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ONTOLOGY REPORT - ANNOTATIONS

Term:prostaglandin H2 endoperoxidase reductase activity
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Accession:GO:0036130 term browser browse the term
Definition:Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).
Synonyms:exact_synonym: PGH2 9,11-endoperoxidase;   PGH2 9-,11-endoperoxide reductase
 xref: KEGG_REACTION:R02264;   RHEA:45312;   reactome:R-HSA-2161549 "PGH2 is reduced to PGF2a by AKR1C3"


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prostaglandin H2 endoperoxidase reductase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 enables ISO (PMID:19010934) RGD PMID:19010934 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
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  molecular_function 21087
    catalytic activity 6127
      oxidoreductase activity 868
        oxidoreductase activity, acting on CH-OH group of donors 165
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 156
            prostaglandin H2 endoperoxidase reductase activity 3
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