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ONTOLOGY REPORT - ANNOTATIONS


Term:Notch receptor processing, ligand-dependent
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Accession:GO:0035333 term browser browse the term
Definition:The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).
Synonyms:narrow_synonym: Notch S2 cleavage;   Notch S3 cleavage



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  biological_process 20536
    cellular process 19525
      signal transduction 7251
        cell surface receptor signaling pathway 2882
          Notch signaling pathway 194
            Notch receptor processing, ligand-dependent 0
Path 2
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  biological_process 20536
    cellular process 19525
      metabolic process 12160
        macromolecule metabolic process 9981
          protein metabolic process 5234
            proteolysis 1701
              membrane protein proteolysis 64
                membrane protein intracellular domain proteolysis 13
                  Notch receptor processing, ligand-dependent 0
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