ONTOLOGY REPORT - ANNOTATIONS
Term: hippo signaling
Accession: GO:0035329
browse the term
Definition: An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.
Synonyms: exact_synonym: hippo signal transduction; hippo signaling pathway
narrow_synonym: SWH pathway; Salvador-Warts-Hippo signaling pathway
related_synonym: hippo signaling cascade; hippo signalling cascade
xref: Reactome:R-HSA-2028269 "Signaling by Hippo"
GViewer not supported for the selected species.
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Amot
angiomotin
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:21205866)
MGI TreeGrafter
PMID:21205866
GO_REF:0000118
NCBI chrNW_004624803:2,405,037...2,491,715
Ensembl chrNW_004624803:2,422,274...2,488,097
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Amotl1
angiomotin like 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624735:39,393,567...39,544,266
Ensembl chrNW_004624735:39,435,338...39,539,826
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Amotl2
angiomotin like 2
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:21205866)
MGI TreeGrafter
PMID:21205866
GO_REF:0000118
NCBI chrNW_004624730:10,695,648...10,713,188
Ensembl chrNW_004624730:10,695,138...10,713,808
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Dchs1
dachsous cadherin-related 1
involved_in
ISO
(PMID:24056717)
UniProt
PMID:24056717
NCBI chrNW_004624817:8,111,714...8,147,699
Ensembl chrNW_004624817:8,111,718...8,134,342
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Fat4
FAT atypical cadherin 4
involved_in
ISO
(PMID:24056717)
UniProt
PMID:24056717
NCBI chrNW_004624777:6,095,166...6,293,142
Ensembl chrNW_004624777:6,095,643...6,292,980
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Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624854:475,098...831,202
Ensembl chrNW_004624854:618,262...824,178
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Lats1
large tumor suppressor kinase 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:18369314)
Ensembl TreeGrafter MGI
PMID:18369314
GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004624785:8,356,238...8,405,877
Ensembl chrNW_004624785:8,369,922...8,408,919
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Lats2
large tumor suppressor kinase 2
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:18369314)
MGI TreeGrafter
PMID:18369314
GO_REF:0000118
NCBI chrNW_004624776:16,572,598...16,640,412
Ensembl chrNW_004624776:16,585,025...16,638,520
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LOC106010110
transcriptional coactivator YAP1-like
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624772:9,206,715...9,209,082
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Mob1a
MOB kinase activator 1A
involved_in
ISO
(PMID:18328708), (PMID:19739119)
UniProt
PMID:18328708 PMID:19739119
NCBI chrNW_004624749:29,284,516...29,308,057
Ensembl chrNW_004624749:29,284,185...29,308,515
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Mob1b
MOB kinase activator 1B
involved_in
ISO
(PMID:18328708), (PMID:19739119)
UniProt
PMID:18328708 PMID:19739119
NCBI chrNW_004624890:2,252,580...2,331,868
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Sav1
salvador family WW domain containing protein 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:21512031) (PMID:18369314)
InterPro TreeGrafter MGI
PMID:18369314 PMID:21512031
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004624731:18,262,110...18,282,386
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Stk3
serine/threonine kinase 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004624763:5,568,079...5,886,722
Ensembl chrNW_004624763:5,564,835...5,886,769
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Stk4
serine/threonine kinase 4
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:18369314)
Ensembl MGI
PMID:18369314
GO_REF:0000107
NCBI chrNW_004624790:9,415,172...9,521,103
Ensembl chrNW_004624790:9,415,177...9,521,051
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Tead1
TEA domain transcription factor 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:19004856)
InterPro TreeGrafter MGI
PMID:19004856
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004624766:4,694,337...4,935,121
Ensembl chrNW_004624766:4,694,016...4,928,302
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Tead2
TEA domain transcription factor 2
involved_in
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004624832:4,821,697...4,837,257
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Tead3
TEA domain transcription factor 3
involved_in
IEA
InterPro UniProt TreeGrafter
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118
NCBI chrNW_004624754:21,971,362...21,987,128
Ensembl chrNW_004624754:21,971,445...21,986,557
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Tead4
TEA domain transcription factor 4
involved_in
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chrNW_004624860:314,404...368,212
Ensembl chrNW_004624860:297,601...368,274
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Wwc1
WW and C2 domain containing 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004624733:21,541,654...21,712,604
Ensembl chrNW_004624733:21,542,389...21,712,457
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Wwc2
WW and C2 domain containing 2
involved_in
ISO
(PMID:35429439)
UniProt
PMID:35429439
NCBI chrNW_004624769:13,829,319...14,058,053
Ensembl chrNW_004624769:13,829,415...14,053,067
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Wwc3
WWC family member 3
involved_in
ISO
(PMID:35429439)
UniProt
PMID:35429439
NCBI chrNW_004624882:4,161,565...4,270,837
Ensembl chrNW_004624882:4,161,485...4,271,362
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Wwox
WW domain containing oxidoreductase
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624746:7,983,863...8,924,312
Ensembl chrNW_004624746:7,984,671...8,924,136
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Wwtr1
WW domain containing transcription regulator 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624730:26,813,716...26,967,615
Ensembl chrNW_004624730:26,813,624...26,967,691
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Yap1
Yes1 associated transcriptional regulator
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:18369314)
MGI TreeGrafter
PMID:18369314
GO_REF:0000118
NCBI chrNW_004624878:621,214...776,363
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Ajuba
ajuba LIM protein
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004624820:9,551,664...9,562,773
Ensembl chrNW_004624820:9,552,287...9,563,472
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Cit
citron rho-interacting serine/threonine kinase
involved_in
ISO
(PMID:30865227)
FlyBase
PMID:30865227
NCBI chrNW_004624747:13,749,126...13,918,222
Ensembl chrNW_004624747:13,750,283...13,915,715
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Dlg5
discs large MAGUK scaffold protein 5
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624754:11,033,649...11,155,271
Ensembl chrNW_004624754:11,036,716...11,155,256
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Limd1
LIM domain containing 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624730:75,176,978...75,218,606
Ensembl chrNW_004624730:75,176,717...75,219,314
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Map2k3
mitogen-activated protein kinase kinase 3
involved_in
ISO
(PMID:27402810)
FlyBase
PMID:27402810
NCBI chrNW_004624849:5,007,185...5,034,488
Ensembl chrNW_004624849:5,006,513...5,035,747
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Mapk14
mitogen-activated protein kinase 14
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004624754:21,528,121...21,598,064
Ensembl chrNW_004624754:21,527,333...21,597,733
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Mark3
microtubule affinity regulating kinase 3
involved_in
ISO
(PMID:28087714)
UniProt
PMID:28087714
NCBI chrNW_004624734:1,362,263...1,469,930
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Ppp2ca
protein phosphatase 2 catalytic subunit alpha
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004624733:38,012,694...38,033,745
Ensembl chrNW_004624733:38,012,392...38,036,914
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Ppp2r1a
protein phosphatase 2 scaffold subunit Aalpha
involved_in
ISO
(PMID:33633399)
UniProt
PMID:33633399
NCBI chrNW_004624832:2,979,270...3,009,189
Ensembl chrNW_004624832:2,979,320...3,011,715
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Shank2
SH3 and multiple ankyrin repeat domains 2
involved_in
ISO
(PMID:32661924)
FlyBase
PMID:32661924
NCBI chrNW_004624767:16,296,053...16,828,714
Ensembl chrNW_004624767:16,380,751...16,823,577
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Sike1
suppressor of IKBKE 1
involved_in
ISO
(PMID:30622739)
UniProt
PMID:30622739
NCBI chrNW_004624772:10,429,676...10,443,540
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Sirt1
sirtuin 1
involved_in
ISO
(PMID:38512451)
UniProt
PMID:38512451
NCBI chrNW_004624754:2,304,476...2,332,705
Ensembl chrNW_004624754:2,304,634...2,330,946
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Slmap
sarcolemma associated protein
involved_in
ISO
(PMID:29063833), (PMID:30622739)
UniProt
PMID:29063833 PMID:30622739
NCBI chrNW_004624821:493,902...638,553
Ensembl chrNW_004624821:493,735...639,801
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
involved_in
ISO
(PMID:33162394)
FlyBase
PMID:33162394
NCBI chrNW_004624842:2,212,561...2,260,514
Ensembl chrNW_004624842:2,211,020...2,230,132
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Strip1
striatin interacting protein 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004624772:5,802,389...5,821,695
Ensembl chrNW_004624772:5,802,065...5,822,901
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Strn3
striatin 3
involved_in
ISO
(PMID:30622739), (PMID:33633399)
UniProt
PMID:30622739 PMID:33633399
NCBI chrNW_004624820:1,264,267...1,364,634
Ensembl chrNW_004624820:1,264,200...1,366,342
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Strn4
striatin 4
involved_in
ISO
(PMID:32640226)
UniProt
PMID:32640226
NCBI chrNW_004624832:6,858,107...6,883,514
Ensembl chrNW_004624832:6,858,123...6,883,514
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Vcp
valosin containing protein
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004624915:253,240...270,440
Ensembl chrNW_004624915:253,240...270,501
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Vgll4
vestigial like family member 4
involved_in
ISO
(PMID:28051067) (PMID:27720608)
UniProt
PMID:27720608 PMID:28051067
NCBI chrNW_004624943:113,215...232,216
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Wtip
WT1 interacting protein
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624794:8,721,261...8,746,923
Ensembl chrNW_004624794:8,722,110...8,745,987
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Wwc1
WW and C2 domain containing 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004624733:21,541,654...21,712,604
Ensembl chrNW_004624733:21,542,389...21,712,457
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Wwc2
WW and C2 domain containing 2
involved_in
ISO
(PMID:24682284)
BHF-UCL
PMID:24682284
NCBI chrNW_004624769:13,829,319...14,058,053
Ensembl chrNW_004624769:13,829,415...14,053,067
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Wwc3
WWC family member 3
involved_in
ISO
(PMID:24682284)
BHF-UCL
PMID:24682284
NCBI chrNW_004624882:4,161,565...4,270,837
Ensembl chrNW_004624882:4,161,485...4,271,362
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Aars1
alanyl-tRNA synthetase 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004624746:12,540,969...12,566,989
Ensembl chrNW_004624746:12,540,633...12,567,376
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Arrdc3
arrestin domain containing 3
involved_in
ISO
(PMID:24114784), (PMID:29364502)
FlyBase
PMID:24114784 PMID:29364502
NCBI chrNW_004624743:10,334,114...10,346,030
Ensembl chrNW_004624743:10,333,693...10,346,272
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Dlg5
discs large MAGUK scaffold protein 5
involved_in
ISO
(PMID:28169360)
UniProt
PMID:28169360
NCBI chrNW_004624754:11,033,649...11,155,271
Ensembl chrNW_004624754:11,036,716...11,155,256
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Frmd6
FERM domain containing 6
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624731:17,284,024...17,380,406
Ensembl chrNW_004624731:17,282,088...17,359,754
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LOC101699238
schwannomin-interacting protein 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624730:36,830,023...37,687,358
Ensembl chrNW_004624730:37,052,401...37,687,893
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Map4k4
mitogen-activated protein kinase kinase kinase kinase 4
involved_in
ISO
(PMID:26437443)
UniProt
PMID:26437443
NCBI chrNW_004624749:6,332,686...6,495,942
Ensembl chrNW_004624749:6,332,534...6,495,942
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Prp4k
pre-mRNA processing factor kinase PRP4K
involved_in
ISO
(PMID:29695716)
UniProt
PMID:29695716
NCBI chrNW_004624756:21,038,438...21,082,607
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Sox11
SRY-box transcription factor 11
involved_in
ISO
(PMID:20596238)
UniProt
PMID:20596238
NCBI chrNW_004624846:4,043,010...4,046,660
Ensembl chrNW_004624846:4,044,893...4,046,248
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Stk3
serine/threonine kinase 3
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:22292086)
MGI Ensembl
PMID:22292086
GO_REF:0000107
NCBI chrNW_004624763:5,568,079...5,886,722
Ensembl chrNW_004624763:5,564,835...5,886,769
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Stk4
serine/threonine kinase 4
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:22292086)
MGI Ensembl
PMID:22292086
GO_REF:0000107
NCBI chrNW_004624790:9,415,172...9,521,103
Ensembl chrNW_004624790:9,415,177...9,521,051
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Tial1
TIA1 cytotoxic granule associated RNA binding protein like 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004624737:27,236,533...27,259,464
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Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
involved_in
ISO
(PMID:11118213)
UniProt
PMID:11118213
NCBI chrNW_004624786:4,080,650...4,135,200
Ensembl chrNW_004624786:4,080,427...4,135,459
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Mob3b
MOB kinase activator 3B
involved_in
ISO
(PMID:28792927)
UniProt
PMID:28792927
NCBI chrNW_004624736:31,534,327...31,735,163
Ensembl chrNW_004624736:31,552,912...31,667,100
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Nek8
NIMA related kinase 8
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chrNW_004624786:1,303,283...1,314,188
Ensembl chrNW_004624786:1,303,308...1,314,188
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Nf2
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
involved_in
ISO
(PMID:20159598)
UniProt
PMID:20159598
NCBI chrNW_004624747:5,923,827...6,011,276
Ensembl chrNW_004624747:5,923,834...6,011,939
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Nuak2
NUAK family kinase 2
involved_in
ISO
(PMID:32845958)
UniProt
PMID:32845958
NCBI chrNW_004624807:5,850,857...5,869,284
Ensembl chrNW_004624807:5,850,600...5,869,547
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Wwc1
WW and C2 domain containing 1
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chrNW_004624733:21,541,654...21,712,604
Ensembl chrNW_004624733:21,542,389...21,712,457
G
Wwc2
WW and C2 domain containing 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624769:13,829,319...14,058,053
Ensembl chrNW_004624769:13,829,415...14,053,067
G
Wwc3
WWC family member 3
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chrNW_004624882:4,161,565...4,270,837
Ensembl chrNW_004624882:4,161,485...4,271,362
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all