ONTOLOGY REPORT - ANNOTATIONS
Term: cargo receptor activity
Accession: GO:0038024
browse the term
Definition: Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
Comment: Notes: (1) this term and its child terms are intended for receptors that bind to and internalize molecules by receptor-mediated endocytosis. For receptors that are coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857.
Synonyms: narrow_synonym: receptor activity involved in receptor-mediated endocytosis
broad_synonym: receptor activity
related_synonym: endocytic receptor activity; transport receptor activity
xref: Reactome:R-HSA-3000103 "CUBN:AMN binds CBLIF:RCbl"; Reactome:R-HSA-3000112 "CD320-mediated TCN2:RCbl uptake and delivery to lysosome"; Reactome:R-HSA-3000122 "CD320 binds extracellular TCN2:RCbl"; Reactome:R-HSA-3000137 "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome"; Reactome:R-HSA-350168 "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D"; Reactome:R-HSA-9759202 "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome"; Reactome:R-HSA-9759209 "LRP2 binds extracellular TCN2:RCbl"
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Amn
amnion associated transmembrane protein
enables
ISO
(PMID:14576052)
RGD
PMID:14576052
NCBI chr 6:130,311,372...130,318,815
Ensembl chr 6:130,311,372...130,318,815
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Cd320
CD320 molecule
enables
ISO
MGI:3858540 (MGI:5506682|PMID:23430977) (PMID:15652495)
RGD
PMID:15652495 PMID:23430977
MGI:5506682
NCBI chr 7:14,626,171...14,631,976
Ensembl chr 7:14,609,146...14,631,976
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Cd44
CD44 molecule (Indian blood group)
enables
ISO
(MGI:7264266|PMID:1703543), (MGI:7264268|PMID:26528478)
RGD
PMID:1703543 PMID:26528478
MGI:7264266 MGI:7264268
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cubn
cubilin
enables
IMP ISO IEA
PMID:14576052 (PMID:14576052), (PMID:20237569), (PMID:30523278) GO_REF:0000107
RGD Ensembl
PMID:14576052 PMID:20237569 PMID:30523278 PMID:14576052
GO_REF:0000107, RGD:8554807
NCBI chr17:76,385,046...76,593,133
Ensembl chr17:76,385,060...76,593,231
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Dab2
DAB adaptor protein 2
enables
IEA ISO
GO_REF:0000107 (PMID:16984970) (MGI:5442508|PMID:16984970)
Ensembl RGD
PMID:16984970
GO_REF:0000107 MGI:5442508
NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
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Hmmr
hyaluronan-mediated motility receptor
enables
ISO
(MGI:7264268|PMID:26528478)
RGD
PMID:26528478
MGI:7264268
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
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Insr
insulin receptor
enables
IMP
PMID:19406747
ARUK-UCL
PMID:19406747
RGD:13210538
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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Itgam
integrin subunit alpha M
contributes_to enables
ISO
(MGI:5905548|PMID:20199584) UniProtKB:P01027|UniProtKB:P05555 (MGI:5319446|PMID:22438044)
RGD
PMID:20199584 PMID:22438044
MGI:5319446 MGI:5905548
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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Itgb2
integrin subunit beta 2
contributes_to
ISO
(MGI:5905548|PMID:20199584)
RGD
PMID:20199584
MGI:5905548
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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Lrp1
LDL receptor related protein 1
enables
ISO IBA
(PMID:23152628), (PMID:24305823) PMID:21873635 (MGI:5897551|PMID:21289173)
RGD
PMID:21289173 PMID:23152628 PMID:24305823 PMID:21873635
MGI:5897551 , RGD:13792537
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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Lrp2
LDL receptor related protein 2
enables
ISO
(PMID:14528014), (PMID:8710919)
RGD
PMID:8710919 PMID:14528014
NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
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Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
enables
ISO
(MGI:2135409|PMID:11278811)
RGD
PMID:11278811
MGI:2135409
NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309
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Marco
macrophage receptor with collagenous structure
enables
IMP
PMID:15987691
ARUK-UCL
PMID:15987691
RGD:13432286
NCBI chr13:31,616,278...31,648,521
Ensembl chr13:31,616,278...31,648,521
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Mia2
MIA SH3 domain ER export factor 2
enables
ISO
(PMID:27138255)
RGD
PMID:27138255
NCBI chr 6:76,787,508...76,885,246
Ensembl chr 6:76,787,508...76,885,211
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Mia3
MIA SH3 domain ER export factor 3
enables
ISO
(PMID:27138255)
RGD
PMID:27138255
NCBI chr13:94,970,421...95,012,071
Ensembl chr13:94,970,424...95,011,972
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Mrc1
mannose receptor, C type 1
enables
ISO
(PMID:20035344)
RGD
PMID:20035344
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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Msr1
macrophage scavenger receptor 1
enables
ISO
UniProtKB:P01027|UniProtKB:P05555 (MGI:5319446|PMID:22438044)
RGD
PMID:22438044
MGI:5319446
NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
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Scarb2
scavenger receptor class B, member 2
enables
ISO
(PMID:18022370) (MGI:3773765|PMID:18022370)
RGD
PMID:18022370
MGI:3773765
NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813
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Sdc1
syndecan 1
enables
ISO
(MGI:6832352|PMID:24788042)
RGD
PMID:24788042
MGI:6832352
NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
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Stab2
stabilin 2
enables
ISO
MGI:5318244 (MGI:5315050|PMID:22371575)
RGD
PMID:22371575
MGI:5315050
NCBI chr 7:21,249,426...21,433,051
Ensembl chr 7:21,249,391...21,434,042
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Stbd1
starch binding domain 1
enables
ISO
MGI:6356543 (MGI:5803726|PMID:27358407), (MGI:7261139|PMID:20810658)
RGD
PMID:20810658 PMID:27358407
MGI:5803726 MGI:7261139
NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443
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Surf4
surfeit 4
enables
ISO
(PMID:29643117), (PMID:30251625), (PMID:32989016), (PMID:34015269)
RGD
PMID:29643117 PMID:30251625 PMID:32989016 PMID:34015269
NCBI chr 3:10,248,360...10,261,537
Ensembl chr 3:10,241,837...10,263,315
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Vldlr
very low density lipoprotein receptor
enables
ISO
(PMID:10571240)
RGD
PMID:10571240
NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
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Lrp1
LDL receptor related protein 1
enables
ISO IEA
(PMID:26142438) GO_REF:0000107
RGD Ensembl
PMID:26142438
GO_REF:0000107
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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Abca1
ATP binding cassette subfamily A member 1
enables
ISO
(PMID:16443932)
RGD
PMID:16443932
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abca7
ATP binding cassette subfamily A member 7
enables
IEA IBA ISS ISO
GO_REF:0000107 PMID:21873635 GO_REF:0000024 (MGI:5559672|PMID:12917409) (PMID:14570867)
Ensembl Alzheimers_University_of_Toronto RGD
PMID:12917409 PMID:14570867 PMID:21873635
GO_REF:0000024 GO_REF:0000107 MGI:5559672 , RGD:13792537
NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
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Apobr
apolipoprotein B receptor
enables
ISO
(PMID:10852956)
RGD
PMID:10852956
NCBI chr 1:181,169,019...181,173,206
Ensembl chr 1:181,168,916...181,173,528
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Asgr1
asialoglycoprotein receptor 1
IDA
RGD
PMID:2995379
RGD:631721
NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
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Tex261
testis expressed 261
enables
IBA IEA
PMID:21873635 GO_REF:0000002
InterPro
PMID:21873635
GO_REF:0000002, RGD:13792537
NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253
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Scara5
scavenger receptor class A, member 5
enables
ISO
(MGI:3833042|PMID:19154717)
RGD
PMID:19154717
MGI:3833042
NCBI chr15:39,880,017...39,985,007
Ensembl chr15:39,880,035...39,983,373
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Timd2
T-cell immunoglobulin and mucin domain containing 2
enables
ISO
(MGI:5288559|PMID:21886823)
RGD
PMID:21886823
MGI:5288559
NCBI chr10:31,060,308...31,101,262
Ensembl chr10:31,060,326...31,094,623
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Folr1
folate receptor alpha
enables
ISO
(PMID:8033114)
RGD
PMID:8033114
NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667
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Folr2
folate receptor beta
enables
ISO
(PMID:4066659)
RGD
PMID:4066659
NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724
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Ildr1
immunoglobulin-like domain containing receptor 1
enables
ISO IBA
(MGI:5514075|PMID:23863714) PMID:21873635
RGD
PMID:23863714 PMID:21873635
MGI:5514075 , RGD:13792537
NCBI chr11:64,085,774...64,118,760
Ensembl chr11:64,008,566...64,118,760
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Scarb1
scavenger receptor class B, member 1
enables
ISO IEA ISS
(PMID:11208913), (PMID:9211901) GO_REF:0000107 GO_REF:0000024 (PMID:15140193)
RGD Ensembl BHF-UCL
PMID:9211901 PMID:11208913 PMID:15140193
GO_REF:0000024 GO_REF:0000107
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Atp5f1b
ATP synthase F1 subunit beta
IDA
RGD
PMID:12511957
RGD:629531
NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
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Cd320
CD320 molecule
enables
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 7:14,626,171...14,631,976
Ensembl chr 7:14,609,146...14,631,976
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Cd36
CD36 molecule
enables
IBA IEA ISO
PMID:21873635 GO_REF:0000107 (MGI:3836139|PMID:10772654) (PMID:10772654)
Ensembl RGD
PMID:10772654 PMID:21873635
GO_REF:0000107 MGI:3836139 , RGD:13792537
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd36l1
CD36 molecule like 1
enables
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 4:17,424,749...17,465,808
Ensembl chr 4:17,354,466...17,513,903
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Cxcl16
C-X-C motif chemokine ligand 16
enables
IBA IEA ISO
PMID:21873635 GO_REF:0000002 (MGI:1929021|PMID:11060282)
InterPro RGD
PMID:11060282 PMID:21873635
GO_REF:0000002 MGI:1929021 , RGD:13792537
NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592
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Ldlr
low density lipoprotein receptor
enables
TAS IEA IBA ISO IDA
GO_REF:0000107 PMID:21873635 MGI:1857212 (MGI:2386141|PMID:12072432), (MGI:3706212|PMID:17148552) (PMID:6091915), (PMID:6299582), (PMID:8626535)
Ensembl RGD
PMID:6091915 PMID:6299582 PMID:8626535 PMID:12072432 PMID:17148552 PMID:12095612 PMID:21873635 PMID:3559401 More...
GO_REF:0000107 MGI:2386141 MGI:3706212 , RGD:633388 , RGD:13792537 , RGD:2324634
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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Lrp10
LDL receptor related protein 10
enables
ISO IBA
(MGI:1928400|PMID:11123907) PMID:21873635
RGD
PMID:11123907 PMID:21873635
MGI:1928400 , RGD:13792537
NCBI chr15:27,921,335...27,927,507
Ensembl chr15:27,920,259...27,927,505
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Lrp1b
LDL receptor related protein 1B
enables
ISO
(MGI:3042677|PMID:15082773)
RGD
PMID:15082773
MGI:3042677
NCBI chr 3:24,594,302...26,715,037
Ensembl chr 3:24,594,991...26,715,505
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Lrp6
LDL receptor related protein 6
enables
ISO
(PMID:16263759)
RGD
PMID:16263759
NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497
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Olr1
oxidized low density lipoprotein receptor 1
enables
TAS ISO IBA
(MGI:1203322|PMID:9588202) PMID:21873635
RGD
PMID:9588202 PMID:12384456 PMID:21873635
MGI:1203322 , RGD:628368 , RGD:13792537
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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Stab1
stabilin 1
enables
ISO
(PMID:12077138)
RGD
PMID:12077138
NCBI chr16:6,330,435...6,360,934
Ensembl chr16:6,330,444...6,360,923
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Stab2
stabilin 2
enables
ISO IEA
(PMID:12077138) GO_REF:0000107
RGD Ensembl
PMID:12077138
GO_REF:0000107
NCBI chr 7:21,249,426...21,433,051
Ensembl chr 7:21,249,391...21,434,042
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Cd36
CD36 molecule
enables
ISO IEA
(PMID:27607416) GO_REF:0000107
RGD Ensembl
PMID:27607416
GO_REF:0000107
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Ackr2
atypical chemokine receptor 2
enables
IEA ISO ISS
GO_REF:0000107 (PMID:23633677) GO_REF:0000024
Ensembl RGD UniProt
PMID:23633677
GO_REF:0000024 GO_REF:0000107
NCBI chr 8:121,559,563...121,573,633
Ensembl chr 8:121,561,211...121,573,582
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Ackr3
atypical chemokine receptor 3
enables
ISO ISS
(PMID:22300987) GO_REF:0000024
RGD UniProt
PMID:22300987
GO_REF:0000024
NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
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Ackr4
atypical chemokine receptor 4
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 8:104,716,537...104,720,972
Ensembl chr 8:104,716,067...104,723,617
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Cd36
CD36 molecule
enables
ISO IEA IBA IMP
(PMID:18941241) GO_REF:0000107 PMID:21873635
RGD Ensembl
PMID:18941241 PMID:21873635 PMID:18941241
GO_REF:0000107, RGD:13792537 , RGD:13825436
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd36l1
CD36 molecule like 1
enables
IMP IBA
PMID:18941241 PMID:21873635
ARUK-UCL GO_Central
PMID:18941241 PMID:21873635
RGD:13825436 , RGD:13792537
NCBI chr 4:17,424,749...17,465,808
Ensembl chr 4:17,354,466...17,513,903
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Colec12
collectin sub-family member 12
enables
ISO
(PMID:11564734)
RGD
PMID:11564734
NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
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Cxcl16
C-X-C motif chemokine ligand 16
enables
IBA IEA ISO
PMID:21873635 GO_REF:0000002 (MGI:1929021|PMID:11060282)
InterPro RGD
PMID:11060282 PMID:21873635
GO_REF:0000002 MGI:1929021 , RGD:13792537
NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592
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Dmbt1
deleted in malignant brain tumors 1
enables
ISO
(PMID:19189310)
RGD
PMID:19189310
NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
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Endou
endonuclease, poly(U)-specific
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 7:128,844,872...128,866,572
Ensembl chr 7:128,844,862...128,866,596
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Enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
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Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
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Megf10
multiple EGF-like domains 10
enables
ISO
(PMID:27170117)
RGD
PMID:27170117
NCBI chr18:50,605,231...50,755,441
Ensembl chr18:50,605,656...50,754,456
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Msr1
macrophage scavenger receptor 1
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
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Prg4
proteoglycan 4
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr13:62,487,257...62,504,657
Ensembl chr13:62,487,257...62,504,119
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Scarb1
scavenger receptor class B, member 1
enables
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Scarb2
scavenger receptor class B, member 2
enables
ISO IEA IBA
(MGI:6112073|PMID:29199275) GO_REF:0000107 GO_REF:0000002 PMID:21873635
RGD Ensembl InterPro
PMID:29199275 PMID:21873635
GO_REF:0000002 GO_REF:0000107 MGI:6112073 , RGD:13792537
NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813
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Scarf1
scavenger receptor class F, member 1
enables
ISO IBA
(PMID:9395444) PMID:21873635
RGD
PMID:9395444 PMID:21873635
RGD:13792537
NCBI chr10:60,359,213...60,371,516
Ensembl chr10:60,359,197...60,371,516
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Scarf2
scavenger receptor class F, member 2
enables
ISO IBA
(MGI:2388377|PMID:12154095) PMID:21873635
RGD
PMID:12154095 PMID:21873635
MGI:2388377 , RGD:13792537
NCBI chr11:83,175,956...83,187,415
Ensembl chr11:83,175,963...83,187,348
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Ssc5d
scavenger receptor cysteine rich family member with 5 domains
enables
ISO
(MGI:4939978|PMID:21217009)
RGD
PMID:21217009
MGI:4939978
NCBI chr 1:68,891,942...68,910,462
Ensembl chr 1:68,891,949...68,909,743
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Stab1
stabilin 1
enables
ISO
(PMID:12077138)
RGD
PMID:12077138
NCBI chr16:6,330,435...6,360,934
Ensembl chr16:6,330,444...6,360,923
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Stab2
stabilin 2
enables
ISO IEA
(PMID:12077138) GO_REF:0000107
RGD Ensembl
PMID:12077138
GO_REF:0000107
NCBI chr 7:21,249,426...21,433,051
Ensembl chr 7:21,249,391...21,434,042
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Vtn
vitronectin
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
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Tfr2
transferrin receptor 2
enables
ISO IEA
(PMID:18353247) GO_REF:0000002
RGD InterPro
PMID:18353247
GO_REF:0000002
NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591
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Tfrc
transferrin receptor
enables
TAS IEA ISO IDA
GO_REF:0000104 (PMID:26642240)
UniProt RGD
PMID:26642240 PMID:9380695 PMID:12707050
GO_REF:0000104, RGD:70300 , RGD:737675
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Apobr
apolipoprotein B receptor
enables
IBA ISO
PMID:21873635 (MGI:2386484|PMID:12177162)
RGD
PMID:12177162 PMID:21873635
MGI:2386484 , RGD:13792537
NCBI chr 1:181,169,019...181,173,206
Ensembl chr 1:181,168,916...181,173,528
G
Ldlr
low density lipoprotein receptor
enables
ISO IEA
(PMID:8626535) GO_REF:0000107 (MGI:3695062|PMID:16166565)
RGD Ensembl
PMID:8626535 PMID:16166565
GO_REF:0000107 MGI:3695062
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
G
Lrp8
LDL receptor related protein 8
enables
ISO
(PMID:8626535)
RGD
PMID:8626535
NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352
G
Vldlr
very low density lipoprotein receptor
enables
IEA ISO ISS
GO_REF:0000107 (PMID:8083232) GO_REF:0000024
Ensembl RGD BHF-UCL
PMID:8083232
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all