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ONTOLOGY REPORT - ANNOTATIONS


Term:biogenic amine biosynthetic process
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Accession:GO:0042401 term browser browse the term
Definition:The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
Synonyms:exact_synonym: biogenic amine anabolism;   biogenic amine biosynthesis;   biogenic amine formation;   biogenic amine synthesis;   cellular biogenic amine biosynthetic process



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catecholamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:17194738 RGD:5131263 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
JBrowse link
G Dbh dopamine beta-hydroxylase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Ddc dopa decarboxylase involved_in TAS
IEA
GO_REF:0000043 UniProt
RGD
PMID:12047348 GO_REF:0000043, RGD:727571 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Hdc histidine decarboxylase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556
JBrowse link
G Th tyrosine hydroxylase involved_in IDA
IEA
GO_REF:0000002
GO_REF:0000043
InterPro
UniProt
RGD
PMID:20025246 GO_REF:0000002 GO_REF:0000043, RGD:4139888 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:20097214 RGD:6903884 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:20097214 RGD:6903884 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEP RGD PMID:12438507 RGD:704388 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:19818757 RGD:5143981 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Dao D-amino-acid oxidase involved_in ISO
IEA
ISS
(PMID:17303072)
GO_REF:0000107
(PMID:17042912)
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17042912 PMID:17303072 GO_REF:0000024 GO_REF:0000107 NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
JBrowse link
G Ddc dopa decarboxylase involved_in IDA
ISO
IEA
(PMID:19703902)
GO_REF:0000107
GO_REF:0000041
RGD
Ensembl
UniProt
PMID:19703902 PMID:12703659 GO_REF:0000041 GO_REF:0000107, RGD:4139893 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO (PMID:16338639) RGD PMID:16338639 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Gpr37 G protein-coupled receptor 37 acts_upstream_of_or_within ISO
IEA
MGI:3027995 (PMID:15218106)
GO_REF:0000107
RGD
Ensembl
PMID:15218106 GO_REF:0000107 NCBI chr 4:54,138,860...54,160,927
Ensembl chr 4:54,138,870...54,161,001
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 acts_upstream_of_or_within ISO MGI:2429971 (PMID:16782508), (PMID:9608532) RGD PMID:9608532 PMID:16782508 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Slc6a3 solute carrier family 6 member 3 acts_upstream_of_or_within ISO
IEA
MGI:2386303 (PMID:9520487)
GO_REF:0000107
RGD
Ensembl
PMID:9520487 GO_REF:0000107 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO
IEA
MGI:1888382 (PMID:10707987)
GO_REF:0000107
RGD
Ensembl
PMID:10707987 GO_REF:0000107 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:16257223)
UniProt
Ensembl
RGD
PMID:16257223 GO_REF:0000024 GO_REF:0000107 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Th tyrosine hydroxylase involved_in IEA
ISO
GO_REF:0000041
(PMID:12457228), (PMID:19703902)
UniProt
RGD
PMID:12457228 PMID:19703902 GO_REF:0000041 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Th tyrosine hydroxylase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
IMP
MGI:1860450 (PMID:7592982), (PMID:7715703), (PMID:9520487)
GO_REF:0000033
PMID:11943812
RGD
GO_Central
PMID:7592982 PMID:7715703 PMID:9520487 PMID:2427363 PMID:11943812 More... GO_REF:0000033, RGD:1580046, RGD:5129111, RGD:5130972 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
epinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnmt phenylethanolamine-N-methyltransferase involved_in TAS
IEA
IDA
IC
GO_REF:0000041 UniProt
RGD
PMID:11514309 PMID:7914070 PMID:7503429 GO_REF:0000041, RGD:628457, RGD:4139902, RGD:4139901 NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556
JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
histamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdc histidine decarboxylase involved_in
acts_upstream_of_or_within
ISO
IEA
IBA
(PMID:22767596)
GO_REF:0000107
MGI:2182618 (PMID:11478947)
GO_REF:0000033
GO_REF:0000041
RGD
Ensembl
GO_Central
UniProt
PMID:11478947 PMID:22767596 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO
IEA
(PMID:10318872)
GO_REF:0000107
RGD
Ensembl
PMID:10318872 GO_REF:0000107 NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102
JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nt5dc2 5'-nucleotidase domain containing 2 involved_in IMP PMID:31279527 UniProt PMID:31279527 RGD:408345212 NCBI chr16:6,322,485...6,330,538
Ensembl chr16:6,322,236...6,330,537
JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856097|MGI:1856098 (PMID:4405722), (PMID:4858102) RGD PMID:4405722 PMID:4858102 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Dbh dopamine beta-hydroxylase acts_upstream_of_or_within
involved_in
TAS
IEA
IMP
ISS
ISO
IBA
GO_REF:0000107
GO_REF:0000041
GO_REF:0000024
(PMID:27148966)
GO_REF:0000033
MGI:1857556 (PMID:10051631), (PMID:9603211)
(PMID:27148966), (PMID:7715704)
Ensembl
UniProt
RGD
GO_Central
PMID:7715704 PMID:9603211 PMID:10051631 PMID:27148966 PMID:11914591 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:727567, RGD:1625403 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO
IEA
MGI:2153826 (PMID:10835639)
GO_REF:0000107
RGD
Ensembl
PMID:10835639 GO_REF:0000107 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 acts_upstream_of_positive_effect ISO
IEA
(PMID:19008477)
GO_REF:0000107
RGD
Ensembl
PMID:19008477 GO_REF:0000107 NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891
JBrowse link
G Insm1 INSM transcriptional repressor 1 involved_in ISO (PMID:18094025) RGD PMID:18094025 NCBI chr 3:133,640,030...133,642,963
Ensembl chr 3:133,639,580...133,643,003
JBrowse link
G Kl Klotho IMP RGD PMID:20086041 RGD:10403068 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Moxd1 monooxygenase, DBH-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:22,894,543...22,984,599
Ensembl chr 1:21,075,122...21,161,779
JBrowse link
G Moxd2 monooxygenase, DBH-like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:70,691,373...70,699,868
Ensembl chr 4:69,724,239...69,733,299
JBrowse link
G Th tyrosine hydroxylase involved_in ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
octopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbh dopamine beta-hydroxylase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Moxd1 monooxygenase, DBH-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:22,894,543...22,984,599
Ensembl chr 1:21,075,122...21,161,779
JBrowse link
G Moxd2 monooxygenase, DBH-like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:70,691,373...70,699,868
Ensembl chr 4:69,724,239...69,733,299
JBrowse link
polyamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
JBrowse link
G Azin1 antizyme inhibitor 1 involved_in IEA GO_REF:0000002
GO_REF:0000043
InterPro
UniProt
GO_REF:0000002 GO_REF:0000043 NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578
JBrowse link
G Azin2 antizyme inhibitor 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397
JBrowse link
G Ldc1 leucine decarboxylase 1 involved_in IEA GO_REF:0000043
GO_REF:0000002
UniProt
InterPro
GO_REF:0000002 GO_REF:0000043 NCBI chr 5:142,551,120...142,563,217
Ensembl chr 5:142,552,008...142,563,074
JBrowse link
G LOC120101528 spermidine synthase-like involved_in IEA GO_REF:0000104
GO_REF:0000043
UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr 3:18,709,548...18,710,782
Ensembl chr 3:18,709,584...18,710,588
JBrowse link
G Oaz1 ornithine decarboxylase antizyme 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310
JBrowse link
G Odc1 ornithine decarboxylase 1 involved_in IEA GO_REF:0000043
GO_REF:0000002
UniProt
InterPro
GO_REF:0000002 GO_REF:0000043 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 involved_in ISO (PMID:15283699) RGD PMID:15283699 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 NOT|involved_in ISO (PMID:15283699) RGD PMID:15283699 NCBI chr10:54,340,756...54,343,507
Ensembl chr10:54,340,372...54,343,224
JBrowse link
G Sms spermine synthase involved_in IEA GO_REF:0000104
GO_REF:0000043
UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822
Ensembl chr 3:37,516,931...37,570,822
JBrowse link
G Smsl1 spermine synthase like 1 involved_in IEA GO_REF:0000043
GO_REF:0000104
UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr13:82,435,500...82,436,942
Ensembl chr13:82,435,520...82,437,158
JBrowse link
G Srm spermidine synthase involved_in IEA GO_REF:0000043
GO_REF:0000104
UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405
JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 IMP RGD PMID:19457096 RGD:5128877 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISS
ISO
GO_REF:0000024
(PMID:19703902)
ParkinsonsUK-UCL
RGD
PMID:19703902 GO_REF:0000024 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO
IEA
(PMID:26203154)
GO_REF:0000107
RGD
Ensembl
PMID:26203154 GO_REF:0000107 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618
JBrowse link
positive regulation of spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Paox polyamine oxidase involved_in ISO
IEA
(PMID:16354669)
GO_REF:0000107
RGD
Ensembl
PMID:16354669 GO_REF:0000107 NCBI chr 1:194,919,655...194,928,498
Ensembl chr 1:194,903,273...194,928,504
JBrowse link
putrescine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Odc1 ornithine decarboxylase 1 IDA RGD PMID:10430362 PMID:1415709 RGD:1578320, RGD:7242912 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Paox polyamine oxidase involved_in ISO
IEA
(PMID:16354669)
GO_REF:0000107
RGD
Ensembl
PMID:16354669 GO_REF:0000107 NCBI chr 1:194,919,655...194,928,498
Ensembl chr 1:194,903,273...194,928,504
JBrowse link
putrescine biosynthetic process from arginine, via agmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agmat agmatinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:154,043,665...154,074,278
Ensembl chr 5:154,060,151...154,074,276
JBrowse link
putrescine biosynthetic process from arginine, via ornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Azin1 antizyme inhibitor 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578
JBrowse link
G Azin2 antizyme inhibitor 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397
JBrowse link
G Ldc1 leucine decarboxylase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:142,551,120...142,563,217
Ensembl chr 5:142,552,008...142,563,074
JBrowse link
G Odc1 ornithine decarboxylase 1 involved_in ISS
IEA
ISO
IBA
GO_REF:0000024
GO_REF:0000107
(PMID:24967154)
GO_REF:0000033
GO_REF:0000041
UniProt
Ensembl
RGD
GO_Central
PMID:24967154 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:26711020)
UniProt
Ensembl
RGD
PMID:26711020 GO_REF:0000024 GO_REF:0000107 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521
JBrowse link
spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 involved_in IDA
IEA
IBA
IMP
GO_REF:0000002
GO_REF:0000043
GO_REF:0000033
InterPro
UniProt
GO_Central
RGD
PMID:10430362 PMID:1415709 PMID:10712236 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043, RGD:1578320, RGD:7242912, RGD:7242911 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
JBrowse link
G LOC120101528 spermidine synthase-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:18,709,548...18,710,782
Ensembl chr 3:18,709,584...18,710,588
JBrowse link
G Srm spermidine synthase involved_in IDA
IBA
ISO
IMP
GO_REF:0000033
(PMID:17585781)
GO_Central
RGD
PMID:17585781 PMID:12843627 PMID:8494549 PMID:16931179 GO_REF:0000033, RGD:1359042, RGD:7242928, RGD:7242920 NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405
JBrowse link
spermine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amd1 adenosylmethionine decarboxylase 1 involved_in IDA
IBA
IEA
IMP
GO_REF:0000033
GO_REF:0000002
GO_Central
InterPro
RGD
PMID:10430362 PMID:1415709 PMID:10712236 GO_REF:0000002 GO_REF:0000033, RGD:1578320, RGD:7242912, RGD:7242911 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
JBrowse link
G Sms spermine synthase involved_in IMP
IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
RGD
PMID:8494549 GO_REF:0000002 GO_REF:0000033, RGD:7242928 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822
Ensembl chr 3:37,516,931...37,570,822
JBrowse link
G Smsl1 spermine synthase like 1 involved_in IBA
IEA
GO_REF:0000033
GO_REF:0000002
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000033 NCBI chr13:82,435,500...82,436,942
Ensembl chr13:82,435,520...82,437,158
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        amine metabolic process 124
          biogenic amine metabolic process 112
            biogenic amine biosynthetic process 44
              catecholamine biosynthetic process + 29
              choline biosynthetic process + 0
              ethanolamine biosynthetic process 0
              histamine biosynthetic process 2
              indolalkylamine biosynthetic process + 0
              nicotianamine biosynthetic process 0
              octopamine biosynthetic process 3
              phenylethylamine biosynthetic process + 0
              polyamine biosynthetic process + 14
paths to the root