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ONTOLOGY REPORT - ANNOTATIONS

Term:cortisol metabolic process
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Accession:GO:0034650 term browser browse the term
Definition:The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties.
Synonyms:exact_synonym: cortisol metabolism


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cortisol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,653,385...108,660,062
Ensembl chr 7:108,653,378...108,660,995
Ensembl chr 7:108,653,378...108,660,995 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 involved_in ISO
IEA 		(PMID:8538347)
GO_REF:0000107 		RGD
Ensembl		 PMID:8538347 GO_REF:0000107 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812 		JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IMP
IEA
ISO 		PMID:19342457
GO_REF:0000107
(PMID:19342457) 		Ensembl
RGD		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IMP PMID:19342457 UniProt PMID:19342457 RGD:4891166 NCBI chr 7:108,653,385...108,660,062
Ensembl chr 7:108,653,378...108,660,995
Ensembl chr 7:108,653,378...108,660,995 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in ISO (PMID:18215163), (PMID:19342457), (PMID:2022736), (PMID:8506298) RGD PMID:2022736 PMID:8506298 PMID:18215163 PMID:19342457 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 NOT|involved_in ISO (PMID:9703385)
(PMID:19342457) 		RGD PMID:9703385 PMID:19342457 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 involved_in ISO
IEA 		(PMID:9452426)
GO_REF:0000107 		RGD
Ensembl		 PMID:9452426 GO_REF:0000107 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:4,028,323...4,031,549
Ensembl chr20:4,028,391...4,031,543 		JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO
IEA 		(PMID:19584291)
GO_REF:0000107 		RGD
Ensembl		 PMID:19584291 GO_REF:0000107 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:85,397,629...85,520,374
Ensembl chr 8:85,396,925...85,520,189 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:175,672,834...175,715,867
Ensembl chr 1:175,672,834...175,715,186 		JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
IMP
IEA 		(PMID:19342457)
GO_REF:0000107 		RGD
Ensembl		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr14:31,213,415...31,233,451
Ensembl chr14:31,213,415...31,248,662 		JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in ISO
IEA 		(PMID:16981135)
GO_REF:0000107 		RGD
Ensembl		 PMID:16981135 GO_REF:0000107 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:154,797,311...154,817,128 		JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta involved_in ISO (PMID:24369117) RGD PMID:24369117 NCBI chr14:1,203,380...1,217,536
Ensembl chr14:1,203,565...1,218,024 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) involved_in ISO
IEA 		(PMID:18628520), (PMID:23132696)
(PMID:16356929)
GO_REF:0000107 		RGD
Ensembl		 PMID:16356929 PMID:18628520 PMID:23132696 GO_REF:0000107 NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:165,721,654...165,753,125 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        ketone metabolic process 265
          cortisol metabolic process 15
            cortisol biosynthetic process + 13
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18484
      metabolic process 11533
        primary metabolic process 10162
          lipid metabolic process 1489
            steroid metabolic process 377
              glucocorticoid metabolic process 30
                cortisol metabolic process 15
                  cortisol biosynthetic process + 13
paths to the root