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ONTOLOGY REPORT - ANNOTATIONS


Term:type 2 immune response
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Accession:GO:0042092 term browser browse the term
Definition:An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects.
Synonyms:narrow_synonym: T-helper 2 type immune response;   Th2 immune response



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type 2 immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:2158438 (PMID:9171827)
GO_Central
RGD
PMID:9171827 GO_REF:0000033 NCBI chr11:90,358,753...90,382,049 JBrowse link
G Bcl6b BCL6B, transcription repressor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:54,940,908...54,947,022 JBrowse link
G Fcer1a Fc epsilon receptor Ia involved_in ISO (PMID:8114916) RGD PMID:8114916 NCBI chr13:85,686,099...85,692,394 JBrowse link
G Ighe immunoglobulin heavy constant epsilon involved_in ISO (PMID:33840121), (PMID:8114916) RGD PMID:8114916 PMID:33840121
G Il33 interleukin 33 involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
(PMID:23630360)
Ensembl
RGD
PMID:23630360 GO_REF:0000107 NCBI chr 1:237,115,478...237,149,897 JBrowse link
G Muc19 mucin 19, oligomeric acts_upstream_of_or_within ISO (PMID:37475871) RGD PMID:37475871 NCBI chr 7:124,897,424...125,018,582 JBrowse link
G Stard7 StAR-related lipid transfer domain containing 7 acts_upstream_of_or_within ISO MGI:4433666 (PMID:25980009) RGD PMID:25980009 NCBI chr 3:114,487,161...114,515,828 JBrowse link
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO MGI:3510784 (PMID:21856933) RGD PMID:21856933 NCBI chr20:44,565,992...44,609,240 JBrowse link
negative regulation of T-helper 2 cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:19360123)
Ensembl
RGD
PMID:19360123 GO_REF:0000107 NCBI chr 1:22,295,093...22,307,720 JBrowse link
G Ifnb1 interferon beta 1 involved_in ISO (PMID:20554961) RGD PMID:20554961 NCBI chr 5:108,066,650...108,067,487 JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:10761931), (PMID:23616576) RGD PMID:10761931 PMID:23616576 NCBI chr10:82,082,322...82,098,831 JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:17008549)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:17008549 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:227,287,713...227,306,739 JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (PMID:24463518) RGD PMID:24463518 NCBI chr 1:198,148,999...198,151,406 JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:96559 (PMID:12594267) RGD PMID:12594267 NCBI chr11:90,358,753...90,382,049 JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (PMID:16424184) RGD PMID:16424184 NCBI chr13:98,811,852...98,817,264 JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) RGD PMID:12242343 NCBI chr 6:13,235,157...13,266,161 JBrowse link
G Zfp35 zinc finger protein 35 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:15,268,852...15,284,334 JBrowse link
negative regulation of type 2 immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:27214549)
Ensembl
RGD
PMID:27214549 GO_REF:0000107 NCBI chr 6:103,669,001...103,694,375 JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034 (PMID:10438949) RGD PMID:10438949 NCBI chr11:90,358,753...90,382,049 JBrowse link
G Ccr2 C-C motif chemokine receptor 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:14662900)
BHF-UCL
RGD
PMID:14662900 GO_REF:0000024 NCBI chr 8:132,611,883...132,619,106 JBrowse link
G Ifnl1 interferon, lambda 1 involved_in ISO (PMID:19346497) RGD PMID:19346497 NCBI chr 1:83,798,651...83,800,297 JBrowse link
G Il27ra interleukin 27 receptor subunit alpha acts_upstream_of_or_within ISO MGI:3525439 (PMID:11057672) RGD PMID:11057672 NCBI chr19:24,109,963...24,121,977 JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3695433 (PMID:17137798)
Ensembl
RGD
PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:107187 (PMID:10438949) RGD PMID:10438949 NCBI chr 7:65,365,505...65,382,825 JBrowse link
positive regulation of T-helper 2 cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:8766544)
GO_REF:0000107
(PMID:11046035)
UniProt
RGD
Ensembl
PMID:8766544 PMID:11046035 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,235,861...198,251,660 JBrowse link
G Dennd1b DENN domain containing 1B involved_in ISO (PMID:26774822) RGD PMID:26774822 NCBI chr13:50,545,324...50,772,922 JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO (PMID:15087456) RGD PMID:15087456 NCBI chr17:73,544,234...73,575,670 JBrowse link
G Il4 interleukin 4 involved_in ISO (PMID:20554961) RGD PMID:20554961 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:11159963) RGD PMID:11159963 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (PMID:26098997) RGD PMID:26098997 NCBI chr10:44,826,299...44,853,373 JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO
GO_REF:0000024
(PMID:15987782)
UniProt
RGD
PMID:15987782 GO_REF:0000024 NCBI chr 5:165,817,786...165,930,386 JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19047684)
UniProt
Ensembl
RGD
PMID:19047684 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:48,774,985...48,788,245 JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:9973465)
Ensembl
RGD
PMID:9973465 GO_REF:0000107 NCBI chr13:77,248,687...77,252,343 JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA
ISO
GO_REF:0000107
(PMID:12829194)
Ensembl
RGD
PMID:12829194 GO_REF:0000107 NCBI chr 8:59,802,072...59,829,275 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:189,545,739...189,570,639 JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) RGD PMID:12594267 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (PMID:26098997) RGD PMID:26098997 NCBI chr10:44,826,299...44,853,373 JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO
GO_REF:0000024
(PMID:15987782)
UniProt
RGD
PMID:15987782 GO_REF:0000024 NCBI chr 5:165,817,786...165,930,386 JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:84,379,780...84,424,371 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18354165) RGD PMID:18354165 NCBI chr13:76,256,654...76,280,133 JBrowse link
positive regulation of type 2 immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule involved_in IBA
ISO
GO_REF:0000033
(PMID:11823488)
GO_Central
RGD
PMID:11823488 GO_REF:0000033 NCBI chr18:56,527,071...56,536,406 JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3505776 (PMID:18436652)
Ensembl
RGD
PMID:18436652 GO_REF:0000107 NCBI chr16:74,133,259...74,145,328 JBrowse link
G Il33 interleukin 33 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:P08226 (PMID:18268038)
(PMID:23630360)
Ensembl
RGD
PMID:18268038 PMID:23630360 GO_REF:0000107 NCBI chr 1:237,115,478...237,149,897 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (PMID:26098997) RGD PMID:26098997 NCBI chr10:44,826,299...44,853,373 JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 involved_in ISO (PMID:21172192) RGD PMID:21172192 NCBI chr19:34,555,832...34,596,281 JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:12496423), (PMID:17785785), (PMID:18354165) RGD PMID:12496423 PMID:17785785 PMID:18354165 NCBI chr13:76,256,654...76,280,133 JBrowse link
regulation of type 2 immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ecm1 extracellular matrix protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:4940879 (PMID:21217760)
Ensembl
RGD
PMID:21217760 GO_REF:0000107 NCBI chr 2:183,287,491...183,292,729 JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO
GO_REF:0000024
(PMID:20421391), (PMID:21572431)
UniProt
RGD
PMID:20421391 PMID:21572431 GO_REF:0000024 NCBI chr 6:105,353,715...105,376,051 JBrowse link
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO MGI:2158443 (PMID:16081776) RGD PMID:16081776 NCBI chr 1:88,599,321...88,613,555 JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of ISO MGI:96559 (PMID:12594267) RGD PMID:12594267 NCBI chr11:90,358,753...90,382,049 JBrowse link
G Gata3 GATA binding protein 3 involved_in
acts_upstream_of_or_within
ISO (PMID:20484083)
(PMID:20706986)
RGD PMID:20484083 PMID:20706986 NCBI chr17:73,544,234...73,575,670 JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of ISO MGI:105367|MGI:2182089 (PMID:16424184) RGD PMID:16424184 NCBI chr13:98,811,852...98,817,264 JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) RGD PMID:20706986 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:189,545,739...189,570,639 JBrowse link
G Il6 interleukin 6 acts_upstream_of ISO (PMID:12594267) RGD PMID:12594267 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Kmt2a lysine methyltransferase 2A involved_in ISO (PMID:20484083) RGD PMID:20484083 NCBI chr 8:54,013,547...54,089,219 JBrowse link
G Men1 menin 1 involved_in ISO
IEA
(PMID:20484083)
GO_REF:0000107
RGD
Ensembl
PMID:20484083 GO_REF:0000107 NCBI chr 1:203,638,905...203,644,871 JBrowse link
G Myb MYB proto-oncogene, transcription factor involved_in ISO (PMID:20484083) RGD PMID:20484083 NCBI chr 1:17,759,309...17,793,306 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    response to stimulus 11012
      immune response 2219
        type 2 immune response 44
          T-helper 2 cell cytokine production + 12
          T-helper 2 cell differentiation + 20
          negative regulation of type 2 immune response + 15
          positive regulation of type 2 immune response + 17
          regulation of type 2 immune response + 33
paths to the root