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ONTOLOGY REPORT - ANNOTATIONS

Term:biogenic amine biosynthetic process
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Accession:GO:0042401 term browser browse the term
Definition:The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
Synonyms:exact_synonym: biogenic amine anabolism;   biogenic amine biosynthesis;   biogenic amine formation;   biogenic amine synthesis;   cellular biogenic amine biosynthetic process

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catecholamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:17194738 RGD:5131263 NCBI chrNW_004955410:31,830,333...31,874,384
Ensembl chrNW_004955410:31,828,506...31,875,100 		JBrowse link
G Th tyrosine hydroxylase ISO RGD PMID:20025246 RGD:4139888 NCBI chrNW_004955422:13,943,590...13,951,102
Ensembl chrNW_004955422:13,943,552...13,951,137 		JBrowse link
dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1 angiotensin II receptor type 1 ISO RGD PMID:20097214 RGD:6903884 NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255 		JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:20097214 RGD:6903884 NCBI chrNW_004955534:3,653,112...3,654,248
Ensembl chrNW_004955534:3,653,157...3,654,248 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO RGD PMID:12438507 RGD:704388 NCBI chrNW_004955416:30,687,518...30,798,700
Ensembl chrNW_004955416:30,687,478...30,798,700 		JBrowse link
G Dao D-amino acid oxidase involved_in ISO (PMID:17303072)
(PMID:17042912) 		UniProt PMID:17042912 PMID:17303072 NCBI chrNW_004955455:10,095,597...10,127,244
Ensembl chrNW_004955455:10,095,300...10,127,666 		JBrowse link
G Ddc dopa decarboxylase involved_in ISO (PMID:19703902) RGD
ParkinsonsUK-UCL		 PMID:12703659 PMID:19703902 RGD:4139893 NCBI chrNW_004955456:3,513,779...3,582,851
Ensembl chrNW_004955456:3,513,042...3,582,911 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO (PMID:16338639) UniProt PMID:16338639 NCBI chrNW_004955409:8,624,225...8,670,436
Ensembl chrNW_004955409:8,624,468...8,668,614 		JBrowse link
G Gpr37 G protein-coupled receptor 37 acts_upstream_of_or_within ISO (PMID:15218106) MGI PMID:15218106 NCBI chrNW_004955479:6,061,424...6,080,129
Ensembl chrNW_004955479:6,057,276...6,080,994 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4 group A member 2 acts_upstream_of_or_within ISO (PMID:16782508), (PMID:9608532) MGI PMID:9608532 PMID:16782508 NCBI chrNW_004955449:16,928,780...16,944,536
Ensembl chrNW_004955449:16,937,794...16,945,731 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 acts_upstream_of_or_within ISO (PMID:9520487) MGI PMID:9520487 NCBI chrNW_004955504:721,470...747,553
Ensembl chrNW_004955504:721,429...747,630 		JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO (PMID:10707987) MGI PMID:10707987 NCBI chrNW_004955405:854,011...962,741
Ensembl chrNW_004955405:853,946...965,403 		JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in ISO (PMID:16257223) UniProt PMID:16257223 NCBI chrNW_004955406:174,949...249,248
Ensembl chrNW_004955406:172,814...249,248 		JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228), (PMID:19703902) ParkinsonsUK-UCL PMID:12457228 PMID:19703902 NCBI chrNW_004955422:13,943,590...13,951,102
Ensembl chrNW_004955422:13,943,552...13,951,137 		JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Th tyrosine hydroxylase acts_upstream_of_or_within
involved_in 		ISO (PMID:9520487)
(PMID:7592982), (PMID:7715703)
PMID:11943812 		RGD
MGI
BHF-UCL		 PMID:2427363 PMID:7592982 PMID:7715703 PMID:9520487 PMID:11943812 More... RGD:1580046 RGD:5129111 RGD:5130972 NCBI chrNW_004955422:13,943,590...13,951,102
Ensembl chrNW_004955422:13,943,552...13,951,137 		JBrowse link
epinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnmt phenylethanolamine N-methyltransferase ISO RGD PMID:7914070 RGD:4139902 NCBI chrNW_004955451:14,414,836...14,417,972
Ensembl chrNW_004955451:14,416,121...14,417,901 		JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228) BHF-UCL PMID:12457228 NCBI chrNW_004955422:13,943,590...13,951,102
Ensembl chrNW_004955422:13,943,552...13,951,137 		JBrowse link
histamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdc histidine decarboxylase involved_in
acts_upstream_of_or_within 		ISO (PMID:22767596)
(PMID:11478947) 		UniProt
MGI		 PMID:11478947 PMID:22767596 NCBI chrNW_004955409:4,051,574...4,072,641
Ensembl chrNW_004955409:4,051,271...4,072,642 		JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nt5dc2 5'-nucleotidase domain containing 2 involved_in ISO PMID:31279527 UniProt PMID:31279527 RGD:408345212 NCBI chrNW_004955430:2,517,943...2,526,423
Ensembl chrNW_004955430:2,517,943...2,526,423 		JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:4405722)
(PMID:4858102) 		MGI PMID:4405722 PMID:4858102 NCBI chrNW_004955557:1,355,471...1,515,725
Ensembl chrNW_004955557:1,355,397...1,515,393 		JBrowse link
G Dbh dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within 		ISO (PMID:27148966), (PMID:7715704)
(PMID:10051631), (PMID:9603211) 		RGD
UniProt
MGI		 PMID:7715704 PMID:9603211 PMID:10051631 PMID:10573542 PMID:27148966 RGD:1625403 NCBI chrNW_004955513:2,918,085...2,932,481
Ensembl chrNW_004955513:2,918,286...2,932,247 		JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chrNW_004955441:13,244,626...13,328,220
Ensembl chrNW_004955441:13,244,626...13,328,369 		JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO (PMID:10835639) MGI PMID:10835639 NCBI chrNW_004955421:24,448,446...24,477,885
Ensembl chrNW_004955421:24,457,496...24,478,744 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 acts_upstream_of_positive_effect ISO (PMID:19008477) BHF-UCL PMID:19008477 NCBI chrNW_004955403:33,478,034...33,481,613
Ensembl chrNW_004955403:33,478,924...33,481,608 		JBrowse link
G Insm1 INSM transcriptional repressor 1 involved_in ISO (PMID:18094025) UniProt PMID:18094025 NCBI chrNW_004955415:28,396,176...28,398,114 JBrowse link
G Kl klotho ISO RGD PMID:20086041 RGD:10403068 NCBI chrNW_004955431:12,782,913...12,833,215
Ensembl chrNW_004955431:12,782,846...12,833,215 		JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228) BHF-UCL PMID:12457228 NCBI chrNW_004955422:13,943,590...13,951,102
Ensembl chrNW_004955422:13,943,552...13,951,137 		JBrowse link
polyamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sat1 spermidine/spermine N1-acetyltransferase 1 involved_in ISO (PMID:15283699) UniProt PMID:15283699 NCBI chrNW_004955509:4,198,876...4,202,103
Ensembl chrNW_004955509:4,198,651...4,202,483 		JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 NOT|involved_in ISO (PMID:15283699) UniProt PMID:15283699 NCBI chrNW_004955467:9,306,210...9,308,668
Ensembl chrNW_004955467:9,305,746...9,308,668 		JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chrNW_004955441:13,244,626...13,328,220
Ensembl chrNW_004955441:13,244,626...13,328,369 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO (PMID:19703902) ParkinsonsUK-UCL PMID:19703902 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (PMID:26203154) ParkinsonsUK-UCL PMID:26203154 NCBI chrNW_004955448:207,582...240,264
Ensembl chrNW_004955448:204,991...240,160 		JBrowse link
positive regulation of spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Paox polyamine oxidase involved_in ISO (PMID:16354669) UniProt PMID:16354669 NCBI chrNW_004955477:11,028,488...11,038,556
Ensembl chrNW_004955477:11,028,488...11,038,556 		JBrowse link
putrescine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Odc1 ornithine decarboxylase 1 ISO RGD PMID:1415709 PMID:10430362 RGD:1578320 RGD:7242912 NCBI chrNW_004955487:5,603,722...5,608,386
Ensembl chrNW_004955487:5,603,722...5,608,386 		JBrowse link
G Paox polyamine oxidase involved_in ISO (PMID:16354669) UniProt PMID:16354669 NCBI chrNW_004955477:11,028,488...11,038,556
Ensembl chrNW_004955477:11,028,488...11,038,556 		JBrowse link
putrescine biosynthetic process from arginine, via ornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Odc1 ornithine decarboxylase 1 involved_in ISO (PMID:24967154) UniProt PMID:24967154 NCBI chrNW_004955487:5,603,722...5,608,386
Ensembl chrNW_004955487:5,603,722...5,608,386 		JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member involved_in ISO (PMID:26711020) UniProt PMID:26711020 NCBI chrNW_004955482:8,352,569...8,383,097
Ensembl chrNW_004955482:8,352,569...8,384,899 		JBrowse link
spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 ISO RGD PMID:1415709 PMID:10430362 PMID:10712236 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chrNW_004955411:35,541,517...35,563,209
Ensembl chrNW_004955411:35,541,517...35,563,209 		JBrowse link
G Srm spermidine synthase involved_in ISO (PMID:17585781) RGD
UniProt		 PMID:8494549 PMID:12843627 PMID:16931179 PMID:17585781 RGD:1359042 RGD:7242920 RGD:7242928 NCBI chrNW_004955486:2,631,579...2,634,779
Ensembl chrNW_004955486:2,631,586...2,634,527 		JBrowse link
spermine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 ISO RGD PMID:1415709 PMID:10430362 PMID:10712236 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chrNW_004955411:35,541,517...35,563,209
Ensembl chrNW_004955411:35,541,517...35,563,209 		JBrowse link
G Sms spermine synthase ISO RGD PMID:8494549 RGD:7242928 NCBI chrNW_004955509:2,277,501...2,328,612
Ensembl chrNW_004955509:2,276,878...2,329,620 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12628
    cellular process 12059
      metabolic process 7975
        amine metabolic process 101
          biogenic amine metabolic process 93
            biogenic amine biosynthetic process 33
              catecholamine biosynthetic process + 25
              choline biosynthetic process + 0
              ethanolamine biosynthetic process 0
              histamine biosynthetic process 1
              indolalkylamine biosynthetic process + 0
              nicotianamine biosynthetic process 0
              octopamine biosynthetic process 0
              phenylethylamine biosynthetic process + 0
              polyamine biosynthetic process + 7
paths to the root