Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:biogenic amine biosynthetic process
go back to main search page
Accession:GO:0042401 term browser browse the term
Definition:The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
Synonyms:exact_synonym: biogenic amine anabolism;   biogenic amine biosynthesis;   biogenic amine formation;   biogenic amine synthesis;   cellular biogenic amine biosynthetic process

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
catecholamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:17194738 RGD:5131263 NCBI chr21:27,703,637...27,738,873
Ensembl chr21:27,708,113...27,739,116 		JBrowse link
G DBH dopamine beta-hydroxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr12:4,474,041...4,498,942
Ensembl chr12:4,474,958...4,498,910 		JBrowse link
G DDC dopa decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr21:8,235,396...8,343,086
Ensembl chr21:8,235,343...8,343,361 		JBrowse link
G HDC histidine decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr26:33,051,048...33,074,872
Ensembl chr26:33,051,966...33,074,563 		JBrowse link
G PNMT phenylethanolamine N-methyltransferase involved_in IEA UniProt GO_REF:0000043 NCBI chr16:66,496,290...66,498,840
Ensembl chr16:66,496,027...66,499,111 		JBrowse link
G TH tyrosine hydroxylase involved_in ISO
IEA 		RGD
InterPro
UniProt		 PMID:20025246 GO_REF:0000002 GO_REF:0000043 RGD:4139888 NCBI chr 1:1,969,194...1,977,263
Ensembl chr 1:1,966,460...1,977,218 		JBrowse link
dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:20097214 RGD:6903884 NCBI chr15:41,957,826...42,002,776 JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:20097214 RGD:6903884
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit ISO RGD PMID:12438507 RGD:704388 NCBI chr26:50,554,143...50,686,847
Ensembl chr26:50,551,829...50,686,803 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO RGD PMID:19818757 RGD:5143981 NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513 		JBrowse link
G DAO D-amino acid oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:104,080,915...104,104,017
Ensembl chr11:104,081,672...104,106,222 		JBrowse link
G DDC dopa decarboxylase involved_in ISO
IEA 		RGD
Ensembl		 PMID:12703659 GO_REF:0000107 RGD:4139893 NCBI chr21:8,235,396...8,343,086
Ensembl chr21:8,235,343...8,343,361 		JBrowse link
G GCH1 GTP cyclohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:32,029,997...32,079,656
Ensembl chr24:32,027,648...32,079,490 		JBrowse link
G GPR37 G protein-coupled receptor 37 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr21:93,487,178...93,507,317
Ensembl chr21:93,486,702...93,507,056 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:41,715,092...41,724,411
Ensembl chr10:41,715,086...41,723,685 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:1,209,013...1,258,797
Ensembl chr 4:1,209,019...1,258,866 		JBrowse link
G SNCA synuclein alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:38,083,154...38,194,068
Ensembl chr 7:38,081,509...38,191,479 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:11,163,651...11,259,868
Ensembl chr25:11,163,100...11,258,470 		JBrowse link
G TH tyrosine hydroxylase involved_in IEA Ensembl
UniProt		 GO_REF:0000041 GO_REF:0000107 NCBI chr 1:1,969,194...1,977,263
Ensembl chr 1:1,966,460...1,977,218 		JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TH tyrosine hydroxylase acts_upstream_of_or_within
involved_in 		ISO
IEA 		RGD
Ensembl
TreeGrafter		 PMID:2427363 PMID:19584816 GO_REF:0000107 GO_REF:0000118 RGD:1580046 RGD:5130972 NCBI chr 1:1,969,194...1,977,263
Ensembl chr 1:1,966,460...1,977,218 		JBrowse link
epinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNMT phenylethanolamine N-methyltransferase ISO RGD PMID:7914070 RGD:4139902 NCBI chr16:66,496,290...66,498,840
Ensembl chr16:66,496,027...66,499,111 		JBrowse link
G TH tyrosine hydroxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:1,969,194...1,977,263
Ensembl chr 1:1,966,460...1,977,218 		JBrowse link
histamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDC histidine decarboxylase involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr26:33,051,048...33,074,872
Ensembl chr26:33,051,966...33,074,563 		JBrowse link
G PRG3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:15,860,460...15,865,716
Ensembl chr 1:15,861,078...15,865,711 		JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NT5DC2 5'-nucleotidase domain containing 2 involved_in ISO PMID:31279527 UniProt PMID:31279527 RGD:408345212 NCBI chr22:13,892,078...13,903,043 JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:66,843,519...66,985,655
Ensembl chr  X:66,843,558...66,985,709 		JBrowse link
G DBH dopamine beta-hydroxylase acts_upstream_of_or_within
involved_in 		ISO
IEA 		RGD
Ensembl
TreeGrafter
UniProt		 PMID:10573542 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 RGD:1625403 NCBI chr12:4,474,041...4,498,942
Ensembl chr12:4,474,958...4,498,910 		JBrowse link
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chr14:60,823,110...60,912,804
Ensembl chr14:60,822,815...60,912,785 		JBrowse link
G GATA3 GATA binding protein 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:8,101,404...8,122,762
Ensembl chr 9:8,101,432...8,123,064 		JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 acts_upstream_of_positive_effect IEA Ensembl GO_REF:0000107 NCBI chr 7:119,635,697...119,639,415
Ensembl chr 7:119,634,741...119,638,546 		JBrowse link
G INSM1 INSM transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:49,360,307...49,363,136
Ensembl chr 2:49,360,448...49,361,992 		JBrowse link
G KL klotho ISO RGD PMID:20086041 RGD:10403068 NCBI chr 3:11,755,015...11,799,537
Ensembl chr 3:11,755,016...11,797,596 		JBrowse link
G LOC103227050 putative DBH-like monooxygenase protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:110,969,853...110,974,087 JBrowse link
G MOXD1 monooxygenase DBH like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:41,138,661...41,271,779
Ensembl chr13:41,139,408...41,248,665 		JBrowse link
G TH tyrosine hydroxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:1,969,194...1,977,263
Ensembl chr 1:1,966,460...1,977,218 		JBrowse link
octopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBH dopamine beta-hydroxylase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:4,474,041...4,498,942
Ensembl chr12:4,474,958...4,498,910 		JBrowse link
G LOC103227050 putative DBH-like monooxygenase protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:110,969,853...110,974,087 JBrowse link
G MOXD1 monooxygenase DBH like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:41,138,661...41,271,779
Ensembl chr13:41,139,408...41,248,665 		JBrowse link
polyamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 involved_in IEA UniProt GO_REF:0000043 Ensembl chr13:62,976,613...62,984,762 JBrowse link
G AZIN1 antizyme inhibitor 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 8:97,679,775...97,717,486
Ensembl chr 8:97,679,468...97,696,928 		JBrowse link
G AZIN2 antizyme inhibitor 2 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 Ensembl chr20:99,757,861...99,804,601 JBrowse link
G LOC103220173 ornithine decarboxylase-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr14:43,751,905...43,753,970 JBrowse link
G OAZ1 ornithine decarboxylase antizyme 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:2,061,774...2,065,595
Ensembl chr 6:2,061,811...2,065,265 		JBrowse link
G ODC1 ornithine decarboxylase 1 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr14:97,173,338...97,182,253 JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:22,231,915...22,234,981
Ensembl chr  X:22,231,855...22,235,031 		JBrowse link
G SAT2 spermidine/spermine N1-acetyltransferase family member 2 NOT|involved_in ISO (PMID:15283699) UniProt PMID:15283699 NCBI chr16:7,001,087...7,003,538
Ensembl chr16:7,001,259...7,002,270 		JBrowse link
G SMS spermine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr  X:20,418,435...20,475,227
Ensembl chr  X:20,418,494...20,476,276 		JBrowse link
G SRM spermidine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr20:120,718,265...120,723,694
Ensembl chr20:120,718,424...120,723,944 		JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chr14:60,823,110...60,912,804
Ensembl chr14:60,822,815...60,912,785 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:123,776,084...123,808,031
Ensembl chr20:123,776,297...123,798,434 		JBrowse link
G VPS35 VPS35 retromer complex component involved_in ISO (PMID:26203154) ParkinsonsUK-UCL PMID:26203154 NCBI chr 5:32,509,037...32,539,371
Ensembl chr 5:32,508,580...32,539,343 		JBrowse link
positive regulation of spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAOX polyamine oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:53,228,320...53,238,362
Ensembl chr26:53,228,396...53,240,508 		JBrowse link
putrescine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ODC1 ornithine decarboxylase 1 ISO RGD PMID:1415709 PMID:10430362 RGD:1578320 RGD:7242912 NCBI chr14:97,173,338...97,182,253 JBrowse link
G PAOX polyamine oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:53,228,320...53,238,362
Ensembl chr26:53,228,396...53,240,508 		JBrowse link
putrescine biosynthetic process from arginine, via agmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGMAT agmatinase (putative) involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:116,710,261...116,721,997
Ensembl chr20:116,710,578...116,722,125 		JBrowse link
putrescine biosynthetic process from arginine, via ornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AZIN1 antizyme inhibitor 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:97,679,775...97,717,486
Ensembl chr 8:97,679,468...97,696,928 		JBrowse link
G AZIN2 antizyme inhibitor 2 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr20:99,757,861...99,804,601 JBrowse link
G LOC103220173 ornithine decarboxylase-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:43,751,905...43,753,970 JBrowse link
G ODC1 ornithine decarboxylase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:97,173,338...97,182,253 JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:107,019,015...107,060,784
Ensembl chr11:107,019,111...107,060,374 		JBrowse link
spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO RGD PMID:1415709 PMID:10430362 PMID:10712236 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chr13:62,977,659...62,999,150 JBrowse link
G AMD1 adenosylmethionine decarboxylase 1 involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 Ensembl chr13:62,976,613...62,984,762 JBrowse link
G SRM spermidine synthase involved_in ISO
IEA 		RGD
TreeGrafter
Ensembl		 PMID:8494549 PMID:12843627 PMID:16931179 GO_REF:0000107 GO_REF:0000118 RGD:1359042 RGD:7242920 RGD:7242928 NCBI chr20:120,718,265...120,723,694
Ensembl chr20:120,718,424...120,723,944 		JBrowse link
spermine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO RGD PMID:1415709 PMID:10430362 PMID:10712236 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chr13:62,977,659...62,999,150 JBrowse link
G AMD1 adenosylmethionine decarboxylase 1 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 Ensembl chr13:62,976,613...62,984,762 JBrowse link
G SMS spermine synthase involved_in ISO
IEA 		RGD
TreeGrafter
InterPro		 PMID:8494549 GO_REF:0000002 GO_REF:0000118 RGD:7242928 NCBI chr  X:20,418,435...20,475,227
Ensembl chr  X:20,418,494...20,476,276 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19826
    cellular process 19340
      metabolic process 13108
        amine metabolic process 124
          biogenic amine metabolic process 112
            biogenic amine biosynthetic process 43
              catecholamine biosynthetic process + 29
              choline biosynthetic process + 0
              ethanolamine biosynthetic process 0
              histamine biosynthetic process 2
              indolalkylamine biosynthetic process + 0
              nicotianamine biosynthetic process 0
              octopamine biosynthetic process 3
              phenylethylamine biosynthetic process + 0
              polyamine biosynthetic process + 13
paths to the root