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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 1 type immune response
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Accession:GO:0042088 term browser browse the term
Definition:An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.
Synonyms:exact_synonym: Th1 immune response


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T-helper 1 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO MGI:1861796 (PMID:9009202) RGD PMID:9009202 NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Hras HRas proto-oncogene, GTPase acts_upstream_of_or_within ISO MGI:2385945 (PMID:21444916) RGD PMID:21444916 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Il18 interleukin 18 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:8766574)		 Ensembl
RGD		 PMID:8766574 PMID:8766574 GO_REF:0000107, RGD:8554620 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il18bp interleukin 18 binding protein involved_in ISO
IEA
IBA		 (PMID:10023777)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:10023777 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:165,784,916...165,787,990
Ensembl chr 1:156,372,883...156,374,963 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO
IEA		 MGI:2179544 (PMID:7845467)
GO_REF:0000107		 RGD
Ensembl		 PMID:7845467 GO_REF:0000107 NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:15795121) RGD PMID:15795121 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Traf6 TNF receptor associated factor 6 acts_upstream_of_or_within ISO MGI:2678775 (PMID:14499111) RGD PMID:14499111 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Vegfa vascular endothelial growth factor A IDA RGD PMID:15034080 RGD:1580562 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO
IEA		 (PMID:24463518)
GO_REF:0000107		 RGD
Ensembl		 PMID:24463518 GO_REF:0000107 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16020505)		 BHF-UCL
RGD		 PMID:16020505 GO_REF:0000024 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO
IEA		 (PMID:9670042)
GO_REF:0000107		 RGD
Ensembl		 PMID:9670042 GO_REF:0000107 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
negative regulation of T-helper 1 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:14556006)
(PMID:16286920)		 RGD PMID:14556006 PMID:16286920 NCBI chr10:31,383,801...31,415,334
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P08226 (PMID:18268038)		 Ensembl
RGD		 PMID:18268038 GO_REF:0000107 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il33 interleukin 33 involved_in ISO UniProtKB:P08226 (PMID:18268038) RGD PMID:18268038 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16286920) RGD PMID:16286920 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
positive regulation of T-helper 1 cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arid5a AT-rich interaction domain 5A involved_in ISO (PMID:27671645) RGD PMID:27671645 NCBI chr 9:46,030,513...46,058,729
Ensembl chr 9:38,534,590...38,547,597 		JBrowse link
G Il18 interleukin 18 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:10653850)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:10653850 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il18r1 interleukin 18 receptor 1 involved_in ISO
IEA		 (PMID:10653850)
GO_REF:0000107		 RGD
Ensembl		 PMID:10653850 GO_REF:0000107 NCBI chr 9:50,223,274...50,257,370
Ensembl chr 9:42,727,869...42,760,715 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO
ISS		 (PMID:10653850)
GO_REF:0000024		 RGD
UniProt		 PMID:10653850 GO_REF:0000024 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 involved_in ISO
ISS
IEA		 (PMID:10653850)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:10653850 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO
IEA		 (PMID:9126961)
GO_REF:0000107		 RGD
Ensembl		 PMID:9126961 GO_REF:0000107 NCBI chr13:86,802,708...86,837,890
Ensembl chr13:84,270,316...84,305,497 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO
IEA		 (PMID:10761931)
GO_REF:0000107		 RGD
Ensembl		 PMID:10761931 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:9973465)		 Ensembl
RGD		 PMID:9973465 GO_REF:0000107 NCBI chr13:79,781,784...79,785,440
Ensembl chr13:77,248,717...77,252,329 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:17008549)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:17008549 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO
IEA		 MGI:105367|MGI:2182089 (PMID:16424184)
GO_REF:0000107		 RGD
Ensembl		 PMID:16424184 GO_REF:0000107 NCBI chr13:98,811,852...98,817,264
Ensembl chr13:96,280,339...96,285,750 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO
IEA		 MGI:2446070 (PMID:11894097)
GO_REF:0000107		 RGD
Ensembl		 PMID:11894097 GO_REF:0000107 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) RGD PMID:12242343 NCBI chr 6:13,235,157...13,266,161
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
positive regulation of T-helper 1 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:10657654)		 BHF-UCL
RGD		 PMID:10657654 GO_REF:0000024 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Il12b interleukin 12B involved_in ISO
IEA		 (PMID:15114670)
GO_REF:0000107
(PMID:14688363)		 RGD
Ensembl		 PMID:14688363 PMID:15114670 GO_REF:0000107 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 involved_in ISO (PMID:15114670) RGD PMID:15114670 NCBI chr16:18,654,207...18,668,887
Ensembl chr16:18,620,770...18,632,769 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO
IEA
IBA		 (PMID:15114670)
GO_REF:0000107
GO_REF:0000033
(PMID:14688363)		 RGD
Ensembl
GO_Central		 PMID:14688363 PMID:15114670 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il23r interleukin 23 receptor involved_in ISO (PMID:15114670) RGD PMID:15114670 NCBI chr 4:97,910,230...98,003,759
Ensembl chr 4:96,580,714...96,674,021 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha acts_upstream_of_or_within ISO
IEA		 MGI:3525439 (PMID:11057672)
GO_REF:0000107		 RGD
Ensembl		 PMID:11057672 GO_REF:0000107 NCBI chr19:41,014,730...41,026,740
Ensembl chr19:24,109,972...24,121,938 		JBrowse link
G Nlrp10 NLR family, pyrin domain containing 10 involved_in ISO
IEA		 (PMID:23071280)
GO_REF:0000107		 RGD
Ensembl		 PMID:23071280 GO_REF:0000107 NCBI chr 1:172,357,648...172,365,205
Ensembl chr 1:162,922,806...162,930,363 		JBrowse link
G Pla2g4a phospholipase A2 group 4A involved_in IEA
ISO		 GO_REF:0000107
(PMID:16172261)		 Ensembl
RGD		 PMID:16172261 GO_REF:0000107 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO
IEA		 MGI:2446070 (PMID:11894097)
GO_REF:0000107		 RGD
Ensembl		 PMID:11894097 GO_REF:0000107 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G RT1-Bb RT1 class II, locus Bb involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 acts_upstream_of_or_within ISO
IEA		 (PMID:18984740)
GO_REF:0000107		 RGD
Ensembl		 PMID:18984740 GO_REF:0000107 NCBI chr 9:83,406,327...83,417,252
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il27 interleukin 27 involved_in ISO
IEA
IBA		 (PMID:12734330)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:12734330 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cracr2a calcium release activated channel regulator 2A involved_in ISO (PMID:29987160) RGD PMID:29987160 NCBI chr 4:160,428,987...160,517,427
Ensembl chr 4:160,408,077...160,518,107 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of ISO
IEA		 MGI:105367|MGI:2182089 (PMID:16424184)
GO_REF:0000107		 RGD
Ensembl		 PMID:16424184 GO_REF:0000107 NCBI chr13:98,811,852...98,817,264
Ensembl chr13:96,280,339...96,285,750 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:15944249) RGD PMID:15944249 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Il18r1 interleukin 18 receptor 1 acts_upstream_of_or_within ISO
IEA		 MGI:2136765 (PMID:10227969)
GO_REF:0000107		 RGD
Ensembl		 PMID:10227969 GO_REF:0000107 NCBI chr 9:50,223,274...50,257,370
Ensembl chr 9:42,727,869...42,760,715 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:18579517)		 Ensembl
RGD		 PMID:18579517 GO_REF:0000107 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:3046930 (PMID:31182790) RGD PMID:31182790 NCBI chr11:58,251,720...58,279,767
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit acts_upstream_of_or_within ISO
IEA		 MGI:2179545 (PMID:16081776)
GO_REF:0000107		 RGD
Ensembl		 PMID:16081776 GO_REF:0000107 NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Sema4a semaphorin 4A involved_in ISO
IEA		 (PMID:15780988)
GO_REF:0000107		 RGD
Ensembl		 PMID:15780988 GO_REF:0000107 NCBI chr 2:176,194,248...176,215,752
Ensembl chr 2:173,896,439...173,914,442 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 involved_in ISO (PMID:14688310) RGD PMID:14688310 NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tmem98 transmembrane protein 98 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:25946230)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:25946230 GO_REF:0000024 GO_REF:0000107 NCBI chr10:66,293,895...66,304,806
Ensembl chr10:65,796,145...65,807,079 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within ISO MGI:103034 (PMID:20706986) RGD PMID:20706986 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IEA
ISO		 GO_REF:0000107
(PMID:26410627)		 Ensembl
RGD		 PMID:26410627 GO_REF:0000107 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Spn sialophorin involved_in ISO
ISS		 (PMID:18036228)
GO_REF:0000024		 RGD
UniProt		 PMID:18036228 GO_REF:0000024 NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:96556 (PMID:20706986) RGD PMID:20706986 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO
IEA		 (PMID:10761931)
GO_REF:0000107		 RGD
Ensembl		 PMID:10761931 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    response to stimulus 11081
      immune response 2238
        adaptive immune response 668
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 474
            T-helper 1 type immune response 50
              T-helper 1 cell cytokine production + 8
              T-helper 1 cell differentiation + 24
              negative regulation of T-helper 1 type immune response + 8
              positive regulation of T-helper 1 type immune response + 19
              regulation of T-helper 1 type immune response + 32
paths to the root