBI chr16:6,328,925...6,336,978
Ensembl chr16:6,322,236...6,330,537 		JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISS
ISO		 GO_REF:0000024
(PMID:19703902)		 ParkinsonsUK-UCL
RGD		 PMID:19703902 GO_REF:0000024 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO
IEA		 (PMID:26203154)
GO_REF:0000107		 RGD
Ensembl		 PMID:26203154 GO_REF:0000107 NCBI chr19:37,938,989...37,974,887
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:26711020)		 UniProt
Ensembl
RGD		 PMID:26711020 GO_REF:0000024 GO_REF:0000107 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    cellular process 19557
      metabolic process 12206
        amine metabolic process 127
          biogenic amine metabolic process 115
            catecholamine metabolic process 68
              dopamine metabolic process 52
                dopamine biosynthetic process 18
                  dopamine biosynthetic process from tyrosine 1
                  negative regulation of dopamine biosynthetic process 1
                  positive regulation of dopamine biosynthetic process 3
                  regulation of dopamine biosynthetic process + 5
paths to the root