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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of cytoplasmic pattern recognition receptor signaling pathway
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Accession:GO:0039532 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway.
Synonyms:exact_synonym: negative regulation of cytosolic pattern recognition receptor signaling pathway
 narrow_synonym: negative regulation of cytoplasmic pattern recognition receptor signaling pathway in response to virus;   negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway;   negative regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway
 related_synonym: negative regulation of MAVS signaling


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negative regulation of cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itch itchy E3 ubiquitin protein ligase involved_in ISO
IEA		 (PMID:27736772)
GO_REF:0000107		 RGD
Ensembl		 PMID:27736772 GO_REF:0000107 NCBI chr 3:164,102,490...164,193,932
Ensembl chr 3:143,645,637...143,733,543 		JBrowse link
G Marchf5 membrane associated ring-CH-type finger 5 involved_in IEA
ISO		 GO_REF:0000107
(PMID:31881323)		 Ensembl
RGD		 PMID:31881323 GO_REF:0000107 NCBI chr 1:244,343,674...244,365,160
Ensembl chr 1:234,931,271...234,952,632 		JBrowse link
G Rnf39 ring finger protein 39 involved_in ISO (PMID:33674311) RGD PMID:33674311 NCBI chr20:1,610,027...1,615,516
Ensembl chr20:1,604,794...1,610,283 		JBrowse link
G Sec14l1 SEC14-like lipid binding 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:23843640)		 Ensembl
RGD		 PMID:23843640 GO_REF:0000107 NCBI chr10:102,818,693...102,865,841
Ensembl chr10:102,319,920...102,367,068 		JBrowse link
G Tarbp2 Tarbp2 subunit of RISC loading complex involved_in ISO
IEA		 (PMID:30927622)
GO_REF:0000107		 RGD
Ensembl		 PMID:30927622 GO_REF:0000107 NCBI chr 7:135,527,710...135,532,826
Ensembl chr 7:133,649,090...133,654,314 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 involved_in ISO
IEA		 (PMID:27736772)
GO_REF:0000107		 RGD
Ensembl		 PMID:27736772 GO_REF:0000107 NCBI chr 4:83,152,549...83,208,463
Ensembl chr 4:81,821,989...81,879,100 		JBrowse link
G Tspan6 tetraspanin 6 involved_in ISO
IEA		 (PMID:22908223)
GO_REF:0000107		 RGD
Ensembl		 PMID:22908223 GO_REF:0000107 NCBI chr  X:101,385,686...101,395,371
Ensembl chr  X:97,092,388...97,099,309 		JBrowse link
negative regulation of AIM2 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trim11 tripartite motif-containing 11 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:27498865)		 UniProt
Ensembl
RGD		 PMID:27498865 GO_REF:0000024 GO_REF:0000107 NCBI chr10:44,255,019...44,270,711
Ensembl chr10:43,758,354...43,771,138 		JBrowse link
negative regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars2 alanyl-tRNA synthetase 2, mitochondrial involved_in ISO
ISS		 (PMID:39322678)
GO_REF:0000024		 RGD
UniProt		 PMID:39322678 GO_REF:0000024 NCBI chr 9:22,981,880...22,993,536
Ensembl chr 9:15,297,531...15,496,090 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:12172553), (PMID:26440888)		 Ensembl
RGD		 PMID:12172553 PMID:26440888 GO_REF:0000107 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aurkb aurora kinase B involved_in IEA
ISO		 GO_REF:0000107
(PMID:33542149)		 Ensembl
RGD		 PMID:33542149 GO_REF:0000107 NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Banf1 barrier to autointegration nuclear assembly factor 1 involved_in ISO
IEA		 (PMID:32792394)
GO_REF:0000107		 RGD
Ensembl		 PMID:32792394 GO_REF:0000107 NCBI chr 1:212,101,523...212,103,568
Ensembl chr 1:202,671,305...202,674,188 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO
IEA		 (PMID:32911482), (PMID:32912999)
GO_REF:0000107		 RGD
Ensembl		 PMID:32911482 PMID:32912999 GO_REF:0000107 NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:79,294,511...79,305,496 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISO (PMID:32715615) RGD PMID:32715615 NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Lyplal1 lysophospholipase-like 1 involved_in ISO (PMID:37802025) RGD PMID:37802025 NCBI chr13:100,158,060...100,189,339
Ensembl chr13:97,626,451...97,657,867 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in ISO
IEA		 (PMID:35460603)
GO_REF:0000107		 RGD
Ensembl		 PMID:35460603 GO_REF:0000107 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcbp2 poly(rC) binding protein 2 involved_in ISO (PMID:35322803) RGD PMID:35322803 NCBI chr 7:135,483,702...135,508,254
Ensembl chr 7:133,605,573...133,629,863 		JBrowse link
G Ppp6c protein phosphatase 6, catalytic subunit involved_in ISO
IEA		 (PMID:32474700)
GO_REF:0000107		 RGD
Ensembl		 PMID:32474700 GO_REF:0000107 NCBI chr 3:43,339,521...43,371,807
Ensembl chr 3:22,931,577...22,962,113 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in ISO (PMID:33273464) RGD PMID:33273464 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:37890481)		 UniProt
Ensembl
RGD		 PMID:37890481 GO_REF:0000024 GO_REF:0000107 NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,132,592...37,155,567 		JBrowse link
G Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 involved_in ISO (PMID:38418882) RGD PMID:38418882 NCBI chr10:14,411,692...14,417,357
Ensembl chr10:13,907,253...13,912,841 		JBrowse link
G Trex1 three prime repair exonuclease 1 involved_in ISO
IEA		 (PMID:33476576)
GO_REF:0000107		 RGD
Ensembl		 PMID:33476576 GO_REF:0000107 NCBI chr 8:118,585,082...118,586,382
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Zdhhc18 zinc finger DHHC-type palmitoyltransferase 18 involved_in IEA
ISO		 GO_REF:0000107
(PMID:35438208)		 Ensembl
RGD		 PMID:35438208 GO_REF:0000107 NCBI chr 5:151,105,303...151,143,843
Ensembl chr 5:145,831,446...145,859,993 		JBrowse link
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in ISO
IEA
ISS		 (PMID:19164550)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:19164550 GO_REF:0000024 GO_REF:0000107 NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Dhx58 DEXH-box helicase 58 involved_in ISO
IEA		 (PMID:21187438)
GO_REF:0000107		 RGD
Ensembl		 PMID:21187438 GO_REF:0000107 NCBI chr10:86,120,677...86,132,095
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G Riok3 RIO kinase 3 involved_in ISO
IEA		 (PMID:25865883)
GO_REF:0000107		 RGD
Ensembl		 PMID:25865883 GO_REF:0000107 NCBI chr18:3,602,535...3,628,108
Ensembl chr18:3,327,776...3,353,343 		JBrowse link
G Tkfc triokinase and FMN cyclase involved_in ISS
ISO		 GO_REF:0000024
(PMID:17600090)		 UniProt
RGD		 PMID:17600090 GO_REF:0000024 NCBI chr 1:216,664,446...216,677,815
Ensembl chr 1:207,236,557...207,252,737 		JBrowse link
negative regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd17a abhydrolase domain containing 17A, depalmitoylase involved_in ISO
IEA		 (PMID:38092000)
GO_REF:0000107		 RGD
Ensembl		 PMID:38092000 GO_REF:0000107 NCBI chr 7:9,775,016...9,781,447
Ensembl chr 7:9,124,332...9,130,762 		JBrowse link
G Abhd8 abhydrolase domain containing 8 involved_in IEA
ISO		 GO_REF:0000107
(PMID:39225180)		 Ensembl
RGD		 PMID:39225180 GO_REF:0000107 NCBI chr16:18,178,441...18,185,178
Ensembl chr16:18,144,464...18,157,667 		JBrowse link
G Cptp ceramide-1-phosphate transfer protein involved_in ISO
ISS		 (PMID:29164996)
GO_REF:0000024		 RGD
UniProt		 PMID:29164996 GO_REF:0000024 NCBI chr 5:171,757,181...171,761,271
Ensembl chr 5:166,474,966...166,479,017 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:34615873)		 UniProt
RGD		 PMID:34615873 GO_REF:0000024 NCBI chr18:57,285,156...57,320,540
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Fbxl2 F-box and leucine-rich repeat protein 2 involved_in ISO
IEA		 (PMID:26037928)
GO_REF:0000107		 RGD
Ensembl		 PMID:26037928 GO_REF:0000107 NCBI chr 8:122,794,870...122,843,265
Ensembl chr 8:113,913,373...113,965,066 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in ISO (PMID:36586411) RGD PMID:36586411 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:30612879)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:30612879 GO_REF:0000024 GO_REF:0000107 NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in ISO (PMID:36586411) RGD PMID:36586411 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Mefv MEFV innate immunity regulator, pyrin involved_in ISS
ISO		 GO_REF:0000024
(PMID:26347139)		 UniProt
RGD		 PMID:26347139 GO_REF:0000024 NCBI chr10:12,288,514...12,303,337
Ensembl chr10:11,787,422...11,796,973 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO
IEA		 (PMID:25277106)
GO_REF:0000107		 RGD
Ensembl		 PMID:25277106 GO_REF:0000107 NCBI chr10:12,055,809...12,093,449
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Sirt2 sirtuin 2 acts_upstream_of_or_within ISO
IEA		 (PMID:23502856)
GO_REF:0000107		 RGD
Ensembl		 PMID:23502856 GO_REF:0000107 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within ISO
IEA		 (PMID:32514138)
(PMID:29887864)
GO_REF:0000107		 RGD
Ensembl		 PMID:29887864 PMID:32514138 GO_REF:0000107 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trim31 tripartite motif-containing 31 involved_in ISO
IEA		 (PMID:27929086)
GO_REF:0000107		 RGD
Ensembl		 PMID:27929086 GO_REF:0000107 NCBI chr20:1,658,386...1,671,711
Ensembl chr20:1,653,165...1,666,494 		JBrowse link
G Trim65 tripartite motif-containing 65 involved_in IEA
ISO		 GO_REF:0000107
(PMID:34512673)		 Ensembl
RGD		 PMID:34512673 GO_REF:0000107 NCBI chr10:101,847,822...101,863,052
Ensembl chr10:101,357,937...101,364,971 		JBrowse link
G Zdhhc12 zinc finger DHHC-type palmitoyltransferase 12 involved_in ISS
ISO		 GO_REF:0000024
(PMID:36586411)		 UniProt
RGD		 PMID:36586411 GO_REF:0000024 NCBI chr 3:33,761,338...33,764,207
Ensembl chr 3:13,363,504...13,366,474 		JBrowse link
negative regulation of non-canonical inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:37962578)		 UniProt
Ensembl
RGD		 PMID:37962578 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:70,811,317...70,856,123
Ensembl chr  X:66,771,349...66,816,146 		JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO
IEA		 (PMID:18342009)
GO_REF:0000107		 RGD
Ensembl		 PMID:18342009 GO_REF:0000107 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbin erbb2 interacting protein involved_in ISO
IEA		 (PMID:16203728)
GO_REF:0000107		 RGD
Ensembl		 PMID:16203728 GO_REF:0000107 NCBI chr 2:36,660,399...36,762,584
Ensembl chr 2:34,928,863...35,027,852 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:23991106) RGD PMID:23991106 NCBI chr 2:194,055,165...194,103,209
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO
IEA		 (PMID:18342009)
GO_REF:0000107		 RGD
Ensembl		 PMID:18342009 GO_REF:0000107 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Znrf4 zinc and ring finger 4 involved_in ISO (PMID:28656966) RGD PMID:28656966 NCBI chr 9:1,440,444...1,441,632
Ensembl chr 9:1,353,306...1,354,584 		JBrowse link
negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in ISO
IEA
ISS		 (PMID:19164550)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:19164550 GO_REF:0000024 GO_REF:0000107 NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Dhx58 DEXH-box helicase 58 involved_in ISO
IEA
IBA		 (PMID:18411269), (PMID:21187438)
GO_REF:0000107
(PMID:17475874)
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:17475874 PMID:18411269 PMID:21187438 GO_REF:0000033 GO_REF:0000107 NCBI chr10:86,120,677...86,132,095
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G Gpatch3 G patch domain containing 3 involved_in ISO
IEA
IBA		 (PMID:28414768)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033		 RGD
InterPro
Ensembl
GO_Central		 PMID:28414768 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:151,083,970...151,093,382
Ensembl chr 5:145,800,111...145,809,250 		JBrowse link
G Nlrx1 NLR family member X1 acts_upstream_of_or_within ISO
IEA		 MGI:5141085 (PMID:21703540)
GO_REF:0000107		 RGD
Ensembl		 PMID:21703540 GO_REF:0000107 NCBI chr 8:53,486,866...53,503,498
Ensembl chr 8:44,590,048...44,606,484 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in ISO
IEA
ISS		 (PMID:26471729)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26471729 GO_REF:0000024 GO_REF:0000107 NCBI chr10:106,152,756...106,208,306
Ensembl chr10:105,654,812...105,709,913 		JBrowse link
G Rnf125 ring finger protein 125 involved_in ISO
IEA		 (PMID:17460044), (PMID:26471729)
GO_REF:0000107		 RGD
Ensembl		 PMID:17460044 PMID:26471729 GO_REF:0000107 NCBI chr18:12,528,995...12,550,646
Ensembl chr18:12,253,852...12,275,983 		JBrowse link
G Sec14l1 SEC14-like lipid binding 1 involved_in ISO
IEA
IBA		 (PMID:23843640)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:23843640 GO_REF:0000033 GO_REF:0000107 NCBI chr10:102,818,693...102,865,841
Ensembl chr10:102,319,920...102,367,068 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in ISO
IEA
ISS		 (PMID:26471729)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26471729 GO_REF:0000024 GO_REF:0000107 NCBI chr11:95,665,971...95,689,423
Ensembl chr11:82,161,619...82,185,087 		JBrowse link
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISO
IEA		 (PMID:19865078)
GO_REF:0000107		 RGD
Ensembl		 PMID:19865078 GO_REF:0000107 NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO
IEA		 (PMID:15474016)
GO_REF:0000107		 RGD
Ensembl		 PMID:15474016 GO_REF:0000107 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21695056)		 Ensembl
RGD		 PMID:21695056 GO_REF:0000107 NCBI chr17:6,438,456...6,482,498
Ensembl chr17:6,439,002...6,477,090 		JBrowse link
negative regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gramd4 GRAM domain containing 4 involved_in IBA
ISO		 GO_REF:0000033
(PMID:25917084)		 GO_Central
RGD		 PMID:25917084 GO_REF:0000033 NCBI chr 7:119,030,225...119,103,875
Ensembl chr 7:117,150,374...117,224,053 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in ISO
IEA		 (PMID:14716310)
GO_REF:0000107		 RGD
Ensembl		 PMID:14716310 GO_REF:0000107 NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S involved_in ISO (PMID:26231120) RGD PMID:26231120 NCBI chr 9:1,332,558...1,394,161
Ensembl chr 9:1,245,410...1,306,947 		JBrowse link
G Rab7b Rab7b, member RAS oncogene family involved_in ISO
IEA		 (PMID:19587007)
GO_REF:0000107		 RGD
Ensembl		 PMID:19587007 GO_REF:0000107 NCBI chr13:45,673,396...45,699,798
Ensembl chr13:43,121,226...43,147,581 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    immune system process 3130
      negative regulation of immune system process 591
        negative regulation of cytoplasmic pattern recognition receptor signaling pathway 57
          negative regulation of MDA-5 signaling pathway 4
          negative regulation of RIG-I signaling pathway 8
          negative regulation of cGAS/STING signaling pathway 15
          negative regulation of inflammasome-mediated signaling pathway + 17
          negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway + 4
          negative regulation of toll-like receptor 11 signaling pathway 0
          negative regulation of toll-like receptor 12 signaling pathway 0
          negative regulation of toll-like receptor 13 signaling pathway 0
          negative regulation of toll-like receptor 3 signaling pathway 3
          negative regulation of toll-like receptor 7 signaling pathway 0
          negative regulation of toll-like receptor 8 signaling pathway 0
          negative regulation of toll-like receptor 9 signaling pathway 4
Path 2
Term Annotations click to browse term
  biological_process 20558
    response to stimulus 11067
      response to external stimulus 2804
        response to external biotic stimulus 1894
          response to other organism 1890
            defense response to other organism 1336
              defense response to symbiont 1112
                innate immune response 1025
                  regulation of innate immune response 491
                    positive regulation of innate immune response 401
                      activation of innate immune response 329
                        innate immune response-activating signaling pathway 301
                          pattern recognition receptor signaling pathway 290
                            cytoplasmic pattern recognition receptor signaling pathway 189
                              regulation of cytoplasmic pattern recognition receptor signaling pathway 130
                                negative regulation of cytoplasmic pattern recognition receptor signaling pathway 57
                                  negative regulation of MDA-5 signaling pathway 4
                                  negative regulation of RIG-I signaling pathway 8
                                  negative regulation of cGAS/STING signaling pathway 15
                                  negative regulation of inflammasome-mediated signaling pathway + 17
                                  negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway + 4
                                  negative regulation of toll-like receptor 11 signaling pathway 0
                                  negative regulation of toll-like receptor 12 signaling pathway 0
                                  negative regulation of toll-like receptor 13 signaling pathway 0
                                  negative regulation of toll-like receptor 3 signaling pathway 3
                                  negative regulation of toll-like receptor 7 signaling pathway 0
                                  negative regulation of toll-like receptor 8 signaling pathway 0
                                  negative regulation of toll-like receptor 9 signaling pathway 4
paths to the root