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ONTOLOGY REPORT - ANNOTATIONS

Term:protein-arginine omega-N symmetric methyltransferase activity
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Accession:GO:0035243 term browser browse the term
Definition:Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.
Comment:Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'.
Synonyms:exact_synonym: protein arginine omega-N symmetric methylase activity
 related_synonym: S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming);   type II PRMT activity;   type II protein arginine methyltransferase activity
 xref: EC:2.1.1.320;   RESID:AA0067;   RESID:AA0069;   RHEA:48108;   reactome:R-HSA-6804383 "PRMT5 methylates TP53"


show annotations for term's descendants           Sort by:
protein-arginine omega-N symmetric methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NDUFAF7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables IEA
IMP
IBA		 (PMID:24089531) UniProt
RHEA
GO_Central		 PMID:24089531 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr 2:37,231,658...37,271,365
Ensembl chr 2:37,231,631...37,253,403 		JBrowse link
G PRMT5 protein arginine methyltransferase 5 enables IMP
EXP
IEA
IDA		 (PMID:17709427)
(PMID:19011621)
(PMID:22143770)		 UniProt
Reactome
RHEA
WB		 PMID:17709427 PMID:19011621 PMID:22143770 GO_REF:0000003 GO_REF:0000116 NCBI chr14:22,920,529...22,929,376
Ensembl chr14:22,920,525...22,929,408 		JBrowse link
G PRMT7 protein arginine methyltransferase 7 enables IMP
IEA
IDA		 (PMID:17709427)
(PMID:15494416), (PMID:19110445)		 UniProt
Ensembl
HGNC-UCL		 PMID:15494416 PMID:17709427 PMID:19110445 GO_REF:0000107 NCBI chr16:68,311,019...68,360,870
Ensembl chr16:68,310,951...68,360,852 		JBrowse link
G PRMT9 protein arginine methyltransferase 9 enables IEA
IMP		 (PMID:25737013) UniProt
RHEA		 PMID:25737013 GO_REF:0000003 GO_REF:0000116 NCBI chr 4:147,637,785...147,684,163
Ensembl chr 4:147,637,785...147,684,163 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19689
    catalytic activity 7147
      catalytic activity, acting on a protein 3004
        protein methyltransferase activity 98
          protein-arginine N-methyltransferase activity 12
            protein-arginine omega-N symmetric methyltransferase activity 4
Path 2
Term Annotations click to browse term
  molecular_function 19689
    catalytic activity 7147
      transferase activity 2735
        transferase activity, transferring one-carbon groups 235
          methyltransferase activity 226
            S-adenosylmethionine-dependent methyltransferase activity 172
              arginine N-methyltransferase activity 12
                protein-arginine N-methyltransferase activity 12
                  protein-arginine omega-N symmetric methyltransferase activity 4
paths to the root