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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of GTPase activity
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Accession:GO:0034260 term browser browse the term
Definition:Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
Comment:An example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649.
Synonyms:exact_synonym: down regulation of GTPase activity;   downregulation of GTPase activity;   negative regulation of guanosinetriphosphatase activity
 narrow_synonym: down regulation of Rab GTPase activity;   down regulation of Ras GTPase activity;   down regulation of Rho GTPase activity;   down regulation of regulation of Ran GTPase activity;   downregulation of Rab GTPase activity;   downregulation of Ras GTPase activity;   downregulation of Rho GTPase activity;   downregulation of regulation of Ran GTPase activity;   inhibition of GTPase activity;   inhibition of Rab GTPase activity;   inhibition of Ras GTPase activity;   inhibition of Rho GTPase activity;   inhibition of regulation of Ran GTPase activity;   negative regulation of Rab GTPase activity;   negative regulation of Ran GTPase activity;   negative regulation of Ras GTPase activity;   negative regulation of Rho GTPase activity
 alt_id: GO:0034259;   GO:0034261;   GO:1902264;   GO:1902881



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negative regulation of GTPase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IDA RGD PMID:15870074 RGD:2325307 NCBI chr 9:113,102,632...113,122,500 JBrowse link
G Amot angiomotin acts_upstream_of_or_within ISO MGI:2656627 (PMID:17699752) RGD PMID:17699752 NCBI chr  X:108,982,399...109,041,265 JBrowse link
G Arfgef1 ARF guanine nucleotide exchange factor 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:15644318)
UniProt
RGD
PMID:15644318 GO_REF:0000024 NCBI chr 5:13,764,507...13,859,237 JBrowse link
G Arl2 ARF like GTPase 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:10831612)
UniProt
RGD
PMID:10831612 GO_REF:0000024 NCBI chr 1:212,863,422...212,875,425 JBrowse link
G Arrb1 arrestin, beta 1 IDA RGD PMID:1517224 RGD:631708 NCBI chr 1:163,249,654...163,321,711 JBrowse link
G Arrb2 arrestin, beta 2 IDA RGD PMID:1517224 RGD:631708 NCBI chr10:55,645,539...55,653,485 JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 acts_upstream_of_or_within ISO MGI:3055492 (PMID:23716571) RGD PMID:23716571 NCBI chr 8:59,731,912...59,765,408 JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
GO_REF:0000024
(PMID:20154697)
(PMID:19948740)
UniProt
RGD
PMID:19948740 PMID:20154697 GO_REF:0000024 NCBI chr 3:18,915,290...19,086,282 JBrowse link
G Gmip Gem-interacting protein involved_in ISO (PMID:12093360) RGD PMID:12093360 NCBI chr16:19,600,723...19,614,459 JBrowse link
G Gpsm1 G-protein signaling modulator 1 involved_in ISO (PMID:11024022) RGD PMID:11024022 NCBI chr 3:29,538,929...29,565,921 JBrowse link
G Hras HRas proto-oncogene, GTPase involved_in ISO (PMID:23027131) RGD PMID:23027131 NCBI chr 1:205,712,625...205,729,406 JBrowse link
G Klre1 killer cell lectin like receptor E1 involved_in ISO (PMID:22585739) RGD PMID:22585739 NCBI chr 4:163,033,581...163,041,641 JBrowse link
G Klrk1 killer cell lectin like receptor K1 involved_in ISO (PMID:22585739) RGD PMID:22585739 NCBI chr 4:163,079,887...163,092,434 JBrowse link
G Lrch1 leucine rich repeats and calponin homology domain containing 1 involved_in ISO (PMID:28028151) RGD PMID:28028151 NCBI chr15:50,070,605...50,249,724 JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 acts_upstream_of_or_within ISO (PMID:22423108) RGD PMID:22423108 NCBI chr 7:124,706,246...124,867,234 JBrowse link
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO MGI:3608879 (PMID:23716571) RGD PMID:23716571 NCBI chr 3:144,654,563...144,672,831 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 IDA RGD PMID:17662049 RGD:7240703 NCBI chr10:92,090,263...92,152,002 JBrowse link
G Plxnb3 plexin B3 involved_in ISS
ISO
GO_REF:0000024
(PMID:20696765)
UniProt
RGD
PMID:20696765 GO_REF:0000024 NCBI chr  X:156,645,505...156,660,011 JBrowse link
G Ptprn2 protein tyrosine phosphatase, receptor type N2 IDA RGD PMID:16413169 RGD:1625628 NCBI chr 6:137,439,572...138,191,575 JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 acts_upstream_of_or_within ISO MGI:3613572 (PMID:26975711), (PMID:29921611) RGD PMID:26975711 PMID:29921611 NCBI chr 2:227,500,366...227,645,213 JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO (PMID:25074804)
(PMID:19738201), (PMID:25074804)
RGD PMID:19738201 PMID:25074804 NCBI chr 5:152,994,406...153,017,223 JBrowse link
G Rdx radixin involved_in ISO (PMID:22467863) RGD PMID:22467863 NCBI chr 8:61,275,792...61,348,260 JBrowse link
G Rgn regucalcin IMP RGD PMID:11510494 RGD:9590205 NCBI chr  X:1,619,030...1,634,456 JBrowse link
G Rrp1b ribosomal RNA processing 1B involved_in ISO (PMID:18081427) RGD PMID:18081427 NCBI chr20:10,122,825...10,148,404 JBrowse link
G Sh3bp4 SH3-domain binding protein 4 involved_in ISS
ISO
GO_REF:0000024
(PMID:22575674)
UniProt
RGD
PMID:22575674 GO_REF:0000024 NCBI chr 9:89,660,156...89,739,163 JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO (PMID:11585837) RGD PMID:11585837 NCBI chr 2:122,484,995...122,490,008 JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO (PMID:11585837) RGD PMID:11585837 NCBI chr15:82,692,291...82,697,408 JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:10761932)
UniProt
RGD
PMID:10761932 GO_REF:0000024 NCBI chr12:32,052,542...32,061,628 JBrowse link
G Tsc1 TSC complex subunit 1 IMP RGD PMID:15611338 RGD:1601406 NCBI chr 3:32,367,434...32,416,565 JBrowse link
G Ttc8 tetratricopeptide repeat domain 8 acts_upstream_of_or_within ISO (PMID:23716571) RGD PMID:23716571 NCBI chr 6:118,198,186...118,252,422 JBrowse link
G Usp17la2 ubiquitin specific peptidase 17-like a2 involved_in ISO (PMID:19188362) RGD PMID:19188362 NCBI chr 1:159,151,417...159,155,192 JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 acts_upstream_of_or_within ISO (PMID:27400149) RGD PMID:27400149 NCBI chr 4:154,800,590...154,926,147 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    negative regulation of biological process 5816
      negative regulation of GTPase activity 32
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of molecular function 1605
        regulation of catalytic activity 1014
          regulation of hydrolase activity 354
            regulation of GTPase activity 182
              negative regulation of GTPase activity 32
paths to the root