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ONTOLOGY REPORT - ANNOTATIONS

Term:cortisol metabolic process
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Accession:GO:0034650 term browser browse the term
Definition:The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.
Synonyms:exact_synonym: cortisol metabolism


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cortisol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 involved_in ISO (PMID:8538347) RGD PMID:8538347 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IMP
IEA
ISO		 PMID:19342457
GO_REF:0000107
(PMID:19342457)		 Ensembl
RGD		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IMP PMID:19342457 UniProt PMID:19342457 RGD:4891166 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in ISO (PMID:19342457), (PMID:2022736), (PMID:8506298) RGD PMID:2022736 PMID:8506298 PMID:19342457 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 NOT|involved_in ISO (PMID:9703385)
(PMID:19342457)		 RGD PMID:9703385 PMID:19342457 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO
IEA		 (PMID:19584291)
GO_REF:0000107		 RGD
Ensembl		 PMID:19584291 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590 		JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
IEA
IMP		 (PMID:19342457)
GO_REF:0000107		 RGD
Ensembl		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354 		JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in ISO
IEA		 (PMID:16981135)
GO_REF:0000107		 RGD
Ensembl		 PMID:16981135 GO_REF:0000107 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta involved_in ISO (PMID:24369117) RGD PMID:24369117 NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) involved_in ISO (PMID:18628520), (PMID:23132696)
(PMID:16356929)		 RGD PMID:16356929 PMID:18628520 PMID:23132696 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        ketone metabolic process 245
          cortisol metabolic process 13
            cortisol biosynthetic process + 11
Path 2
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        primary metabolic process 10582
          lipid metabolic process 1452
            steroid metabolic process 360
              glucocorticoid metabolic process 28
                cortisol metabolic process 13
                  cortisol biosynthetic process + 11
paths to the root