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ONTOLOGY REPORT - ANNOTATIONS


Term:sperm-egg recognition
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Accession:GO:0035036 term browser browse the term
Definition:The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.
Synonyms:xref: Reactome:R-HSA-1300642 "Sperm Motility And Taxes";   Reactome:R-HSA-2534343 "Interaction With Cumulus Cells And The Zona Pellucida"



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sperm-egg recognition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd9 CD9 molecule involved_in ISS
ISO
GO_REF:0000024
(PMID:10634790), (PMID:10634791), (PMID:21690351)
UniProt
RGD
PMID:10634790 PMID:10634791 PMID:21690351 GO_REF:0000024 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
JBrowse link
G Dcst1 DC-STAMP domain containing 1 involved_in ISO (PMID:33871360) RGD PMID:33871360 NCBI chr 2:174,765,203...174,784,023
Ensembl chr 2:174,765,350...174,781,806
JBrowse link
G Dcst2 DC-STAMP domain containing 2 involved_in ISO (PMID:33871360) RGD PMID:33871360 NCBI chr 2:174,781,806...174,795,834
Ensembl chr 2:174,781,902...174,795,832
JBrowse link
G Folr1 folate receptor alpha involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667
JBrowse link
G Folr2 folate receptor beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724
JBrowse link
G Frey1 Frey regulator of sperm-oocyte fusion 1 involved_in IBA
ISO
GO_REF:0000033
(PMID:35960805), (PMID:36050562)
GO_Central
RGD
PMID:35960805 PMID:36050562 GO_REF:0000033 NCBI chr 3:78,354,303...78,355,055
Ensembl chr 3:78,354,303...78,355,055
JBrowse link
G Izumo1 izumo sperm-oocyte fusion 1 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:39423812)
GO_REF:0000033
(PMID:24739963), (PMID:35960805)
UniProt
RGD
GO_Central
PMID:24739963 PMID:35960805 PMID:39423812 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:96,090,817...96,096,893 JBrowse link
G Izumo1r IZUMO1 receptor, JUNO involved_in IBA
ISO
GO_REF:0000033
(PMID:24739963), (PMID:27416963)
GO_Central
RGD
PMID:24739963 PMID:27416963 GO_REF:0000033 NCBI chr 8:11,744,384...11,748,131
Ensembl chr 8:11,725,863...11,748,465
JBrowse link
G Spaca3 sperm acrosome associated 3 acts_upstream_of_or_within ISO (PMID:15982649) RGD PMID:15982649 NCBI chr10:65,850,618...65,858,090
Ensembl chr10:65,854,893...65,858,094
JBrowse link
G Spaca4 sperm acrosome associated 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:96,195,514...96,196,187
Ensembl chr 1:96,195,315...96,196,237
JBrowse link
G Spaca6 sperm acrosome associated 6 involved_in ISO (PMID:39423812) RGD PMID:39423812 NCBI chr 1:67,345,996...67,365,210
Ensembl chr 1:58,677,797...58,688,562
JBrowse link
G Spesp1 sperm equatorial segment protein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:25761597)
UniProt
RGD
PMID:25761597 GO_REF:0000024 NCBI chr 8:62,751,313...62,766,657
Ensembl chr 8:62,751,297...62,766,718
JBrowse link
G Tmem81 transmembrane protein 81 involved_in ISS
ISO
GO_REF:0000024
(PMID:39423812)
UniProt
RGD
PMID:39423812 GO_REF:0000024 NCBI chr13:43,939,677...43,942,108
Ensembl chr13:43,939,630...43,942,113
JBrowse link
binding of sperm to zona pellucida term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin acts_upstream_of_or_within ISO MGI:1888530|MGI:96945|MGI:98785 (PMID:15685642) RGD PMID:15685642 NCBI chr 7:120,636,581...120,644,474
Ensembl chr 7:120,638,321...120,644,474
JBrowse link
G Adam1a ADAM metallopeptidase domain 1a involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:3052660 (PMID:15194697)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:15194697 GO_REF:0000033 GO_REF:0000107 NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311
JBrowse link
G Adam1b a disintegrin and metallopeptidase domain 1b involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:35,037,161...35,040,574
Ensembl chr12:35,037,343...35,041,082
JBrowse link
G Adam2 ADAM metallopeptidase domain 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:40,242,651...40,284,025
Ensembl chr15:40,242,783...40,283,952
JBrowse link
G Adam32 ADAM metallopeptidase domain 32 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:67,102,384...67,212,163
Ensembl chr16:67,102,320...67,212,161
JBrowse link
G Adam3a ADAM metallopeptidase domain 3A involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:2156167|MGI:6358812 (PMID:15194697), (PMID:16330764), (PMID:32529245)
GO_Central
RGD
PMID:15194697 PMID:16330764 PMID:32529245 GO_REF:0000033 NCBI chr16:74,002,566...74,052,579
Ensembl chr16:67,299,949...67,349,968
JBrowse link
G Adam5 ADAM metallopeptidase domain 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:67,223,095...67,298,733
Ensembl chr16:67,223,143...67,298,737
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A involved_in ISO (PMID:23355646) RGD PMID:23355646 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Arsa arylsulfatase A acts_upstream_of_or_within ISO (PMID:12080020) RGD PMID:12080020 NCBI chr 7:120,542,788...120,547,577
Ensembl chr 7:120,543,362...120,548,783
JBrowse link
G Atp8b3 ATPase phospholipid transporting 8B3 acts_upstream_of_or_within ISO MGI:3039498 (PMID:14975727) RGD PMID:14975727 NCBI chr 7:9,175,544...9,195,449
Ensembl chr 7:9,175,391...9,195,442
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2178779|PR:P10761 (PMID:8089187), (PMID:9374408)
Ensembl
RGD
PMID:8089187 PMID:9374408 GO_REF:0000107 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
JBrowse link
G C4bpa complement component 4 binding protein, alpha acts_upstream_of_or_within
involved_in
ISO (PMID:21880732), (PMID:7604284)
(PMID:11417900), (PMID:7604284)
RGD PMID:7604284 PMID:11417900 PMID:21880732 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:21880732)
Ensembl
RGD
PMID:21880732 GO_REF:0000107 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 acts_upstream_of_or_within ISO (PMID:21880732) RGD PMID:21880732 NCBI chr 2:173,765,701...173,790,353
Ensembl chr 2:173,765,698...173,790,757
JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 acts_upstream_of_or_within ISO (PMID:21880732) RGD PMID:21880732 NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 acts_upstream_of_or_within ISO (PMID:21880732) RGD PMID:21880732 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A acts_upstream_of_or_within ISO (PMID:21880732) RGD PMID:21880732 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 acts_upstream_of_or_within ISO (PMID:21880732) RGD PMID:21880732 NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 acts_upstream_of_or_within ISO (PMID:21880732) RGD PMID:21880732 NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079
JBrowse link
G Clgn calmegin acts_upstream_of_or_within ISO MGI:2156041 (PMID:11784061), (PMID:9177349) RGD PMID:9177349 PMID:11784061 NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758
JBrowse link
G Crisp1 cysteine-rich secretory protein 1 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:5431546 (PMID:21865554)
GO_Central
RGD
PMID:21865554 GO_REF:0000033 NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796
JBrowse link
G Fetub fetuin B involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:23562279)
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:23562279 GO_REF:0000024 GO_REF:0000033 NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135
JBrowse link
G Glipr1l1 GLIPR1 like 1 acts_upstream_of_or_within ISO (PMID:8260598) RGD PMID:8260598 NCBI chr 7:47,550,637...47,577,611
Ensembl chr 7:47,550,631...47,577,617
JBrowse link
G H1f6 H1.6 linker histone, cluster member acts_upstream_of_or_within ISO MGI:87884|MGI:96945|MGI:98785 (PMID:15685642) RGD PMID:15685642 NCBI chr17:41,855,216...41,855,960
Ensembl chr17:41,427,323...41,428,119
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B acts_upstream_of_or_within ISO (PMID:21880732) RGD PMID:21880732 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like acts_upstream_of_or_within ISO (PMID:21880732) RGD PMID:21880732 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Izumo1 izumo sperm-oocyte fusion 1 involved_in IMP
ISO
PMID:35096839
(PMID:35096839)
RGD PMID:35096839 PMID:35096839 RGD:329845585 NCBI chr 1:96,090,817...96,096,893 JBrowse link
G Ly6k lymphocyte antigen 6 family member K acts_upstream_of_or_within ISO MGI:5618096 (PMID:24501175) RGD PMID:24501175 NCBI chr 7:108,572,732...108,575,450
Ensembl chr 7:106,683,753...106,686,372
JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
MGI:2665512 (PMID:16371590)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:16371590 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:9,381,366...9,389,589
Ensembl chr 7:9,381,361...9,389,585
JBrowse link
G Pmis2 PMIS2 transmembrane protein acts_upstream_of_or_within ISO MGI:5429746 (PMID:22621904) RGD PMID:22621904 NCBI chr 1:85,931,220...85,931,993 JBrowse link
G Prss37 serine protease 37 acts_upstream_of_or_within ISO MGI:5520954 (PMID:23553430) RGD PMID:23553430 NCBI chr 4:69,322,977...69,334,555
Ensembl chr 4:69,322,977...69,334,555
JBrowse link
G Prss55 serine protease 55 involved_in ISO (PMID:30032357) RGD PMID:30032357 NCBI chr15:42,489,022...42,507,310
Ensembl chr15:38,312,982...38,323,103
JBrowse link
G Smcp sperm mitochondria-associated cysteine-rich protein acts_upstream_of_or_within ISO MGI:1888530|MGI:87884|MGI:98785 (PMID:15685642) RGD PMID:15685642 NCBI chr 2:180,856,561...180,861,564
Ensembl chr 2:178,160,127...178,166,001
JBrowse link
G Spa17 sperm autoantigenic protein 17 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:37,307,432...37,318,519
Ensembl chr 8:37,307,557...37,318,639
JBrowse link
G Spaca4 sperm acrosome associated 4 involved_in ISO (PMID:37377732)
(PMID:34556579)
RGD PMID:34556579 PMID:37377732 NCBI chr 1:96,195,514...96,196,187
Ensembl chr 1:96,195,315...96,196,237
JBrowse link
G Tcp1 t-complex 1 acts_upstream_of_or_within ISO (PMID:21880732) RGD PMID:21880732 NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839
JBrowse link
G Tex101 testis expressed 101 involved_in ISS
ISO
IBA
IEA
GO_REF:0000024
(PMID:23633567)
GO_REF:0000033
GO_REF:0000107
UniProt
RGD
GO_Central
Ensembl
PMID:23633567 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:89,382,974...89,387,340
Ensembl chr 1:80,255,076...80,259,442
JBrowse link
G Tmprss12 transmembrane serine protease 12 acts_upstream_of_or_within ISO MGI:6455010 (PMID:32529245) RGD PMID:32529245 NCBI chr 7:131,433,158...131,445,806
Ensembl chr 7:131,433,484...131,445,791
JBrowse link
G Tnp2 transition protein 2 acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:1888530|MGI:87884|MGI:96945 (PMID:15685642)
GO_REF:0000107
RGD
Ensembl
PMID:15685642 GO_REF:0000107 NCBI chr10:5,386,735...5,387,463
Ensembl chr10:4,879,812...4,880,538
JBrowse link
G Ubap2l ubiquitin associated protein 2-like involved_in ISO (PMID:19945174) RGD PMID:19945174 NCBI chr 2:175,438,703...175,494,085
Ensembl chr 2:175,438,703...175,493,998
JBrowse link
G Vdac2 voltage-dependent anion channel 2 involved_in ISO (PMID:23355646) RGD PMID:23355646 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
JBrowse link
G Zan zonadhesin acts_upstream_of_or_within ISO (PMID:7592795) RGD PMID:7592795 NCBI chr12:19,215,018...19,322,789
Ensembl chr12:19,215,102...19,271,240
JBrowse link
G Zp1 zona pellucida glycoprotein 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:207,560,881...207,567,261
Ensembl chr 1:207,560,881...207,567,261
JBrowse link
G Zp2 zona pellucida glycoprotein 2 involved_in
acts_upstream_of_or_within
ISS
ISO
IBA
IEA
PMID:22472438
(PMID:22472438)
(PMID:11739644)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:11739644 PMID:22472438 PMID:22472438 GO_REF:0000033 GO_REF:0000107, RGD:8554097 NCBI chr 1:174,513,507...174,525,288
Ensembl chr 1:174,513,511...174,525,288
JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
ISS
GO_REF:0000104
UniProtKB:P21754 (PMID:11417900), (PMID:9609824)
PR:P15535 (PMID:11739644), (PMID:9374408)
GO_REF:0000033
GO_REF:0000024
(PMID:12052239)
UniProtKB:P10761 (PMID:19004505), (PMID:19246320), (PMID:19700799), (PMID:9609824)
UniProt
RGD
GO_Central
PMID:9374408 PMID:9609824 PMID:11417900 PMID:11739644 PMID:12052239 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr12:20,690,547...20,697,513
Ensembl chr12:20,690,547...20,697,513
JBrowse link
G Zp3r zona pellucida 3 receptor IMP RGD PMID:12737520 RGD:1299568 NCBI chr13:42,019,998...42,064,836
Ensembl chr13:42,020,018...42,064,812
JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:63,697,147...63,703,700
Ensembl chr17:59,005,649...59,012,202
JBrowse link
G Zpbp zona pellucida binding protein involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:21880732)
GO_Central
RGD
PMID:21880732 GO_REF:0000033 NCBI chr14:85,830,971...86,030,778
Ensembl chr14:85,833,548...86,033,095
JBrowse link
G Zpbp2 zona pellucida binding protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000002
(PMID:21880732)
GO_REF:0000033
InterPro
RGD
GO_Central
PMID:21880732 GO_REF:0000002 GO_REF:0000033 NCBI chr10:83,558,772...83,567,511
Ensembl chr10:83,559,016...83,567,508
JBrowse link
negative regulation of binding of sperm to zona pellucida term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Astl astacin like metalloendopeptidase involved_in ISO (PMID:22472438) RGD PMID:22472438 NCBI chr 3:114,563,135...114,580,295
Ensembl chr 3:114,563,135...114,578,868
JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISO
ISS
(PMID:18667750)
GO_REF:0000024
RGD
UniProt
PMID:18667750 GO_REF:0000024 NCBI chr12:20,690,547...20,697,513
Ensembl chr12:20,690,547...20,697,513
JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in ISO (PMID:18667750) RGD PMID:18667750 NCBI chr17:63,697,147...63,703,700
Ensembl chr17:59,005,649...59,012,202
JBrowse link
regulation of binding of sperm to zona pellucida term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Paep progestagen associated endometrial protein involved_in ISO (PMID:17192260) RGD PMID:17192260 NCBI chr 3:8,531,136...8,534,430
Ensembl chr 3:8,531,138...8,534,430
JBrowse link
G Zan zonadhesin acts_upstream_of_or_within ISO (PMID:20529856) RGD PMID:20529856 NCBI chr12:19,215,018...19,322,789
Ensembl chr12:19,215,102...19,271,240
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    reproductive process 1970
      fertilization 238
        single fertilization 188
          sperm-egg recognition 62
            binding of sperm to zona pellucida + 51
Path 2
Term Annotations click to browse term
  biological_process 20536
    reproductive process 1970
      sexual reproduction 1250
        fertilization 238
          single fertilization 188
            sperm-egg recognition 62
              binding of sperm to zona pellucida + 51
paths to the root