Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:site of double-strand break
go back to main search page
Accession:GO:0035861 term browser browse the term
Definition:A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
Synonyms:exact_synonym: site of DSB
 related_synonym: DNA damage foci;   DNA damage focus;   IRIF;   ionizing radiation-induced foci


show annotations for term's descendants           Sort by:
site of double-strand break term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 located_in ISO
ISS
IEA		 (PMID:29925947)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:29925947 GO_REF:0000024 GO_REF:0000107 NCBI chr14:98,500,119...98,535,092
Ensembl chr14:94,296,443...94,340,524 		JBrowse link
G Actr3 actin related protein 3 located_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr13:39,353,413...39,396,509
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Aim2 absent in melanoma 2 is_active_in ISO
IEA		 (PMID:27846608)
GO_REF:0000107		 RGD
Ensembl		 PMID:27846608 GO_REF:0000107 NCBI chr13:88,397,516...88,439,325
Ensembl chr13:85,866,284...85,906,975 		JBrowse link
G Aplf aprataxin and PNKP like factor located_in
is_active_in		 ISO
IBA		 (PMID:21211721)
(PMID:23689425)
GO_REF:0000033		 RGD
GO_Central		 PMID:21211721 PMID:23689425 GO_REF:0000033 NCBI chr 4:121,627,800...121,679,980
Ensembl chr 4:120,070,471...120,122,633 		JBrowse link
G Arpc1a actin related protein 2/3 complex, subunit 1A located_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr12:9,502,496...9,525,304
Ensembl chr12:9,502,501...9,525,330 		JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 located_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 9:83,269,884...83,300,610
Ensembl chr 9:75,820,770...75,851,471 		JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 located_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410 		JBrowse link
G Asf1a anti-silencing function 1A histone chaperone is_active_in ISO (PMID:29478807) RGD PMID:29478807 NCBI chr20:32,893,962...32,908,808
Ensembl chr20:32,893,573...32,908,808 		JBrowse link
G Atf2 activating transcription factor 2 located_in ISS
ISO		 GO_REF:0000024
(PMID:15916964)		 UniProt
RGD		 PMID:15916964 GO_REF:0000024 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atm ATM serine/threonine kinase is_active_in ISO (PMID:26240375) RGD PMID:26240375 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Brme1 break repair meiotic recombinase recruitment factor 1 is_active_in ISO (PMID:32463460) RGD PMID:32463460 NCBI chr19:23,990,049...24,011,774
Ensembl chr19:23,990,045...24,011,850 		JBrowse link
G Cgas cyclic GMP-AMP synthase located_in
is_active_in		 ISO
IBA
IEA		 (PMID:30356214)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:30356214 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:79,294,511...79,305,496 		JBrowse link
G Chd1l chromodomain helicase DNA binding protein 1-like is_active_in ISO
IEA		 (PMID:29220652), (PMID:29220653)
GO_REF:0000107		 RGD
Ensembl		 PMID:29220652 PMID:29220653 GO_REF:0000107 NCBI chr 2:187,819,869...187,906,359
Ensembl chr 2:185,139,308...185,217,595 		JBrowse link
G Cyren cell cycle regulator of NHEJ is_active_in ISS
ISO		 GO_REF:0000024
(PMID:30017584)		 UniProt
RGD		 PMID:30017584 GO_REF:0000024 NCBI chr 4:63,547,311...63,553,394
Ensembl chr 4:63,547,335...63,551,602 		JBrowse link
G Ddb1 damage-specific DNA binding protein 1 is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:216,677,810...216,703,605
Ensembl chr 1:207,252,890...207,278,676 		JBrowse link
G Dmc1 DNA meiotic recombinase 1 is_active_in ISO
IEA		 (PMID:30760716), (PMID:32463460)
GO_REF:0000107		 RGD
Ensembl		 PMID:30760716 PMID:32463460 GO_REF:0000107 NCBI chr 7:113,005,278...113,047,854
Ensembl chr 7:111,124,888...111,167,952 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 is_active_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:37696958)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:37696958 GO_REF:0000024 GO_REF:0000107 NCBI chr12:46,945,291...46,976,867
Ensembl chr12:41,312,367...41,314,741 		JBrowse link
G Epc1 enhancer of polycomb homolog 1 is_active_in ISO (PMID:27153538) RGD PMID:27153538 NCBI chr17:59,198,513...59,289,535
Ensembl chr17:54,503,358...54,594,425 		JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 located_in ISO (PMID:22614755), (PMID:22699483) RGD PMID:22614755 PMID:22699483 NCBI chr15:44,210,124...44,230,785
Ensembl chr15:40,034,568...40,055,306
Ensembl chr15:40,034,568...40,055,306 		JBrowse link
G Fh fumarate hydratase located_in ISO (PMID:26237645) RGD PMID:26237645 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G H2ax H2A.X variant histone located_in
is_active_in		 ISO (PMID:21270334)
(PMID:22699483), (PMID:23133398)
(PMID:12419185)		 RGD PMID:12419185 PMID:21270334 PMID:22699483 PMID:23133398 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Helb DNA helicase B located_in ISO
IEA		 (PMID:26774285)
GO_REF:0000107		 RGD
Ensembl		 PMID:26774285 GO_REF:0000107 NCBI chr 7:57,474,115...57,502,221
Ensembl chr 7:55,588,798...55,615,585 		JBrowse link
G Htatsf1 HIV-1 Tat specific factor 1 is_active_in ISO
IEA		 (PMID:35597237)
GO_REF:0000107		 RGD
Ensembl		 PMID:35597237 GO_REF:0000107 NCBI chr  X:139,972,742...139,986,923
Ensembl chr  X:134,935,426...134,949,607 		JBrowse link
G Hus1 HUS1 checkpoint clamp component is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:87,902,458...87,917,221
Ensembl chr14:83,688,708...83,703,442 		JBrowse link
G Iffo1 intermediate filament family orphan 1 located_in ISO (PMID:31548606) RGD PMID:31548606 NCBI chr 4:157,945,075...157,962,302
Ensembl chr 4:157,945,107...157,962,302 		JBrowse link
G Inip INTS3 and NABP interacting protein located_in ISO
IEA		 (PMID:19683501)
GO_REF:0000107		 RGD
Ensembl		 PMID:19683501 GO_REF:0000107 NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628 		JBrowse link
G Ints3 integrator complex subunit 3 located_in ISO
IEA		 (PMID:19683501)
GO_REF:0000107		 RGD
Ensembl		 PMID:19683501 GO_REF:0000107 NCBI chr 2:175,859,421...175,911,683
Ensembl chr 2:175,859,440...175,911,709 		JBrowse link
G Kat5 lysine acetyltransferase 5 is_active_in ISO
IEA		 (PMID:27153538)
GO_REF:0000107		 RGD
Ensembl		 PMID:27153538 GO_REF:0000107 NCBI chr 1:212,325,089...212,332,640
Ensembl chr 1:202,895,751...202,903,458 		JBrowse link
G Kdm4d lysine demethylase 4D located_in ISO (PMID:24550317) RGD PMID:24550317 NCBI chr 8:19,561,253...19,586,412
Ensembl chr 8:11,268,859...11,305,290 		JBrowse link
G Lmna lamin A/C located_in ISO
ISS
IEA		 (PMID:31548606)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:31548606 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G LOC102557137 E3 ubiquitin-protein ligase RNF168-like is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:40,065,873...40,067,029
Ensembl chr  X:40,065,873...40,067,207 		JBrowse link
G Mbtd1 mbt domain containing 1 is_active_in ISO
IEA		 (PMID:27153538), (PMID:32209463)
GO_REF:0000107		 RGD
Ensembl		 PMID:27153538 PMID:32209463 GO_REF:0000107 NCBI chr10:79,336,041...79,392,315
Ensembl chr10:78,839,036...78,893,720 		JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 is_active_in ISS
ISO		 GO_REF:0000024
(PMID:16377563), (PMID:18411307), (PMID:18582474), (PMID:18583988), (PMID:18678890), (PMID:30898438)		 UniProt
RGD		 PMID:16377563 PMID:18411307 PMID:18582474 PMID:18583988 PMID:18678890 More... GO_REF:0000024 NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,895,505...2,910,240 		JBrowse link
G Mms22l MMS22-like, DNA repair protein is_active_in ISO
IEA		 (PMID:27797818)
GO_REF:0000107		 RGD
Ensembl		 PMID:27797818 GO_REF:0000107 NCBI chr 5:42,994,382...43,110,371
Ensembl chr 5:38,197,779...38,313,745 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease located_in
is_active_in		 ISS
ISO
IBA		 GO_REF:0000024
(PMID:15916964), (PMID:30612738)
GO_REF:0000033
(PMID:26240375), (PMID:28867292), (PMID:36050397)		 UniProt
RGD
GO_Central		 PMID:15916964 PMID:26240375 PMID:28867292 PMID:30612738 PMID:36050397 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Nabp1 nucleic acid binding protein 1 located_in ISO (PMID:19683501) RGD PMID:19683501 NCBI chr 9:57,570,326...57,625,926
Ensembl chr 9:50,126,726...50,134,107 		JBrowse link
G Nabp2 nucleic acid binding protein 2 located_in ISO
IEA		 (PMID:19683501)
GO_REF:0000107		 RGD
Ensembl		 PMID:19683501 GO_REF:0000107 NCBI chr 7:1,415,491...1,421,113
Ensembl chr 7:830,949...838,027 		JBrowse link
G Nbn nibrin located_in
is_active_in		 IEA
ISO
ISS		 GO_REF:0000107
(PMID:15916964)
GO_REF:0000024
(PMID:16622404), (PMID:18411307), (PMID:18582474), (PMID:18583988), (PMID:18678890), (PMID:19338747), (PMID:23115235), (PMID:24534091), (PMID:28867292), (PMID:38961290)		 Ensembl
RGD
UniProt		 PMID:15916964 PMID:16622404 PMID:18411307 PMID:18582474 PMID:18583988 More... GO_REF:0000024 GO_REF:0000107 NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Nhej1 nonhomologous end-joining factor 1 is_active_in ISO
ISS
IEA		 (PMID:18064046), (PMID:18644470), (PMID:27437582), (PMID:28500754)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:18064046 PMID:18644470 PMID:27437582 PMID:28500754 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:83,974,995...84,071,161
Ensembl chr 9:76,526,324...76,622,444 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 located_in
is_active_in		 ISO
ISS
IEA		 (PMID:26344098), (PMID:27568560), (PMID:30356214)
(PMID:29234005)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:26344098 PMID:27568560 PMID:29234005 PMID:30356214 GO_REF:0000024 GO_REF:0000107 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Parp3 poly (ADP-ribose) polymerase family, member 3 located_in
is_active_in		 ISO
IBA
IEA		 (PMID:21270334)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:21270334 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:115,989,721...115,995,822
Ensembl chr 8:107,111,012...107,116,782 		JBrowse link
G Paxx PAXX, non-homologous end joining factor located_in
is_active_in		 ISO
IBA
IEA		 (PMID:25670504)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:25670504 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:28,672,906...28,676,252
Ensembl chr 3:8,274,762...8,276,521 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 is_active_in ISO
IEA		 (PMID:30952868)
GO_REF:0000107		 RGD
Ensembl		 PMID:30952868 GO_REF:0000107 NCBI chr14:99,455,970...99,510,474
Ensembl chr14:95,254,589...95,308,285
Ensembl chr 1:95,254,589...95,308,285 		JBrowse link
G Phf1 PHD finger protein 1 located_in ISO
IEA		 (PMID:23142980)
GO_REF:0000107		 RGD
Ensembl		 PMID:23142980 GO_REF:0000107 NCBI chr20:5,019,650...5,024,732
Ensembl chr20:5,017,893...5,022,871 		JBrowse link
G Pnkp polynucleotide kinase 3'-phosphatase is_active_in ISO
IEA		 (PMID:28453785)
(PMID:26774286)
GO_REF:0000107		 RGD
Ensembl		 PMID:26774286 PMID:28453785 GO_REF:0000107 NCBI chr 1:104,476,801...104,483,409
Ensembl chr 1:95,341,620...95,346,920 		JBrowse link
G Polh DNA polymerase eta is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:22,275,929...22,310,576
Ensembl chr 9:14,777,888...14,812,723 		JBrowse link
G Poll DNA polymerase lambda is_active_in ISO
ISS
IEA		 (PMID:30250067)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:30250067 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662 		JBrowse link
G Polq DNA polymerase theta is_active_in ISO
IEA		 (PMID:37440612), (PMID:37674080)
GO_REF:0000107		 RGD
Ensembl		 PMID:37440612 PMID:37674080 GO_REF:0000107 NCBI chr11:77,179,190...77,281,270
Ensembl chr11:63,673,816...63,775,878 		JBrowse link
G Prpf19 pre-mRNA processing factor 19 located_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:18263876)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:18263876 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:216,966,104...216,977,549
Ensembl chr 1:207,541,595...207,552,662 		JBrowse link
G Rad17 RAD17 checkpoint clamp loader component is_active_in ISO
IEA		 (PMID:24534091)
GO_REF:0000107		 RGD
Ensembl		 PMID:24534091 GO_REF:0000107 NCBI chr 2:33,498,335...33,528,614
Ensembl chr 2:31,764,261...31,794,072 		JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase located_in ISO
IEA		 (PMID:25931565)
GO_REF:0000107		 RGD
Ensembl		 PMID:25931565 GO_REF:0000107 NCBI chr 4:147,291,463...147,376,904
Ensembl chr 4:145,735,654...145,821,069 		JBrowse link
G Rad50 RAD50 double strand break repair protein located_in
is_active_in		 ISO
IEA
ISS		 (PMID:15916964)
GO_REF:0000107
GO_REF:0000024
(PMID:16622404), (PMID:21757780), (PMID:28867292)		 RGD
Ensembl
UniProt		 PMID:15916964 PMID:16622404 PMID:21757780 PMID:28867292 GO_REF:0000024 GO_REF:0000107 NCBI chr10:38,310,147...38,362,100
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Rad51 RAD51 recombinase located_in
is_active_in		 ISO
IEA		 (PMID:24550317)
(PMID:26811421), (PMID:27797818)
(PMID:30760716), (PMID:32463460)
GO_REF:0000107		 RGD
Ensembl		 PMID:24550317 PMID:26811421 PMID:27797818 PMID:30760716 PMID:32463460 GO_REF:0000107 NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease is_active_in ISO
IEA		 (PMID:27814491), (PMID:27889449), (PMID:33836577)
GO_REF:0000107		 RGD
Ensembl		 PMID:27814491 PMID:27889449 PMID:33836577 GO_REF:0000107 NCBI chr18:3,198,188...3,263,643
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 located_in ISO (PMID:21504906) RGD PMID:21504906 NCBI chr19:56,145,221...56,177,871
Ensembl chr19:39,236,787...39,268,479 		JBrowse link
G Rhno1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 is_active_in ISS
ISO		 GO_REF:0000024
(PMID:37440612)		 UniProt
RGD		 PMID:37440612 GO_REF:0000024 NCBI chr 4:163,320,141...163,325,527
Ensembl chr 4:161,634,048...161,639,371 		JBrowse link
G Rif1 replication timing regulatory factor 1 located_in ISO
IEA		 (PMID:28241136)
(PMID:23306437), (PMID:23306439), (PMID:23333305)
GO_REF:0000107		 RGD
Ensembl		 PMID:23306437 PMID:23306439 PMID:23333305 PMID:28241136 GO_REF:0000107 NCBI chr 3:56,963,840...57,017,106
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Rnf138 ring finger protein 138 located_in
is_active_in		 ISO
ISS
IBA
IEA		 (PMID:26502055), (PMID:26502057)
GO_REF:0000024
GO_REF:0000033
GO_REF:0000107		 RGD
UniProt
GO_Central
Ensembl		 PMID:26502055 PMID:26502057 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr18:12,558,430...12,590,849
Ensembl chr18:12,291,590...12,315,930 		JBrowse link
G Rnf138l1 ring finger protein 138 like 1 is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:34,371,379...34,372,452
Ensembl chr  X:30,739,413...30,740,613 		JBrowse link
G Rnf168 ring finger protein 168 located_in
is_active_in		 ISO
ISS
IBA		 (PMID:19500350), (PMID:21041483)
GO_REF:0000024
(PMID:27153538)
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:19500350 PMID:21041483 PMID:27153538 GO_REF:0000024 GO_REF:0000033 NCBI chr11:81,991,352...82,013,306
Ensembl chr11:68,486,321...68,508,277 		JBrowse link
G Rnf169 ring finger protein 169 located_in
is_active_in		 ISO
IBA		 (PMID:22492721), (PMID:22733822), (PMID:22742833)
GO_REF:0000033		 RGD
GO_Central		 PMID:22492721 PMID:22733822 PMID:22742833 GO_REF:0000033 NCBI chr 1:163,662,582...163,724,154
Ensembl chr 1:154,254,473...154,311,653 		JBrowse link
G Rnf8 ring finger protein 8 located_in
is_active_in		 ISO
ISS
IBA		 (PMID:22266820)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:22266820 GO_REF:0000024 GO_REF:0000033 NCBI chr20:7,683,890...7,708,437
Ensembl chr20:7,682,322...7,708,491 		JBrowse link
G Rpa1 replication protein A1 is_active_in ISO
IEA		 (PMID:35597237)
GO_REF:0000107		 RGD
Ensembl		 PMID:35597237 GO_REF:0000107 NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,148,793...60,199,949 		JBrowse link
G Rpa2 replication protein A2 located_in
is_active_in		 ISS
ISO
IBA		 GO_REF:0000024
(PMID:21504906)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:21504906 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:150,260,668...150,271,329
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Rpa3 replication protein A3 is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:37,270,966...37,273,997
Ensembl chr 4:36,304,651...36,307,709 		JBrowse link
G Rpa3l1 replication protein A3 like 1 is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:51,568,413...51,568,839
Ensembl chr12:45,908,683...45,909,048 		JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 located_in ISO
IEA		 (PMID:28834754), (PMID:29670289)
GO_REF:0000107		 RGD
Ensembl		 PMID:28834754 PMID:29670289 GO_REF:0000107 NCBI chr 3:166,179,742...166,214,448
Ensembl chr 3:145,761,558...145,794,386 		JBrowse link
G Setmar SET domain and mariner transposase fusion gene located_in ISO (PMID:18263876), (PMID:21187428), (PMID:22231448) RGD PMID:18263876 PMID:21187428 PMID:22231448 NCBI chr 4:142,602,066...142,614,208
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
G Shld1 shieldin complex subunit 1 located_in
is_active_in		 ISO
IBA		 (PMID:29656893)
GO_REF:0000033		 RGD
GO_Central		 PMID:29656893 GO_REF:0000033 NCBI chr 3:140,391,611...140,462,273
Ensembl chr 3:119,938,833...120,009,550 		JBrowse link
G Shld2 shieldin complex subunit 2 located_in
is_active_in		 ISO
IBA		 (PMID:29656893)
GO_REF:0000033		 RGD
GO_Central		 PMID:29656893 GO_REF:0000033 NCBI chr16:9,554,921...9,646,186
Ensembl chr16:9,548,660...9,639,965 		JBrowse link
G Shld3 shieldin complex subunit 3 located_in ISO
IEA		 (PMID:29656893)
GO_REF:0000107		 RGD
Ensembl		 PMID:29656893 GO_REF:0000107 NCBI chr 2:35,297,255...35,302,071
Ensembl chr 2:35,295,859...35,302,346 		JBrowse link
G Sirt6 sirtuin 6 is_active_in ISO (PMID:21680843), (PMID:23911928), (PMID:27568560), (PMID:31995034), (PMID:32538779) RGD PMID:21680843 PMID:23911928 PMID:27568560 PMID:31995034 PMID:32538779 NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Sirt7 sirtuin 7 located_in ISS
ISO		 GO_REF:0000024
(PMID:27436229)
(PMID:27225932)		 UniProt
RGD		 PMID:27225932 PMID:27436229 GO_REF:0000024 NCBI chr10:106,394,802...106,401,627
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
G Slf1 SMC5-SMC6 complex localization factor 1 located_in ISO (PMID:25931565) RGD PMID:25931565 NCBI chr 2:8,498,776...8,606,251
Ensembl chr 2:6,767,015...6,867,149 		JBrowse link
G Slf2 SMC5-SMC6 complex localization factor 2 located_in
is_active_in		 ISO
IBA
IEA		 (PMID:25931565)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:25931565 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:253,731,979...253,794,577
Ensembl chr 1:243,782,246...243,845,250 		JBrowse link
G Smarca5 SNF2 related chromatin remodeling ATPase 5 is_active_in ISO
IEA		 (PMID:23911928)
GO_REF:0000107		 RGD
Ensembl		 PMID:23911928 GO_REF:0000107 NCBI chr19:44,172,465...44,208,967
Ensembl chr19:27,271,148...27,304,594 		JBrowse link
G Smarcad1 SNF2 related chromatin remodeling ATPase with DExD box 1 located_in ISO
ISS
IEA		 (PMID:22960744)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:22960744 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:95,639,722...95,709,055
Ensembl chr 4:94,311,489...94,372,563 		JBrowse link
G Smarcal1 SNF2 related chromatin remodeling annealing helicase 1 located_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19793862), (PMID:19793863)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19793862 PMID:19793863 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:81,689,446...81,735,406
Ensembl chr 9:74,240,241...74,286,146 		JBrowse link
G Smc5 structural maintenance of chromosomes 5 located_in ISO (PMID:25931565) RGD PMID:25931565 NCBI chr 1:230,195,894...230,265,677
Ensembl chr 1:220,769,366...220,839,096 		JBrowse link
G Smc6 structural maintenance of chromosomes 6 located_in
is_active_in		 ISO
IBA
IEA		 (PMID:25931565)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:25931565 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:39,697,810...39,752,275
Ensembl chr 6:33,978,716...34,031,746 		JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 located_in ISO
IEA		 (PMID:24790221), (PMID:25294876)
GO_REF:0000107		 RGD
Ensembl		 PMID:24790221 PMID:25294876 GO_REF:0000107 NCBI chr 9:118,690,050...118,837,281
Ensembl chr 9:111,247,702...111,349,665 		JBrowse link
G Stk38 serine/threonine kinase 38 is_active_in ISO
IEA		 (PMID:32537488)
GO_REF:0000107		 RGD
Ensembl		 PMID:32537488 GO_REF:0000107 NCBI chr20:7,035,923...7,070,657
Ensembl chr20:7,034,242...7,068,198 		JBrowse link
G Timeless timeless circadian regulator located_in ISO
ISS
IEA		 (PMID:26344098), (PMID:30356214)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:26344098 PMID:30356214 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:1,239,388...1,263,344
Ensembl chr 7:654,822...678,738 		JBrowse link
G Tonsl tonsoku-like, DNA repair protein is_active_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:26527279), (PMID:27338793), (PMID:29478807)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:26527279 PMID:27338793 PMID:29478807 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:110,226,696...110,241,459
Ensembl chr 7:108,346,047...108,360,750 		JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 is_active_in ISO
IEA		 (PMID:26811421), (PMID:30898438), (PMID:31135337), (PMID:35597237), (PMID:37674080)
GO_REF:0000107		 RGD
Ensembl		 PMID:26811421 PMID:30898438 PMID:31135337 PMID:35597237 PMID:37674080 GO_REF:0000107 NCBI chr 8:112,766,791...112,815,203
Ensembl chr 8:103,887,865...103,931,674 		JBrowse link
G Tp53 tumor protein p53 located_in IEA
ISO		 GO_REF:0000107
(PMID:24550317)		 Ensembl
RGD		 PMID:24550317 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 located_in
is_active_in		 ISO
IEA		 (PMID:23333306), (PMID:23760478), (PMID:28241136)
(PMID:22492721), (PMID:27153538), (PMID:31135337), (PMID:32209463), (PMID:37696958)
(PMID:23209566), (PMID:23333305)
GO_REF:0000107		 RGD
Ensembl		 PMID:22492721 PMID:23209566 PMID:23333305 PMID:23333306 PMID:23760478 More... GO_REF:0000107 NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Ufl1 Ufm1-specific ligase 1 located_in ISO
ISS
IEA		 (PMID:30886146)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:30886146 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:43,759,271...43,791,682
Ensembl chr 5:38,962,171...38,995,199 		JBrowse link
G Uimc1 ubiquitin interaction motif containing 1 is_active_in ISO
IEA		 (PMID:22492721)
GO_REF:0000107		 RGD
Ensembl		 PMID:22492721 GO_REF:0000107 NCBI chr17:9,528,923...9,597,967
Ensembl chr17:9,527,794...9,592,799 		JBrowse link
G Vcp valosin-containing protein located_in ISO
ISS
IEA		 (PMID:22120668)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:22120668 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Was WASP actin nucleation promoting factor located_in ISO
IEA		 (PMID:29925947)
GO_REF:0000107		 RGD
Ensembl		 PMID:29925947 GO_REF:0000107 NCBI chr  X:17,077,057...17,085,802
Ensembl chr  X:14,405,124...14,413,849 		JBrowse link
G Wdr70 WD repeat domain 70 is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:58,678,651...58,918,523
Ensembl chr 2:56,951,355...57,191,187 		JBrowse link
G Wrap53 WD repeat containing, antisense to TP53 located_in ISO
ISS
IEA		 (PMID:25512560), (PMID:26734725), (PMID:27715493)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:25512560 PMID:26734725 PMID:27715493 GO_REF:0000024 GO_REF:0000107 NCBI chr10:54,780,873...54,797,919
Ensembl chr10:54,282,105...54,298,929 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 located_in
is_active_in		 ISO
IEA		 (PMID:31548606)
(PMID:26774286), (PMID:27437582), (PMID:28500754)
GO_REF:0000107		 RGD
Ensembl		 PMID:26774286 PMID:27437582 PMID:28500754 PMID:31548606 GO_REF:0000107 NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
G Zbtb7a zinc finger and BTB domain containing 7a located_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:26446488)		 Ensembl
UniProt
RGD		 PMID:26446488 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:9,211,733...9,229,273
Ensembl chr 7:8,563,779...8,576,539 		JBrowse link
G Zgrf1 zinc finger, GRF-type containing 1 is_active_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:218,687,413...218,750,104
Ensembl chr 2:216,013,005...216,074,750 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21366
    cellular anatomical structure 21071
      site of DNA damage 129
        site of double-strand break 96
Path 2
Term Annotations click to browse term
  cellular_component 21366
    cellular anatomical structure 21071
      organelle 14293
        membraneless organelle 5412
          intracellular membraneless organelle 5412
            chromosome 1423
              site of DNA damage 129
                site of double-strand break 96
paths to the root