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ONTOLOGY REPORT - ANNOTATIONS


Term:biogenic amine biosynthetic process
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Accession:GO:0042401 term browser browse the term
Definition:The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
Synonyms:exact_synonym: biogenic amine anabolism;   biogenic amine biosynthesis;   biogenic amine formation;   biogenic amine synthesis;   cellular biogenic amine biosynthetic process


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catecholamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:17194738 RGD:5131263 NCBI chrNW_004624739:114,383...161,010
Ensembl chrNW_004624739:114,342...161,044
JBrowse link
G Dbh dopamine beta-hydroxylase involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:2,016,066...2,030,240
Ensembl chrNW_004624760:2,015,474...2,029,939
JBrowse link
G Ddc dopa decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624740:3,674,727...3,732,058
Ensembl chrNW_004624740:3,674,609...3,732,676
JBrowse link
G Hdc histidine decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624731:9,835,585...9,856,743
Ensembl chrNW_004624731:9,835,596...9,856,743
JBrowse link
G Pnmt phenylethanolamine N-methyltransferase involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624795:3,408,559...3,410,669
Ensembl chrNW_004624795:3,408,627...3,410,304
JBrowse link
G Th tyrosine hydroxylase involved_in ISO
IEA
RGD
UniProt
InterPro
PMID:20025246 GO_REF:0000002 GO_REF:0000043 RGD:4139888 NCBI chrNW_004624767:15,003,073...15,010,207
Ensembl chrNW_004624767:15,003,092...15,010,154
JBrowse link
dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:20097214 RGD:6903884 NCBI chrNW_004624730:25,964,848...26,006,468
Ensembl chrNW_004624730:25,964,811...26,006,463
JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:20097214 RGD:6903884 NCBI chrNW_004624967:327,627...332,000
Ensembl chrNW_004624967:329,284...330,372
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO RGD PMID:12438507 RGD:704388 NCBI chrNW_004624768:908,907...1,024,953
Ensembl chrNW_004624768:909,099...1,024,902
JBrowse link
G Dao D-amino acid oxidase involved_in ISO (PMID:17303072)
(PMID:17042912)
UniProt PMID:17042912 PMID:17303072 NCBI chrNW_004624747:12,094,658...12,117,000
Ensembl chrNW_004624747:12,105,133...12,116,604
JBrowse link
G Ddc dopa decarboxylase involved_in ISO
IEA
RGD
Ensembl
PMID:12703659 GO_REF:0000107 RGD:4139893 NCBI chrNW_004624740:3,674,727...3,732,058
Ensembl chrNW_004624740:3,674,609...3,732,676
JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO (PMID:16338639) UniProt PMID:16338639 NCBI chrNW_004624731:14,459,164...14,502,485
Ensembl chrNW_004624731:14,459,303...14,500,429
JBrowse link
G Gpr37 G protein-coupled receptor 37 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624783:11,291,601...11,319,467
Ensembl chrNW_004624783:11,291,497...11,320,952
JBrowse link
G Nr4a2 nuclear receptor subfamily 4 group A member 2 acts_upstream_of_or_within ISO (PMID:16782508), (PMID:9608532) MGI PMID:9608532 PMID:16782508 NCBI chrNW_004624732:9,572,160...9,589,624
Ensembl chrNW_004624732:9,581,779...9,589,942
JBrowse link
G Slc6a3 solute carrier family 6 member 3 acts_upstream_of_or_within ISO (PMID:9520487) MGI PMID:9520487 NCBI chrNW_004624751:694,165...720,287
Ensembl chrNW_004624751:694,099...719,465
JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO (PMID:10707987) MGI PMID:10707987 NCBI chrNW_004624757:17,393,046...17,528,783
Ensembl chrNW_004624757:17,392,998...17,528,320
JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624835:2,363,059...2,436,536
Ensembl chrNW_004624835:2,363,139...2,437,643
JBrowse link
G Th tyrosine hydroxylase involved_in IEA UniProt GO_REF:0000041 NCBI chrNW_004624767:15,003,073...15,010,207
Ensembl chrNW_004624767:15,003,092...15,010,154
JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Th tyrosine hydroxylase involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:7592982), (PMID:7715703)
(PMID:9520487)
RGD
TreeGrafter
MGI
PMID:2427363 PMID:7592982 PMID:7715703 PMID:9520487 PMID:19584816 GO_REF:0000118 RGD:1580046 RGD:5130972 NCBI chrNW_004624767:15,003,073...15,010,207
Ensembl chrNW_004624767:15,003,092...15,010,154
JBrowse link
epinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnmt phenylethanolamine N-methyltransferase ISO RGD PMID:7914070 RGD:4139902 NCBI chrNW_004624795:3,408,559...3,410,669
Ensembl chrNW_004624795:3,408,627...3,410,304
JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228) BHF-UCL PMID:12457228 NCBI chrNW_004624767:15,003,073...15,010,207
Ensembl chrNW_004624767:15,003,092...15,010,154
JBrowse link
histamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdc histidine decarboxylase involved_in
acts_upstream_of_or_within
IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624731:9,835,585...9,856,743
Ensembl chrNW_004624731:9,835,596...9,856,743
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) UniProt PMID:10318872 NCBI chrNW_004624864:3,220,811...3,225,556
Ensembl chrNW_004624864:3,220,811...3,225,554
JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nt5dc2 5'-nucleotidase domain containing 2 involved_in ISO PMID:31279527 UniProt PMID:31279527 RGD:408345212 NCBI chrNW_004624822:4,675,430...4,684,074
Ensembl chrNW_004624822:4,675,430...4,685,553
JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624836:2,804,349...3,058,125
Ensembl chrNW_004624836:2,808,681...2,993,452
JBrowse link
G Dbh dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:10051631), (PMID:9603211) RGD
TreeGrafter
MGI
UniProt
PMID:9603211 PMID:10051631 PMID:10573542 GO_REF:0000041 GO_REF:0000118 RGD:1625403 NCBI chrNW_004624760:2,016,066...2,030,240
Ensembl chrNW_004624760:2,015,474...2,029,939
JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chrNW_004624738:27,747,770...27,831,213
Ensembl chrNW_004624738:27,747,696...27,834,054
JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624775:2,985,077...3,014,567
Ensembl chrNW_004624775:2,994,164...3,015,392
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 acts_upstream_of_positive_effect ISO (PMID:19008477) BHF-UCL PMID:19008477 NCBI chrNW_004624769:5,035,669...5,038,333
Ensembl chrNW_004624769:5,033,932...5,038,343
JBrowse link
G Insm1 INSM transcriptional repressor 1 involved_in ISO (PMID:18094025) UniProt PMID:18094025 NCBI chrNW_004624741:20,862,835...20,866,176
Ensembl chrNW_004624741:20,863,088...20,864,584
JBrowse link
G Kl klotho ISO RGD PMID:20086041 RGD:10403068 NCBI chrNW_004624915:95,155...110,834 JBrowse link
G LOC101701601 putative DBH-like monooxygenase protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624821:9,598,949...9,603,373 JBrowse link
G LOC101711916 putative DBH-like monooxygenase protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624765:22,256,119...22,264,715 JBrowse link
G Moxd1 monooxygenase DBH like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624753:6,379,583...6,471,020
Ensembl chrNW_004624753:6,377,330...6,471,085
JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228) BHF-UCL PMID:12457228 NCBI chrNW_004624767:15,003,073...15,010,207
Ensembl chrNW_004624767:15,003,092...15,010,154
JBrowse link
octopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbh dopamine beta-hydroxylase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624760:2,016,066...2,030,240
Ensembl chrNW_004624760:2,015,474...2,029,939
JBrowse link
G LOC101701601 putative DBH-like monooxygenase protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624821:9,598,949...9,603,373 JBrowse link
G LOC101711916 putative DBH-like monooxygenase protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624765:22,256,119...22,264,715 JBrowse link
G Moxd1 monooxygenase DBH like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624753:6,379,583...6,471,020
Ensembl chrNW_004624753:6,377,330...6,471,085
JBrowse link
polyamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624916:1,837,258...1,855,450
Ensembl chrNW_004624916:1,837,242...1,854,883
JBrowse link
G Azin1 antizyme inhibitor 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624763:19,643,980...19,667,125
Ensembl chrNW_004624763:19,643,980...19,667,125
JBrowse link
G Azin2 antizyme inhibitor 2 involved_in IEA InterPro
UniProt
GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624764:16,145,696...16,177,588
Ensembl chrNW_004624764:16,145,308...16,175,000
JBrowse link
G LOC101700675 S-adenosylmethionine decarboxylase proenzyme 1-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624905:46,356...53,446 JBrowse link
G LOC101705036 antizyme inhibitor 2-like involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624764:14,797,768...14,806,415 JBrowse link
G LOC101707712 S-adenosylmethionine decarboxylase proenzyme 1 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624761:3,529,362...3,530,491 JBrowse link
G LOC101711473 S-adenosylmethionine decarboxylase proenzyme 1 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624792:2,483,727...2,485,169 JBrowse link
G LOC101713051 S-adenosylmethionine decarboxylase proenzyme-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624743:17,283,384...17,285,140 JBrowse link
G LOC101713365 S-adenosylmethionine decarboxylase proenzyme-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624913:1,986,750...1,987,931 JBrowse link
G LOC101718865 spermine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chrNW_004624805:6,647,484...6,648,581 JBrowse link
G Oaz1 ornithine decarboxylase antizyme 1 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624828:6,617,342...6,620,466
Ensembl chrNW_004624828:6,617,727...6,620,402
JBrowse link
G Odc1 ornithine decarboxylase 1 involved_in IEA InterPro
UniProt
GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624865:4,851,565...4,858,868
Ensembl chrNW_004624865:4,851,878...4,860,558
JBrowse link
G Sat1 spermidine/spermine N1-acetyltransferase 1 involved_in ISO (PMID:15283699) UniProt PMID:15283699 NCBI chrNW_004624897:176,414...179,322
Ensembl chrNW_004624897:176,278...181,912
JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 NOT|involved_in ISO (PMID:15283699) UniProt PMID:15283699 NCBI chrNW_004624786:10,232,078...10,233,602
Ensembl chrNW_004624786:10,227,937...10,233,723
JBrowse link
G Sms spermine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chrNW_004624829:6,883,018...6,931,646
Ensembl chrNW_004624829:6,883,027...6,931,389
JBrowse link
G Srm spermidine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chrNW_004624818:1,725,614...1,729,374
Ensembl chrNW_004624818:1,725,480...1,732,186
JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chrNW_004624738:27,747,770...27,831,213
Ensembl chrNW_004624738:27,747,696...27,834,054
JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO (PMID:19703902) ParkinsonsUK-UCL PMID:19703902 NCBI chrNW_004624818:3,900,917...3,915,457
Ensembl chrNW_004624818:3,900,917...3,911,042
JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (PMID:26203154) ParkinsonsUK-UCL PMID:26203154 NCBI chrNW_004624914:160,483...188,534
Ensembl chrNW_004624914:160,483...188,490
JBrowse link
positive regulation of spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Paox polyamine oxidase involved_in ISO (PMID:16354669) UniProt PMID:16354669 NCBI chrNW_004624737:13,312,728...13,324,559
Ensembl chrNW_004624737:13,312,201...13,324,559
JBrowse link
putrescine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Odc1 ornithine decarboxylase 1 ISO RGD PMID:1415709 PMID:10430362 RGD:1578320 RGD:7242912 NCBI chrNW_004624865:4,851,565...4,858,868
Ensembl chrNW_004624865:4,851,878...4,860,558
JBrowse link
G Paox polyamine oxidase involved_in ISO (PMID:16354669) UniProt PMID:16354669 NCBI chrNW_004624737:13,312,728...13,324,559
Ensembl chrNW_004624737:13,312,201...13,324,559
JBrowse link
putrescine biosynthetic process from arginine, via agmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agmat agmatinase (putative) involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:1,839,667...1,853,344
Ensembl chrNW_004624764:1,843,227...1,853,350
JBrowse link
putrescine biosynthetic process from arginine, via ornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Azin1 antizyme inhibitor 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624763:19,643,980...19,667,125
Ensembl chrNW_004624763:19,643,980...19,667,125
JBrowse link
G Azin2 antizyme inhibitor 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:16,145,696...16,177,588
Ensembl chrNW_004624764:16,145,308...16,175,000
JBrowse link
G LOC101705036 antizyme inhibitor 2-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:14,797,768...14,806,415 JBrowse link
G Odc1 ornithine decarboxylase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624865:4,851,565...4,858,868
Ensembl chrNW_004624865:4,851,878...4,860,558
JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member involved_in ISO (PMID:26711020) UniProt PMID:26711020 NCBI chrNW_004624747:20,407,190...20,438,605
Ensembl chrNW_004624747:20,403,717...20,438,690
JBrowse link
spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 involved_in ISO
IEA
RGD
TreeGrafter
UniProt
InterPro
PMID:1415709 PMID:10430362 PMID:10712236 GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chrNW_004624916:1,837,258...1,855,450
Ensembl chrNW_004624916:1,837,242...1,854,883
JBrowse link
G LOC101700675 S-adenosylmethionine decarboxylase proenzyme 1-like involved_in IEA InterPro
UniProt
TreeGrafter
GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004624905:46,356...53,446 JBrowse link
G LOC101707712 S-adenosylmethionine decarboxylase proenzyme 1 involved_in IEA InterPro
UniProt
TreeGrafter
GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004624761:3,529,362...3,530,491 JBrowse link
G LOC101711473 S-adenosylmethionine decarboxylase proenzyme 1 involved_in IEA TreeGrafter
InterPro
UniProt
GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004624792:2,483,727...2,485,169 JBrowse link
G LOC101713051 S-adenosylmethionine decarboxylase proenzyme-like involved_in IEA TreeGrafter
UniProt
InterPro
GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004624743:17,283,384...17,285,140 JBrowse link
G LOC101713365 S-adenosylmethionine decarboxylase proenzyme-like involved_in IEA UniProt
InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004624913:1,986,750...1,987,931 JBrowse link
G Srm spermidine synthase involved_in ISO
IEA
RGD
TreeGrafter
Ensembl
PMID:8494549 PMID:12843627 PMID:16931179 GO_REF:0000107 GO_REF:0000118 RGD:1359042 RGD:7242920 RGD:7242928 NCBI chrNW_004624818:1,725,614...1,729,374
Ensembl chrNW_004624818:1,725,480...1,732,186
JBrowse link
spermine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 involved_in ISO
IEA
RGD
TreeGrafter
InterPro
PMID:1415709 PMID:10430362 PMID:10712236 GO_REF:0000002 GO_REF:0000118 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chrNW_004624916:1,837,258...1,855,450
Ensembl chrNW_004624916:1,837,242...1,854,883
JBrowse link
G LOC101700675 S-adenosylmethionine decarboxylase proenzyme 1-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624905:46,356...53,446 JBrowse link
G LOC101707712 S-adenosylmethionine decarboxylase proenzyme 1 involved_in IEA TreeGrafter
InterPro
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624761:3,529,362...3,530,491 JBrowse link
G LOC101711473 S-adenosylmethionine decarboxylase proenzyme 1 involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624792:2,483,727...2,485,169 JBrowse link
G LOC101713051 S-adenosylmethionine decarboxylase proenzyme-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624743:17,283,384...17,285,140 JBrowse link
G LOC101713365 S-adenosylmethionine decarboxylase proenzyme-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624913:1,986,750...1,987,931 JBrowse link
G LOC101718865 spermine synthase involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624805:6,647,484...6,648,581 JBrowse link
G Sms spermine synthase involved_in ISO
IEA
RGD
TreeGrafter
InterPro
PMID:8494549 GO_REF:0000002 GO_REF:0000118 RGD:7242928 NCBI chrNW_004624829:6,883,018...6,931,646
Ensembl chrNW_004624829:6,883,027...6,931,389
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17647
    cellular process 17219
      metabolic process 10996
        amine metabolic process 123
          biogenic amine metabolic process 112
            biogenic amine biosynthetic process 48
              catecholamine biosynthetic process + 29
              choline biosynthetic process + 0
              ethanolamine biosynthetic process 0
              histamine biosynthetic process 2
              indolalkylamine biosynthetic process + 0
              nicotianamine biosynthetic process 0
              octopamine biosynthetic process 4
              phenylethylamine biosynthetic process + 0
              polyamine biosynthetic process + 18
paths to the root