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ONTOLOGY REPORT - ANNOTATIONS

Term:biogenic amine biosynthetic process
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Accession:GO:0042401 term browser browse the term
Definition:The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
Synonyms:exact_synonym: biogenic amine anabolism;   biogenic amine biosynthesis;   biogenic amine formation;   biogenic amine synthesis;   cellular biogenic amine biosynthetic process


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catecholamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr2 corticotropin releasing hormone receptor 2 involved_in ISO RGD
GO_Central		 PMID:17194738 GO_REF:0000096 RGD:5131263 NCBI chr 6:55,067,033...55,110,001
Ensembl chr 6:55,067,034...55,110,001 		JBrowse link
G Hdc histidine decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219 		JBrowse link
G Th tyrosine hydroxylase involved_in ISO RGD
GO_Central		 PMID:20025246 GO_REF:0000096 RGD:4139888 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a involved_in ISO
IEA 		RGD
GO_Central
Ensembl		 PMID:20097214 GO_REF:0000096 GO_REF:0000107 RGD:6903884 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 involved_in ISO
IEA 		RGD
Ensembl
GO_Central		 PMID:20097214 GO_REF:0000096 GO_REF:0000107 RGD:6903884 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 ISO RGD PMID:12438507 RGD:704388 NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 involved_in ISO RGD
GO_Central		 PMID:19818757 GO_REF:0000096 RGD:5143981 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Dao D-amino acid oxidase involved_in IMP
ISO 		(PMID:17042912) UniProt
GO_Central		 PMID:17042912 GO_REF:0000119 NCBI chr 5:114,137,696...114,163,736
Ensembl chr 5:114,141,764...114,163,743 		JBrowse link
G Ddc dopa decarboxylase involved_in ISO
IEA 		RGD
UniProt
GO_Central		 PMID:12703659 GO_REF:0000041 GO_REF:0000096 RGD:4139893 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in IEA
ISO 		Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Gpr37 G protein-coupled receptor 37 acts_upstream_of_or_within IMP (PMID:15218106) MGI PMID:15218106 NCBI chr 6:25,668,522...25,689,979
Ensembl chr 6:25,665,877...25,690,728 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 acts_upstream_of_or_within IMP (PMID:16782508), (PMID:9608532) MGI PMID:9608532 PMID:16782508 NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 acts_upstream_of_or_within IMP (PMID:9520487) MGI PMID:9520487 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Snca synuclein, alpha acts_upstream_of_or_within IMP (PMID:10707987) MGI PMID:10707987 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in IMP (PMID:16257223) UniProt PMID:16257223 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Th tyrosine hydroxylase involved_in ISO GO_Central GO_REF:0000119 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Th tyrosine hydroxylase involved_in
acts_upstream_of_or_within 		ISO
IBA
IMP
TAS
IDA 		(PMID:7592982), (PMID:7715703)
(PMID:10212311)
(PMID:9520487) 		RGD
GO_Central
MGI		 PMID:2427363 PMID:7592982 PMID:7715703 PMID:9520487 PMID:10212311 More... GO_REF:0000033 GO_REF:0000096 RGD:1580046 RGD:5130972 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
epinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnmt phenylethanolamine-N-methyltransferase involved_in ISO
IEA 		RGD
UniProt
GO_Central		 PMID:7914070 GO_REF:0000041 GO_REF:0000096 RGD:4139902 NCBI chr11:98,277,449...98,279,006
Ensembl chr11:98,277,276...98,279,007 		JBrowse link
G Th tyrosine hydroxylase involved_in IEA
ISO 		Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
histamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdc histidine decarboxylase acts_upstream_of_or_within
involved_in 		IMP
IBA
IEA
ISO 		(PMID:11478947) MGI
GO_Central
UniProt		 PMID:11478947 GO_REF:0000033 GO_REF:0000041 GO_REF:0000119 NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219 		JBrowse link
G Prg3 proteoglycan 3 involved_in IEA
ISO 		Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:84,818,540...84,826,903
Ensembl chr 2:84,818,559...84,824,230 		JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nt5dc2 5'-nucleotidase domain containing 2 involved_in ISO PMID:31279527 UniProt PMID:31279527 RGD:408345212 NCBI chr14:30,853,046...30,861,081
Ensembl chr14:30,853,010...30,861,081 		JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase, copper transporting, alpha polypeptide acts_upstream_of_or_within IMP (PMID:4405722)
(PMID:4858102) 		MGI PMID:4405722 PMID:4858102 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532 		JBrowse link
G Dbh dopamine beta hydroxylase acts_upstream_of_or_within
involved_in 		ISO
IMP
IEA
ISS
IBA 		(PMID:10051631), (PMID:9603211)
(PMID:27148966), (PMID:7715704) 		RGD
MGI
GO_Central
UniProt		 PMID:7715704 PMID:9603211 PMID:10051631 PMID:10573542 PMID:27148966 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000096 GO_REF:0000119 RGD:1625403 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212 		JBrowse link
G Epas1 endothelial PAS domain protein 1 involved_in ISO RGD
GO_Central		 PMID:19457096 GO_REF:0000096 RGD:5128877 NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within IMP (PMID:10835639) MGI PMID:10835639 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 acts_upstream_of_positive_effect IMP (PMID:19008477) BHF-UCL PMID:19008477 NCBI chr 8:57,774,018...57,777,552
Ensembl chr 8:57,774,018...57,777,668 		JBrowse link
G Insm1 insulinoma-associated 1 involved_in IMP (PMID:18094025) UniProt PMID:18094025 NCBI chr 2:146,064,021...146,066,940
Ensembl chr 2:146,063,841...146,066,940 		JBrowse link
G Kl klotho involved_in ISO
IEA 		RGD
Ensembl
GO_Central		 PMID:20086041 GO_REF:0000096 GO_REF:0000107 RGD:10403068 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282 		JBrowse link
G Moxd1 monooxygenase, DBH-like 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:24,099,415...24,178,681
Ensembl chr10:24,099,415...24,178,688 		JBrowse link
G Moxd2 monooxygenase, DBH-like 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:40,855,728...40,864,428
Ensembl chr 6:40,855,728...40,864,428 		JBrowse link
G Th tyrosine hydroxylase involved_in IEA
ISO 		Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
octopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbh dopamine beta hydroxylase involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212 		JBrowse link
G Moxd1 monooxygenase, DBH-like 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:24,099,415...24,178,681
Ensembl chr10:24,099,415...24,178,688 		JBrowse link
G Moxd2 monooxygenase, DBH-like 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:40,855,728...40,864,428
Ensembl chr 6:40,855,728...40,864,428 		JBrowse link
polyamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Azin1 antizyme inhibitor 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr15:38,487,674...38,523,506
Ensembl chr15:38,487,671...38,519,510 		JBrowse link
G Azin2 antizyme inhibitor 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:128,824,026...128,856,250
Ensembl chr 4:128,824,026...128,856,235 		JBrowse link
G Oaz1 ornithine decarboxylase antizyme 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr10:80,662,490...80,665,124
Ensembl chr10:80,662,516...80,665,124 		JBrowse link
G Oaz2 ornithine decarboxylase antizyme 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:65,583,830...65,597,582
Ensembl chr 9:65,575,283...65,597,582 		JBrowse link
G Oaz3 ornithine decarboxylase antizyme 3 involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:94,340,694...94,343,958
Ensembl chr 3:94,339,721...94,351,222 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 involved_in ISS
ISO 		UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr  X:153,996,128...153,999,345
Ensembl chr  X:153,996,128...153,999,445 		JBrowse link
G Sat2 spermidine/spermine N1-acetyl transferase 2 NOT|involved_in ISS UniProt GO_REF:0000024 NCBI chr11:69,512,824...69,514,857
Ensembl chr11:69,512,850...69,514,696 		JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 involved_in ISO RGD
GO_Central		 PMID:19457096 GO_REF:0000096 RGD:5128877 NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 involved_in ISO
IEA 		GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in IMP (PMID:26203154) ParkinsonsUK-UCL PMID:26203154 NCBI chr 8:85,987,014...86,026,146
Ensembl chr 8:85,987,021...86,026,431 		JBrowse link
positive regulation of spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Paox polyamine oxidase (exo-N4-amino) involved_in ISO
IEA 		GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 7:139,693,182...139,714,249
Ensembl chr 7:139,695,712...139,717,137 		JBrowse link
putrescine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Odc1 ornithine decarboxylase, structural 1 involved_in ISO RGD
GO_Central		 PMID:1415709 PMID:10430362 GO_REF:0000096 RGD:1578320 RGD:7242912 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
G Paox polyamine oxidase (exo-N4-amino) involved_in ISO
IEA 		GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 7:139,693,182...139,714,249
Ensembl chr 7:139,695,712...139,717,137 		JBrowse link
putrescine biosynthetic process from arginine, via agmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agmat agmatinase involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:141,473,986...141,486,574
Ensembl chr 4:141,473,983...141,486,574 		JBrowse link
putrescine biosynthetic process from arginine, via ornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Azin1 antizyme inhibitor 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:38,487,674...38,523,506
Ensembl chr15:38,487,671...38,519,510 		JBrowse link
G Azin2 antizyme inhibitor 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:128,824,026...128,856,250
Ensembl chr 4:128,824,026...128,856,235 		JBrowse link
G Ldc1 leucine decarboxylase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:130,102,816...130,116,221
Ensembl chr 4:130,102,902...130,116,194 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 involved_in IDA
IBA
IEA 		(PMID:24967154) UniProt
GO_Central		 PMID:24967154 GO_REF:0000033 GO_REF:0000041 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial involved_in IMP (PMID:26711020) UniProt PMID:26711020 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 S-adenosylmethionine decarboxylase 1 involved_in ISO
IBA
IEA 		RGD
GO_Central
UniProt		 PMID:1415709 PMID:10430362 PMID:10712236 GO_REF:0000033 GO_REF:0000043 GO_REF:0000096 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chr10:40,163,454...40,178,184
Ensembl chr10:40,163,454...40,178,184 		JBrowse link
G Amd2 S-adenosylmethionine decarboxylase 2 involved_in IEA
IBA
ISO 		UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000043 GO_REF:0000096 NCBI chr10:35,584,687...35,587,887
Ensembl chr10:35,584,671...35,587,888 		JBrowse link
G Srm spermidine synthase involved_in ISO
IBA
ISS
IEA 		RGD
GO_Central
UniProt		 PMID:8494549 PMID:12843627 PMID:16931179 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000096 GO_REF:0000119 RGD:1359042 RGD:7242920 RGD:7242928 NCBI chr 4:148,675,970...148,679,076
Ensembl chr 4:148,675,960...148,679,450 		JBrowse link
spermine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 S-adenosylmethionine decarboxylase 1 involved_in ISO
IBA
IEA 		RGD
GO_Central
InterPro		 PMID:1415709 PMID:10430362 PMID:10712236 GO_REF:0000002 GO_REF:0000033 GO_REF:0000096 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chr10:40,163,454...40,178,184
Ensembl chr10:40,163,454...40,178,184 		JBrowse link
G Amd2 S-adenosylmethionine decarboxylase 2 involved_in IEA
IBA
ISO 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000096 NCBI chr10:35,584,687...35,587,887
Ensembl chr10:35,584,671...35,587,888 		JBrowse link
G Sms spermine synthase involved_in ISO
IBA
IEA 		RGD
GO_Central
UniProt		 PMID:8494549 GO_REF:0000033 GO_REF:0000041 GO_REF:0000096 RGD:7242928 NCBI chr  X:156,226,847...156,275,283
Ensembl chr  X:156,226,851...156,275,283 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28625
    cellular process 18393
      metabolic process 11623
        amine metabolic process 130
          biogenic amine metabolic process 119
            biogenic amine biosynthetic process 45
              catecholamine biosynthetic process + 29
              choline biosynthetic process + 0
              ethanolamine biosynthetic process 0
              histamine biosynthetic process 2
              indolalkylamine biosynthetic process + 0
              nicotianamine biosynthetic process 0
              octopamine biosynthetic process 3
              phenylethylamine biosynthetic process + 0
              polyamine biosynthetic process + 15
paths to the root