ONTOLOGY REPORT - ANNOTATIONS
Term: site of double-strand break
Accession: GO:0035861
browse the term
Definition: A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
Synonyms: exact_synonym: site of DSB
related_synonym: DNA damage foci; DNA damage focus; IRIF; ionizing radiation-induced foci
G
ACTR2
actin related protein 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr2A:65,289,675...65,333,219
Ensembl chr2A:66,413,011...66,456,857
G
AIM2
absent in melanoma 2
located_in is_active_in
IEA ISO
(PMID:27846608)
Ensembl UniProt
PMID:27846608
GO_REF:0000107
NCBI chr 1:134,413,232...134,540,344
Ensembl chr 1:138,210,946...138,221,753
G
APLF
aprataxin and PNKP like factor
is_active_in located_in
ISO IEA
(PMID:23689425)
UniProt TreeGrafter Ensembl
PMID:23689425
GO_REF:0000107 GO_REF:0000118
NCBI chr2A:68,509,314...68,629,192
Ensembl chr2A:69,632,459...69,744,611
G
ASF1A
anti-silencing function 1A histone chaperone
located_in is_active_in
IEA ISO
(PMID:29478807)
Ensembl UniProt
PMID:29478807
GO_REF:0000107
NCBI chr 6:116,702,314...116,717,445
Ensembl chr 6:120,843,461...120,858,471
G
ATF2
activating transcription factor 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr2B:62,348,245...62,444,428
Ensembl chr2B:179,799,365...179,895,007
G
ATM
ATM serine/threonine kinase
located_in is_active_in
IEA ISO
(PMID:26240375)
Ensembl UniProt
PMID:26240375
GO_REF:0000107
NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041
G
BRME1
break repair meiotic recombinase recruitment factor 1
is_active_in
ISO
(PMID:32463460)
UniProt
PMID:32463460
NCBI chr19:13,444,811...13,468,748
Ensembl chr19:14,175,306...14,196,501
G
CGAS
cyclic GMP-AMP synthase
located_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 6:71,252,050...71,279,121
Ensembl chr 6:74,544,251...74,566,965
G
CHD1L
chromodomain helicase DNA binding protein 1 like
located_in is_active_in
IEA ISO
(PMID:29220652), (PMID:29220653)
Ensembl UniProt
PMID:29220652 PMID:29220653
GO_REF:0000107
NCBI chr 1:122,595,246...122,720,788
Ensembl chr 1:112,809,274...112,862,219
G
CNTD1
cyclin N-terminal domain containing 1
located_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr17:14,506,354...14,519,279
Ensembl chr17:14,731,829...14,744,338
G
CYREN
cell cycle regulator of NHEJ
is_active_in
ISO
(PMID:30017584)
UniProt
PMID:30017584
NCBI chr 7:127,130,587...127,148,824
G
DMC1
DNA meiotic recombinase 1
located_in is_active_in
IEA ISO
(PMID:30760716), (PMID:32463460)
Ensembl UniProt
PMID:30760716 PMID:32463460
GO_REF:0000107
NCBI chr22:19,433,989...19,485,804
Ensembl chr22:37,253,609...37,305,769
G
DYNLL1
dynein light chain LC8-type 1
is_active_in
ISO
(PMID:37696958)
UniProt
PMID:37696958
NCBI chr12:118,078,401...118,080,822
Ensembl chr12:121,452,118...121,454,550
G
EPC1
enhancer of polycomb homolog 1
located_in is_active_in
IEA ISO
(PMID:27153538)
Ensembl UniProt
PMID:27153538
GO_REF:0000107
NCBI chr10:32,398,557...32,509,146
Ensembl chr10:32,985,456...33,095,070
G
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:27,049,858...27,080,396
Ensembl chr 8:24,251,557...24,284,001
G
FH
fumarate hydratase
located_in
ISO
(PMID:26237645)
UniProt
PMID:26237645
NCBI chr 1:217,059,847...217,081,795
Ensembl chr 1:222,041,142...222,064,212
G
HELB
DNA helicase B
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:22,571,448...22,607,417
Ensembl chr12:23,078,732...23,114,134
G
HTATSF1
HIV-1 Tat specific factor 1
is_active_in located_in
ISO IEA
(PMID:35597237)
UniProt Ensembl
PMID:35597237
GO_REF:0000107
NCBI chr X:125,626,714...125,641,988
Ensembl chr X:135,892,697...135,910,919
G
HUS1
HUS1 checkpoint clamp component
located_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 7:48,606,848...48,622,194
Ensembl chr 7:48,714,668...48,731,005
G
HUS1B
HUS1 checkpoint clamp component B
located_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:466,508...469,590
Ensembl chr 6:601,288...602,124
G
IFFO1
intermediate filament family orphan 1
located_in
ISO
(PMID:31548606)
UniProt
PMID:31548606
NCBI chr12:6,670,415...6,686,972
Ensembl chr12:6,588,975...6,605,262
G
INIP
INTS3 and NABP interacting protein
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:83,811,378...83,845,638
Ensembl chr 9:111,965,947...111,999,561
G
INTS3
integrator complex subunit 3
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:129,084,681...129,130,669
Ensembl chr 1:132,714,200...132,759,842
G
KAT5
lysine acetyltransferase 5
is_active_in located_in
ISO IEA
(PMID:27153538)
UniProt Ensembl
PMID:27153538
GO_REF:0000107
NCBI chr11:61,071,118...61,078,667
Ensembl chr11:64,404,572...64,412,667
G
KDM4D
lysine demethylase 4D
located_in
ISO
(PMID:24550317)
MGI
PMID:24550317
NCBI chr11:89,987,537...90,013,421
G
LMNA
lamin A/C
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:131,456,819...131,482,275
Ensembl chr 1:135,253,700...135,311,539
G
LOC100986203
histone-lysine N-methyltransferase SETMAR
located_in
IEA
TreeGrafter Ensembl
GO_REF:0000107 GO_REF:0000118
NCBI chr 3:4,256,539...4,271,593
Ensembl chr 3:4,357,890...4,371,791
G
LOC100994157
histone H2AX
located_in is_active_in
ISO
(PMID:22699483), (PMID:23133398) (PMID:21270334) (PMID:12419185)
MGI UniProt
PMID:12419185 PMID:21270334 PMID:22699483 PMID:23133398
NCBI chr11:113,932,078...113,933,679
G
MBTD1
mbt domain containing 1
located_in is_active_in
IEA ISO
(PMID:27153538), (PMID:32209463)
Ensembl UniProt
PMID:27153538 PMID:32209463
GO_REF:0000107
NCBI chr17:45,267,275...45,350,751
Ensembl chr17:50,137,395...50,215,078
G
MDC1
mediator of DNA damage checkpoint 1
is_active_in located_in
ISO IEA
(PMID:16377563), (PMID:18411307), (PMID:18582474), (PMID:18583988), (PMID:18678890), (PMID:30898438)
UniProt Ensembl
PMID:16377563 PMID:18411307 PMID:18582474 PMID:18583988 PMID:18678890 PMID:30898438 More...
GO_REF:0000107
NCBI chr 6:30,444,570...30,462,432
Ensembl chr 6:31,314,560...31,329,243
G
MMS22L
MMS22 like, DNA repair protein
located_in is_active_in
IEA ISO
(PMID:27797818)
Ensembl UniProt
PMID:27797818
GO_REF:0000107
NCBI chr 6:94,989,906...95,127,260
Ensembl chr 6:98,861,299...99,011,773
G
MRE11
MRE11 homolog, double strand break repair nuclease
located_in is_active_in
IEA ISO
(PMID:26240375), (PMID:28867292), (PMID:36050397)
Ensembl TreeGrafter UniProt
PMID:26240375 PMID:28867292 PMID:36050397
GO_REF:0000107 GO_REF:0000118
NCBI chr11:89,418,537...89,500,705
Ensembl chr11:92,918,549...92,985,966
G
NABP1
nucleic acid binding protein 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr2B:78,980,156...78,989,309
Ensembl chr2B:196,895,166...196,903,977
G
NABP2
nucleic acid binding protein 2
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:32,685,521...32,693,318
Ensembl chr12:32,937,017...32,944,754
G
NBN
nibrin
located_in is_active_in
IEA ISO
(PMID:16622404), (PMID:18411307), (PMID:18582474), (PMID:18583988), (PMID:18678890), (PMID:19338747), (PMID:23115235), (PMID:24534091), (PMID:28867292), (PMID:38961290)
Ensembl UniProt
PMID:16622404 PMID:18411307 PMID:18582474 PMID:18583988 PMID:18678890 PMID:19338747 PMID:23115235 PMID:24534091 PMID:28867292 PMID:38961290 More...
GO_REF:0000107
NCBI chr 8:86,622,797...86,674,202
Ensembl chr 8:88,575,198...88,626,307
G
NHEJ1
non-homologous end joining factor 1
is_active_in located_in
ISO IEA
(PMID:18064046), (PMID:18644470), (PMID:27437582), (PMID:28500754)
UniProt Ensembl
PMID:18064046 PMID:18644470 PMID:27437582 PMID:28500754
GO_REF:0000107
NCBI chr2B:106,326,596...106,419,928
Ensembl chr2B:224,926,183...225,008,788
G
PARP1
poly(ADP-ribose) polymerase 1
located_in is_active_in
IEA ISO
(PMID:29234005)
Ensembl UniProt
PMID:29234005
GO_REF:0000107
NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356
G
PARP3
poly(ADP-ribose) polymerase family member 3
located_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 3:51,883,695...51,890,266
Ensembl chr 3:53,112,494...53,119,053
G
PAXX
PAXX non-homologous end joining factor
located_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 9:108,052,793...108,055,298
Ensembl chr 9:137,021,230...137,022,805
G
PELI1
pellino E3 ubiquitin protein ligase 1
located_in is_active_in
IEA ISO
(PMID:30952868)
Ensembl UniProt
PMID:30952868
GO_REF:0000107
NCBI chr2A:64,160,362...64,213,200
Ensembl chr2A:65,284,480...65,336,339
G
PHF1
PHD finger protein 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:32,990,080...32,995,785
Ensembl chr 6:34,101,371...34,107,124
G
PNKP
polynucleotide kinase 3'-phosphatase
is_active_in located_in
ISO IEA
(PMID:28453785) (PMID:26774286)
UniProt Ensembl
PMID:26774286 PMID:28453785
GO_REF:0000107
NCBI chr19:46,874,216...46,880,954
Ensembl chr19:55,790,048...55,796,762
G
POLH
DNA polymerase eta
located_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:43,168,195...43,205,811
Ensembl chr 6:44,462,225...44,495,704
G
POLL
DNA polymerase lambda
is_active_in located_in
ISO IEA
(PMID:30250067)
UniProt Ensembl
PMID:30250067
GO_REF:0000107
NCBI chr10:98,181,049...98,190,463
Ensembl chr10:101,653,978...101,663,360
G
POLQ
DNA polymerase theta
located_in is_active_in
IEA ISO
(PMID:37440612), (PMID:37674080)
Ensembl UniProt
PMID:37440612 PMID:37674080
GO_REF:0000107
NCBI chr 3:118,535,968...118,648,275
Ensembl chr 3:125,446,829...125,559,283
G
PRPF19
pre-mRNA processing factor 19
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:56,153,965...56,169,821
Ensembl chr11:59,595,120...59,607,828
G
RAD17
RAD17 checkpoint clamp loader component
is_active_in located_in
ISO IEA
(PMID:24534091)
UniProt Ensembl
PMID:24534091
GO_REF:0000107
NCBI chr 5:44,586,083...44,630,719
Ensembl chr 5:46,156,294...46,202,197
G
RAD18
RAD18 E3 ubiquitin protein ligase
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:8,832,910...8,918,067
Ensembl chr 3:9,076,500...9,161,585
G
RAD50
RAD50 double strand break repair protein
located_in is_active_in
IEA ISO
(PMID:16622404), (PMID:21757780), (PMID:28867292)
Ensembl UniProt
PMID:16622404 PMID:21757780 PMID:28867292
GO_REF:0000107
NCBI chr 5:127,972,630...128,059,911
Ensembl chr 5:134,134,495...134,222,261
G
RAD51
RAD51 recombinase
located_in is_active_in
IEA ISO
(PMID:30760716), (PMID:32463460) (PMID:26811421), (PMID:27797818)
Ensembl UniProt
PMID:26811421 PMID:27797818 PMID:30760716 PMID:32463460
GO_REF:0000107
NCBI chr15:19,638,310...19,672,474
Ensembl chr15:37,891,056...37,925,207
G
RBBP8
RB binding protein 8, endonuclease
located_in is_active_in
IEA ISO
(PMID:27814491), (PMID:27889449), (PMID:33836577)
Ensembl UniProt
PMID:27814491 PMID:27889449 PMID:33836577
GO_REF:0000107
NCBI chr18:16,181,652...16,274,597
Ensembl chr18:19,811,989...19,903,522
G
RFWD3
ring finger and WD repeat domain 3
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:55,187,178...55,233,265
Ensembl chr16:74,541,450...74,586,951
G
RHNO1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
is_active_in located_in
ISO IEA
(PMID:37440612)
UniProt Ensembl
PMID:37440612
GO_REF:0000107
NCBI chr12:2,999,089...3,011,911
Ensembl chr12:2,930,957...2,943,419
G
RIF1
replication timing regulatory factor 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr2B:38,721,658...38,818,488
Ensembl chr2B:155,985,960...156,052,926
G
RNF138
ring finger protein 138
located_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr18:25,300,480...25,340,010
G
RNF138
ring finger protein 138
located_in
IEA
TreeGrafter
GO_REF:0000118
Ensembl chr18:28,897,138...28,932,652
G
RNF168
ring finger protein 168
located_in is_active_in
IEA ISO
(PMID:27153538)
Ensembl TreeGrafter UniProt
PMID:27153538
GO_REF:0000107 GO_REF:0000118
NCBI chr 3:193,814,785...193,848,620
Ensembl chr 3:203,756,589...203,790,687
G
RNF169
ring finger protein 169
located_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr11:69,821,842...69,909,297
Ensembl chr11:73,126,127...73,207,340
G
RNF8
ring finger protein 8
located_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 6:36,918,705...36,955,380
Ensembl chr 6:38,108,414...38,145,949
G
RPA1
replication protein A1
located_in is_active_in
IEA ISO
(PMID:35597237)
Ensembl UniProt
PMID:35597237
GO_REF:0000107
NCBI chr17:1,813,610...1,886,093
Ensembl chr17:1,705,380...1,775,596
G
RPA2
replication protein A2
located_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 1:27,151,784...27,175,110
Ensembl chr 1:28,191,731...28,214,666
G
RPA3
replication protein A3
located_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 7:8,361,623...8,365,098
Ensembl chr 7:7,713,629...7,717,169
G
SAMHD1
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:33,224,200...33,282,018
Ensembl chr20:34,341,367...34,398,314
G
SHLD1
shieldin complex subunit 1
located_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr20:5,753,262...5,858,728
Ensembl chr20:5,537,488...5,642,107
G
SHLD2
shieldin complex subunit 2
located_in
ISO
(PMID:29656893)
UniProt
PMID:29656893
NCBI chr10:83,639,020...83,643,420
G
SHLD3
shieldin complex subunit 3
located_in
ISO
(PMID:29656893)
UniProt
PMID:29656893
NCBI chr 5:48,376,338...48,382,052
G
SIRT6
sirtuin 6
is_active_in located_in
ISO IEA
(PMID:21680843), (PMID:23911928), (PMID:27568560), (PMID:31995034), (PMID:32538779)
UniProt Ensembl
PMID:21680843 PMID:23911928 PMID:27568560 PMID:31995034 PMID:32538779
GO_REF:0000107
NCBI chr19:3,196,092...3,204,602
Ensembl chr19:4,146,057...4,154,126
G
SIRT7
sirtuin 7
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:76,317,560...76,323,761
Ensembl chr17:82,020,077...82,026,289
G
SLF1
SMC5-SMC6 complex localization factor 1
located_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 5:20,660,101...20,757,072
Ensembl chr 5:20,817,614...20,884,453
G
SLF2
SMC5-SMC6 complex localization factor 2
located_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr10:97,511,398...97,566,386
Ensembl chr10:100,989,044...101,042,730
G
SMARCA5
SNF2 related chromatin remodeling ATPase 5
is_active_in located_in
ISO IEA
(PMID:23911928)
UniProt Ensembl
PMID:23911928
GO_REF:0000107
NCBI chr 4:135,874,888...135,917,096
Ensembl chr 4:147,174,060...147,214,809
G
SMARCAD1
SNF2 related chromatin remodeling ATPase with DExD box 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:86,567,722...86,651,527
Ensembl chr 4:97,240,614...97,324,366
G
SMARCAL1
SNF2 related chromatin remodeling annealing helicase 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr2B:103,672,934...103,743,802
Ensembl chr2B:222,276,353...222,347,258
G
SMC5
structural maintenance of chromosomes 5
located_in
ISO
(PMID:25931565)
UniProt
PMID:25931565
NCBI chr 9:54,446,863...54,543,249
G
SMC6
structural maintenance of chromosomes 6
located_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr2A:17,648,371...17,735,910
Ensembl chr2A:17,776,276...17,854,052
G
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr18:11,479,742...11,627,035
Ensembl chr18:13,785,912...13,933,887
G
STK38
serine/threonine kinase 38
is_active_in located_in
ISO IEA
(PMID:32537488)
UniProt Ensembl
PMID:32537488
GO_REF:0000107
NCBI chr 6:36,056,585...36,110,531
Ensembl chr 6:37,255,183...37,308,102
G
TIMELESS
timeless circadian regulator
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:32,465,529...32,497,581
Ensembl chr12:32,718,649...32,750,728
G
TONSL
tonsoku like, DNA repair protein
located_in is_active_in
IEA ISO
(PMID:26527279), (PMID:27338793), (PMID:29478807)
Ensembl UniProt
PMID:26527279 PMID:27338793 PMID:29478807
GO_REF:0000107
NCBI chr 8:141,195,959...141,211,849
Ensembl chr 8:144,185,674...144,201,040
G
TOPBP1
DNA topoisomerase II binding protein 1
is_active_in located_in
ISO IEA
(PMID:26811421), (PMID:30898438), (PMID:31135337), (PMID:35597237), (PMID:37674080)
UniProt Ensembl
PMID:26811421 PMID:30898438 PMID:31135337 PMID:35597237 PMID:37674080
GO_REF:0000107
NCBI chr 3:130,667,998...130,729,569
Ensembl chr 3:138,143,893...138,203,363
G
TP53
tumor protein p53
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
G
TP53BP1
tumor protein p53 binding protein 1
located_in is_active_in
IEA ISO
(PMID:22492721), (PMID:27153538), (PMID:31135337), (PMID:32209463), (PMID:37696958)
Ensembl UniProt
PMID:22492721 PMID:27153538 PMID:31135337 PMID:32209463 PMID:37696958
GO_REF:0000107
NCBI chr15:22,364,696...22,472,499
Ensembl chr15:40,519,012...40,626,741
G
UFL1
UFM1 specific ligase 1
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:94,356,440...94,389,920
Ensembl chr 6:98,242,756...98,274,377
G
UIMC1
ubiquitin interaction motif containing 1
located_in is_active_in
IEA ISO
(PMID:22492721)
Ensembl UniProt
PMID:22492721
GO_REF:0000107
NCBI chr 5:172,205,958...172,321,758
Ensembl chr 5:179,271,577...179,374,229
G
VCP
valosin containing protein
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:34,907,147...34,923,227
Ensembl chr 9:35,712,937...35,729,588
G
WAS
WASP actin nucleation promoting factor
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:40,982,132...40,989,767
Ensembl chr X:48,842,765...48,850,380
G
WRAP53
WD repeat containing antisense to TP53
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:7,715,897...7,735,873
Ensembl chr17:7,707,221...7,723,394
G
XRCC4
X-ray repair cross complementing 4
is_active_in located_in
ISO IEA
(PMID:26774286), (PMID:27437582), (PMID:28500754)
UniProt Ensembl
PMID:26774286 PMID:27437582 PMID:28500754
GO_REF:0000107
NCBI chr 5:31,927,463...32,202,394
Ensembl chr 5:32,246,320...32,521,490
G
ZBTB7A
zinc finger and BTB domain containing 7A
located_in
IEA
Ensembl
GO_REF:0000107
NCBI chr19:3,066,554...3,090,285
G
ZGRF1
zinc finger GRF-type containing 1
located_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 4:105,026,069...105,128,226
Ensembl chr 4:115,590,311...115,686,089
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all