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ONTOLOGY REPORT - ANNOTATIONS

Term:biogenic amine biosynthetic process
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Accession:GO:0042401 term browser browse the term
Definition:The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
Synonyms:exact_synonym: biogenic amine anabolism;   biogenic amine biosynthesis;   biogenic amine formation;   biogenic amine synthesis;   cellular biogenic amine biosynthetic process


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catecholamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:17194738 RGD:5131263 NCBI chr 7:30,651,942...30,700,103
Ensembl chr 7:30,651,942...30,700,129 		JBrowse link
G DBH dopamine beta-hydroxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329 		JBrowse link
G DDC dopa decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405 		JBrowse link
G HDC histidine decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr15:50,241,947...50,265,726
Ensembl chr15:50,241,947...50,265,965 		JBrowse link
G PAH phenylalanine hydroxylase involved_in NAS (PMID:2872999) BHF-UCL PMID:2872999 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410 		JBrowse link
G PNMT phenylethanolamine N-methyltransferase involved_in IEA
TAS 		UniProt
Reactome		 GO_REF:0000043 Reactome:R-HSA-209905 NCBI chr17:39,668,019...39,670,475
Ensembl chr17:39,667,981...39,670,475 		JBrowse link
G TH tyrosine hydroxylase involved_in ISO
IEA 		RGD
UniProt
InterPro		 PMID:20025246 GO_REF:0000002 GO_REF:0000043 RGD:4139888 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:20097214 RGD:6903884 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:20097214 RGD:6903884 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit ISO RGD PMID:12438507 RGD:704388 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) ISO RGD PMID:19818757 RGD:5143981 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G DAO D-amino acid oxidase involved_in IDA
IEA 		(PMID:17303072) UniProt
Ensembl		 PMID:17303072 GO_REF:0000107 NCBI chr12:108,880,092...108,901,043
Ensembl chr12:108,858,932...108,901,043 		JBrowse link
G DDC dopa decarboxylase involved_in ISO
IDA
IEA 		(PMID:19703902) RGD
ParkinsonsUK-UCL
UniProt		 PMID:12703659 PMID:19703902 GO_REF:0000041 RGD:4139893 NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405 		JBrowse link
G GCH1 GTP cyclohydrolase 1 involved_in IDA (PMID:16338639) UniProt PMID:16338639 NCBI chr14:54,842,017...54,902,826
Ensembl chr14:54,842,008...54,902,826 		JBrowse link
G GPR37 G protein-coupled receptor 37 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:124,743,885...124,765,792
Ensembl chr 7:124,743,885...124,765,792 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440 		JBrowse link
G SNCA synuclein alpha involved_in
acts_upstream_of_or_within 		TAS
IEA 		(PMID:21320589) UniProt
Ensembl		 PMID:21320589 GO_REF:0000107 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G TH tyrosine hydroxylase involved_in IEA
IDA 		(PMID:12457228), (PMID:19703902) UniProt
ParkinsonsUK-UCL		 PMID:12457228 PMID:19703902 GO_REF:0000041 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TH tyrosine hydroxylase acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA
NAS 		(PMID:10907721) RGD
Ensembl
GO_Central
BHF-UCL		 PMID:2427363 PMID:10907721 PMID:19584816 GO_REF:0000033 GO_REF:0000107 RGD:1580046 RGD:5130972 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
epinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNMT phenylethanolamine N-methyltransferase involved_in ISO
IEA 		RGD
UniProt		 PMID:7914070 GO_REF:0000041 RGD:4139902 NCBI chr17:39,668,019...39,670,475
Ensembl chr17:39,667,981...39,670,475 		JBrowse link
G TH tyrosine hydroxylase involved_in IDA (PMID:12457228) BHF-UCL PMID:12457228 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
histamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDC histidine decarboxylase involved_in
acts_upstream_of_or_within 		IDA
IEA
IBA 		(PMID:22767596) UniProt
Ensembl
GO_Central		 PMID:22767596 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr15:50,241,947...50,265,726
Ensembl chr15:50,241,947...50,265,965 		JBrowse link
G PRG3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in IDA (PMID:10318872) UniProt PMID:10318872 NCBI chr11:57,376,769...57,381,150
Ensembl chr11:57,376,769...57,381,150 		JBrowse link
indolalkylamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AANAT aralkylamine N-acetyltransferase involved_in TAS Reactome Reactome:R-HSA-209931 NCBI chr17:76,453,351...76,470,117
Ensembl chr17:76,453,351...76,470,117 		JBrowse link
G ASMT acetylserotonin O-methyltransferase involved_in TAS Reactome Reactome:R-HSA-209931 NCBI chr  X:1,615,059...1,643,081
NCBI chr  Y:1,615,059...1,643,081
Ensembl chr  Y:1,615,059...1,643,081
Ensembl chr  X:1,615,059...1,643,081 		JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NT5DC2 5'-nucleotidase domain containing 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 3:52,524,387...52,535,027
Ensembl chr 3:52,524,385...52,535,054 		JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,690...78,050,395 		JBrowse link
G DBH dopamine beta-hydroxylase acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA
IMP 		(PMID:27148966) RGD
Ensembl
GO_Central
UniProt		 PMID:10573542 PMID:27148966 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 RGD:1625403 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329 		JBrowse link
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697 		JBrowse link
G GATA3 GATA binding protein 3 involved_in
acts_upstream_of_or_within 		ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198 		JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 acts_upstream_of_positive_effect IEA Ensembl GO_REF:0000107 NCBI chr 4:173,526,091...173,530,229
Ensembl chr 4:173,524,969...173,530,229 		JBrowse link
G INSM1 INSM transcriptional repressor 1 involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr20:20,368,104...20,370,949
Ensembl chr20:20,368,104...20,370,949 		JBrowse link
G KL klotho involved_in ISO
IEA 		RGD
Ensembl		 PMID:20086041 GO_REF:0000107 RGD:10403068 NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143 		JBrowse link
G MOXD1 monooxygenase DBH like 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:132,296,055...132,401,475
Ensembl chr 6:132,296,055...132,401,475 		JBrowse link
G MOXD2P monooxygenase DBH like 2, pseudogene involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:142,240,737...142,247,067
Ensembl chr 7:142,240,740...142,247,067 		JBrowse link
G TH tyrosine hydroxylase involved_in IDA (PMID:12457228) BHF-UCL PMID:12457228 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
octopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBH dopamine beta-hydroxylase involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329 		JBrowse link
G MOXD1 monooxygenase DBH like 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:132,296,055...132,401,475
Ensembl chr 6:132,296,055...132,401,475 		JBrowse link
G MOXD2P monooxygenase DBH like 2, pseudogene involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:142,240,737...142,247,067
Ensembl chr 7:142,240,740...142,247,067 		JBrowse link
polyamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:110,814,617...110,895,713
Ensembl chr 6:110,874,770...110,898,879 		JBrowse link
G AZIN1 antizyme inhibitor 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 8:102,826,302...102,864,200
Ensembl chr 8:102,826,111...102,893,864 		JBrowse link
G AZIN2 antizyme inhibitor 2 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr 1:33,081,153...33,166,795
Ensembl chr 1:33,081,104...33,123,492 		JBrowse link
G OAZ1 ornithine decarboxylase antizyme 1 involved_in IEA
TAS 		(PMID:7813017) UniProt
PINC		 PMID:7813017 GO_REF:0000043 NCBI chr19:2,269,486...2,273,488
Ensembl chr19:2,269,509...2,273,492 		JBrowse link
G OAZ2 ornithine decarboxylase antizyme 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr15:64,687,574...64,703,281
Ensembl chr15:64,687,573...64,703,281 		JBrowse link
G OAZ3 ornithine decarboxylase antizyme 3 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:151,762,969...151,771,330
Ensembl chr 1:151,762,899...151,771,334 		JBrowse link
G ODC1 ornithine decarboxylase 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327 		JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 involved_in TAS
IDA 		(PMID:15283699) Reactome
UniProt		 PMID:15283699 Reactome:R-HSA-351200 NCBI chr  X:23,783,173...23,786,210
Ensembl chr  X:23,783,173...23,786,210 		JBrowse link
G SAT2 spermidine/spermine N1-acetyltransferase family member 2 NOT|involved_in IDA (PMID:15283699) UniProt PMID:15283699 NCBI chr17:7,626,234...7,627,876
Ensembl chr17:7,626,234...7,627,876 		JBrowse link
G SMOX spermine oxidase involved_in TAS Reactome Reactome:R-HSA-351200 NCBI chr20:4,148,828...4,187,727
Ensembl chr20:4,120,980...4,187,747 		JBrowse link
G SMS spermine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr  X:21,940,709...21,994,837
Ensembl chr  X:21,940,709...21,994,837 		JBrowse link
G SRM spermidine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr 1:11,054,589...11,060,018
Ensembl chr 1:11,054,584...11,060,020 		JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in
acts_upstream_of 		IDA
IC 		(PMID:19703902)
(PMID:16731528) 		ParkinsonsUK-UCL PMID:16731528 PMID:19703902 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505 		JBrowse link
G VPS35 VPS35 retromer complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:46,656,132...46,689,178
Ensembl chr16:46,656,132...46,689,518 		JBrowse link
positive regulation of spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAOX polyamine oxidase involved_in IDA (PMID:16354669) UniProt PMID:16354669 NCBI chr10:133,379,262...133,391,694
Ensembl chr10:133,379,261...133,391,694 		JBrowse link
putrescine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ODC1 ornithine decarboxylase 1 ISO RGD PMID:1415709 PMID:10430362 RGD:1578320 RGD:7242912 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327 		JBrowse link
G PAOX polyamine oxidase involved_in IDA (PMID:16354669) UniProt PMID:16354669 NCBI chr10:133,379,262...133,391,694
Ensembl chr10:133,379,261...133,391,694 		JBrowse link
putrescine biosynthetic process from arginine, via agmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGMAT agmatinase (putative) involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:15,571,699...15,585,051
Ensembl chr 1:15,571,699...15,585,051 		JBrowse link
putrescine biosynthetic process from arginine, via ornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AZIN1 antizyme inhibitor 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 8:102,826,302...102,864,200
Ensembl chr 8:102,826,111...102,893,864 		JBrowse link
G AZIN2 antizyme inhibitor 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:33,081,153...33,166,795
Ensembl chr 1:33,081,104...33,123,492 		JBrowse link
G ODC1 ornithine decarboxylase 1 involved_in IEA
IBA
ISS 		UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327 		JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 involved_in ISO
IBA
IEA 		RGD
GO_Central
InterPro
UniProt		 PMID:1415709 PMID:10430362 PMID:10712236 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chr 6:110,814,617...110,895,713
Ensembl chr 6:110,874,770...110,898,879 		JBrowse link
G SRM spermidine synthase involved_in ISO
IBA
IDA
IEA 		(PMID:17585781) RGD
GO_Central
UniProt		 PMID:8494549 PMID:12843627 PMID:16931179 PMID:17585781 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 RGD:1359042 RGD:7242920 RGD:7242928 NCBI chr 1:11,054,589...11,060,018
Ensembl chr 1:11,054,584...11,060,020 		JBrowse link
spermine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 involved_in ISO
IBA
IEA 		RGD
GO_Central
InterPro		 PMID:1415709 PMID:10430362 PMID:10712236 GO_REF:0000002 GO_REF:0000033 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chr 6:110,814,617...110,895,713
Ensembl chr 6:110,874,770...110,898,879 		JBrowse link
G SMS spermine synthase involved_in ISO
IBA
IEA 		RGD
GO_Central
UniProt
InterPro		 PMID:8494549 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 RGD:7242928 NCBI chr  X:21,940,709...21,994,837
Ensembl chr  X:21,940,709...21,994,837 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27207
    cellular process 19782
      metabolic process 13524
        amine metabolic process 139
          biogenic amine metabolic process 124
            biogenic amine biosynthetic process 47
              catecholamine biosynthetic process + 30
              choline biosynthetic process + 0
              ethanolamine biosynthetic process 0
              histamine biosynthetic process 2
              indolalkylamine biosynthetic process + 2
              nicotianamine biosynthetic process 0
              octopamine biosynthetic process 3
              phenylethylamine biosynthetic process + 0
              polyamine biosynthetic process + 14
paths to the root