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ONTOLOGY REPORT - ANNOTATIONS


Term:hippo signaling
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Accession:GO:0035329 term browser browse the term
Definition:An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.
Synonyms:exact_synonym: hippo signal transduction;   hippo signaling pathway
 narrow_synonym: SWH pathway;   Salvador-Warts-Hippo signaling pathway
 related_synonym: hippo signaling cascade;   hippo signalling cascade
 xref: Reactome:R-HSA-2028269 "Signaling by Hippo"


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hippo signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amot angiomotin acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:21205866) MGI
TreeGrafter
PMID:21205866 GO_REF:0000118 NCBI chrNW_004624803:2,405,037...2,491,715
Ensembl chrNW_004624803:2,422,274...2,488,097
JBrowse link
G Amotl1 angiomotin like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624735:39,393,567...39,544,266
Ensembl chrNW_004624735:39,435,338...39,539,826
JBrowse link
G Amotl2 angiomotin like 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:21205866) MGI
TreeGrafter
PMID:21205866 GO_REF:0000118 NCBI chrNW_004624730:10,695,648...10,713,188
Ensembl chrNW_004624730:10,695,138...10,713,808
JBrowse link
G Dchs1 dachsous cadherin-related 1 involved_in ISO (PMID:24056717) UniProt PMID:24056717 NCBI chrNW_004624817:8,111,714...8,147,699
Ensembl chrNW_004624817:8,111,718...8,134,342
JBrowse link
G Fat4 FAT atypical cadherin 4 involved_in ISO (PMID:24056717) UniProt PMID:24056717 NCBI chrNW_004624777:6,095,166...6,293,142
Ensembl chrNW_004624777:6,095,643...6,292,980
JBrowse link
G Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624854:475,098...831,202
Ensembl chrNW_004624854:618,262...824,178
JBrowse link
G Lats1 large tumor suppressor kinase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:18369314) Ensembl
TreeGrafter
MGI
PMID:18369314 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624785:8,356,238...8,405,877
Ensembl chrNW_004624785:8,369,922...8,408,919
JBrowse link
G Lats2 large tumor suppressor kinase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:18369314) MGI
TreeGrafter
PMID:18369314 GO_REF:0000118 NCBI chrNW_004624776:16,572,598...16,640,412
Ensembl chrNW_004624776:16,585,025...16,638,520
JBrowse link
G LOC106010110 transcriptional coactivator YAP1-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624772:9,206,715...9,209,082 JBrowse link
G Mob1a MOB kinase activator 1A involved_in ISO (PMID:18328708), (PMID:19739119) UniProt PMID:18328708 PMID:19739119 NCBI chrNW_004624749:29,284,516...29,308,057
Ensembl chrNW_004624749:29,284,185...29,308,515
JBrowse link
G Mob1b MOB kinase activator 1B involved_in ISO (PMID:18328708), (PMID:19739119) UniProt PMID:18328708 PMID:19739119 NCBI chrNW_004624890:2,252,580...2,331,868 JBrowse link
G Sav1 salvador family WW domain containing protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21512031)
(PMID:18369314)
InterPro
TreeGrafter
MGI
PMID:18369314 PMID:21512031 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624731:18,262,110...18,282,386 JBrowse link
G Stk3 serine/threonine kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624763:5,568,079...5,886,722
Ensembl chrNW_004624763:5,564,835...5,886,769
JBrowse link
G Stk4 serine/threonine kinase 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:18369314) Ensembl
MGI
PMID:18369314 GO_REF:0000107 NCBI chrNW_004624790:9,415,172...9,521,103
Ensembl chrNW_004624790:9,415,177...9,521,051
JBrowse link
G Tead1 TEA domain transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:19004856) InterPro
TreeGrafter
MGI
PMID:19004856 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624766:4,694,337...4,935,121
Ensembl chrNW_004624766:4,694,016...4,928,302
JBrowse link
G Tead2 TEA domain transcription factor 2 involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624832:4,821,697...4,837,257 JBrowse link
G Tead3 TEA domain transcription factor 3 involved_in IEA InterPro
UniProt
TreeGrafter
GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004624754:21,971,362...21,987,128
Ensembl chrNW_004624754:21,971,445...21,986,557
JBrowse link
G Tead4 TEA domain transcription factor 4 involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624860:314,404...368,212
Ensembl chrNW_004624860:297,601...368,274
JBrowse link
G Wwc1 WW and C2 domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624733:21,541,654...21,712,604
Ensembl chrNW_004624733:21,542,389...21,712,457
JBrowse link
G Wwc2 WW and C2 domain containing 2 involved_in ISO (PMID:35429439) UniProt PMID:35429439 NCBI chrNW_004624769:13,829,319...14,058,053
Ensembl chrNW_004624769:13,829,415...14,053,067
JBrowse link
G Wwc3 WWC family member 3 involved_in ISO (PMID:35429439) UniProt PMID:35429439 NCBI chrNW_004624882:4,161,565...4,270,837
Ensembl chrNW_004624882:4,161,485...4,271,362
JBrowse link
G Wwox WW domain containing oxidoreductase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624746:7,983,863...8,924,312
Ensembl chrNW_004624746:7,984,671...8,924,136
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:26,813,716...26,967,615
Ensembl chrNW_004624730:26,813,624...26,967,691
JBrowse link
G Yap1 Yes1 associated transcriptional regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:18369314) MGI
TreeGrafter
PMID:18369314 GO_REF:0000118 NCBI chrNW_004624878:621,214...776,363 JBrowse link
negative regulation of hippo signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ajuba ajuba LIM protein involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624820:9,551,664...9,562,773
Ensembl chrNW_004624820:9,552,287...9,563,472
JBrowse link
G Cit citron rho-interacting serine/threonine kinase involved_in ISO (PMID:30865227) FlyBase PMID:30865227 NCBI chrNW_004624747:13,749,126...13,918,222
Ensembl chrNW_004624747:13,750,283...13,915,715
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624754:11,033,649...11,155,271
Ensembl chrNW_004624754:11,036,716...11,155,256
JBrowse link
G Limd1 LIM domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:75,176,978...75,218,606
Ensembl chrNW_004624730:75,176,717...75,219,314
JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 involved_in ISO (PMID:27402810) FlyBase PMID:27402810 NCBI chrNW_004624849:5,007,185...5,034,488
Ensembl chrNW_004624849:5,006,513...5,035,747
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624754:21,528,121...21,598,064
Ensembl chrNW_004624754:21,527,333...21,597,733
JBrowse link
G Mark3 microtubule affinity regulating kinase 3 involved_in ISO (PMID:28087714) UniProt PMID:28087714 NCBI chrNW_004624734:1,362,263...1,469,930 JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624733:38,012,694...38,033,745
Ensembl chrNW_004624733:38,012,392...38,036,914
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit Aalpha involved_in ISO (PMID:33633399) UniProt PMID:33633399 NCBI chrNW_004624832:2,979,270...3,009,189
Ensembl chrNW_004624832:2,979,320...3,011,715
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 involved_in ISO (PMID:32661924) FlyBase PMID:32661924 NCBI chrNW_004624767:16,296,053...16,828,714
Ensembl chrNW_004624767:16,380,751...16,823,577
JBrowse link
G Sike1 suppressor of IKBKE 1 involved_in ISO (PMID:30622739) UniProt PMID:30622739 NCBI chrNW_004624772:10,429,676...10,443,540 JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:38512451) UniProt PMID:38512451 NCBI chrNW_004624754:2,304,476...2,332,705
Ensembl chrNW_004624754:2,304,634...2,330,946
JBrowse link
G Slmap sarcolemma associated protein involved_in ISO (PMID:29063833), (PMID:30622739) UniProt PMID:29063833 PMID:30622739 NCBI chrNW_004624821:493,902...638,553
Ensembl chrNW_004624821:493,735...639,801
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:33162394) FlyBase PMID:33162394 NCBI chrNW_004624842:2,212,561...2,260,514
Ensembl chrNW_004624842:2,211,020...2,230,132
JBrowse link
G Strip1 striatin interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:5,802,389...5,821,695
Ensembl chrNW_004624772:5,802,065...5,822,901
JBrowse link
G Strn3 striatin 3 involved_in ISO (PMID:30622739), (PMID:33633399) UniProt PMID:30622739 PMID:33633399 NCBI chrNW_004624820:1,264,267...1,364,634
Ensembl chrNW_004624820:1,264,200...1,366,342
JBrowse link
G Strn4 striatin 4 involved_in ISO (PMID:32640226) UniProt PMID:32640226 NCBI chrNW_004624832:6,858,107...6,883,514
Ensembl chrNW_004624832:6,858,123...6,883,514
JBrowse link
G Vcp valosin containing protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624915:253,240...270,440
Ensembl chrNW_004624915:253,240...270,501
JBrowse link
G Vgll4 vestigial like family member 4 involved_in ISO (PMID:28051067)
(PMID:27720608)
UniProt PMID:27720608 PMID:28051067 NCBI chrNW_004624943:113,215...232,216 JBrowse link
G Wtip WT1 interacting protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624794:8,721,261...8,746,923
Ensembl chrNW_004624794:8,722,110...8,745,987
JBrowse link
G Wwc1 WW and C2 domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624733:21,541,654...21,712,604
Ensembl chrNW_004624733:21,542,389...21,712,457
JBrowse link
G Wwc2 WW and C2 domain containing 2 involved_in ISO (PMID:24682284) BHF-UCL PMID:24682284 NCBI chrNW_004624769:13,829,319...14,058,053
Ensembl chrNW_004624769:13,829,415...14,053,067
JBrowse link
G Wwc3 WWC family member 3 involved_in ISO (PMID:24682284) BHF-UCL PMID:24682284 NCBI chrNW_004624882:4,161,565...4,270,837
Ensembl chrNW_004624882:4,161,485...4,271,362
JBrowse link
positive regulation of hippo signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624746:12,540,969...12,566,989
Ensembl chrNW_004624746:12,540,633...12,567,376
JBrowse link
G Arrdc3 arrestin domain containing 3 involved_in ISO (PMID:24114784), (PMID:29364502) FlyBase PMID:24114784 PMID:29364502 NCBI chrNW_004624743:10,334,114...10,346,030
Ensembl chrNW_004624743:10,333,693...10,346,272
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 involved_in ISO (PMID:28169360) UniProt PMID:28169360 NCBI chrNW_004624754:11,033,649...11,155,271
Ensembl chrNW_004624754:11,036,716...11,155,256
JBrowse link
G Frmd6 FERM domain containing 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:17,284,024...17,380,406
Ensembl chrNW_004624731:17,282,088...17,359,754
JBrowse link
G LOC101699238 schwannomin-interacting protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:36,830,023...37,687,358
Ensembl chrNW_004624730:37,052,401...37,687,893
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 involved_in ISO (PMID:26437443) UniProt PMID:26437443 NCBI chrNW_004624749:6,332,686...6,495,942
Ensembl chrNW_004624749:6,332,534...6,495,942
JBrowse link
G Prp4k pre-mRNA processing factor kinase PRP4K involved_in ISO (PMID:29695716) UniProt PMID:29695716 NCBI chrNW_004624756:21,038,438...21,082,607 JBrowse link
G Sox11 SRY-box transcription factor 11 involved_in ISO (PMID:20596238) UniProt PMID:20596238 NCBI chrNW_004624846:4,043,010...4,046,660
Ensembl chrNW_004624846:4,044,893...4,046,248
JBrowse link
G Stk3 serine/threonine kinase 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:22292086) MGI
Ensembl
PMID:22292086 GO_REF:0000107 NCBI chrNW_004624763:5,568,079...5,886,722
Ensembl chrNW_004624763:5,564,835...5,886,769
JBrowse link
G Stk4 serine/threonine kinase 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:22292086) MGI
Ensembl
PMID:22292086 GO_REF:0000107 NCBI chrNW_004624790:9,415,172...9,521,103
Ensembl chrNW_004624790:9,415,177...9,521,051
JBrowse link
G Tial1 TIA1 cytotoxic granule associated RNA binding protein like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:27,236,533...27,259,464 JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon involved_in ISO (PMID:11118213) UniProt PMID:11118213 NCBI chrNW_004624786:4,080,650...4,135,200
Ensembl chrNW_004624786:4,080,427...4,135,459
JBrowse link
regulation of hippo signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mob3b MOB kinase activator 3B involved_in ISO (PMID:28792927) UniProt PMID:28792927 NCBI chrNW_004624736:31,534,327...31,735,163
Ensembl chrNW_004624736:31,552,912...31,667,100
JBrowse link
G Nek8 NIMA related kinase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624786:1,303,283...1,314,188
Ensembl chrNW_004624786:1,303,308...1,314,188
JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor involved_in ISO (PMID:20159598) UniProt PMID:20159598 NCBI chrNW_004624747:5,923,827...6,011,276
Ensembl chrNW_004624747:5,923,834...6,011,939
JBrowse link
G Nuak2 NUAK family kinase 2 involved_in ISO (PMID:32845958) UniProt PMID:32845958 NCBI chrNW_004624807:5,850,857...5,869,284
Ensembl chrNW_004624807:5,850,600...5,869,547
JBrowse link
G Wwc1 WW and C2 domain containing 1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624733:21,541,654...21,712,604
Ensembl chrNW_004624733:21,542,389...21,712,457
JBrowse link
G Wwc2 WW and C2 domain containing 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624769:13,829,319...14,058,053
Ensembl chrNW_004624769:13,829,415...14,053,067
JBrowse link
G Wwc3 WWC family member 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624882:4,161,565...4,270,837
Ensembl chrNW_004624882:4,161,485...4,271,362
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17638
    cellular process 17218
      signal transduction 6091
        intracellular signal transduction 2834
          hippo signaling 57
            negative regulation of hippo signaling 23
            positive regulation of hippo signaling 12
            regulation of hippo signaling + 38
Path 2
Term Annotations click to browse term
  biological_process 17638
    biological regulation 11844
      regulation of biological process 11485
        signaling 6585
          signal transduction 6091
            intracellular signal transduction 2834
              hippo signaling 57
                negative regulation of hippo signaling 23
                positive regulation of hippo signaling 12
                regulation of hippo signaling + 38
paths to the root